Incidental Mutation 'R4872:Or2l13b'
ID 376692
Institutional Source Beutler Lab
Gene Symbol Or2l13b
Ensembl Gene ENSMUSG00000061361
Gene Name olfactory receptor family 2 subfamily L member 13B
Synonyms GA_x54KRFPKG5P-15979009-15978071, Olfr168, MOR271-1
MMRRC Submission 042482-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.075) question?
Stock # R4872 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 19348730-19349668 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 19349383 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 96 (C96S)
Ref Sequence ENSEMBL: ENSMUSP00000149405 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078554] [ENSMUST00000213480]
AlphaFold Q8VF05
Predicted Effect probably damaging
Transcript: ENSMUST00000078554
AA Change: C96S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000077632
Gene: ENSMUSG00000061361
AA Change: C96S

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5e-50 PFAM
Pfam:7TM_GPCR_Srsx 34 295 3.7e-8 PFAM
Pfam:7tm_1 40 289 3.6e-27 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213480
AA Change: C96S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Meta Mutation Damage Score 0.7634 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.1%
Validation Efficiency 98% (81/83)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcd2 C A 15: 91,075,514 (GRCm39) V100L probably benign Het
Acad11 G A 9: 103,963,465 (GRCm39) probably benign Het
Actb C T 5: 142,891,307 (GRCm39) probably benign Het
Ano9 G A 7: 140,687,117 (GRCm39) A374V probably damaging Het
Baz2b T C 2: 59,773,103 (GRCm39) probably null Het
Bltp3a G T 17: 28,109,110 (GRCm39) D1110Y probably benign Het
Bpifb9b T A 2: 154,155,551 (GRCm39) L350Q probably damaging Het
Cd27 T A 6: 125,211,281 (GRCm39) probably null Het
Cd72 A G 4: 43,449,563 (GRCm39) probably benign Het
Cdadc1 A T 14: 59,801,973 (GRCm39) S516T probably benign Het
Chst5 T A 8: 112,617,192 (GRCm39) I143F possibly damaging Het
Col20a1 T C 2: 180,639,156 (GRCm39) V452A possibly damaging Het
Cox11 C A 11: 90,535,229 (GRCm39) Q227K probably benign Het
Cpa6 A G 1: 10,665,843 (GRCm39) probably null Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dpm2 T C 2: 32,461,203 (GRCm39) probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Frem1 A C 4: 82,881,387 (GRCm39) N1273K probably damaging Het
Fry T C 5: 150,317,704 (GRCm39) probably null Het
Gm10306 G T 4: 94,445,069 (GRCm39) probably benign Het
Gm5565 T C 5: 146,094,913 (GRCm39) T278A probably benign Het
Gm8180 A G 14: 44,019,802 (GRCm39) I40T probably benign Het
Iah1 T C 12: 21,367,426 (GRCm39) V44A probably benign Het
Iqgap3 C T 3: 88,020,435 (GRCm39) P360S probably damaging Het
Klhl28 T A 12: 65,003,896 (GRCm39) I206F possibly damaging Het
Krt13 A G 11: 100,012,332 (GRCm39) probably benign Het
Lipo2 T A 19: 33,726,914 (GRCm39) D41V probably benign Het
Lrig2 C G 3: 104,398,842 (GRCm39) V229L possibly damaging Het
Lrrc32 C T 7: 98,147,727 (GRCm39) T169I probably damaging Het
Lrriq1 T C 10: 103,014,649 (GRCm39) N1053S possibly damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mgat4c G C 10: 102,224,599 (GRCm39) R271P probably damaging Het
Mylk A G 16: 34,735,360 (GRCm39) N780S possibly damaging Het
N4bp1 T C 8: 87,587,676 (GRCm39) T421A probably benign Het
Nat8f1 T C 6: 85,887,295 (GRCm39) T222A probably benign Het
Nsun2 T C 13: 69,691,992 (GRCm39) probably benign Het
Oas2 T A 5: 120,876,599 (GRCm39) D448V probably damaging Het
Or10al7 C A 17: 38,366,467 (GRCm39) V6F probably benign Het
Or5ak22 T C 2: 85,230,772 (GRCm39) Y35C probably damaging Het
Pgm2l1 T A 7: 99,877,204 (GRCm39) L25Q probably damaging Het
Pigp A T 16: 94,166,309 (GRCm39) V133D probably benign Het
Pnkp C T 7: 44,511,827 (GRCm39) S113L probably damaging Het
Pomt2 C T 12: 87,156,881 (GRCm39) D752N possibly damaging Het
Ppat T C 5: 77,074,640 (GRCm39) K65E probably damaging Het
Ptprn2 T C 12: 117,125,314 (GRCm39) L616P probably damaging Het
Rad54l2 A G 9: 106,595,091 (GRCm39) S289P probably damaging Het
Rbm39 G A 2: 156,019,266 (GRCm39) R31C possibly damaging Het
Rhbdf2 C A 11: 116,492,771 (GRCm39) V417L probably benign Het
Rnf157 T A 11: 116,246,298 (GRCm39) E255D possibly damaging Het
Rpl6l A T 10: 110,962,304 (GRCm39) noncoding transcript Het
Sec24c A G 14: 20,743,813 (GRCm39) D1006G probably damaging Het
Sh3bp1 G T 15: 78,792,237 (GRCm39) A401S probably benign Het
Slc17a8 A T 10: 89,412,367 (GRCm39) D539E probably benign Het
Slc38a9 T A 13: 112,826,098 (GRCm39) S136R probably damaging Het
Smoc2 A C 17: 14,589,295 (GRCm39) T255P probably benign Het
Smyd2 T C 1: 189,628,847 (GRCm39) D152G probably damaging Het
Stab1 A G 14: 30,862,350 (GRCm39) V2328A probably damaging Het
Taar2 A G 10: 23,816,591 (GRCm39) I44V probably benign Het
Tbc1d4 T C 14: 101,682,144 (GRCm39) K1251E probably benign Het
Thada G A 17: 84,754,027 (GRCm39) L315F probably damaging Het
Trbv14 T C 6: 41,112,259 (GRCm39) S19P probably benign Het
Ttc39c T C 18: 12,820,173 (GRCm39) probably benign Het
Ttc39d A G 17: 80,524,527 (GRCm39) I395M probably benign Het
Ttn T C 2: 76,548,728 (GRCm39) E31891G probably damaging Het
Ubr3 T C 2: 69,800,527 (GRCm39) V950A probably damaging Het
Usp9y T A Y: 1,307,920 (GRCm39) K2305N probably damaging Het
Vmn1r158 G A 7: 22,490,179 (GRCm39) T10I possibly damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r78 T A 7: 86,603,916 (GRCm39) I698K possibly damaging Het
Vmn2r86 G T 10: 130,289,460 (GRCm39) T145K probably damaging Het
Zfp51 T C 17: 21,684,933 (GRCm39) V516A probably benign Het
Zfp654 A T 16: 64,606,145 (GRCm39) S686T probably benign Het
Zfp846 T A 9: 20,502,111 (GRCm39) C55S probably benign Het
Other mutations in Or2l13b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01635:Or2l13b APN 16 19,348,845 (GRCm39) missense probably benign 0.13
IGL02139:Or2l13b APN 16 19,349,640 (GRCm39) missense probably benign 0.05
IGL02347:Or2l13b APN 16 19,349,529 (GRCm39) missense probably damaging 1.00
IGL03402:Or2l13b APN 16 19,349,667 (GRCm39) start codon destroyed probably null 0.99
R0542:Or2l13b UTSW 16 19,348,732 (GRCm39) makesense probably null
R1496:Or2l13b UTSW 16 19,349,133 (GRCm39) missense possibly damaging 0.94
R1707:Or2l13b UTSW 16 19,348,927 (GRCm39) missense probably benign 0.18
R2006:Or2l13b UTSW 16 19,349,455 (GRCm39) missense probably benign 0.02
R2220:Or2l13b UTSW 16 19,348,895 (GRCm39) nonsense probably null
R3734:Or2l13b UTSW 16 19,349,398 (GRCm39) missense probably damaging 0.99
R4134:Or2l13b UTSW 16 19,349,452 (GRCm39) missense possibly damaging 0.90
R4135:Or2l13b UTSW 16 19,349,452 (GRCm39) missense possibly damaging 0.90
R4538:Or2l13b UTSW 16 19,349,381 (GRCm39) nonsense probably null
R4631:Or2l13b UTSW 16 19,348,891 (GRCm39) nonsense probably null
R4633:Or2l13b UTSW 16 19,349,034 (GRCm39) missense possibly damaging 0.94
R4910:Or2l13b UTSW 16 19,348,768 (GRCm39) missense probably benign 0.03
R4945:Or2l13b UTSW 16 19,349,307 (GRCm39) missense probably benign 0.03
R5345:Or2l13b UTSW 16 19,349,527 (GRCm39) missense probably damaging 1.00
R5847:Or2l13b UTSW 16 19,349,076 (GRCm39) missense probably damaging 0.99
R5899:Or2l13b UTSW 16 19,349,551 (GRCm39) missense probably damaging 1.00
R7074:Or2l13b UTSW 16 19,348,855 (GRCm39) missense possibly damaging 0.90
R7439:Or2l13b UTSW 16 19,349,650 (GRCm39) missense probably benign 0.03
R7723:Or2l13b UTSW 16 19,349,358 (GRCm39) nonsense probably null
R7860:Or2l13b UTSW 16 19,349,167 (GRCm39) missense probably damaging 1.00
R8871:Or2l13b UTSW 16 19,349,536 (GRCm39) missense
R9515:Or2l13b UTSW 16 19,349,026 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTGAGCCCAATATCCAGGATC -3'
(R):5'- AGGGTTGCTTCCACAAAACC -3'

Sequencing Primer
(F):5'- TTGAGCCCAATATCCAGGATCCTATG -3'
(R):5'- CAAACTGGCCTACTACTTATGATGC -3'
Posted On 2016-03-17