Incidental Mutation 'R4875:Krt9'
ID 376738
Institutional Source Beutler Lab
Gene Symbol Krt9
Ensembl Gene ENSMUSG00000051617
Gene Name keratin 9
Synonyms K9, Krt1-9
MMRRC Submission 044392-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4875 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 100077607-100084072 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 100080863 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 330 (I330V)
Ref Sequence ENSEMBL: ENSMUSP00000055255 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059707]
AlphaFold Q6RHW0
Predicted Effect probably benign
Transcript: ENSMUST00000059707
AA Change: I330V

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000055255
Gene: ENSMUSG00000051617
AA Change: I330V

DomainStartEndE-ValueType
low complexity region 6 125 N/A INTRINSIC
Filament 130 442 2.96e-124 SMART
low complexity region 462 716 N/A INTRINSIC
low complexity region 721 737 N/A INTRINSIC
Meta Mutation Damage Score 0.1422 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 95% (57/60)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 81 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak1 A T 2: 32,521,189 (GRCm39) E119D probably benign Het
Alox5 A T 6: 116,390,811 (GRCm39) probably null Het
Atad5 T C 11: 80,011,515 (GRCm39) V1294A probably damaging Het
BB019430 A G 10: 58,539,865 (GRCm39) noncoding transcript Het
Bbs9 T C 9: 22,490,011 (GRCm39) F261L probably benign Het
Catsperb A T 12: 101,554,244 (GRCm39) N646I possibly damaging Het
Ccdc112 A G 18: 46,429,356 (GRCm39) I114T probably damaging Het
Cecr2 T C 6: 120,727,877 (GRCm39) L340P probably damaging Het
Ces2e T A 8: 105,653,817 (GRCm39) V85E probably damaging Het
Cnpy2 C A 10: 128,161,964 (GRCm39) T79K probably damaging Het
Cntn4 G A 6: 106,414,874 (GRCm39) R135H possibly damaging Het
Cpne8 T A 15: 90,532,771 (GRCm39) probably benign Het
Ctso C T 3: 81,849,688 (GRCm39) probably benign Het
Cyp3a16 C A 5: 145,389,659 (GRCm39) M235I probably benign Het
Dll3 A G 7: 27,995,860 (GRCm39) C314R probably damaging Het
Dnah7c A G 1: 46,728,085 (GRCm39) N2928D probably benign Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dqx1 C A 6: 83,037,993 (GRCm39) D460E probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Ehbp1 A G 11: 22,051,164 (GRCm39) C438R probably damaging Het
Ehd3 T G 17: 74,112,299 (GRCm39) V21G probably damaging Het
Ero1b G A 13: 12,619,325 (GRCm39) V440I probably damaging Het
Fpgt G A 3: 154,793,550 (GRCm39) A159V probably damaging Het
Gcn1 T C 5: 115,714,229 (GRCm39) L123P possibly damaging Het
Gm14496 A T 2: 181,639,226 (GRCm39) R439W probably damaging Het
Gm4353 G C 7: 115,683,648 (GRCm39) P49R probably damaging Het
Gsdmc2 C T 15: 63,700,101 (GRCm39) A224T probably benign Het
Helz T A 11: 107,528,560 (GRCm39) probably benign Het
Hnf1a T C 5: 115,108,732 (GRCm39) T58A probably benign Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kcns1 T C 2: 164,010,021 (GRCm39) Y246C probably damaging Het
Kif26b A G 1: 178,742,892 (GRCm39) E549G probably benign Het
Lair1 A T 7: 4,032,033 (GRCm39) S25T probably benign Het
Lhx4 T C 1: 155,581,013 (GRCm39) T171A possibly damaging Het
Luzp2 A G 7: 54,816,996 (GRCm39) I149V possibly damaging Het
Mcoln1 T A 8: 3,557,422 (GRCm39) S143T probably benign Het
Mcph1 A G 8: 18,675,574 (GRCm39) probably null Het
Mgat5 G A 1: 127,396,986 (GRCm39) V578M probably damaging Het
Mis18bp1 G A 12: 65,208,209 (GRCm39) T168M probably benign Het
Mospd4 G T 18: 46,598,804 (GRCm39) noncoding transcript Het
Mroh2a G T 1: 88,182,657 (GRCm39) R1195L possibly damaging Het
Myom1 T C 17: 71,379,114 (GRCm39) V626A probably damaging Het
Naa80 C T 9: 107,460,818 (GRCm39) R238C probably damaging Het
Ncam1 T C 9: 49,418,921 (GRCm39) probably benign Het
Ncor1 AGCTGCTGCTGCTGCTGCTGCTGCTG AGCTGCTGCTGCTGCTGCTGCTG 11: 62,324,437 (GRCm39) probably benign Het
Ndufv1 T C 19: 4,062,653 (GRCm39) probably null Het
Nlrp2 A T 7: 5,301,858 (GRCm39) F211L probably benign Het
Or10a49 A T 7: 108,467,993 (GRCm39) F123I probably damaging Het
Or10q12 T A 19: 13,746,126 (GRCm39) M140K probably damaging Het
Or2ad1 T A 13: 21,326,450 (GRCm39) Y259F probably damaging Het
Osbpl11 G A 16: 33,054,863 (GRCm39) V649I probably benign Het
Pax8 T A 2: 24,331,652 (GRCm39) M144L probably benign Het
Pcnt T C 10: 76,205,688 (GRCm39) T2555A probably benign Het
Plat T A 8: 23,258,466 (GRCm39) I23K probably benign Het
Plpp2 G A 10: 79,366,763 (GRCm39) T51M probably damaging Het
Pnkp C T 7: 44,511,827 (GRCm39) S113L probably damaging Het
Prl7c1 T C 13: 27,957,742 (GRCm39) M233V probably benign Het
Prox1 A C 1: 189,894,319 (GRCm39) F42C probably damaging Het
Pwwp2b A T 7: 138,835,978 (GRCm39) Q473L possibly damaging Het
Rims4 A T 2: 163,707,443 (GRCm39) N127K probably null Het
Scn1a T C 2: 66,158,820 (GRCm39) T367A possibly damaging Het
Slc23a2 A G 2: 131,898,800 (GRCm39) I579T possibly damaging Het
Sp9 T C 2: 73,103,962 (GRCm39) V172A possibly damaging Het
Spta1 T A 1: 174,003,396 (GRCm39) L109Q probably damaging Het
Strap ACCTGCCCTCCT ACCT 6: 137,726,316 (GRCm39) probably benign Het
Synj2 A T 17: 6,038,343 (GRCm39) probably benign Het
Tcstv2c T C 13: 120,616,206 (GRCm39) V15A probably damaging Het
Tgif2-ps2 A G 17: 40,426,274 (GRCm39) noncoding transcript Het
Tnrc18 A T 5: 142,750,932 (GRCm39) M1216K unknown Het
Tpst2 T A 5: 112,457,687 (GRCm39) Y69* probably null Het
Tpx2 C A 2: 152,735,535 (GRCm39) A721E probably benign Het
Trmt1l A G 1: 151,330,755 (GRCm39) T591A probably benign Het
Tuba8 T A 6: 121,203,042 (GRCm39) probably benign Het
Ubiad1 T C 4: 148,528,556 (GRCm39) T118A possibly damaging Het
Unc13c T C 9: 73,424,566 (GRCm39) T2017A probably damaging Het
Vmn1r59 G T 7: 5,457,108 (GRCm39) N217K probably benign Het
Vmn2r87 T C 10: 130,308,367 (GRCm39) I624V probably damaging Het
Wdr4 A G 17: 31,718,129 (GRCm39) V315A probably benign Het
Xpo7 T C 14: 70,914,256 (GRCm39) probably null Het
Zfp827 T A 8: 79,787,403 (GRCm39) W190R probably damaging Het
Zfp971 A G 2: 177,674,940 (GRCm39) T180A probably benign Het
Other mutations in Krt9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00725:Krt9 APN 11 100,080,832 (GRCm39) missense probably damaging 1.00
IGL01695:Krt9 APN 11 100,082,263 (GRCm39) critical splice donor site probably null
IGL02383:Krt9 APN 11 100,082,041 (GRCm39) missense probably damaging 1.00
IGL02529:Krt9 APN 11 100,080,792 (GRCm39) missense probably damaging 0.99
IGL02819:Krt9 APN 11 100,082,346 (GRCm39) missense probably damaging 1.00
droplet UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R5944_Krt9_487 UTSW 11 100,079,265 (GRCm39) missense unknown
G1citation:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R1356:Krt9 UTSW 11 100,079,640 (GRCm39) small insertion probably benign
R1397:Krt9 UTSW 11 100,083,464 (GRCm39) missense probably damaging 1.00
R1498:Krt9 UTSW 11 100,079,195 (GRCm39) nonsense probably null
R1772:Krt9 UTSW 11 100,082,131 (GRCm39) missense probably damaging 0.99
R1871:Krt9 UTSW 11 100,081,614 (GRCm39) missense probably damaging 1.00
R1883:Krt9 UTSW 11 100,079,523 (GRCm39) missense unknown
R1985:Krt9 UTSW 11 100,080,817 (GRCm39) missense probably benign 0.02
R2056:Krt9 UTSW 11 100,082,321 (GRCm39) missense probably damaging 1.00
R2253:Krt9 UTSW 11 100,081,685 (GRCm39) missense possibly damaging 0.83
R2305:Krt9 UTSW 11 100,083,942 (GRCm39) missense unknown
R2875:Krt9 UTSW 11 100,080,031 (GRCm39) nonsense probably null
R3813:Krt9 UTSW 11 100,080,503 (GRCm39) missense probably damaging 1.00
R3874:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4157:Krt9 UTSW 11 100,079,475 (GRCm39) missense unknown
R4762:Krt9 UTSW 11 100,081,675 (GRCm39) missense probably damaging 1.00
R4873:Krt9 UTSW 11 100,080,863 (GRCm39) missense probably benign 0.06
R4923:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R4973:Krt9 UTSW 11 100,079,538 (GRCm39) missense unknown
R5153:Krt9 UTSW 11 100,082,068 (GRCm39) missense probably damaging 0.99
R5658:Krt9 UTSW 11 100,081,593 (GRCm39) missense probably damaging 0.98
R5696:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R5944:Krt9 UTSW 11 100,079,265 (GRCm39) missense unknown
R6147:Krt9 UTSW 11 100,079,665 (GRCm39) missense unknown
R6403:Krt9 UTSW 11 100,080,485 (GRCm39) missense probably damaging 0.99
R6476:Krt9 UTSW 11 100,081,640 (GRCm39) missense probably damaging 1.00
R6822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7159:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7174:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7203:Krt9 UTSW 11 100,081,617 (GRCm39) missense probably damaging 1.00
R7805:Krt9 UTSW 11 100,083,522 (GRCm39) missense possibly damaging 0.85
R7817:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7822:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7834:Krt9 UTSW 11 100,083,492 (GRCm39) missense probably benign 0.06
R7947:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R7977:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R8943:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9092:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9099:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9203:Krt9 UTSW 11 100,079,734 (GRCm39) missense unknown
R9313:Krt9 UTSW 11 100,079,547 (GRCm39) missense unknown
R9361:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9370:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9438:Krt9 UTSW 11 100,079,824 (GRCm39) missense unknown
R9448:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9455:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9620:Krt9 UTSW 11 100,079,186 (GRCm39) missense unknown
R9676:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
R9719:Krt9 UTSW 11 100,079,903 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- CCAGGGCTGATTTCTAGGAAG -3'
(R):5'- ACTGGTCAACCTGGTCAGTG -3'

Sequencing Primer
(F):5'- GGAAACTTCAGAAGGGATGTTCC -3'
(R):5'- GGGACCCAGAATTCAGTAGTATATCC -3'
Posted On 2016-03-17