Incidental Mutation 'R4874:Or5t9'
ID 376761
Institutional Source Beutler Lab
Gene Symbol Or5t9
Ensembl Gene ENSMUSG00000044213
Gene Name olfactory receptor family 5 subfamily T member 9
Synonyms Olfr1094, GA_x6K02T2Q125-48321457-48322449, MOR179-7
MMRRC Submission 042484-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.190) question?
Stock # R4874 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 86659020-86660166 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 86659598 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Glutamine at position 167 (H167Q)
Ref Sequence ENSEMBL: ENSMUSP00000148902 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105211] [ENSMUST00000217509]
AlphaFold Q8VF13
Predicted Effect probably damaging
Transcript: ENSMUST00000105211
AA Change: H167Q

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000100846
Gene: ENSMUSG00000044213
AA Change: H167Q

DomainStartEndE-ValueType
Pfam:7tm_4 43 320 4.6e-52 PFAM
Pfam:7tm_1 53 316 3.5e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217509
AA Change: H167Q

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.1786 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 94% (51/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat G A 8: 60,969,147 (GRCm39) probably null Het
Adamtsl1 A G 4: 86,260,729 (GRCm39) N988S possibly damaging Het
Aph1b A T 9: 66,697,878 (GRCm39) probably null Het
B4galnt3 C A 6: 120,184,167 (GRCm39) R880L probably damaging Het
Bcam T C 7: 19,503,247 (GRCm39) probably benign Het
Cr2 A T 1: 194,858,878 (GRCm39) I14N possibly damaging Het
Dcdc5 T C 2: 106,198,451 (GRCm39) noncoding transcript Het
Dll1 A T 17: 15,590,501 (GRCm39) M405K probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Ern2 T C 7: 121,775,810 (GRCm39) D428G probably benign Het
Esp36 A T 17: 38,727,987 (GRCm39) M98K unknown Het
Foxd2 G T 4: 114,764,768 (GRCm39) H417Q possibly damaging Het
Glrb T C 3: 80,758,349 (GRCm39) N304D possibly damaging Het
Haus3 A G 5: 34,324,972 (GRCm39) V229A probably benign Het
Hpgd A T 8: 56,770,838 (GRCm39) I159F possibly damaging Het
Ighv1-22 T A 12: 114,710,036 (GRCm39) I70F probably benign Het
Il16 A T 7: 83,310,153 (GRCm39) F584L possibly damaging Het
Lamc2 T C 1: 153,030,141 (GRCm39) D167G probably null Het
Megf10 G A 18: 57,426,930 (GRCm39) V1083I probably benign Het
Mertk T C 2: 128,592,079 (GRCm39) S268P probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mki67 T C 7: 135,310,500 (GRCm39) D132G probably damaging Het
Nbas A G 12: 13,371,756 (GRCm39) N419D probably damaging Het
Negr1 T C 3: 156,565,082 (GRCm39) L56S probably damaging Het
Nup214 A G 2: 31,870,596 (GRCm39) probably null Het
Opn5 C G 17: 42,891,610 (GRCm39) A276P probably damaging Het
Or10j5 A G 1: 172,785,166 (GRCm39) E268G probably benign Het
Or2d3 C T 7: 106,490,642 (GRCm39) V225I probably benign Het
Papln G T 12: 83,823,917 (GRCm39) V499L probably benign Het
Pgap1 A T 1: 54,569,296 (GRCm39) W357R probably damaging Het
Pibf1 T C 14: 99,377,992 (GRCm39) Y373H probably damaging Het
Pitpnm1 T C 19: 4,162,252 (GRCm39) probably null Het
Prcd T A 11: 116,550,597 (GRCm39) W3R probably null Het
Prkaa1 A G 15: 5,203,838 (GRCm39) N249S probably benign Het
Reg3b T A 6: 78,349,809 (GRCm39) N116K possibly damaging Het
Rpusd2 T C 2: 118,865,360 (GRCm39) L19P probably benign Het
Rufy1 T C 11: 50,297,277 (GRCm39) T392A possibly damaging Het
Sall3 T C 18: 81,017,188 (GRCm39) K247E probably benign Het
Shank1 C T 7: 43,965,497 (GRCm39) T191M unknown Het
Slit1 C T 19: 41,717,493 (GRCm39) probably null Het
Sorl1 A T 9: 41,975,048 (GRCm39) V520E probably damaging Het
Vmn2r115 T A 17: 23,578,825 (GRCm39) F766Y probably damaging Het
Wdr87-ps A G 7: 29,235,608 (GRCm39) noncoding transcript Het
Zfp644 A G 5: 106,783,279 (GRCm39) S1032P probably damaging Het
Other mutations in Or5t9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02839:Or5t9 APN 2 86,659,712 (GRCm39) missense probably benign
IGL03053:Or5t9 APN 2 86,659,607 (GRCm39) missense possibly damaging 0.93
IGL03168:Or5t9 APN 2 86,659,607 (GRCm39) missense possibly damaging 0.93
IGL02799:Or5t9 UTSW 2 86,659,300 (GRCm39) missense probably damaging 0.99
R0511:Or5t9 UTSW 2 86,659,950 (GRCm39) missense probably benign 0.02
R0944:Or5t9 UTSW 2 86,659,281 (GRCm39) missense probably benign 0.01
R1065:Or5t9 UTSW 2 86,659,888 (GRCm39) missense probably damaging 0.98
R1476:Or5t9 UTSW 2 86,659,542 (GRCm39) missense probably benign 0.31
R1807:Or5t9 UTSW 2 86,659,445 (GRCm39) missense probably benign 0.03
R2865:Or5t9 UTSW 2 86,659,198 (GRCm39) missense probably benign 0.21
R2915:Or5t9 UTSW 2 86,659,570 (GRCm39) missense probably benign 0.02
R3055:Or5t9 UTSW 2 86,659,471 (GRCm39) missense possibly damaging 0.94
R3104:Or5t9 UTSW 2 86,660,035 (GRCm39) missense probably benign 0.03
R4862:Or5t9 UTSW 2 86,659,876 (GRCm39) missense probably damaging 1.00
R5505:Or5t9 UTSW 2 86,659,845 (GRCm39) missense possibly damaging 0.88
R5507:Or5t9 UTSW 2 86,659,661 (GRCm39) missense probably damaging 1.00
R6318:Or5t9 UTSW 2 86,659,998 (GRCm39) missense possibly damaging 0.73
R6538:Or5t9 UTSW 2 86,659,869 (GRCm39) missense possibly damaging 0.55
R8058:Or5t9 UTSW 2 86,660,052 (GRCm39) missense probably benign 0.01
R8285:Or5t9 UTSW 2 86,659,443 (GRCm39) missense probably benign 0.03
R9563:Or5t9 UTSW 2 86,659,098 (GRCm39) start codon destroyed probably null 0.04
Predicted Primers PCR Primer
(F):5'- TGTCACTCCGAAGATGTTGG -3'
(R):5'- AGGATGGTGATGATCTCAATGG -3'

Sequencing Primer
(F):5'- CATACCCTGGTTGTGTAACAGAG -3'
(R):5'- GTGATGATCTCAATGGAGCCTACAC -3'
Posted On 2016-03-17