Incidental Mutation 'R4874:Prcd'
ID 376787
Institutional Source Beutler Lab
Gene Symbol Prcd
Ensembl Gene ENSMUSG00000075410
Gene Name photoreceptor disc component
Synonyms Gm11744
MMRRC Submission 042484-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R4874 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 116544603-116559224 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 116550597 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 3 (W3R)
Ref Sequence ENSEMBL: ENSMUSP00000136058 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106381] [ENSMUST00000116318] [ENSMUST00000148484] [ENSMUST00000178875]
AlphaFold Q00LT2
Predicted Effect probably benign
Transcript: ENSMUST00000106381
AA Change: W90R

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000101989
Gene: ENSMUSG00000075410
AA Change: W90R

DomainStartEndE-ValueType
low complexity region 7 17 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000116318
SMART Domains Protein: ENSMUSP00000112020
Gene: ENSMUSG00000075410

DomainStartEndE-ValueType
Pfam:Rod_cone_degen 1 53 2.8e-40 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000148484
SMART Domains Protein: ENSMUSP00000119671
Gene: ENSMUSG00000075410

DomainStartEndE-ValueType
low complexity region 7 17 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156088
Predicted Effect probably null
Transcript: ENSMUST00000178875
AA Change: W3R
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 94% (51/54)
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat G A 8: 60,969,147 (GRCm39) probably null Het
Adamtsl1 A G 4: 86,260,729 (GRCm39) N988S possibly damaging Het
Aph1b A T 9: 66,697,878 (GRCm39) probably null Het
B4galnt3 C A 6: 120,184,167 (GRCm39) R880L probably damaging Het
Bcam T C 7: 19,503,247 (GRCm39) probably benign Het
Cr2 A T 1: 194,858,878 (GRCm39) I14N possibly damaging Het
Dcdc5 T C 2: 106,198,451 (GRCm39) noncoding transcript Het
Dll1 A T 17: 15,590,501 (GRCm39) M405K probably benign Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Ern2 T C 7: 121,775,810 (GRCm39) D428G probably benign Het
Esp36 A T 17: 38,727,987 (GRCm39) M98K unknown Het
Foxd2 G T 4: 114,764,768 (GRCm39) H417Q possibly damaging Het
Glrb T C 3: 80,758,349 (GRCm39) N304D possibly damaging Het
Haus3 A G 5: 34,324,972 (GRCm39) V229A probably benign Het
Hpgd A T 8: 56,770,838 (GRCm39) I159F possibly damaging Het
Ighv1-22 T A 12: 114,710,036 (GRCm39) I70F probably benign Het
Il16 A T 7: 83,310,153 (GRCm39) F584L possibly damaging Het
Lamc2 T C 1: 153,030,141 (GRCm39) D167G probably null Het
Megf10 G A 18: 57,426,930 (GRCm39) V1083I probably benign Het
Mertk T C 2: 128,592,079 (GRCm39) S268P probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Mki67 T C 7: 135,310,500 (GRCm39) D132G probably damaging Het
Nbas A G 12: 13,371,756 (GRCm39) N419D probably damaging Het
Negr1 T C 3: 156,565,082 (GRCm39) L56S probably damaging Het
Nup214 A G 2: 31,870,596 (GRCm39) probably null Het
Opn5 C G 17: 42,891,610 (GRCm39) A276P probably damaging Het
Or10j5 A G 1: 172,785,166 (GRCm39) E268G probably benign Het
Or2d3 C T 7: 106,490,642 (GRCm39) V225I probably benign Het
Or5t9 T A 2: 86,659,598 (GRCm39) H167Q probably damaging Het
Papln G T 12: 83,823,917 (GRCm39) V499L probably benign Het
Pgap1 A T 1: 54,569,296 (GRCm39) W357R probably damaging Het
Pibf1 T C 14: 99,377,992 (GRCm39) Y373H probably damaging Het
Pitpnm1 T C 19: 4,162,252 (GRCm39) probably null Het
Prkaa1 A G 15: 5,203,838 (GRCm39) N249S probably benign Het
Reg3b T A 6: 78,349,809 (GRCm39) N116K possibly damaging Het
Rpusd2 T C 2: 118,865,360 (GRCm39) L19P probably benign Het
Rufy1 T C 11: 50,297,277 (GRCm39) T392A possibly damaging Het
Sall3 T C 18: 81,017,188 (GRCm39) K247E probably benign Het
Shank1 C T 7: 43,965,497 (GRCm39) T191M unknown Het
Slit1 C T 19: 41,717,493 (GRCm39) probably null Het
Sorl1 A T 9: 41,975,048 (GRCm39) V520E probably damaging Het
Vmn2r115 T A 17: 23,578,825 (GRCm39) F766Y probably damaging Het
Wdr87-ps A G 7: 29,235,608 (GRCm39) noncoding transcript Het
Zfp644 A G 5: 106,783,279 (GRCm39) S1032P probably damaging Het
Other mutations in Prcd
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1721:Prcd UTSW 11 116,548,371 (GRCm39) missense probably benign 0.41
R3176:Prcd UTSW 11 116,550,637 (GRCm39) missense possibly damaging 0.82
R3276:Prcd UTSW 11 116,550,637 (GRCm39) missense possibly damaging 0.82
R4666:Prcd UTSW 11 116,558,990 (GRCm39) unclassified probably benign
R5523:Prcd UTSW 11 116,559,110 (GRCm39) unclassified probably benign
R5918:Prcd UTSW 11 116,548,366 (GRCm39) missense probably damaging 0.98
R8307:Prcd UTSW 11 116,550,199 (GRCm39) missense possibly damaging 0.66
R9570:Prcd UTSW 11 116,550,583 (GRCm39) missense possibly damaging 0.83
Z1176:Prcd UTSW 11 116,550,194 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TGTTTCAGGCCATGGAGCTG -3'
(R):5'- CTCGGAAATGAGAACCCAGG -3'

Sequencing Primer
(F):5'- AGAATTGAGTGTGATCCTGACATG -3'
(R):5'- GAGGCCTAAGCATCCCATGTTC -3'
Posted On 2016-03-17