Incidental Mutation 'R4876:Fasn'
| ID |
376903 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
042485-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4876 (G1)
|
| Quality Score |
204 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 120703138 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1629
(V1629A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000055655]
[ENSMUST00000206589]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: V1629A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: V1629A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055655
AA Change: V1629A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: V1629A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000146541
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000155276
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206589
AA Change: V1627A
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206589
AA Change: V1627A
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Meta Mutation Damage Score |
0.3081 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.4%
- 20x: 92.5%
|
| Validation Efficiency |
99% (97/98) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930562C15Rik |
T |
C |
16: 4,667,536 (GRCm39) |
F309S |
unknown |
Het |
| A630001G21Rik |
C |
T |
1: 85,646,761 (GRCm39) |
V167M |
probably damaging |
Het |
| Anks6 |
C |
T |
4: 47,030,795 (GRCm39) |
G601S |
probably damaging |
Het |
| Ano4 |
A |
G |
10: 88,948,697 (GRCm39) |
F138L |
probably damaging |
Het |
| Aoc1 |
T |
C |
6: 48,883,681 (GRCm39) |
V519A |
possibly damaging |
Het |
| Arhgef37 |
A |
T |
18: 61,631,310 (GRCm39) |
Y558* |
probably null |
Het |
| Atxn3 |
T |
A |
12: 101,914,638 (GRCm39) |
S29C |
probably damaging |
Het |
| Bbs2 |
T |
C |
8: 94,796,788 (GRCm39) |
|
probably benign |
Het |
| Bicral |
A |
T |
17: 47,136,502 (GRCm39) |
I236N |
probably damaging |
Het |
| Cabcoco1 |
A |
G |
10: 68,377,599 (GRCm39) |
V30A |
probably benign |
Het |
| Cap2 |
A |
G |
13: 46,684,497 (GRCm39) |
M1V |
probably null |
Het |
| Ccdc153 |
T |
C |
9: 44,152,305 (GRCm39) |
M1T |
probably null |
Het |
| Ccnf |
A |
T |
17: 24,449,311 (GRCm39) |
V489D |
probably damaging |
Het |
| Cdin1 |
A |
C |
2: 115,500,539 (GRCm39) |
H159P |
probably damaging |
Het |
| Cntnap3 |
T |
C |
13: 64,935,520 (GRCm39) |
T448A |
probably benign |
Het |
| Cpa4 |
G |
A |
6: 30,590,814 (GRCm39) |
D371N |
probably benign |
Het |
| Csl |
T |
A |
10: 99,594,402 (GRCm39) |
Y221F |
possibly damaging |
Het |
| Dalrd3 |
T |
C |
9: 108,448,635 (GRCm39) |
|
probably benign |
Het |
| Dennd4a |
T |
A |
9: 64,803,872 (GRCm39) |
N1070K |
probably benign |
Het |
| Dipk2a |
C |
T |
9: 94,419,630 (GRCm39) |
R100H |
probably damaging |
Het |
| Dmwd |
A |
T |
7: 18,814,472 (GRCm39) |
D374V |
probably damaging |
Het |
| Eea1 |
G |
T |
10: 95,831,475 (GRCm39) |
A189S |
probably benign |
Het |
| Fcgbpl1 |
A |
T |
7: 27,842,225 (GRCm39) |
|
probably benign |
Het |
| Fndc1 |
T |
C |
17: 7,990,471 (GRCm39) |
D1075G |
unknown |
Het |
| Fsip2 |
A |
G |
2: 82,805,202 (GRCm39) |
N507S |
possibly damaging |
Het |
| Gabra5 |
T |
G |
7: 57,063,413 (GRCm39) |
E337A |
probably damaging |
Het |
| Gsg1l |
A |
G |
7: 125,490,841 (GRCm39) |
Y288H |
probably benign |
Het |
| H2-M11 |
A |
T |
17: 36,858,401 (GRCm39) |
D65V |
probably benign |
Het |
| Hmgxb3 |
A |
T |
18: 61,279,606 (GRCm39) |
C736S |
possibly damaging |
Het |
| Hsd3b3 |
A |
T |
3: 98,649,960 (GRCm39) |
I121N |
probably damaging |
Het |
| Ikbke |
GCC |
G |
1: 131,203,004 (GRCm39) |
|
probably null |
Het |
| Il16 |
A |
C |
7: 83,322,302 (GRCm39) |
S338A |
probably benign |
Het |
| Itpr1 |
G |
A |
6: 108,459,867 (GRCm39) |
A2054T |
probably damaging |
Het |
| Lamp3 |
T |
A |
16: 19,474,220 (GRCm39) |
I385F |
probably damaging |
Het |
| Limch1 |
G |
A |
5: 67,039,270 (GRCm39) |
V66I |
possibly damaging |
Het |
| Lmod2 |
A |
G |
6: 24,604,278 (GRCm39) |
R418G |
probably benign |
Het |
| Ly6g6c |
A |
T |
17: 35,288,416 (GRCm39) |
D96V |
probably damaging |
Het |
| Map2k2 |
G |
A |
10: 80,950,947 (GRCm39) |
V131M |
probably damaging |
Het |
| Mapk9 |
T |
C |
11: 49,745,152 (GRCm39) |
V22A |
probably damaging |
Het |
| Mettl2 |
T |
C |
11: 105,019,894 (GRCm39) |
I177T |
probably damaging |
Het |
| Mob4 |
C |
T |
1: 55,191,995 (GRCm39) |
|
probably benign |
Het |
| Mybpc1 |
A |
T |
10: 88,372,286 (GRCm39) |
N781K |
probably benign |
Het |
| Mybpc1 |
T |
C |
10: 88,358,853 (GRCm39) |
I1113V |
probably benign |
Het |
| Myom1 |
A |
G |
17: 71,384,405 (GRCm39) |
T707A |
probably damaging |
Het |
| Ncam2 |
G |
A |
16: 81,287,234 (GRCm39) |
A383T |
probably benign |
Het |
| Nomo1 |
T |
C |
7: 45,715,915 (GRCm39) |
S761P |
probably damaging |
Het |
| Nsd3 |
T |
A |
8: 26,181,161 (GRCm39) |
S921T |
possibly damaging |
Het |
| Omp |
A |
T |
7: 97,794,233 (GRCm39) |
D131E |
probably benign |
Het |
| Or10d1c |
A |
T |
9: 38,893,922 (GRCm39) |
C139* |
probably null |
Het |
| Or4f7d-ps1 |
C |
G |
2: 111,675,040 (GRCm39) |
|
noncoding transcript |
Het |
| Or8d4 |
C |
T |
9: 40,038,514 (GRCm39) |
V248I |
probably damaging |
Het |
| Pard3 |
T |
C |
8: 128,287,950 (GRCm39) |
|
probably benign |
Het |
| Parg |
A |
G |
14: 31,993,625 (GRCm39) |
T286A |
probably damaging |
Het |
| Parp1 |
T |
A |
1: 180,396,600 (GRCm39) |
M1K |
probably null |
Het |
| Pclo |
T |
A |
5: 14,861,694 (GRCm39) |
S4882R |
unknown |
Het |
| Pcnx2 |
C |
T |
8: 126,498,847 (GRCm39) |
E1551K |
probably damaging |
Het |
| Pcyox1l |
A |
G |
18: 61,832,565 (GRCm39) |
Y161H |
probably damaging |
Het |
| Pdzd8 |
A |
T |
19: 59,289,236 (GRCm39) |
C721* |
probably null |
Het |
| Piwil4 |
T |
C |
9: 14,651,761 (GRCm39) |
D90G |
probably benign |
Het |
| Plxdc2 |
T |
A |
2: 16,708,129 (GRCm39) |
C306S |
probably damaging |
Het |
| Plxna2 |
T |
A |
1: 194,326,083 (GRCm39) |
F6I |
probably benign |
Het |
| Prkaa1 |
T |
C |
15: 5,203,886 (GRCm39) |
M265T |
probably benign |
Het |
| Prrc2b |
T |
C |
2: 32,104,212 (GRCm39) |
V1230A |
probably benign |
Het |
| Rfx2 |
T |
C |
17: 57,091,706 (GRCm39) |
E329G |
probably benign |
Het |
| Scg2 |
T |
C |
1: 79,413,636 (GRCm39) |
I322M |
probably damaging |
Het |
| Scly |
T |
A |
1: 91,247,850 (GRCm39) |
N399K |
probably damaging |
Het |
| Sec23b |
T |
A |
2: 144,428,281 (GRCm39) |
|
probably null |
Het |
| Sephs2 |
A |
T |
7: 126,872,219 (GRCm39) |
Y291* |
probably null |
Het |
| Slc45a3 |
T |
C |
1: 131,909,285 (GRCm39) |
I494T |
possibly damaging |
Het |
| Slc6a21 |
C |
A |
7: 44,929,535 (GRCm39) |
Y76* |
probably null |
Het |
| Slfn14 |
T |
A |
11: 83,167,098 (GRCm39) |
I806L |
possibly damaging |
Het |
| Slfn4 |
T |
A |
11: 83,077,844 (GRCm39) |
S211T |
probably benign |
Het |
| Sptbn4 |
A |
G |
7: 27,071,577 (GRCm39) |
V1624A |
probably damaging |
Het |
| Sugp1 |
T |
A |
8: 70,523,834 (GRCm39) |
M567K |
probably damaging |
Het |
| Tmem121 |
A |
T |
12: 113,152,348 (GRCm39) |
M189L |
probably benign |
Het |
| Tmem201 |
A |
G |
4: 149,806,727 (GRCm39) |
S444P |
probably damaging |
Het |
| Tmem63a |
T |
C |
1: 180,800,751 (GRCm39) |
V744A |
probably benign |
Het |
| Tnrc18 |
G |
A |
5: 142,717,380 (GRCm39) |
S2358F |
unknown |
Het |
| Ubash3b |
A |
G |
9: 40,929,405 (GRCm39) |
V404A |
probably benign |
Het |
| Unc13c |
A |
T |
9: 73,656,821 (GRCm39) |
C1127S |
probably damaging |
Het |
| Unc5a |
T |
C |
13: 55,145,042 (GRCm39) |
V253A |
probably benign |
Het |
| Vmn1r-ps123 |
C |
T |
13: 23,180,535 (GRCm39) |
|
noncoding transcript |
Het |
| Wdr74 |
A |
G |
19: 8,716,849 (GRCm39) |
E253G |
possibly damaging |
Het |
| Wwox |
T |
C |
8: 115,174,988 (GRCm39) |
Y107H |
probably damaging |
Het |
| Zdhhc22 |
A |
T |
12: 87,035,012 (GRCm39) |
Y147N |
probably damaging |
Het |
| Zfp131 |
T |
C |
13: 120,250,491 (GRCm39) |
H44R |
possibly damaging |
Het |
| Zfp235 |
A |
G |
7: 23,840,384 (GRCm39) |
T268A |
probably benign |
Het |
| Zfp280d |
T |
C |
9: 72,206,140 (GRCm39) |
|
probably benign |
Het |
| Zfp358 |
T |
C |
8: 3,546,170 (GRCm39) |
S251P |
probably damaging |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0304:Fasn
|
UTSW |
11 |
120,710,762 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCTGAACCTGAGTGGATGAG -3'
(R):5'- TGACAACCTGTCCTAGAGTGGG -3'
Sequencing Primer
(F):5'- AGTGGATGAGCACGGTCTC -3'
(R):5'- ACCTGTCCTAGAGTGGGGTCTAAC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation