Incidental Mutation 'R4887:Ubr3'
| ID |
376944 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr3
|
| Ensembl Gene |
ENSMUSG00000044308 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 3 |
| Synonyms |
1110059H15Rik, 4833421P10Rik, A130030D10Rik, Zfp650 |
| MMRRC Submission |
041979-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R4887 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
69727590-69854357 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 69843475 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Histidine
at position 1572
(Y1572H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107870
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055758]
[ENSMUST00000112251]
[ENSMUST00000152610]
|
| AlphaFold |
Q5U430 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000055758
AA Change: Y1569H
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000060159
Gene: ENSMUSG00000044308
AA Change: Y1569H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
118 |
188 |
1.6e-19 |
PFAM |
|
low complexity region
|
339 |
354 |
N/A |
INTRINSIC |
|
low complexity region
|
570 |
580 |
N/A |
INTRINSIC |
|
low complexity region
|
1016 |
1027 |
N/A |
INTRINSIC |
|
low complexity region
|
1082 |
1101 |
N/A |
INTRINSIC |
|
coiled coil region
|
1167 |
1199 |
N/A |
INTRINSIC |
|
Blast:RING
|
1289 |
1363 |
8e-39 |
BLAST |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112251
AA Change: Y1572H
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000107870
Gene: ENSMUSG00000044308
AA Change: Y1572H
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
40 |
N/A |
INTRINSIC |
|
low complexity region
|
67 |
88 |
N/A |
INTRINSIC |
|
Pfam:zf-UBR
|
119 |
187 |
1.7e-21 |
PFAM |
|
low complexity region
|
338 |
353 |
N/A |
INTRINSIC |
|
low complexity region
|
569 |
579 |
N/A |
INTRINSIC |
|
low complexity region
|
1015 |
1026 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1100 |
N/A |
INTRINSIC |
|
coiled coil region
|
1166 |
1198 |
N/A |
INTRINSIC |
|
Blast:RING
|
1288 |
1362 |
8e-39 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125608
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126165
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150301
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000152610
|
| SMART Domains |
Protein: ENSMUSP00000122027
Gene: ENSMUSG00000044308
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:RING
|
1 |
57 |
1e-34 |
BLAST |
|
SCOP:d1jm7a_
|
20 |
84 |
4e-3 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Homozygous null mice obtained on a coisogenic 129S1 background die early in embryogenesis while those on a mixed 129S1/B6 background are born at a slightly reduced frequency. On a congenic C57BL/6 background, homozygotes display neonatal lethality, impaired suckling and female behavioral anosmia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 94 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310009B15Rik |
A |
C |
1: 138,779,903 (GRCm39) |
Y116* |
probably null |
Het |
| Abtb3 |
C |
T |
10: 85,223,242 (GRCm39) |
T17M |
unknown |
Het |
| Acer3 |
T |
C |
7: 97,906,908 (GRCm39) |
T91A |
possibly damaging |
Het |
| Acsbg3 |
A |
T |
17: 57,183,324 (GRCm39) |
I22F |
possibly damaging |
Het |
| Adam12 |
T |
C |
7: 133,774,550 (GRCm39) |
K20E |
possibly damaging |
Het |
| Adamtsl3 |
T |
C |
7: 82,223,822 (GRCm39) |
V275A |
possibly damaging |
Het |
| Afg1l |
C |
T |
10: 42,330,374 (GRCm39) |
V98I |
probably benign |
Het |
| Ajm1 |
G |
A |
2: 25,469,759 (GRCm39) |
R51C |
possibly damaging |
Het |
| Alpk1 |
C |
T |
3: 127,467,124 (GRCm39) |
G1052R |
probably damaging |
Het |
| Anln |
A |
T |
9: 22,291,484 (GRCm39) |
S115T |
possibly damaging |
Het |
| Apob |
T |
A |
12: 8,063,099 (GRCm39) |
N3827K |
probably damaging |
Het |
| Aqr |
G |
A |
2: 113,980,990 (GRCm39) |
L264F |
probably damaging |
Het |
| Arhgap33 |
T |
C |
7: 30,231,617 (GRCm39) |
S123G |
probably damaging |
Het |
| Arvcf |
C |
T |
16: 18,216,863 (GRCm39) |
R333* |
probably null |
Het |
| Brca2 |
T |
A |
5: 150,480,402 (GRCm39) |
L2724Q |
probably damaging |
Het |
| C2cd6 |
T |
A |
1: 59,133,893 (GRCm39) |
T43S |
probably benign |
Het |
| Cacna1h |
A |
G |
17: 25,596,261 (GRCm39) |
V1920A |
possibly damaging |
Het |
| Capsl |
A |
T |
15: 9,457,858 (GRCm39) |
I26F |
possibly damaging |
Het |
| Card10 |
A |
T |
15: 78,665,724 (GRCm39) |
V673E |
possibly damaging |
Het |
| Catspere2 |
A |
G |
1: 177,931,515 (GRCm39) |
Y478C |
unknown |
Het |
| Ccar1 |
A |
G |
10: 62,588,997 (GRCm39) |
S829P |
unknown |
Het |
| Ccdc121 |
A |
G |
5: 31,643,596 (GRCm39) |
I109V |
probably benign |
Het |
| Cdc42bpa |
T |
C |
1: 179,972,200 (GRCm39) |
M1334T |
possibly damaging |
Het |
| Ceacam2 |
C |
T |
7: 25,220,257 (GRCm39) |
C267Y |
probably benign |
Het |
| Cep68 |
G |
A |
11: 20,189,239 (GRCm39) |
T591M |
probably benign |
Het |
| Chil4 |
T |
C |
3: 106,111,460 (GRCm39) |
K218R |
probably benign |
Het |
| Cldn14 |
G |
T |
16: 93,716,747 (GRCm39) |
T33K |
possibly damaging |
Het |
| Copa |
T |
A |
1: 171,919,843 (GRCm39) |
C140S |
probably benign |
Het |
| Coq6 |
T |
C |
12: 84,419,070 (GRCm39) |
L358P |
probably damaging |
Het |
| Cyfip1 |
C |
T |
7: 55,521,816 (GRCm39) |
P40L |
probably damaging |
Het |
| Dennd2a |
A |
C |
6: 39,474,093 (GRCm39) |
S414A |
probably benign |
Het |
| Dpm1 |
T |
C |
2: 168,059,679 (GRCm39) |
N139S |
probably benign |
Het |
| Dpp7 |
T |
A |
2: 25,242,770 (GRCm39) |
|
probably null |
Het |
| Ednrb |
T |
C |
14: 104,057,447 (GRCm39) |
I372V |
possibly damaging |
Het |
| Edrf1 |
G |
T |
7: 133,260,339 (GRCm39) |
M83I |
probably damaging |
Het |
| Fam135a |
G |
A |
1: 24,063,334 (GRCm39) |
Q1087* |
probably null |
Het |
| Fancg |
T |
C |
4: 43,006,866 (GRCm39) |
T275A |
probably benign |
Het |
| Fbn1 |
T |
A |
2: 125,151,694 (GRCm39) |
H2520L |
probably damaging |
Het |
| Fmn2 |
T |
C |
1: 174,409,527 (GRCm39) |
S587P |
unknown |
Het |
| Foxr2 |
A |
G |
X: 151,913,312 (GRCm39) |
Q61R |
probably damaging |
Het |
| Frrs1 |
A |
G |
3: 116,696,065 (GRCm39) |
*124W |
probably null |
Het |
| Gm7535 |
T |
A |
17: 18,131,333 (GRCm39) |
|
probably benign |
Het |
| H4c1 |
T |
C |
13: 23,944,935 (GRCm39) |
D69G |
probably damaging |
Het |
| Herc3 |
T |
C |
6: 58,864,484 (GRCm39) |
V706A |
probably damaging |
Het |
| Hivep3 |
A |
G |
4: 119,980,131 (GRCm39) |
E1723G |
probably damaging |
Het |
| Igsf9b |
A |
G |
9: 27,233,946 (GRCm39) |
I382V |
probably benign |
Het |
| Ints1 |
G |
T |
5: 139,756,911 (GRCm39) |
T467N |
possibly damaging |
Het |
| Iqca1 |
G |
A |
1: 89,973,423 (GRCm39) |
T783M |
probably damaging |
Het |
| Kng1 |
A |
G |
16: 22,886,448 (GRCm39) |
K131R |
possibly damaging |
Het |
| Krt35 |
T |
C |
11: 99,983,956 (GRCm39) |
Y348C |
probably damaging |
Het |
| Ldlrad3 |
A |
G |
2: 101,943,881 (GRCm39) |
C64R |
probably damaging |
Het |
| Lilrb4b |
C |
T |
10: 51,360,616 (GRCm39) |
A272V |
possibly damaging |
Het |
| Lrrc37 |
T |
C |
11: 103,505,698 (GRCm39) |
H2090R |
probably benign |
Het |
| Ltn1 |
A |
T |
16: 87,195,697 (GRCm39) |
C1276* |
probably null |
Het |
| Matn1 |
G |
A |
4: 130,679,425 (GRCm39) |
A360T |
probably benign |
Het |
| Minpp1 |
G |
A |
19: 32,475,784 (GRCm39) |
V306I |
probably benign |
Het |
| Mkx |
G |
A |
18: 6,992,904 (GRCm39) |
R127W |
probably damaging |
Het |
| Mrpl48 |
G |
T |
7: 100,195,616 (GRCm39) |
|
probably benign |
Het |
| Ms4a2 |
A |
G |
19: 11,595,793 (GRCm39) |
L166S |
possibly damaging |
Het |
| Mtus2 |
T |
A |
5: 148,013,913 (GRCm39) |
Y235* |
probably null |
Het |
| Myh4 |
G |
T |
11: 67,131,880 (GRCm39) |
W113C |
probably damaging |
Het |
| Nav2 |
T |
A |
7: 49,198,182 (GRCm39) |
C1270* |
probably null |
Het |
| Ncoa5 |
A |
G |
2: 164,844,070 (GRCm39) |
L111P |
probably damaging |
Het |
| Nup107 |
T |
C |
10: 117,606,383 (GRCm39) |
Y453C |
probably damaging |
Het |
| Oca2 |
C |
T |
7: 55,980,106 (GRCm39) |
Q604* |
probably null |
Het |
| Or13a19 |
T |
C |
7: 139,903,014 (GRCm39) |
M134T |
probably benign |
Het |
| Or13p5 |
A |
C |
4: 118,591,885 (GRCm39) |
H53P |
probably benign |
Het |
| Or14j10 |
A |
T |
17: 37,934,782 (GRCm39) |
V248D |
probably damaging |
Het |
| Or5p58 |
T |
A |
7: 107,694,303 (GRCm39) |
N158I |
probably benign |
Het |
| Or8g33 |
T |
C |
9: 39,337,531 (GRCm39) |
T279A |
possibly damaging |
Het |
| Pde3a |
G |
T |
6: 141,416,668 (GRCm39) |
G514V |
possibly damaging |
Het |
| Pik3cb |
A |
T |
9: 98,983,381 (GRCm39) |
C76S |
probably damaging |
Het |
| Plk1 |
T |
C |
7: 121,767,828 (GRCm39) |
V411A |
probably damaging |
Het |
| Pole |
C |
T |
5: 110,472,619 (GRCm39) |
P1600L |
probably damaging |
Het |
| Prr36 |
T |
C |
8: 4,260,881 (GRCm39) |
T979A |
probably benign |
Het |
| Rdh7 |
T |
A |
10: 127,721,590 (GRCm39) |
T229S |
probably benign |
Het |
| Rnpepl1 |
A |
T |
1: 92,842,835 (GRCm39) |
T140S |
probably damaging |
Het |
| Rps6kc1 |
A |
T |
1: 190,530,891 (GRCm39) |
S947T |
probably benign |
Het |
| Rtl1 |
A |
G |
12: 109,558,138 (GRCm39) |
F1234L |
probably damaging |
Het |
| Sdc1 |
G |
A |
12: 8,841,708 (GRCm39) |
M279I |
probably damaging |
Het |
| Siae |
T |
C |
9: 37,539,096 (GRCm39) |
L169P |
possibly damaging |
Het |
| Slc22a22 |
C |
T |
15: 57,113,148 (GRCm39) |
V364I |
probably benign |
Het |
| Sltm |
G |
T |
9: 70,496,260 (GRCm39) |
V932F |
probably damaging |
Het |
| Smad1 |
A |
G |
8: 80,076,381 (GRCm39) |
L279P |
probably damaging |
Het |
| Spag17 |
G |
T |
3: 99,958,147 (GRCm39) |
G935V |
probably damaging |
Het |
| Srgap3 |
A |
G |
6: 112,723,895 (GRCm39) |
S546P |
probably damaging |
Het |
| Stxbp5 |
T |
C |
10: 9,684,844 (GRCm39) |
I519V |
probably benign |
Het |
| Syt16 |
A |
T |
12: 74,176,160 (GRCm39) |
I10F |
probably damaging |
Het |
| Trim43b |
C |
G |
9: 88,973,365 (GRCm39) |
G123R |
probably damaging |
Het |
| Umodl1 |
G |
A |
17: 31,227,639 (GRCm39) |
R1324H |
probably benign |
Het |
| Vmn2r44 |
A |
T |
7: 8,380,985 (GRCm39) |
W303R |
probably benign |
Het |
| Wdr93 |
T |
C |
7: 79,435,522 (GRCm39) |
Y684H |
probably damaging |
Het |
| Wnk2 |
G |
A |
13: 49,224,478 (GRCm39) |
R268C |
probably damaging |
Het |
| Zfp438 |
C |
T |
18: 5,213,776 (GRCm39) |
C394Y |
possibly damaging |
Het |
|
| Other mutations in Ubr3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00088:Ubr3
|
APN |
2 |
69,819,154 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL00985:Ubr3
|
APN |
2 |
69,833,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01061:Ubr3
|
APN |
2 |
69,813,569 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL01325:Ubr3
|
APN |
2 |
69,747,441 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL01398:Ubr3
|
APN |
2 |
69,789,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01484:Ubr3
|
APN |
2 |
69,851,888 (GRCm39) |
nonsense |
probably null |
|
|
IGL01599:Ubr3
|
APN |
2 |
69,768,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01616:Ubr3
|
APN |
2 |
69,850,828 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01634:Ubr3
|
APN |
2 |
69,803,916 (GRCm39) |
missense |
probably benign |
|
|
IGL01684:Ubr3
|
APN |
2 |
69,846,502 (GRCm39) |
nonsense |
probably null |
|
|
IGL01810:Ubr3
|
APN |
2 |
69,833,809 (GRCm39) |
splice site |
probably null |
|
|
IGL01813:Ubr3
|
APN |
2 |
69,781,914 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL01994:Ubr3
|
APN |
2 |
69,851,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02188:Ubr3
|
APN |
2 |
69,789,955 (GRCm39) |
nonsense |
probably null |
|
|
IGL02318:Ubr3
|
APN |
2 |
69,809,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02379:Ubr3
|
APN |
2 |
69,778,832 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL02635:Ubr3
|
APN |
2 |
69,850,827 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02858:Ubr3
|
APN |
2 |
69,783,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03140:Ubr3
|
APN |
2 |
69,800,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03343:Ubr3
|
APN |
2 |
69,803,490 (GRCm39) |
splice site |
probably benign |
|
|
Hyrax
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
manatee
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
sea_cow
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0094:Ubr3
|
UTSW |
2 |
69,781,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0122:Ubr3
|
UTSW |
2 |
69,809,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Ubr3
|
UTSW |
2 |
69,781,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0710:Ubr3
|
UTSW |
2 |
69,783,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0787:Ubr3
|
UTSW |
2 |
69,781,765 (GRCm39) |
splice site |
probably benign |
|
|
R1137:Ubr3
|
UTSW |
2 |
69,768,659 (GRCm39) |
splice site |
probably benign |
|
|
R1191:Ubr3
|
UTSW |
2 |
69,851,525 (GRCm39) |
nonsense |
probably null |
|
|
R1416:Ubr3
|
UTSW |
2 |
69,775,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1623:Ubr3
|
UTSW |
2 |
69,808,067 (GRCm39) |
nonsense |
probably null |
|
|
R1735:Ubr3
|
UTSW |
2 |
69,839,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Ubr3
|
UTSW |
2 |
69,846,711 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1793:Ubr3
|
UTSW |
2 |
69,830,895 (GRCm39) |
splice site |
probably benign |
|
|
R1932:Ubr3
|
UTSW |
2 |
69,783,820 (GRCm39) |
splice site |
probably null |
|
|
R2042:Ubr3
|
UTSW |
2 |
69,808,118 (GRCm39) |
nonsense |
probably null |
|
|
R2085:Ubr3
|
UTSW |
2 |
69,784,108 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2090:Ubr3
|
UTSW |
2 |
69,766,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2112:Ubr3
|
UTSW |
2 |
69,808,136 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2173:Ubr3
|
UTSW |
2 |
69,727,743 (GRCm39) |
missense |
probably benign |
|
|
R2215:Ubr3
|
UTSW |
2 |
69,809,661 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2273:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2274:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2275:Ubr3
|
UTSW |
2 |
69,846,685 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2292:Ubr3
|
UTSW |
2 |
69,727,604 (GRCm39) |
unclassified |
probably benign |
|
|
R2447:Ubr3
|
UTSW |
2 |
69,833,724 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Ubr3
|
UTSW |
2 |
69,768,542 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2517:Ubr3
|
UTSW |
2 |
69,766,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2901:Ubr3
|
UTSW |
2 |
69,846,536 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R3109:Ubr3
|
UTSW |
2 |
69,819,184 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3737:Ubr3
|
UTSW |
2 |
69,801,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3793:Ubr3
|
UTSW |
2 |
69,747,525 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R3821:Ubr3
|
UTSW |
2 |
69,824,157 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3918:Ubr3
|
UTSW |
2 |
69,846,474 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4157:Ubr3
|
UTSW |
2 |
69,790,013 (GRCm39) |
splice site |
probably null |
|
|
R4235:Ubr3
|
UTSW |
2 |
69,846,729 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Ubr3
|
UTSW |
2 |
69,768,731 (GRCm39) |
nonsense |
probably null |
|
|
R4544:Ubr3
|
UTSW |
2 |
69,786,437 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4678:Ubr3
|
UTSW |
2 |
69,766,263 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4707:Ubr3
|
UTSW |
2 |
69,768,714 (GRCm39) |
intron |
probably benign |
|
|
R4785:Ubr3
|
UTSW |
2 |
69,789,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4872:Ubr3
|
UTSW |
2 |
69,800,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4920:Ubr3
|
UTSW |
2 |
69,783,212 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4989:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5104:Ubr3
|
UTSW |
2 |
69,768,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5134:Ubr3
|
UTSW |
2 |
69,850,790 (GRCm39) |
splice site |
probably benign |
|
|
R5137:Ubr3
|
UTSW |
2 |
69,803,679 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Ubr3
|
UTSW |
2 |
69,839,506 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5195:Ubr3
|
UTSW |
2 |
69,786,378 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5437:Ubr3
|
UTSW |
2 |
69,774,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5539:Ubr3
|
UTSW |
2 |
69,850,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5781:Ubr3
|
UTSW |
2 |
69,846,588 (GRCm39) |
splice site |
probably null |
|
|
R5809:Ubr3
|
UTSW |
2 |
69,795,855 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R5913:Ubr3
|
UTSW |
2 |
69,851,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5969:Ubr3
|
UTSW |
2 |
69,809,730 (GRCm39) |
nonsense |
probably null |
|
|
R6136:Ubr3
|
UTSW |
2 |
69,824,107 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6140:Ubr3
|
UTSW |
2 |
69,803,673 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6185:Ubr3
|
UTSW |
2 |
69,768,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6220:Ubr3
|
UTSW |
2 |
69,850,819 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6258:Ubr3
|
UTSW |
2 |
69,813,208 (GRCm39) |
splice site |
probably null |
|
|
R6319:Ubr3
|
UTSW |
2 |
69,803,758 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6322:Ubr3
|
UTSW |
2 |
69,786,429 (GRCm39) |
nonsense |
probably null |
|
|
R6470:Ubr3
|
UTSW |
2 |
69,795,804 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6477:Ubr3
|
UTSW |
2 |
69,809,773 (GRCm39) |
nonsense |
probably null |
|
|
R6702:Ubr3
|
UTSW |
2 |
69,786,393 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6709:Ubr3
|
UTSW |
2 |
69,843,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6803:Ubr3
|
UTSW |
2 |
69,766,368 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6806:Ubr3
|
UTSW |
2 |
69,786,308 (GRCm39) |
splice site |
probably benign |
|
|
R6834:Ubr3
|
UTSW |
2 |
69,830,825 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6841:Ubr3
|
UTSW |
2 |
69,850,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6847:Ubr3
|
UTSW |
2 |
69,813,472 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6889:Ubr3
|
UTSW |
2 |
69,774,644 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R7065:Ubr3
|
UTSW |
2 |
69,784,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7102:Ubr3
|
UTSW |
2 |
69,728,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Ubr3
|
UTSW |
2 |
69,851,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Ubr3
|
UTSW |
2 |
69,846,478 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7273:Ubr3
|
UTSW |
2 |
69,809,677 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7314:Ubr3
|
UTSW |
2 |
69,821,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7422:Ubr3
|
UTSW |
2 |
69,783,886 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7584:Ubr3
|
UTSW |
2 |
69,821,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7588:Ubr3
|
UTSW |
2 |
69,801,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7597:Ubr3
|
UTSW |
2 |
69,803,812 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R7697:Ubr3
|
UTSW |
2 |
69,728,030 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7737:Ubr3
|
UTSW |
2 |
69,821,910 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7743:Ubr3
|
UTSW |
2 |
69,774,793 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7946:Ubr3
|
UTSW |
2 |
69,781,739 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7991:Ubr3
|
UTSW |
2 |
69,783,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8071:Ubr3
|
UTSW |
2 |
69,819,220 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8136:Ubr3
|
UTSW |
2 |
69,851,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8296:Ubr3
|
UTSW |
2 |
69,784,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R8313:Ubr3
|
UTSW |
2 |
69,775,478 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8675:Ubr3
|
UTSW |
2 |
69,850,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8834:Ubr3
|
UTSW |
2 |
69,833,785 (GRCm39) |
missense |
probably benign |
|
|
R8975:Ubr3
|
UTSW |
2 |
69,752,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9060:Ubr3
|
UTSW |
2 |
69,839,489 (GRCm39) |
nonsense |
probably null |
|
|
R9153:Ubr3
|
UTSW |
2 |
69,795,822 (GRCm39) |
missense |
|
|
|
R9234:Ubr3
|
UTSW |
2 |
69,727,990 (GRCm39) |
missense |
probably benign |
|
|
R9293:Ubr3
|
UTSW |
2 |
69,727,769 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9312:Ubr3
|
UTSW |
2 |
69,784,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9710:Ubr3
|
UTSW |
2 |
69,727,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9762:Ubr3
|
UTSW |
2 |
69,839,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1088:Ubr3
|
UTSW |
2 |
69,752,711 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,803,550 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,728,010 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Ubr3
|
UTSW |
2 |
69,727,805 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTACAGCTGAAGCGAGG -3'
(R):5'- CCATGACAAATACATACTCTCATTTGC -3'
Sequencing Primer
(F):5'- ACATATTTGGTCGCAGCAGC -3'
(R):5'- GCTTCCATTCCACCTTCAATGGC -3'
|
| Posted On |
2016-03-17 |
Incidental Mutation