Incidental Mutation 'R4890:Mroh9'
ID 377231
Institutional Source Beutler Lab
Gene Symbol Mroh9
Ensembl Gene ENSMUSG00000071890
Gene Name maestro heat-like repeat family member 9
Synonyms 4921528O07Rik, Armc11
MMRRC Submission 042495-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4890 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 162851871-162913239 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 162854093 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 769 (Y769C)
Ref Sequence ENSEMBL: ENSMUSP00000094365 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096608]
AlphaFold G5E8L9
Predicted Effect probably damaging
Transcript: ENSMUST00000096608
AA Change: Y769C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: Y769C

DomainStartEndE-ValueType
SCOP:d1gw5b_ 231 716 2e-8 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195132
Meta Mutation Damage Score 0.2694 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.4%
Validation Efficiency 99% (81/82)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 T C 1: 130,668,725 (GRCm39) probably benign Het
Adcy4 C T 14: 56,016,486 (GRCm39) D322N probably damaging Het
Adgrb3 T C 1: 25,260,908 (GRCm39) N916S probably damaging Het
Aox1 T C 1: 58,373,862 (GRCm39) V841A probably benign Het
Baz2b A T 2: 59,756,383 (GRCm39) M983K probably damaging Het
C2cd2l A G 9: 44,222,430 (GRCm39) F682L probably damaging Het
Ccsap T G 8: 124,572,160 (GRCm39) E114A possibly damaging Het
Cept1 T A 3: 106,413,123 (GRCm39) T201S probably damaging Het
Cfap221 T C 1: 119,883,476 (GRCm39) M232V probably benign Het
Chsy1 A G 7: 65,759,974 (GRCm39) R106G probably benign Het
Cit C T 5: 116,126,182 (GRCm39) probably benign Het
Cldn7 G A 11: 69,857,918 (GRCm39) V42I probably benign Het
Cnnm4 T A 1: 36,511,345 (GRCm39) V191E probably benign Het
Cntf A T 19: 12,741,326 (GRCm39) V178D possibly damaging Het
Ctsz C A 2: 174,270,393 (GRCm39) R263L probably damaging Het
Dclk1 T C 3: 55,429,353 (GRCm39) M407T probably benign Het
Dennd1a A T 2: 38,066,238 (GRCm39) probably benign Het
Dnhd1 A G 7: 105,306,164 (GRCm39) I368V possibly damaging Het
Gak A T 5: 108,728,742 (GRCm39) probably benign Het
Hepacam2 A T 6: 3,487,231 (GRCm39) V42D probably damaging Het
Il1rl2 CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT 1: 40,366,470 (GRCm39) probably benign Het
Insr T A 8: 3,248,234 (GRCm39) Q437L probably benign Het
Itga8 G A 2: 12,198,102 (GRCm39) probably benign Het
Kansl1 A T 11: 104,233,868 (GRCm39) C732S probably benign Het
Kdsr T C 1: 106,680,964 (GRCm39) K78R probably benign Het
Kif14 T C 1: 136,414,868 (GRCm39) S785P possibly damaging Het
Lbr C A 1: 181,645,133 (GRCm39) L506F probably benign Het
Macf1 C A 4: 123,342,031 (GRCm39) C2720F probably damaging Het
Mapt G A 11: 104,218,975 (GRCm39) D738N probably damaging Het
Mylk2 A G 2: 152,762,274 (GRCm39) N515S possibly damaging Het
Myorg G A 4: 41,498,877 (GRCm39) T251M probably benign Het
Nek10 T A 14: 14,860,986 (GRCm38) L513M possibly damaging Het
Nrxn2 A T 19: 6,498,308 (GRCm39) S258C possibly damaging Het
Nudt16l2 A T 9: 105,021,786 (GRCm39) S87T possibly damaging Het
Or52e15 G A 7: 104,645,311 (GRCm39) H267Y probably benign Het
Or5m12 C T 2: 85,735,092 (GRCm39) C102Y possibly damaging Het
Or6c1b C T 10: 129,272,948 (GRCm39) T89I probably benign Het
Or6z5 T A 7: 6,477,848 (GRCm39) C246* probably null Het
Or8c15 G T 9: 38,120,586 (GRCm39) C79F probably benign Het
Osgin2 G A 4: 16,013,739 (GRCm39) probably benign Het
Otud3 G A 4: 138,641,060 (GRCm39) R27W probably damaging Het
Pcare C T 17: 72,059,306 (GRCm39) V124I possibly damaging Het
Pcdhga12 T A 18: 37,901,290 (GRCm39) F707L possibly damaging Het
Pik3r1 T C 13: 101,894,118 (GRCm39) E17G probably damaging Het
Pramel19 A G 4: 101,798,788 (GRCm39) E253G probably damaging Het
Prickle4 AAGAGAGAGAGAGAGA AAGAGAGAGAGAGA 17: 48,000,806 (GRCm39) probably benign Het
Prokr1 G A 6: 87,565,678 (GRCm39) R56W probably benign Het
Ptprz1 G A 6: 23,024,957 (GRCm39) C1731Y probably damaging Het
Rbm15b A T 9: 106,763,028 (GRCm39) F380Y possibly damaging Het
Rfc5 G A 5: 117,524,885 (GRCm39) L56F probably damaging Het
Rhpn2 A T 7: 35,090,228 (GRCm39) M617L probably benign Het
Rusc1 T C 3: 88,995,577 (GRCm39) probably null Het
Sec23ip A G 7: 128,354,634 (GRCm39) N297D probably damaging Het
Sema3c A T 5: 17,880,157 (GRCm39) H259L probably benign Het
Sgsm1 G A 5: 113,428,328 (GRCm39) probably benign Het
Shisal2a A G 4: 108,224,998 (GRCm39) V188A probably benign Het
Sipa1l2 T A 8: 126,218,606 (GRCm39) S244C probably damaging Het
Slc39a5 T C 10: 128,234,316 (GRCm39) I196V probably benign Het
Smim22 G A 16: 4,825,722 (GRCm39) A36T probably damaging Het
Spag6 A G 2: 18,747,588 (GRCm39) I408V probably benign Het
Sult2a5 A G 7: 13,359,311 (GRCm39) I96V probably benign Het
Tmcc2 C A 1: 132,308,517 (GRCm39) A126S probably benign Het
Tsc2 A T 17: 24,819,009 (GRCm39) S1276T probably damaging Het
Ttc21a A G 9: 119,788,103 (GRCm39) S843G probably benign Het
Tubd1 G C 11: 86,443,621 (GRCm39) V110L possibly damaging Het
Ugt1a2 T A 1: 88,128,534 (GRCm39) V59D probably damaging Het
Vmn2r-ps158 A G 7: 42,697,024 (GRCm39) R687G probably damaging Het
Vsig8 T A 1: 172,389,142 (GRCm39) H131Q probably benign Het
Zbtb42 C A 12: 112,646,861 (GRCm39) Y345* probably null Het
Zfp612 T A 8: 110,816,576 (GRCm39) C594* probably null Het
Zfp940 A G 7: 29,544,824 (GRCm39) V361A probably benign Het
Other mutations in Mroh9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00593:Mroh9 APN 1 162,873,350 (GRCm39) missense possibly damaging 0.89
IGL00705:Mroh9 APN 1 162,907,072 (GRCm39) missense probably damaging 1.00
IGL00788:Mroh9 APN 1 162,852,227 (GRCm39) missense probably benign 0.06
IGL00795:Mroh9 APN 1 162,888,191 (GRCm39) missense probably damaging 1.00
IGL00815:Mroh9 APN 1 162,866,700 (GRCm39) missense probably damaging 1.00
IGL01025:Mroh9 APN 1 162,875,435 (GRCm39) missense possibly damaging 0.67
IGL01303:Mroh9 APN 1 162,908,144 (GRCm39) missense probably benign 0.00
IGL01526:Mroh9 APN 1 162,883,172 (GRCm39) missense probably damaging 0.99
IGL01680:Mroh9 APN 1 162,875,551 (GRCm39) splice site probably null
IGL01823:Mroh9 APN 1 162,883,178 (GRCm39) missense probably benign 0.39
IGL02024:Mroh9 APN 1 162,890,071 (GRCm39) missense possibly damaging 0.65
IGL02213:Mroh9 APN 1 162,885,648 (GRCm39) missense probably damaging 1.00
IGL02455:Mroh9 APN 1 162,903,149 (GRCm39) missense probably benign 0.03
IGL02546:Mroh9 APN 1 162,908,145 (GRCm39) missense probably benign 0.04
IGL03059:Mroh9 APN 1 162,852,205 (GRCm39) missense possibly damaging 0.95
IGL03061:Mroh9 APN 1 162,854,071 (GRCm39) missense probably damaging 1.00
IGL03071:Mroh9 APN 1 162,866,766 (GRCm39) missense probably damaging 1.00
R0048:Mroh9 UTSW 1 162,890,056 (GRCm39) missense probably damaging 0.97
R0048:Mroh9 UTSW 1 162,890,056 (GRCm39) missense probably damaging 0.97
R0441:Mroh9 UTSW 1 162,888,331 (GRCm39) missense probably damaging 1.00
R0506:Mroh9 UTSW 1 162,888,205 (GRCm39) missense possibly damaging 0.90
R0629:Mroh9 UTSW 1 162,888,205 (GRCm39) missense possibly damaging 0.90
R0751:Mroh9 UTSW 1 162,893,693 (GRCm39) missense possibly damaging 0.84
R1301:Mroh9 UTSW 1 162,871,552 (GRCm39) critical splice donor site probably null
R1481:Mroh9 UTSW 1 162,854,078 (GRCm39) missense probably damaging 1.00
R1618:Mroh9 UTSW 1 162,852,110 (GRCm39) missense probably benign 0.00
R1647:Mroh9 UTSW 1 162,873,625 (GRCm39) missense probably damaging 1.00
R1648:Mroh9 UTSW 1 162,873,625 (GRCm39) missense probably damaging 1.00
R1668:Mroh9 UTSW 1 162,852,161 (GRCm39) missense possibly damaging 0.52
R1795:Mroh9 UTSW 1 162,884,347 (GRCm39) missense probably damaging 0.97
R1796:Mroh9 UTSW 1 162,873,279 (GRCm39) missense probably damaging 1.00
R1857:Mroh9 UTSW 1 162,866,714 (GRCm39) missense probably damaging 0.98
R1869:Mroh9 UTSW 1 162,854,082 (GRCm39) missense probably damaging 0.97
R1923:Mroh9 UTSW 1 162,903,860 (GRCm39) missense probably damaging 1.00
R2325:Mroh9 UTSW 1 162,854,099 (GRCm39) splice site probably null
R2511:Mroh9 UTSW 1 162,866,514 (GRCm39) missense probably benign 0.13
R2912:Mroh9 UTSW 1 162,871,572 (GRCm39) missense probably damaging 1.00
R2913:Mroh9 UTSW 1 162,871,572 (GRCm39) missense probably damaging 1.00
R2919:Mroh9 UTSW 1 162,884,341 (GRCm39) missense probably damaging 1.00
R2973:Mroh9 UTSW 1 162,884,338 (GRCm39) missense probably damaging 1.00
R3912:Mroh9 UTSW 1 162,893,638 (GRCm39) missense probably damaging 0.97
R4034:Mroh9 UTSW 1 162,908,122 (GRCm39) critical splice donor site probably null
R4551:Mroh9 UTSW 1 162,871,662 (GRCm39) missense probably damaging 0.98
R4656:Mroh9 UTSW 1 162,893,593 (GRCm39) missense probably damaging 1.00
R4662:Mroh9 UTSW 1 162,883,162 (GRCm39) missense probably damaging 0.97
R4743:Mroh9 UTSW 1 162,852,061 (GRCm39) missense probably benign 0.05
R5128:Mroh9 UTSW 1 162,888,329 (GRCm39) missense probably damaging 1.00
R5129:Mroh9 UTSW 1 162,888,329 (GRCm39) missense probably damaging 1.00
R5147:Mroh9 UTSW 1 162,888,329 (GRCm39) missense probably damaging 1.00
R5157:Mroh9 UTSW 1 162,871,690 (GRCm39) missense probably damaging 0.96
R5324:Mroh9 UTSW 1 162,888,329 (GRCm39) missense probably damaging 1.00
R5325:Mroh9 UTSW 1 162,888,329 (GRCm39) missense probably damaging 1.00
R5340:Mroh9 UTSW 1 162,908,156 (GRCm39) start gained probably benign
R6005:Mroh9 UTSW 1 162,903,246 (GRCm39) missense probably damaging 0.99
R6182:Mroh9 UTSW 1 162,893,612 (GRCm39) nonsense probably null
R6414:Mroh9 UTSW 1 162,902,271 (GRCm39) missense probably damaging 1.00
R6477:Mroh9 UTSW 1 162,903,873 (GRCm39) missense probably damaging 1.00
R6540:Mroh9 UTSW 1 162,866,541 (GRCm39) missense possibly damaging 0.87
R6541:Mroh9 UTSW 1 162,885,607 (GRCm39) missense possibly damaging 0.78
R6643:Mroh9 UTSW 1 162,903,130 (GRCm39) missense probably damaging 1.00
R6811:Mroh9 UTSW 1 162,873,610 (GRCm39) missense possibly damaging 0.86
R6830:Mroh9 UTSW 1 162,903,935 (GRCm39) missense probably benign
R7026:Mroh9 UTSW 1 162,888,251 (GRCm39) missense probably benign 0.00
R7052:Mroh9 UTSW 1 162,866,525 (GRCm39) missense possibly damaging 0.92
R7068:Mroh9 UTSW 1 162,866,750 (GRCm39) missense probably damaging 1.00
R7350:Mroh9 UTSW 1 162,903,858 (GRCm39) critical splice donor site probably null
R7545:Mroh9 UTSW 1 162,902,277 (GRCm39) missense possibly damaging 0.56
R7615:Mroh9 UTSW 1 162,873,601 (GRCm39) missense probably benign 0.40
R7743:Mroh9 UTSW 1 162,852,122 (GRCm39) missense probably benign
R7808:Mroh9 UTSW 1 162,866,678 (GRCm39) missense probably damaging 1.00
R8024:Mroh9 UTSW 1 162,866,802 (GRCm39) missense probably benign 0.02
R8062:Mroh9 UTSW 1 162,866,544 (GRCm39) missense probably damaging 1.00
R8145:Mroh9 UTSW 1 162,890,096 (GRCm39) missense probably benign 0.00
R8426:Mroh9 UTSW 1 162,852,294 (GRCm39) missense probably damaging 0.98
R8458:Mroh9 UTSW 1 162,883,250 (GRCm39) missense probably damaging 1.00
R8555:Mroh9 UTSW 1 162,899,595 (GRCm39) splice site probably null
R8960:Mroh9 UTSW 1 162,883,196 (GRCm39) missense probably benign 0.25
R9040:Mroh9 UTSW 1 162,890,069 (GRCm39) missense probably benign 0.06
R9125:Mroh9 UTSW 1 162,875,412 (GRCm39) missense probably benign 0.19
R9154:Mroh9 UTSW 1 162,890,030 (GRCm39) missense
R9596:Mroh9 UTSW 1 162,893,576 (GRCm39) missense probably damaging 0.98
R9612:Mroh9 UTSW 1 162,866,498 (GRCm39) missense probably damaging 1.00
RF003:Mroh9 UTSW 1 162,885,630 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCCTAATCGTAAACCCACTGC -3'
(R):5'- TTGCAAAAGGCTTGTTGAATGC -3'

Sequencing Primer
(F):5'- GCCAACCGATTTCCATTCTGTAAC -3'
(R):5'- GTTGAATGCTTGTAGGACATGAACC -3'
Posted On 2016-03-17