Mutagenetix > Incidental Mutation

Incidental Mutation 'R4890:Olfr893'

377268

Institutional Source

Beutler Lab

Gene Symbol

Olfr893

Ensembl Gene

ENSMUSG00000093901

Gene Name

olfactory receptor 893

Synonyms

GA_x6K02T2PVTD-31889215-31890153, MOR170-11

MMRRC Submission

042495-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.205) question?

Stock #

R4890 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

38208365-38211598 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 38209290 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Phenylalanine at position 79 (C79F)

Ref Sequence

ENSEMBL: ENSMUSP00000091390 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093867] [ENSMUST00000211975]

AlphaFold

K7N678

Predicted Effect

probably benign
Transcript: ENSMUST00000093867
AA Change: C79F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000091390
Gene: ENSMUSG00000093901
AA Change: C79F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	309	1.2e-45	PFAM
Pfam:7tm_1	43	292	8e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211975
AA Change: C77F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Predicted Effect

unknown
Transcript: ENSMUST00000212815
AA Change: C26F

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.7%
20x: 93.4%

Validation Efficiency

99% (81/82)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700080E11Rik	A	T	9: 105,144,587	S87T	possibly damaging	Het
AA986860	T	C	1: 130,740,988		probably benign	Het
Adcy4	C	T	14: 55,779,029	D322N	probably damaging	Het
Adgrb3	T	C	1: 25,221,827	N916S	probably damaging	Het
AI464131	G	A	4: 41,498,877	T251M	probably benign	Het
Aox2	T	C	1: 58,334,703	V841A	probably benign	Het
Baz2b	A	T	2: 59,926,039	M983K	probably damaging	Het
BC027072	C	T	17: 71,752,311	V124I	possibly damaging	Het
C2cd2l	A	G	9: 44,311,133	F682L	probably damaging	Het
Ccsap	T	G	8: 123,845,421	E114A	possibly damaging	Het
Cept1	T	A	3: 106,505,807	T201S	probably damaging	Het
Cfap221	T	C	1: 119,955,746	M232V	probably benign	Het
Chsy1	A	G	7: 66,110,226	R106G	probably benign	Het
Cit	C	T	5: 115,988,123		probably benign	Het
Cldn7	G	A	11: 69,967,092	V42I	probably benign	Het
Cnnm4	T	A	1: 36,472,264	V191E	probably benign	Het
Cntf	A	T	19: 12,763,962	V178D	possibly damaging	Het
Ctsz	C	A	2: 174,428,600	R263L	probably damaging	Het
Dclk1	T	C	3: 55,521,932	M407T	probably benign	Het
Dennd1a	A	T	2: 38,176,226		probably benign	Het
Dnhd1	A	G	7: 105,656,957	I368V	possibly damaging	Het
Fam159a	A	G	4: 108,367,801	V188A	probably benign	Het
Gak	A	T	5: 108,580,876		probably benign	Het
Gm12794	A	G	4: 101,941,591	E253G	probably damaging	Het
Gm9268	A	G	7: 43,047,600	R687G	probably damaging	Het
Hepacam2	A	T	6: 3,487,231	V42D	probably damaging	Het
Il1rl2	CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT	CTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATTTTATT	1: 40,327,310		probably benign	Het
Insr	T	A	8: 3,198,234	Q437L	probably benign	Het
Itga8	G	A	2: 12,193,291		probably benign	Het
Kansl1	A	T	11: 104,343,042	C732S	probably benign	Het
Kdsr	T	C	1: 106,753,234	K78R	probably benign	Het
Kif14	T	C	1: 136,487,130	S785P	possibly damaging	Het
Lbr	C	A	1: 181,817,568	L506F	probably benign	Het
Macf1	C	A	4: 123,448,238	C2720F	probably damaging	Het
Mapt	G	A	11: 104,328,149	D738N	probably damaging	Het
Mroh9	T	C	1: 163,026,524	Y769C	probably damaging	Het
Mylk2	A	G	2: 152,920,354	N515S	possibly damaging	Het
Nek10	T	A	14: 14,860,986	L513M	possibly damaging	Het
Nrxn2	A	T	19: 6,448,278	S258C	possibly damaging	Het
Olfr1024	C	T	2: 85,904,748	C102Y	possibly damaging	Het
Olfr1346	T	A	7: 6,474,849	C246*	probably null	Het
Olfr672	G	A	7: 104,996,104	H267Y	probably benign	Het
Olfr786	C	T	10: 129,437,079	T89I	probably benign	Het
Osgin2	G	A	4: 16,013,739		probably benign	Het
Otud3	G	A	4: 138,913,749	R27W	probably damaging	Het
Pcdhga12	T	A	18: 37,768,237	F707L	possibly damaging	Het
Pik3r1	T	C	13: 101,757,610	E17G	probably damaging	Het
Prickle4	AAGAGAGAGAGAGAGA	AAGAGAGAGAGAGA	17: 47,689,881		probably benign	Het
Prokr1	G	A	6: 87,588,696	R56W	probably benign	Het
Ptprz1	G	A	6: 23,024,958	C1731Y	probably damaging	Het
Rbm15b	A	T	9: 106,885,829	F380Y	possibly damaging	Het
Rfc5	G	A	5: 117,386,820	L56F	probably damaging	Het
Rhpn2	A	T	7: 35,390,803	M617L	probably benign	Het
Rusc1	T	C	3: 89,088,270		probably null	Het
Sec23ip	A	G	7: 128,752,910	N297D	probably damaging	Het
Sema3c	A	T	5: 17,675,159	H259L	probably benign	Het
Sgsm1	G	A	5: 113,280,462		probably benign	Het
Sipa1l2	T	A	8: 125,491,867	S244C	probably damaging	Het
Slc39a5	T	C	10: 128,398,447	I196V	probably benign	Het
Smim22	G	A	16: 5,007,858	A36T	probably damaging	Het
Spag6	A	G	2: 18,742,777	I408V	probably benign	Het
Sult2a5	A	G	7: 13,625,386	I96V	probably benign	Het
Tmcc2	C	A	1: 132,380,779	A126S	probably benign	Het
Tsc2	A	T	17: 24,600,035	S1276T	probably damaging	Het
Ttc21a	A	G	9: 119,959,037	S843G	probably benign	Het
Tubd1	G	C	11: 86,552,795	V110L	possibly damaging	Het
Ugt1a2	T	A	1: 88,200,812	V59D	probably damaging	Het
Vsig8	T	A	1: 172,561,575	H131Q	probably benign	Het
Zbtb42	C	A	12: 112,680,427	Y345*	probably null	Het
Zfp612	T	A	8: 110,089,944	C594*	probably null	Het
Zfp940	A	G	7: 29,845,399	V361A	probably benign	Het

Other mutations in Olfr893

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Olfr893	APN	9	38209238	missense	probably damaging	1.00
IGL00914:Olfr893	APN	9	38209799	splice site	probably null
IGL01563:Olfr893	APN	9	38209701	missense	probably damaging	1.00
IGL01696:Olfr893	APN	9	38209049	unclassified	probably benign
IGL02064:Olfr893	APN	9	38209578	missense	probably damaging	1.00
IGL02605:Olfr893	APN	9	38209236	missense	probably damaging	0.99
R0415:Olfr893	UTSW	9	38209973	missense	probably benign
R0463:Olfr893	UTSW	9	38209064	missense	probably benign	0.00
R0843:Olfr893	UTSW	9	38209283	missense	possibly damaging	0.81
R1441:Olfr893	UTSW	9	38209481	missense	probably damaging	1.00
R1939:Olfr893	UTSW	9	38209429	nonsense	probably null
R2512:Olfr893	UTSW	9	38209374	missense	probably damaging	1.00
R5439:Olfr893	UTSW	9	38209754	missense	probably benign	0.00
R6918:Olfr893	UTSW	9	38209652	missense	possibly damaging	0.95
R7621:Olfr893	UTSW	9	38209151	missense	probably benign	0.09
R7715:Olfr893	UTSW	9	38209479	missense	probably benign	0.30
R7940:Olfr893	UTSW	9	38209200	missense	probably benign	0.00
R8710:Olfr893	UTSW	9	38209770	missense	possibly damaging	0.60
R8712:Olfr893	UTSW	9	38209803	missense	probably benign	0.39
R8882:Olfr893	UTSW	9	38209165	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- ACAACCTGAGTTACGGCTGC -3'
(R):5'- CTTGCAAATCCCATTAAGTAGGACC -3'

Sequencing Primer
(F):5'- CCTGAGTTACGGCTGCCTTTG -3'
(R):5'- TTAAGTAGGACCCAATCATTAGCAGG -3'

Posted On

2016-03-17