Incidental Mutation 'R4892:Or9s27'
ID 377329
Institutional Source Beutler Lab
Gene Symbol Or9s27
Ensembl Gene ENSMUSG00000046300
Gene Name olfactory receptor family 9 subfamily S member 27
Synonyms MOR208-4, Olfr1412, GA_x6K02T2R7CC-81165686-81164721
MMRRC Submission 042497-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4892 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 92516054-92517019 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 92516643 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 197 (N197S)
Ref Sequence ENSEMBL: ENSMUSP00000150943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062964] [ENSMUST00000190505]
AlphaFold Q8VET3
Predicted Effect probably benign
Transcript: ENSMUST00000062964
AA Change: N197S

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000060291
Gene: ENSMUSG00000046300
AA Change: N197S

DomainStartEndE-ValueType
transmembrane domain 10 27 N/A INTRINSIC
Pfam:7tm_4 38 314 7.8e-47 PFAM
Pfam:7tm_1 48 321 1.4e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000190505
AA Change: N197S

PolyPhen 2 Score 0.052 (Sensitivity: 0.94; Specificity: 0.83)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204141
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T C 8: 87,236,431 (GRCm39) T1128A probably benign Het
Apol11a A T 15: 77,401,190 (GRCm39) K226* probably null Het
Atp4a A G 7: 30,411,899 (GRCm39) M45V probably benign Het
Babam1 T A 8: 71,855,696 (GRCm39) M263K probably benign Het
Capn11 GACA GA 17: 45,944,023 (GRCm39) probably null Het
Ccdc190 C A 1: 169,757,678 (GRCm39) L46I possibly damaging Het
Cep131 C T 11: 119,958,883 (GRCm39) R717H probably damaging Het
Cpt1c A G 7: 44,609,012 (GRCm39) F770L probably benign Het
Dhx30 A T 9: 109,914,924 (GRCm39) probably null Het
Dido1 G A 2: 180,316,822 (GRCm39) Q662* probably null Het
Dip2a T C 10: 76,116,593 (GRCm39) E910G probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Fmo3 T A 1: 162,796,300 (GRCm39) I91F probably benign Het
Gdap1 A C 1: 17,230,218 (GRCm39) D217A possibly damaging Het
Grm1 T C 10: 10,595,331 (GRCm39) S766G possibly damaging Het
Kat8 T A 7: 127,514,710 (GRCm39) I123N possibly damaging Het
Kcnt2 C A 1: 140,440,763 (GRCm39) S23* probably null Het
Krt73 G A 15: 101,704,244 (GRCm39) T432I probably damaging Het
Lgals9 T A 11: 78,856,909 (GRCm39) I223L probably benign Het
Mpo T A 11: 87,693,507 (GRCm39) N48K probably benign Het
Myo9a T G 9: 59,731,525 (GRCm39) H632Q probably damaging Het
Or2y1c C A 11: 49,361,043 (GRCm39) Q22K probably benign Het
Prelid2 A G 18: 42,084,209 (GRCm39) F11S possibly damaging Het
Setd1a G T 7: 127,377,696 (GRCm39) V57L probably damaging Het
Sgip1 A G 4: 102,823,431 (GRCm39) D704G probably damaging Het
Spryd3 T C 15: 102,026,537 (GRCm39) E378G probably benign Het
Stk17b A T 1: 53,810,770 (GRCm39) Y112N probably damaging Het
Syndig1 A T 2: 149,741,811 (GRCm39) K132N probably damaging Het
Tcf20 C T 15: 82,738,400 (GRCm39) R1017Q possibly damaging Het
Tenm3 T A 8: 48,729,896 (GRCm39) D1370V probably damaging Het
Tnrc6a C T 7: 122,769,134 (GRCm39) T308I probably damaging Het
Ttc29 T C 8: 79,060,274 (GRCm39) V398A probably damaging Het
Ubr4 A G 4: 139,155,828 (GRCm39) T2218A probably benign Het
Other mutations in Or9s27
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01472:Or9s27 APN 1 92,516,694 (GRCm39) missense possibly damaging 0.52
IGL02177:Or9s27 APN 1 92,516,479 (GRCm39) missense possibly damaging 0.96
IGL02507:Or9s27 APN 1 92,516,648 (GRCm39) missense possibly damaging 0.68
IGL02888:Or9s27 APN 1 92,516,925 (GRCm39) missense probably damaging 1.00
IGL03001:Or9s27 APN 1 92,516,273 (GRCm39) missense probably damaging 1.00
R1771:Or9s27 UTSW 1 92,516,837 (GRCm39) missense probably benign 0.03
R1780:Or9s27 UTSW 1 92,516,111 (GRCm39) missense probably benign 0.01
R2215:Or9s27 UTSW 1 92,516,708 (GRCm39) missense probably benign 0.00
R2437:Or9s27 UTSW 1 92,516,688 (GRCm39) missense possibly damaging 0.46
R3176:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3177:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3276:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R3277:Or9s27 UTSW 1 92,516,535 (GRCm39) missense probably benign 0.32
R4475:Or9s27 UTSW 1 92,516,301 (GRCm39) missense probably benign 0.00
R5910:Or9s27 UTSW 1 92,516,429 (GRCm39) missense probably damaging 1.00
R6808:Or9s27 UTSW 1 92,516,768 (GRCm39) missense probably damaging 0.99
R7130:Or9s27 UTSW 1 92,516,634 (GRCm39) missense probably benign 0.10
R7476:Or9s27 UTSW 1 92,516,986 (GRCm39) missense probably benign
R9695:Or9s27 UTSW 1 92,516,595 (GRCm39) missense probably benign 0.01
Z1088:Or9s27 UTSW 1 92,516,273 (GRCm39) missense probably damaging 1.00
Z1177:Or9s27 UTSW 1 92,516,100 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TTGCTGTGATGGCCTATGACC -3'
(R):5'- ACAGCTGTCAAATGGGAGC -3'

Sequencing Primer
(F):5'- GATGGCCTATGACCGCTTCATG -3'
(R):5'- CCACAGGTAGAGAAGACCTTGTGC -3'
Posted On 2016-03-17