Incidental Mutation 'R4892:Or2y1c'
ID 377353
Institutional Source Beutler Lab
Gene Symbol Or2y1c
Ensembl Gene ENSMUSG00000108167
Gene Name olfactory receptor family 2 subfamily Y member 1C
Synonyms GA_x6K02T2QP88-5964781-5963852, Olfr1386, MOR256-50
MMRRC Submission 042497-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.299) question?
Stock # R4892 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49360881-49362008 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 49361043 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 22 (Q22K)
Ref Sequence ENSEMBL: ENSMUSP00000150448 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000071905] [ENSMUST00000204518] [ENSMUST00000213674]
AlphaFold Q7TQT0
Predicted Effect probably benign
Transcript: ENSMUST00000071905
AA Change: Q22K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000071801
Gene: ENSMUSG00000108167
AA Change: Q22K

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.2e-5 PFAM
Pfam:7tm_1 41 289 7.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204518
AA Change: Q22K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000145320
Gene: ENSMUSG00000108167
AA Change: Q22K

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.2e-49 PFAM
Pfam:7TM_GPCR_Srsx 35 227 1.2e-5 PFAM
Pfam:7tm_1 41 289 7.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213674
AA Change: Q22K

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T C 8: 87,236,431 (GRCm39) T1128A probably benign Het
Apol11a A T 15: 77,401,190 (GRCm39) K226* probably null Het
Atp4a A G 7: 30,411,899 (GRCm39) M45V probably benign Het
Babam1 T A 8: 71,855,696 (GRCm39) M263K probably benign Het
Capn11 GACA GA 17: 45,944,023 (GRCm39) probably null Het
Ccdc190 C A 1: 169,757,678 (GRCm39) L46I possibly damaging Het
Cep131 C T 11: 119,958,883 (GRCm39) R717H probably damaging Het
Cpt1c A G 7: 44,609,012 (GRCm39) F770L probably benign Het
Dhx30 A T 9: 109,914,924 (GRCm39) probably null Het
Dido1 G A 2: 180,316,822 (GRCm39) Q662* probably null Het
Dip2a T C 10: 76,116,593 (GRCm39) E910G probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Fmo3 T A 1: 162,796,300 (GRCm39) I91F probably benign Het
Gdap1 A C 1: 17,230,218 (GRCm39) D217A possibly damaging Het
Grm1 T C 10: 10,595,331 (GRCm39) S766G possibly damaging Het
Kat8 T A 7: 127,514,710 (GRCm39) I123N possibly damaging Het
Kcnt2 C A 1: 140,440,763 (GRCm39) S23* probably null Het
Krt73 G A 15: 101,704,244 (GRCm39) T432I probably damaging Het
Lgals9 T A 11: 78,856,909 (GRCm39) I223L probably benign Het
Mpo T A 11: 87,693,507 (GRCm39) N48K probably benign Het
Myo9a T G 9: 59,731,525 (GRCm39) H632Q probably damaging Het
Or9s27 A G 1: 92,516,643 (GRCm39) N197S probably benign Het
Prelid2 A G 18: 42,084,209 (GRCm39) F11S possibly damaging Het
Setd1a G T 7: 127,377,696 (GRCm39) V57L probably damaging Het
Sgip1 A G 4: 102,823,431 (GRCm39) D704G probably damaging Het
Spryd3 T C 15: 102,026,537 (GRCm39) E378G probably benign Het
Stk17b A T 1: 53,810,770 (GRCm39) Y112N probably damaging Het
Syndig1 A T 2: 149,741,811 (GRCm39) K132N probably damaging Het
Tcf20 C T 15: 82,738,400 (GRCm39) R1017Q possibly damaging Het
Tenm3 T A 8: 48,729,896 (GRCm39) D1370V probably damaging Het
Tnrc6a C T 7: 122,769,134 (GRCm39) T308I probably damaging Het
Ttc29 T C 8: 79,060,274 (GRCm39) V398A probably damaging Het
Ubr4 A G 4: 139,155,828 (GRCm39) T2218A probably benign Het
Other mutations in Or2y1c
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01383:Or2y1c APN 11 49,361,880 (GRCm39) missense probably benign 0.00
IGL02698:Or2y1c APN 11 49,361,690 (GRCm39) missense probably benign 0.02
IGL02727:Or2y1c APN 11 49,361,893 (GRCm39) missense probably benign 0.04
R0826:Or2y1c UTSW 11 49,361,158 (GRCm39) missense probably damaging 1.00
R1512:Or2y1c UTSW 11 49,361,286 (GRCm39) missense probably benign 0.00
R1822:Or2y1c UTSW 11 49,361,795 (GRCm39) missense probably benign 0.03
R1942:Or2y1c UTSW 11 49,360,981 (GRCm39) start codon destroyed probably null 0.98
R2282:Or2y1c UTSW 11 49,361,470 (GRCm39) missense probably damaging 0.96
R4646:Or2y1c UTSW 11 49,361,451 (GRCm39) missense probably benign 0.00
R4762:Or2y1c UTSW 11 49,361,112 (GRCm39) missense probably damaging 1.00
R4968:Or2y1c UTSW 11 49,361,358 (GRCm39) missense probably damaging 1.00
R6882:Or2y1c UTSW 11 49,361,290 (GRCm39) missense probably benign
R7107:Or2y1c UTSW 11 49,361,261 (GRCm39) nonsense probably null
R7300:Or2y1c UTSW 11 49,361,473 (GRCm39) missense probably benign 0.00
R7308:Or2y1c UTSW 11 49,360,754 (GRCm39) start gained probably benign
R8876:Or2y1c UTSW 11 49,361,386 (GRCm39) missense probably damaging 0.97
R8901:Or2y1c UTSW 11 49,361,035 (GRCm39) missense probably damaging 1.00
R9048:Or2y1c UTSW 11 49,361,880 (GRCm39) missense probably benign 0.00
R9641:Or2y1c UTSW 11 49,361,509 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATTCAACAGATGTAGCTGAGCAG -3'
(R):5'- GGTCCTGTCTTGTCCATAGAGG -3'

Sequencing Primer
(F):5'- CTGAGCAGCAACATGGAAATC -3'
(R):5'- CTTGTCCATAGAGGTTGATGAGGAGC -3'
Posted On 2016-03-17