|Institutional Source||Beutler Lab|
|Gene Name||calpain 11|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R4892 (G1)|
|Chromosomal Location||45630204-45659325 bp(-) (GRCm38)|
|Type of Mutation||frame shift|
|DNA Base Change (assembly)||GACA to GA at 45633097 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000113132 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000120717]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Capn11||
(F):5'- TTCGCCATCCTAGGAGAAAC -3'
(R):5'- TCTCCAAGAGGTAACAGGAAGC -3'
(F):5'- TTCGCCATCCTAGGAGAAACAGATG -3'
(R):5'- CAAGACAGGGTTTCTCTGTATAGCC -3'