Incidental Mutation 'R4892:Capn11'
ID 377364
Institutional Source Beutler Lab
Gene Symbol Capn11
Ensembl Gene ENSMUSG00000058626
Gene Name calpain 11
Synonyms
MMRRC Submission 042497-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4892 (G1)
Quality Score 217
Status Not validated
Chromosome 17
Chromosomal Location 45941130-45970251 bp(-) (GRCm39)
Type of Mutation frame shift
DNA Base Change (assembly) GACA to GA at 45944023 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000113132 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000120717]
AlphaFold Q6J756
Predicted Effect probably null
Transcript: ENSMUST00000120717
SMART Domains Protein: ENSMUSP00000113132
Gene: ENSMUSG00000058626

DomainStartEndE-ValueType
CysPc 37 362 2.75e-157 SMART
calpain_III 366 523 2.57e-84 SMART
EFh 590 618 3.91e-4 SMART
EFh 620 648 6.88e-1 SMART
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Calpains constitute a family of intracellular calcium-dependent cysteine proteases. There are eight members in this superfamily. They consist of a variable 80 kDa subunit and an invariant 30 kDa subunit. This calpain protein appears to have protease activity and calcium-binding ability. A similar mouse protein may play a functional role in spermatogenesis and in the regulation of calcium-dependent signal transduction events during meiosis. [provided by RefSeq, Dec 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T C 8: 87,236,431 (GRCm39) T1128A probably benign Het
Apol11a A T 15: 77,401,190 (GRCm39) K226* probably null Het
Atp4a A G 7: 30,411,899 (GRCm39) M45V probably benign Het
Babam1 T A 8: 71,855,696 (GRCm39) M263K probably benign Het
Ccdc190 C A 1: 169,757,678 (GRCm39) L46I possibly damaging Het
Cep131 C T 11: 119,958,883 (GRCm39) R717H probably damaging Het
Cpt1c A G 7: 44,609,012 (GRCm39) F770L probably benign Het
Dhx30 A T 9: 109,914,924 (GRCm39) probably null Het
Dido1 G A 2: 180,316,822 (GRCm39) Q662* probably null Het
Dip2a T C 10: 76,116,593 (GRCm39) E910G probably benign Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Fmo3 T A 1: 162,796,300 (GRCm39) I91F probably benign Het
Gdap1 A C 1: 17,230,218 (GRCm39) D217A possibly damaging Het
Grm1 T C 10: 10,595,331 (GRCm39) S766G possibly damaging Het
Kat8 T A 7: 127,514,710 (GRCm39) I123N possibly damaging Het
Kcnt2 C A 1: 140,440,763 (GRCm39) S23* probably null Het
Krt73 G A 15: 101,704,244 (GRCm39) T432I probably damaging Het
Lgals9 T A 11: 78,856,909 (GRCm39) I223L probably benign Het
Mpo T A 11: 87,693,507 (GRCm39) N48K probably benign Het
Myo9a T G 9: 59,731,525 (GRCm39) H632Q probably damaging Het
Or2y1c C A 11: 49,361,043 (GRCm39) Q22K probably benign Het
Or9s27 A G 1: 92,516,643 (GRCm39) N197S probably benign Het
Prelid2 A G 18: 42,084,209 (GRCm39) F11S possibly damaging Het
Setd1a G T 7: 127,377,696 (GRCm39) V57L probably damaging Het
Sgip1 A G 4: 102,823,431 (GRCm39) D704G probably damaging Het
Spryd3 T C 15: 102,026,537 (GRCm39) E378G probably benign Het
Stk17b A T 1: 53,810,770 (GRCm39) Y112N probably damaging Het
Syndig1 A T 2: 149,741,811 (GRCm39) K132N probably damaging Het
Tcf20 C T 15: 82,738,400 (GRCm39) R1017Q possibly damaging Het
Tenm3 T A 8: 48,729,896 (GRCm39) D1370V probably damaging Het
Tnrc6a C T 7: 122,769,134 (GRCm39) T308I probably damaging Het
Ttc29 T C 8: 79,060,274 (GRCm39) V398A probably damaging Het
Ubr4 A G 4: 139,155,828 (GRCm39) T2218A probably benign Het
Other mutations in Capn11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00339:Capn11 APN 17 45,954,693 (GRCm39) missense probably damaging 1.00
IGL01116:Capn11 APN 17 45,949,806 (GRCm39) unclassified probably benign
IGL01121:Capn11 APN 17 45,950,058 (GRCm39) missense probably benign 0.04
IGL01366:Capn11 APN 17 45,964,126 (GRCm39) missense probably damaging 1.00
IGL01533:Capn11 APN 17 45,943,830 (GRCm39) missense probably benign
IGL01595:Capn11 APN 17 45,950,360 (GRCm39) missense probably benign 0.02
IGL02197:Capn11 APN 17 45,950,782 (GRCm39) missense probably benign 0.14
IGL02683:Capn11 APN 17 45,964,517 (GRCm39) missense probably damaging 1.00
IGL02696:Capn11 APN 17 45,943,635 (GRCm39) missense probably damaging 1.00
IGL02711:Capn11 APN 17 45,943,341 (GRCm39) missense probably damaging 1.00
IGL02900:Capn11 APN 17 45,941,540 (GRCm39) splice site probably null
IGL03033:Capn11 APN 17 45,953,473 (GRCm39) missense probably damaging 1.00
R0883:Capn11 UTSW 17 45,949,807 (GRCm39) unclassified probably benign
R1494:Capn11 UTSW 17 45,954,735 (GRCm39) missense probably damaging 1.00
R1735:Capn11 UTSW 17 45,943,327 (GRCm39) nonsense probably null
R1785:Capn11 UTSW 17 45,949,623 (GRCm39) missense probably benign 0.02
R1952:Capn11 UTSW 17 45,953,885 (GRCm39) missense probably damaging 1.00
R2149:Capn11 UTSW 17 45,944,033 (GRCm39) critical splice acceptor site probably null
R2397:Capn11 UTSW 17 45,964,147 (GRCm39) missense probably damaging 1.00
R2495:Capn11 UTSW 17 45,949,689 (GRCm39) missense probably damaging 0.97
R2516:Capn11 UTSW 17 45,944,725 (GRCm39) missense probably damaging 0.98
R3934:Capn11 UTSW 17 45,945,213 (GRCm39) splice site probably benign
R4016:Capn11 UTSW 17 45,964,682 (GRCm39) missense probably damaging 1.00
R4226:Capn11 UTSW 17 45,953,392 (GRCm39) critical splice donor site probably null
R4227:Capn11 UTSW 17 45,953,392 (GRCm39) critical splice donor site probably null
R4774:Capn11 UTSW 17 45,944,006 (GRCm39) missense probably benign 0.00
R5244:Capn11 UTSW 17 45,944,818 (GRCm39) missense probably damaging 1.00
R5667:Capn11 UTSW 17 45,950,600 (GRCm39) missense possibly damaging 0.87
R5671:Capn11 UTSW 17 45,950,600 (GRCm39) missense possibly damaging 0.87
R5991:Capn11 UTSW 17 45,970,278 (GRCm39) splice site probably null
R6180:Capn11 UTSW 17 45,941,692 (GRCm39) missense probably damaging 1.00
R6193:Capn11 UTSW 17 45,964,430 (GRCm39) critical splice donor site probably null
R6774:Capn11 UTSW 17 45,968,256 (GRCm39) intron probably benign
R7047:Capn11 UTSW 17 45,949,622 (GRCm39) nonsense probably null
R7302:Capn11 UTSW 17 45,954,738 (GRCm39) missense probably damaging 1.00
R7516:Capn11 UTSW 17 45,949,766 (GRCm39) missense possibly damaging 0.95
R7563:Capn11 UTSW 17 45,944,891 (GRCm39) missense probably damaging 0.99
R7718:Capn11 UTSW 17 45,954,707 (GRCm39) missense probably damaging 1.00
R7999:Capn11 UTSW 17 45,950,132 (GRCm39) missense probably damaging 1.00
R8058:Capn11 UTSW 17 45,954,681 (GRCm39) missense probably null 1.00
R8194:Capn11 UTSW 17 45,944,325 (GRCm39) missense probably damaging 0.96
R8737:Capn11 UTSW 17 45,943,801 (GRCm39) missense probably benign 0.01
R8989:Capn11 UTSW 17 45,954,783 (GRCm39) missense probably damaging 1.00
R9037:Capn11 UTSW 17 45,950,357 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTCGCCATCCTAGGAGAAAC -3'
(R):5'- TCTCCAAGAGGTAACAGGAAGC -3'

Sequencing Primer
(F):5'- TTCGCCATCCTAGGAGAAACAGATG -3'
(R):5'- CAAGACAGGGTTTCTCTGTATAGCC -3'
Posted On 2016-03-17