Incidental Mutation 'R4893:Olfr31'
ID377424
Institutional Source Beutler Lab
Gene Symbol Olfr31
Ensembl Gene ENSMUSG00000072707
Gene Nameolfactory receptor 31
SynonymsMOR274-1, GA_x6K02T2PLTE-6714644-6715597, MTPCR53
MMRRC Submission 042498-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.143) question?
Stock #R4893 (G1)
Quality Score225
Status Not validated
Chromosome14
Chromosomal Location14322828-14331791 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 14328852 bp
ZygosityHeterozygous
Amino Acid Change Valine to Alanine at position 247 (V247A)
Ref Sequence ENSEMBL: ENSMUSP00000149019 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100872] [ENSMUST00000206009] [ENSMUST00000217035]
Predicted Effect probably damaging
Transcript: ENSMUST00000100872
AA Change: V247A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000098434
Gene: ENSMUSG00000072707
AA Change: V247A

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 5.7e-50 PFAM
Pfam:7tm_1 40 289 3.1e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000206009
AA Change: V247A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000217035
AA Change: V247A

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224991
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700030J22Rik A G 8: 116,971,165 I401T probably damaging Het
2700049A03Rik G T 12: 71,164,546 E685* probably null Het
2700049A03Rik A T 12: 71,164,547 E685V possibly damaging Het
Acss1 C A 2: 150,629,866 V323F probably damaging Het
Adgrf3 T G 5: 30,200,478 D286A probably benign Het
Akap5 T C 12: 76,329,969 V718A probably damaging Het
Ankk1 A G 9: 49,415,683 V732A probably benign Het
Antxr2 T A 5: 98,004,072 D180V probably damaging Het
Arfgef2 T G 2: 166,866,956 F1063V probably benign Het
Ascl5 A T 1: 136,051,179 I126F probably damaging Het
Aspm T A 1: 139,489,839 probably null Het
Atf6b T C 17: 34,648,612 S100P probably damaging Het
Baz2a C A 10: 128,123,415 H1266Q possibly damaging Het
Cdh4 A T 2: 179,847,419 probably benign Het
Celsr3 C G 9: 108,849,421 S3283C probably damaging Het
Clca4b C T 3: 144,925,173 V309M possibly damaging Het
Cnbd2 T C 2: 156,365,184 Y436H probably damaging Het
Csnk1a1 T C 18: 61,585,301 probably benign Het
Cstf1 C T 2: 172,380,524 R401C probably damaging Het
Cul3 A G 1: 80,288,850 I117T probably damaging Het
Dlgap3 A G 4: 127,194,983 D124G probably damaging Het
Dnah12 A G 14: 26,710,170 D381G possibly damaging Het
Dtna T C 18: 23,569,667 L85P probably damaging Het
Ephb2 A G 4: 136,659,753 I722T probably damaging Het
Epn3 A T 11: 94,491,996 F421I probably damaging Het
Fam160b1 T A 19: 57,381,756 H477Q probably benign Het
Fam83f T A 15: 80,691,955 L269H probably damaging Het
Gata4 G A 14: 63,201,596 A139V probably benign Het
Glce T C 9: 62,068,495 D241G probably benign Het
Gm17728 A T 17: 9,422,231 I58F probably benign Het
Inhba A T 13: 16,026,549 D232V possibly damaging Het
Itgb2l C A 16: 96,427,821 R394L probably benign Het
Klhl14 T C 18: 21,557,935 Y486C probably damaging Het
Krt1 A G 15: 101,850,120 I203T probably damaging Het
Lims2 T C 18: 31,941,811 probably null Het
Lrrc31 T G 3: 30,679,297 I423L probably benign Het
Map7d1 C T 4: 126,233,222 D732N unknown Het
Mau2 A T 8: 70,030,640 probably null Het
Mbtps1 G A 8: 119,518,193 R840W probably damaging Het
Morn3 T C 5: 123,037,682 I214M probably damaging Het
Mrpl44 A G 1: 79,777,865 K63E probably damaging Het
Muc20 T C 16: 32,794,672 T112A possibly damaging Het
Myo6 T A 9: 80,228,877 L94Q probably damaging Het
Nos1 C A 5: 117,952,877 T1423K possibly damaging Het
Olfr166 A G 16: 19,486,903 T22A probably benign Het
Pdzd2 T C 15: 12,385,343 T1114A probably benign Het
Pgm1 T C 5: 64,105,940 V310A probably benign Het
Pi4ka T C 16: 17,377,036 E166G probably benign Het
Pign A T 1: 105,646,711 D303E probably damaging Het
Pik3c3 G T 18: 30,282,000 V149L probably benign Het
Pkd1l3 A T 8: 109,638,394 Y1126F probably benign Het
Pkd2l1 T A 19: 44,153,771 Q516L probably benign Het
Pnliprp2 C A 19: 58,771,421 Q355K probably benign Het
Pnpla7 T A 2: 25,053,676 Y1314* probably null Het
Ppp1r1b A G 11: 98,355,344 T51A possibly damaging Het
Prkcd A T 14: 30,599,425 S544T probably damaging Het
Pusl1 G A 4: 155,889,541 T252I probably benign Het
Rnf44 A G 13: 54,681,932 probably null Het
Slc24a2 A T 4: 87,226,908 V303E probably damaging Het
Slc28a2 T A 2: 122,455,216 probably null Het
Sox8 T C 17: 25,568,989 D162G probably damaging Het
Spag1 T C 15: 36,197,846 probably null Het
Taar6 T C 10: 23,985,400 I83V probably benign Het
Tes T A 6: 17,104,596 C359S probably damaging Het
Vmn2r4 A T 3: 64,406,255 L435H probably damaging Het
Zfhx3 G T 8: 108,957,007 D3693Y unknown Het
Zfp931 G A 2: 178,068,203 P130L probably damaging Het
Zfr T G 15: 12,136,542 V95G unknown Het
Zw10 A G 9: 49,074,025 E587G possibly damaging Het
Other mutations in Olfr31
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02550:Olfr31 APN 14 14328423 missense possibly damaging 0.91
IGL02566:Olfr31 APN 14 14328138 missense probably benign 0.05
IGL02902:Olfr31 APN 14 14328789 missense probably benign
IGL03106:Olfr31 APN 14 14328851 missense probably damaging 0.97
IGL03214:Olfr31 APN 14 14328284 missense probably damaging 0.98
R0333:Olfr31 UTSW 14 14328498 missense probably damaging 1.00
R0828:Olfr31 UTSW 14 14328800 missense probably benign 0.00
R1231:Olfr31 UTSW 14 14328515 missense probably benign 0.00
R1725:Olfr31 UTSW 14 14328977 missense probably damaging 1.00
R1823:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R1824:Olfr31 UTSW 14 14328774 missense probably damaging 1.00
R2026:Olfr31 UTSW 14 14328891 missense probably benign 0.10
R3891:Olfr31 UTSW 14 14328114 start codon destroyed probably null 0.99
R4327:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4328:Olfr31 UTSW 14 14328193 missense probably damaging 1.00
R4608:Olfr31 UTSW 14 14328887 missense probably benign 0.06
R5197:Olfr31 UTSW 14 14328462 missense probably damaging 1.00
R5402:Olfr31 UTSW 14 14328878 missense probably damaging 1.00
R5787:Olfr31 UTSW 14 14328725 missense probably damaging 0.98
R5897:Olfr31 UTSW 14 14328120 missense probably benign 0.00
R7340:Olfr31 UTSW 14 14328401 missense possibly damaging 0.90
R7709:Olfr31 UTSW 14 14328384 missense probably damaging 1.00
R8284:Olfr31 UTSW 14 14329011 missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- CTGAAGTTGGCATGTGCAGAC -3'
(R):5'- AGTCTTTGGACACTCGCTGAG -3'

Sequencing Primer
(F):5'- GTGCAGACACAGCCCTCTATGAG -3'
(R):5'- TTGGACACTCGCTGAGAACTC -3'
Posted On2016-03-17