Incidental Mutation 'R4895:Vmn2r3'
ID 377549
Institutional Source Beutler Lab
Gene Symbol Vmn2r3
Ensembl Gene ENSMUSG00000091572
Gene Name vomeronasal 2, receptor 3
Synonyms EG637004
MMRRC Submission 042499-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4895 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 64166225-64197130 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 64167182 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Asparagine at position 650 (H650N)
Ref Sequence ENSEMBL: ENSMUSP00000134891 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000170244] [ENSMUST00000176328]
AlphaFold H3BJ88
Predicted Effect probably benign
Transcript: ENSMUST00000170244
AA Change: H622N

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000126165
Gene: ENSMUSG00000091572
AA Change: H622N

DomainStartEndE-ValueType
Pfam:ANF_receptor 64 479 4e-64 PFAM
Pfam:NCD3G 521 574 1.1e-17 PFAM
Pfam:7tm_3 605 842 2.9e-75 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176328
AA Change: H650N

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000134891
Gene: ENSMUSG00000091572
AA Change: H650N

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:ANF_receptor 92 507 9.5e-66 PFAM
Pfam:NCD3G 549 602 8.8e-17 PFAM
Pfam:7tm_3 635 869 8.5e-48 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 98% (84/86)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519P11Rik C A 2: 154,454,990 (GRCm39) probably benign Het
Abat G A 16: 8,433,826 (GRCm39) A392T probably benign Het
Abca14 G A 7: 119,846,572 (GRCm39) probably null Het
Abcc6 A T 7: 45,630,414 (GRCm39) L1282Q possibly damaging Het
Acss2 A G 2: 155,392,401 (GRCm39) probably benign Het
Adgrf1 G T 17: 43,621,511 (GRCm39) V583L probably benign Het
Aftph T C 11: 20,646,801 (GRCm39) D825G probably damaging Het
Ahnak T C 19: 8,994,805 (GRCm39) V5363A probably benign Het
Apba3 G A 10: 81,107,117 (GRCm39) probably null Het
Asb13 T C 13: 3,693,589 (GRCm39) Y116H probably damaging Het
Asb4 C A 6: 5,398,266 (GRCm39) T77K probably damaging Het
Atp8b4 A T 2: 126,256,289 (GRCm39) H223Q probably benign Het
Best1 A G 19: 9,970,135 (GRCm39) L159P probably benign Het
Cacna1h A T 17: 25,608,396 (GRCm39) M731K probably damaging Het
Catspere1 T A 1: 177,687,427 (GRCm39) noncoding transcript Het
Cenpv A T 11: 62,418,346 (GRCm39) Y202* probably null Het
Cep57 A T 9: 13,727,449 (GRCm39) probably benign Het
Cfap100 T A 6: 90,383,084 (GRCm39) D363V possibly damaging Het
Cluh A G 11: 74,558,231 (GRCm39) Y1126C probably damaging Het
Cyp2j5 A G 4: 96,551,347 (GRCm39) probably null Het
Dnajc11 T C 4: 152,064,390 (GRCm39) F514L probably damaging Het
Efcab3 C T 11: 104,611,112 (GRCm39) T318I probably benign Het
Efcab3 T A 11: 105,008,227 (GRCm39) probably benign Het
Efcab3 A G 11: 104,640,496 (GRCm39) D1026G probably damaging Het
Eif2b4 T G 5: 31,350,298 (GRCm39) Q8P probably benign Het
Epha6 A T 16: 59,486,918 (GRCm39) V1043E probably benign Het
Gm11562 G T 11: 99,511,141 (GRCm39) Q20K unknown Het
Gm14415 A T 2: 176,796,114 (GRCm39) noncoding transcript Het
Gm5431 A G 11: 48,779,855 (GRCm39) S634P probably damaging Het
Gpld1 C A 13: 25,163,711 (GRCm39) N501K probably damaging Het
Gsn C T 2: 35,192,590 (GRCm39) R513C probably damaging Het
Gulp1 T C 1: 44,827,757 (GRCm39) F300L probably benign Het
H2aj T C 6: 136,785,660 (GRCm39) V108A possibly damaging Het
Haus3 T C 5: 34,325,414 (GRCm39) R82G probably benign Het
Herc2 G A 7: 55,872,734 (GRCm39) R4424H probably damaging Het
Hmcn1 T A 1: 150,553,130 (GRCm39) Q2520L probably benign Het
Hs2st1 T C 3: 144,171,014 (GRCm39) I53V probably benign Het
Inpp5e C T 2: 26,287,924 (GRCm39) R624Q probably damaging Het
Ints8 G T 4: 11,230,367 (GRCm39) C491* probably null Het
Itpkb C A 1: 180,241,460 (GRCm39) A710D probably damaging Het
Kcnk4 A C 19: 6,905,784 (GRCm39) probably null Het
Kmt2d T C 15: 98,742,368 (GRCm39) probably benign Het
Lamb3 C T 1: 193,014,622 (GRCm39) R594* probably null Het
Map3k20 A G 2: 72,232,700 (GRCm39) probably benign Het
Maz A T 7: 126,624,472 (GRCm39) probably null Het
Mtr T C 13: 12,231,752 (GRCm39) T651A probably benign Het
Nbeal1 A G 1: 60,332,062 (GRCm39) E2252G probably damaging Het
Ndufa10 A G 1: 92,397,618 (GRCm39) Y61H probably damaging Het
Npat T A 9: 53,481,789 (GRCm39) L1166M probably damaging Het
Or12e1 A C 2: 87,022,192 (GRCm39) I54L probably benign Het
Or4c108 A T 2: 88,804,055 (GRCm39) F60Y probably benign Het
Or5ak20 A T 2: 85,183,341 (GRCm39) *310K probably null Het
Or5b97 C T 19: 12,878,251 (GRCm39) V298M probably damaging Het
Or5h22 C T 16: 58,895,020 (GRCm39) C141Y probably benign Het
Or5p66 A C 7: 107,885,802 (GRCm39) I177S probably damaging Het
Pcdhb3 T C 18: 37,434,759 (GRCm39) F242L probably damaging Het
Phip A G 9: 82,841,648 (GRCm39) V57A probably benign Het
Plekha7 A T 7: 115,788,626 (GRCm39) probably null Het
Pot1a A C 6: 25,753,205 (GRCm39) F444V probably damaging Het
Ppm1a C T 12: 72,831,126 (GRCm39) P217L probably damaging Het
Prepl A G 17: 85,388,494 (GRCm39) F203S probably damaging Het
Prl8a1 T C 13: 27,759,513 (GRCm39) I175V probably benign Het
Ranbp6 A T 19: 29,787,175 (GRCm39) I1059N possibly damaging Het
Rhag A G 17: 41,122,242 (GRCm39) Q59R probably benign Het
Sema4c A C 1: 36,592,651 (GRCm39) probably null Het
Sf3b3 T C 8: 111,542,656 (GRCm39) D902G probably benign Het
Tbc1d23 A G 16: 57,019,220 (GRCm39) probably null Het
Tbrg1 A T 9: 37,566,375 (GRCm39) I54N probably damaging Het
Tchh A T 3: 93,352,993 (GRCm39) E811V unknown Het
Tenm3 T A 8: 48,754,006 (GRCm39) D799V probably damaging Het
Tlr5 T C 1: 182,801,764 (GRCm39) L342P probably damaging Het
Tppp C T 13: 74,178,996 (GRCm39) R146* probably null Het
Trpm4 A T 7: 44,967,482 (GRCm39) M574K probably damaging Het
Uggt1 A T 1: 36,195,345 (GRCm39) F1288Y probably damaging Het
Uggt2 T A 14: 119,256,298 (GRCm39) K1124N probably damaging Het
Usf3 A C 16: 44,041,459 (GRCm39) S1980R possibly damaging Het
Vav2 T C 2: 27,208,973 (GRCm39) D100G probably damaging Het
Vmn2r59 T A 7: 41,695,218 (GRCm39) Y398F probably damaging Het
Zfp619 A G 7: 39,187,396 (GRCm39) D1142G possibly damaging Het
Zfp933 G A 4: 147,910,892 (GRCm39) R235* probably null Het
Other mutations in Vmn2r3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Vmn2r3 APN 3 64,167,304 (GRCm39) missense probably damaging 1.00
IGL01468:Vmn2r3 APN 3 64,182,382 (GRCm39) missense possibly damaging 0.57
IGL02032:Vmn2r3 APN 3 64,182,476 (GRCm39) missense possibly damaging 0.95
IGL02405:Vmn2r3 APN 3 64,178,620 (GRCm39) splice site probably benign
IGL02640:Vmn2r3 APN 3 64,194,816 (GRCm39) missense probably benign
IGL02719:Vmn2r3 APN 3 64,183,031 (GRCm39) missense probably damaging 1.00
IGL02746:Vmn2r3 APN 3 64,167,239 (GRCm39) missense possibly damaging 0.74
IGL02952:Vmn2r3 APN 3 64,186,256 (GRCm39) missense probably damaging 1.00
IGL03390:Vmn2r3 APN 3 64,182,767 (GRCm39) missense possibly damaging 0.55
G1citation:Vmn2r3 UTSW 3 64,194,876 (GRCm39) missense probably benign 0.30
R0023:Vmn2r3 UTSW 3 64,182,787 (GRCm39) missense probably damaging 0.99
R0433:Vmn2r3 UTSW 3 64,183,054 (GRCm39) missense possibly damaging 0.51
R0647:Vmn2r3 UTSW 3 64,183,046 (GRCm39) missense probably damaging 1.00
R1071:Vmn2r3 UTSW 3 64,182,697 (GRCm39) missense possibly damaging 0.79
R1536:Vmn2r3 UTSW 3 64,182,538 (GRCm39) missense probably damaging 1.00
R1806:Vmn2r3 UTSW 3 64,194,810 (GRCm39) missense possibly damaging 0.73
R1806:Vmn2r3 UTSW 3 64,182,893 (GRCm39) missense probably benign 0.03
R1852:Vmn2r3 UTSW 3 64,166,815 (GRCm39) missense probably damaging 1.00
R1868:Vmn2r3 UTSW 3 64,166,537 (GRCm39) missense probably damaging 1.00
R2072:Vmn2r3 UTSW 3 64,182,493 (GRCm39) missense possibly damaging 0.87
R2240:Vmn2r3 UTSW 3 64,166,483 (GRCm39) missense probably benign 0.44
R2446:Vmn2r3 UTSW 3 64,182,733 (GRCm39) missense probably damaging 0.98
R4133:Vmn2r3 UTSW 3 64,183,138 (GRCm39) missense probably damaging 0.99
R4159:Vmn2r3 UTSW 3 64,194,850 (GRCm39) nonsense probably null
R4494:Vmn2r3 UTSW 3 64,182,692 (GRCm39) missense probably damaging 1.00
R4860:Vmn2r3 UTSW 3 64,183,022 (GRCm39) missense probably benign 0.00
R4912:Vmn2r3 UTSW 3 64,166,618 (GRCm39) missense probably damaging 1.00
R5018:Vmn2r3 UTSW 3 64,178,774 (GRCm39) missense probably benign
R5033:Vmn2r3 UTSW 3 64,167,220 (GRCm39) missense probably benign 0.09
R5126:Vmn2r3 UTSW 3 64,166,740 (GRCm39) missense probably damaging 1.00
R5148:Vmn2r3 UTSW 3 64,186,247 (GRCm39) missense probably damaging 1.00
R5414:Vmn2r3 UTSW 3 64,166,978 (GRCm39) nonsense probably null
R5785:Vmn2r3 UTSW 3 64,166,444 (GRCm39) missense possibly damaging 0.89
R5905:Vmn2r3 UTSW 3 64,182,698 (GRCm39) missense probably benign 0.19
R5992:Vmn2r3 UTSW 3 64,167,068 (GRCm39) missense probably damaging 1.00
R6028:Vmn2r3 UTSW 3 64,182,698 (GRCm39) missense probably benign 0.19
R6331:Vmn2r3 UTSW 3 64,186,182 (GRCm39) missense probably damaging 1.00
R6378:Vmn2r3 UTSW 3 64,182,517 (GRCm39) missense probably damaging 1.00
R6775:Vmn2r3 UTSW 3 64,183,039 (GRCm39) missense possibly damaging 0.88
R6822:Vmn2r3 UTSW 3 64,194,876 (GRCm39) missense probably benign 0.30
R6826:Vmn2r3 UTSW 3 64,182,327 (GRCm39) nonsense probably null
R6886:Vmn2r3 UTSW 3 64,166,927 (GRCm39) missense probably damaging 1.00
R6971:Vmn2r3 UTSW 3 64,166,668 (GRCm39) missense probably damaging 0.99
R7154:Vmn2r3 UTSW 3 64,194,732 (GRCm39) missense probably benign 0.02
R7192:Vmn2r3 UTSW 3 64,167,364 (GRCm39) missense probably benign 0.24
R7282:Vmn2r3 UTSW 3 64,168,825 (GRCm39) missense possibly damaging 0.90
R7472:Vmn2r3 UTSW 3 64,182,953 (GRCm39) missense probably benign 0.00
R7563:Vmn2r3 UTSW 3 64,182,770 (GRCm39) missense possibly damaging 0.60
R7726:Vmn2r3 UTSW 3 64,182,939 (GRCm39) nonsense probably null
R7966:Vmn2r3 UTSW 3 64,186,235 (GRCm39) missense probably damaging 0.99
R8025:Vmn2r3 UTSW 3 64,182,871 (GRCm39) missense possibly damaging 0.91
R8050:Vmn2r3 UTSW 3 64,178,714 (GRCm39) missense probably damaging 0.99
R8300:Vmn2r3 UTSW 3 64,182,347 (GRCm39) missense probably benign 0.00
R8402:Vmn2r3 UTSW 3 64,178,617 (GRCm39) splice site probably benign
R8486:Vmn2r3 UTSW 3 64,186,370 (GRCm39) missense probably damaging 1.00
R8523:Vmn2r3 UTSW 3 64,182,311 (GRCm39) missense probably benign 0.03
R8678:Vmn2r3 UTSW 3 64,166,896 (GRCm39) missense possibly damaging 0.76
R8885:Vmn2r3 UTSW 3 64,182,383 (GRCm39) missense probably benign 0.00
R8886:Vmn2r3 UTSW 3 64,194,892 (GRCm39) missense possibly damaging 0.47
R8905:Vmn2r3 UTSW 3 64,166,695 (GRCm39) missense probably damaging 0.99
R8937:Vmn2r3 UTSW 3 64,166,673 (GRCm39) missense probably damaging 1.00
R8955:Vmn2r3 UTSW 3 64,168,803 (GRCm39) missense possibly damaging 0.56
R9172:Vmn2r3 UTSW 3 64,186,403 (GRCm39) missense possibly damaging 0.79
R9485:Vmn2r3 UTSW 3 64,183,046 (GRCm39) missense probably damaging 1.00
R9575:Vmn2r3 UTSW 3 64,178,735 (GRCm39) missense probably benign 0.01
R9618:Vmn2r3 UTSW 3 64,178,724 (GRCm39) missense probably damaging 0.98
X0022:Vmn2r3 UTSW 3 64,182,389 (GRCm39) missense probably damaging 1.00
X0022:Vmn2r3 UTSW 3 64,178,669 (GRCm39) missense possibly damaging 0.62
Predicted Primers PCR Primer
(F):5'- CTGGGGTGCATGGATATAAGC -3'
(R):5'- ATGTAATCCATGCAGTGAAGATGAC -3'

Sequencing Primer
(F):5'- AGAGTGAAATAGTCTTTCCAAGAATG -3'
(R):5'- TCCATGCAGTGAAGATGACTGGTC -3'
Posted On 2016-03-17