Incidental Mutation 'R4895:Zfp619'
ID 377564
Institutional Source Beutler Lab
Gene Symbol Zfp619
Ensembl Gene ENSMUSG00000068959
Gene Name zinc finger protein 619
Synonyms 3000002G13Rik
MMRRC Submission 042499-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.066) question?
Stock # R4895 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 39167190-39189844 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 39187396 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 1142 (D1142G)
Ref Sequence ENSEMBL: ENSMUSP00000103650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000108015]
AlphaFold G3X9T2
Predicted Effect possibly damaging
Transcript: ENSMUST00000108015
AA Change: D1142G

PolyPhen 2 Score 0.680 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000103650
Gene: ENSMUSG00000068959
AA Change: D1142G

DomainStartEndE-ValueType
KRAB 4 61 2.19e-20 SMART
ZnF_C2H2 218 240 2.91e-2 SMART
ZnF_C2H2 246 268 5.81e-2 SMART
ZnF_C2H2 274 296 3.16e-3 SMART
ZnF_C2H2 302 324 2.4e-3 SMART
ZnF_C2H2 330 352 2.95e-3 SMART
ZnF_C2H2 358 380 6.32e-3 SMART
ZnF_C2H2 386 408 8.47e-4 SMART
ZnF_C2H2 414 436 5.06e-2 SMART
ZnF_C2H2 442 464 1.58e-3 SMART
ZnF_C2H2 470 492 5.42e-2 SMART
ZnF_C2H2 526 548 2.09e-3 SMART
ZnF_C2H2 554 576 3.39e-3 SMART
ZnF_C2H2 582 604 1.56e-2 SMART
ZnF_C2H2 610 632 2.24e-3 SMART
ZnF_C2H2 638 660 4.72e-2 SMART
ZnF_C2H2 666 688 7.78e-3 SMART
ZnF_C2H2 694 716 5.9e-3 SMART
ZnF_C2H2 722 744 1.12e-3 SMART
ZnF_C2H2 748 770 6.42e-4 SMART
ZnF_C2H2 776 798 1.38e-3 SMART
ZnF_C2H2 804 826 9.44e-2 SMART
ZnF_C2H2 832 854 2.36e-2 SMART
ZnF_C2H2 860 882 8.94e-3 SMART
ZnF_C2H2 888 910 3.58e-2 SMART
ZnF_C2H2 916 938 6.42e-4 SMART
ZnF_C2H2 942 964 4.72e-2 SMART
ZnF_C2H2 970 992 2.3e-5 SMART
ZnF_C2H2 998 1020 8.34e-3 SMART
ZnF_C2H2 1026 1048 8.81e-2 SMART
ZnF_C2H2 1054 1076 1.69e-3 SMART
ZnF_C2H2 1082 1104 6.32e-3 SMART
ZnF_C2H2 1110 1132 1.47e-3 SMART
ZnF_C2H2 1138 1160 7.15e-2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000191753
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 98% (84/86)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519P11Rik C A 2: 154,454,990 (GRCm39) probably benign Het
Abat G A 16: 8,433,826 (GRCm39) A392T probably benign Het
Abca14 G A 7: 119,846,572 (GRCm39) probably null Het
Abcc6 A T 7: 45,630,414 (GRCm39) L1282Q possibly damaging Het
Acss2 A G 2: 155,392,401 (GRCm39) probably benign Het
Adgrf1 G T 17: 43,621,511 (GRCm39) V583L probably benign Het
Aftph T C 11: 20,646,801 (GRCm39) D825G probably damaging Het
Ahnak T C 19: 8,994,805 (GRCm39) V5363A probably benign Het
Apba3 G A 10: 81,107,117 (GRCm39) probably null Het
Asb13 T C 13: 3,693,589 (GRCm39) Y116H probably damaging Het
Asb4 C A 6: 5,398,266 (GRCm39) T77K probably damaging Het
Atp8b4 A T 2: 126,256,289 (GRCm39) H223Q probably benign Het
Best1 A G 19: 9,970,135 (GRCm39) L159P probably benign Het
Cacna1h A T 17: 25,608,396 (GRCm39) M731K probably damaging Het
Catspere1 T A 1: 177,687,427 (GRCm39) noncoding transcript Het
Cenpv A T 11: 62,418,346 (GRCm39) Y202* probably null Het
Cep57 A T 9: 13,727,449 (GRCm39) probably benign Het
Cfap100 T A 6: 90,383,084 (GRCm39) D363V possibly damaging Het
Cluh A G 11: 74,558,231 (GRCm39) Y1126C probably damaging Het
Cyp2j5 A G 4: 96,551,347 (GRCm39) probably null Het
Dnajc11 T C 4: 152,064,390 (GRCm39) F514L probably damaging Het
Efcab3 C T 11: 104,611,112 (GRCm39) T318I probably benign Het
Efcab3 T A 11: 105,008,227 (GRCm39) probably benign Het
Efcab3 A G 11: 104,640,496 (GRCm39) D1026G probably damaging Het
Eif2b4 T G 5: 31,350,298 (GRCm39) Q8P probably benign Het
Epha6 A T 16: 59,486,918 (GRCm39) V1043E probably benign Het
Gm11562 G T 11: 99,511,141 (GRCm39) Q20K unknown Het
Gm14415 A T 2: 176,796,114 (GRCm39) noncoding transcript Het
Gm5431 A G 11: 48,779,855 (GRCm39) S634P probably damaging Het
Gpld1 C A 13: 25,163,711 (GRCm39) N501K probably damaging Het
Gsn C T 2: 35,192,590 (GRCm39) R513C probably damaging Het
Gulp1 T C 1: 44,827,757 (GRCm39) F300L probably benign Het
H2aj T C 6: 136,785,660 (GRCm39) V108A possibly damaging Het
Haus3 T C 5: 34,325,414 (GRCm39) R82G probably benign Het
Herc2 G A 7: 55,872,734 (GRCm39) R4424H probably damaging Het
Hmcn1 T A 1: 150,553,130 (GRCm39) Q2520L probably benign Het
Hs2st1 T C 3: 144,171,014 (GRCm39) I53V probably benign Het
Inpp5e C T 2: 26,287,924 (GRCm39) R624Q probably damaging Het
Ints8 G T 4: 11,230,367 (GRCm39) C491* probably null Het
Itpkb C A 1: 180,241,460 (GRCm39) A710D probably damaging Het
Kcnk4 A C 19: 6,905,784 (GRCm39) probably null Het
Kmt2d T C 15: 98,742,368 (GRCm39) probably benign Het
Lamb3 C T 1: 193,014,622 (GRCm39) R594* probably null Het
Map3k20 A G 2: 72,232,700 (GRCm39) probably benign Het
Maz A T 7: 126,624,472 (GRCm39) probably null Het
Mtr T C 13: 12,231,752 (GRCm39) T651A probably benign Het
Nbeal1 A G 1: 60,332,062 (GRCm39) E2252G probably damaging Het
Ndufa10 A G 1: 92,397,618 (GRCm39) Y61H probably damaging Het
Npat T A 9: 53,481,789 (GRCm39) L1166M probably damaging Het
Or12e1 A C 2: 87,022,192 (GRCm39) I54L probably benign Het
Or4c108 A T 2: 88,804,055 (GRCm39) F60Y probably benign Het
Or5ak20 A T 2: 85,183,341 (GRCm39) *310K probably null Het
Or5b97 C T 19: 12,878,251 (GRCm39) V298M probably damaging Het
Or5h22 C T 16: 58,895,020 (GRCm39) C141Y probably benign Het
Or5p66 A C 7: 107,885,802 (GRCm39) I177S probably damaging Het
Pcdhb3 T C 18: 37,434,759 (GRCm39) F242L probably damaging Het
Phip A G 9: 82,841,648 (GRCm39) V57A probably benign Het
Plekha7 A T 7: 115,788,626 (GRCm39) probably null Het
Pot1a A C 6: 25,753,205 (GRCm39) F444V probably damaging Het
Ppm1a C T 12: 72,831,126 (GRCm39) P217L probably damaging Het
Prepl A G 17: 85,388,494 (GRCm39) F203S probably damaging Het
Prl8a1 T C 13: 27,759,513 (GRCm39) I175V probably benign Het
Ranbp6 A T 19: 29,787,175 (GRCm39) I1059N possibly damaging Het
Rhag A G 17: 41,122,242 (GRCm39) Q59R probably benign Het
Sema4c A C 1: 36,592,651 (GRCm39) probably null Het
Sf3b3 T C 8: 111,542,656 (GRCm39) D902G probably benign Het
Tbc1d23 A G 16: 57,019,220 (GRCm39) probably null Het
Tbrg1 A T 9: 37,566,375 (GRCm39) I54N probably damaging Het
Tchh A T 3: 93,352,993 (GRCm39) E811V unknown Het
Tenm3 T A 8: 48,754,006 (GRCm39) D799V probably damaging Het
Tlr5 T C 1: 182,801,764 (GRCm39) L342P probably damaging Het
Tppp C T 13: 74,178,996 (GRCm39) R146* probably null Het
Trpm4 A T 7: 44,967,482 (GRCm39) M574K probably damaging Het
Uggt1 A T 1: 36,195,345 (GRCm39) F1288Y probably damaging Het
Uggt2 T A 14: 119,256,298 (GRCm39) K1124N probably damaging Het
Usf3 A C 16: 44,041,459 (GRCm39) S1980R possibly damaging Het
Vav2 T C 2: 27,208,973 (GRCm39) D100G probably damaging Het
Vmn2r3 G T 3: 64,167,182 (GRCm39) H650N probably benign Het
Vmn2r59 T A 7: 41,695,218 (GRCm39) Y398F probably damaging Het
Zfp933 G A 4: 147,910,892 (GRCm39) R235* probably null Het
Other mutations in Zfp619
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02157:Zfp619 APN 7 39,184,288 (GRCm39) missense probably damaging 1.00
IGL02221:Zfp619 APN 7 39,186,334 (GRCm39) missense probably benign 0.00
IGL02625:Zfp619 APN 7 39,183,609 (GRCm39) splice site probably benign
3-1:Zfp619 UTSW 7 39,186,189 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0035:Zfp619 UTSW 7 39,186,706 (GRCm39) missense probably damaging 1.00
R0113:Zfp619 UTSW 7 39,187,183 (GRCm39) missense probably benign 0.01
R0377:Zfp619 UTSW 7 39,186,221 (GRCm39) nonsense probably null
R0614:Zfp619 UTSW 7 39,187,099 (GRCm39) missense possibly damaging 0.79
R0848:Zfp619 UTSW 7 39,185,983 (GRCm39) missense probably damaging 1.00
R1157:Zfp619 UTSW 7 39,186,282 (GRCm39) missense probably damaging 0.98
R2047:Zfp619 UTSW 7 39,187,062 (GRCm39) missense probably damaging 0.99
R2074:Zfp619 UTSW 7 39,184,185 (GRCm39) missense probably benign 0.00
R2419:Zfp619 UTSW 7 39,185,307 (GRCm39) missense possibly damaging 0.71
R2571:Zfp619 UTSW 7 39,186,595 (GRCm39) missense probably damaging 1.00
R2890:Zfp619 UTSW 7 39,184,393 (GRCm39) missense probably benign 0.00
R3814:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4003:Zfp619 UTSW 7 39,186,730 (GRCm39) missense possibly damaging 0.91
R4059:Zfp619 UTSW 7 39,184,823 (GRCm39) missense probably benign 0.01
R4503:Zfp619 UTSW 7 39,186,280 (GRCm39) missense probably damaging 1.00
R4664:Zfp619 UTSW 7 39,183,559 (GRCm39) missense probably benign 0.00
R4696:Zfp619 UTSW 7 39,186,412 (GRCm39) missense probably benign 0.00
R4975:Zfp619 UTSW 7 39,186,504 (GRCm39) missense possibly damaging 0.90
R4977:Zfp619 UTSW 7 39,186,811 (GRCm39) missense probably damaging 1.00
R5049:Zfp619 UTSW 7 39,184,938 (GRCm39) missense probably benign 0.02
R5240:Zfp619 UTSW 7 39,186,642 (GRCm39) missense possibly damaging 0.68
R5468:Zfp619 UTSW 7 39,185,152 (GRCm39) missense unknown
R5546:Zfp619 UTSW 7 39,184,577 (GRCm39) missense probably benign 0.01
R5572:Zfp619 UTSW 7 39,184,663 (GRCm39) missense probably benign 0.01
R6106:Zfp619 UTSW 7 39,184,558 (GRCm39) missense probably benign 0.01
R6329:Zfp619 UTSW 7 39,186,969 (GRCm39) missense probably damaging 1.00
R6354:Zfp619 UTSW 7 39,184,243 (GRCm39) missense probably benign 0.02
R6395:Zfp619 UTSW 7 39,186,454 (GRCm39) missense possibly damaging 0.91
R6490:Zfp619 UTSW 7 39,183,586 (GRCm39) missense probably benign 0.00
R6560:Zfp619 UTSW 7 39,186,954 (GRCm39) missense probably damaging 1.00
R6713:Zfp619 UTSW 7 39,187,322 (GRCm39) missense probably damaging 0.99
R7011:Zfp619 UTSW 7 39,187,186 (GRCm39) missense probably damaging 1.00
R7022:Zfp619 UTSW 7 39,184,387 (GRCm39) missense probably benign 0.00
R7046:Zfp619 UTSW 7 39,186,787 (GRCm39) missense possibly damaging 0.95
R7206:Zfp619 UTSW 7 39,184,824 (GRCm39) missense probably benign 0.00
R7780:Zfp619 UTSW 7 39,184,432 (GRCm39) missense possibly damaging 0.68
R7787:Zfp619 UTSW 7 39,186,226 (GRCm39) missense possibly damaging 0.91
R8001:Zfp619 UTSW 7 39,184,645 (GRCm39) missense probably benign 0.29
R8559:Zfp619 UTSW 7 39,186,559 (GRCm39) missense probably benign 0.31
R8775:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R8775-TAIL:Zfp619 UTSW 7 39,184,639 (GRCm39) missense possibly damaging 0.75
R9014:Zfp619 UTSW 7 39,187,246 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- GTGCGGGTTACCTTCGAATTC -3'
(R):5'- TGAATCCTTCTAAACTTTCCATAGCA -3'

Sequencing Primer
(F):5'- TGTGCTAAAGCCTTCCGAAG -3'
(R):5'- TCTAAACTTTCCATAGCAAACTACAG -3'
Posted On 2016-03-17