Incidental Mutation 'R4895:Vmn2r59'
ID 377565
Institutional Source Beutler Lab
Gene Symbol Vmn2r59
Ensembl Gene ENSMUSG00000092032
Gene Name vomeronasal 2, receptor 59
Synonyms EG628444
MMRRC Submission 042499-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R4895 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 41661216-41708405 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41695218 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 398 (Y398F)
Ref Sequence ENSEMBL: ENSMUSP00000131856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000168489]
AlphaFold E9PUT5
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121359
Predicted Effect probably damaging
Transcript: ENSMUST00000168489
AA Change: Y398F

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131856
Gene: ENSMUSG00000092032
AA Change: Y398F

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-44 PFAM
Pfam:NCD3G 514 567 4.3e-23 PFAM
Pfam:7tm_3 600 835 5.4e-53 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 98% (84/86)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930519P11Rik C A 2: 154,454,990 (GRCm39) probably benign Het
Abat G A 16: 8,433,826 (GRCm39) A392T probably benign Het
Abca14 G A 7: 119,846,572 (GRCm39) probably null Het
Abcc6 A T 7: 45,630,414 (GRCm39) L1282Q possibly damaging Het
Acss2 A G 2: 155,392,401 (GRCm39) probably benign Het
Adgrf1 G T 17: 43,621,511 (GRCm39) V583L probably benign Het
Aftph T C 11: 20,646,801 (GRCm39) D825G probably damaging Het
Ahnak T C 19: 8,994,805 (GRCm39) V5363A probably benign Het
Apba3 G A 10: 81,107,117 (GRCm39) probably null Het
Asb13 T C 13: 3,693,589 (GRCm39) Y116H probably damaging Het
Asb4 C A 6: 5,398,266 (GRCm39) T77K probably damaging Het
Atp8b4 A T 2: 126,256,289 (GRCm39) H223Q probably benign Het
Best1 A G 19: 9,970,135 (GRCm39) L159P probably benign Het
Cacna1h A T 17: 25,608,396 (GRCm39) M731K probably damaging Het
Catspere1 T A 1: 177,687,427 (GRCm39) noncoding transcript Het
Cenpv A T 11: 62,418,346 (GRCm39) Y202* probably null Het
Cep57 A T 9: 13,727,449 (GRCm39) probably benign Het
Cfap100 T A 6: 90,383,084 (GRCm39) D363V possibly damaging Het
Cluh A G 11: 74,558,231 (GRCm39) Y1126C probably damaging Het
Cyp2j5 A G 4: 96,551,347 (GRCm39) probably null Het
Dnajc11 T C 4: 152,064,390 (GRCm39) F514L probably damaging Het
Efcab3 C T 11: 104,611,112 (GRCm39) T318I probably benign Het
Efcab3 T A 11: 105,008,227 (GRCm39) probably benign Het
Efcab3 A G 11: 104,640,496 (GRCm39) D1026G probably damaging Het
Eif2b4 T G 5: 31,350,298 (GRCm39) Q8P probably benign Het
Epha6 A T 16: 59,486,918 (GRCm39) V1043E probably benign Het
Gm11562 G T 11: 99,511,141 (GRCm39) Q20K unknown Het
Gm14415 A T 2: 176,796,114 (GRCm39) noncoding transcript Het
Gm5431 A G 11: 48,779,855 (GRCm39) S634P probably damaging Het
Gpld1 C A 13: 25,163,711 (GRCm39) N501K probably damaging Het
Gsn C T 2: 35,192,590 (GRCm39) R513C probably damaging Het
Gulp1 T C 1: 44,827,757 (GRCm39) F300L probably benign Het
H2aj T C 6: 136,785,660 (GRCm39) V108A possibly damaging Het
Haus3 T C 5: 34,325,414 (GRCm39) R82G probably benign Het
Herc2 G A 7: 55,872,734 (GRCm39) R4424H probably damaging Het
Hmcn1 T A 1: 150,553,130 (GRCm39) Q2520L probably benign Het
Hs2st1 T C 3: 144,171,014 (GRCm39) I53V probably benign Het
Inpp5e C T 2: 26,287,924 (GRCm39) R624Q probably damaging Het
Ints8 G T 4: 11,230,367 (GRCm39) C491* probably null Het
Itpkb C A 1: 180,241,460 (GRCm39) A710D probably damaging Het
Kcnk4 A C 19: 6,905,784 (GRCm39) probably null Het
Kmt2d T C 15: 98,742,368 (GRCm39) probably benign Het
Lamb3 C T 1: 193,014,622 (GRCm39) R594* probably null Het
Map3k20 A G 2: 72,232,700 (GRCm39) probably benign Het
Maz A T 7: 126,624,472 (GRCm39) probably null Het
Mtr T C 13: 12,231,752 (GRCm39) T651A probably benign Het
Nbeal1 A G 1: 60,332,062 (GRCm39) E2252G probably damaging Het
Ndufa10 A G 1: 92,397,618 (GRCm39) Y61H probably damaging Het
Npat T A 9: 53,481,789 (GRCm39) L1166M probably damaging Het
Or12e1 A C 2: 87,022,192 (GRCm39) I54L probably benign Het
Or4c108 A T 2: 88,804,055 (GRCm39) F60Y probably benign Het
Or5ak20 A T 2: 85,183,341 (GRCm39) *310K probably null Het
Or5b97 C T 19: 12,878,251 (GRCm39) V298M probably damaging Het
Or5h22 C T 16: 58,895,020 (GRCm39) C141Y probably benign Het
Or5p66 A C 7: 107,885,802 (GRCm39) I177S probably damaging Het
Pcdhb3 T C 18: 37,434,759 (GRCm39) F242L probably damaging Het
Phip A G 9: 82,841,648 (GRCm39) V57A probably benign Het
Plekha7 A T 7: 115,788,626 (GRCm39) probably null Het
Pot1a A C 6: 25,753,205 (GRCm39) F444V probably damaging Het
Ppm1a C T 12: 72,831,126 (GRCm39) P217L probably damaging Het
Prepl A G 17: 85,388,494 (GRCm39) F203S probably damaging Het
Prl8a1 T C 13: 27,759,513 (GRCm39) I175V probably benign Het
Ranbp6 A T 19: 29,787,175 (GRCm39) I1059N possibly damaging Het
Rhag A G 17: 41,122,242 (GRCm39) Q59R probably benign Het
Sema4c A C 1: 36,592,651 (GRCm39) probably null Het
Sf3b3 T C 8: 111,542,656 (GRCm39) D902G probably benign Het
Tbc1d23 A G 16: 57,019,220 (GRCm39) probably null Het
Tbrg1 A T 9: 37,566,375 (GRCm39) I54N probably damaging Het
Tchh A T 3: 93,352,993 (GRCm39) E811V unknown Het
Tenm3 T A 8: 48,754,006 (GRCm39) D799V probably damaging Het
Tlr5 T C 1: 182,801,764 (GRCm39) L342P probably damaging Het
Tppp C T 13: 74,178,996 (GRCm39) R146* probably null Het
Trpm4 A T 7: 44,967,482 (GRCm39) M574K probably damaging Het
Uggt1 A T 1: 36,195,345 (GRCm39) F1288Y probably damaging Het
Uggt2 T A 14: 119,256,298 (GRCm39) K1124N probably damaging Het
Usf3 A C 16: 44,041,459 (GRCm39) S1980R possibly damaging Het
Vav2 T C 2: 27,208,973 (GRCm39) D100G probably damaging Het
Vmn2r3 G T 3: 64,167,182 (GRCm39) H650N probably benign Het
Zfp619 A G 7: 39,187,396 (GRCm39) D1142G possibly damaging Het
Zfp933 G A 4: 147,910,892 (GRCm39) R235* probably null Het
Other mutations in Vmn2r59
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00088:Vmn2r59 APN 7 41,661,488 (GRCm39) missense possibly damaging 0.91
IGL01432:Vmn2r59 APN 7 41,661,983 (GRCm39) missense possibly damaging 0.82
IGL02119:Vmn2r59 APN 7 41,695,593 (GRCm39) missense probably benign 0.36
IGL02216:Vmn2r59 APN 7 41,661,817 (GRCm39) missense probably damaging 1.00
IGL02327:Vmn2r59 APN 7 41,661,655 (GRCm39) missense probably benign
IGL03346:Vmn2r59 APN 7 41,693,253 (GRCm39) missense probably benign 0.00
IGL03411:Vmn2r59 APN 7 41,708,340 (GRCm39) missense probably benign 0.43
IGL03412:Vmn2r59 APN 7 41,661,862 (GRCm39) missense probably benign
PIT4366001:Vmn2r59 UTSW 7 41,695,205 (GRCm39) missense possibly damaging 0.91
R0068:Vmn2r59 UTSW 7 41,695,725 (GRCm39) missense probably damaging 0.99
R0094:Vmn2r59 UTSW 7 41,661,722 (GRCm39) missense probably benign 0.07
R0179:Vmn2r59 UTSW 7 41,696,432 (GRCm39) nonsense probably null
R0370:Vmn2r59 UTSW 7 41,662,150 (GRCm39) missense probably benign 0.23
R0412:Vmn2r59 UTSW 7 41,695,916 (GRCm39) splice site probably benign
R0465:Vmn2r59 UTSW 7 41,696,332 (GRCm39) missense probably benign
R0487:Vmn2r59 UTSW 7 41,696,528 (GRCm39) nonsense probably null
R0576:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R0632:Vmn2r59 UTSW 7 41,708,308 (GRCm39) missense probably damaging 1.00
R1356:Vmn2r59 UTSW 7 41,661,218 (GRCm39) makesense probably null
R1387:Vmn2r59 UTSW 7 41,695,521 (GRCm39) missense probably damaging 1.00
R1388:Vmn2r59 UTSW 7 41,695,133 (GRCm39) missense probably benign 0.01
R1435:Vmn2r59 UTSW 7 41,695,629 (GRCm39) missense possibly damaging 0.50
R1750:Vmn2r59 UTSW 7 41,695,251 (GRCm39) missense possibly damaging 0.50
R2020:Vmn2r59 UTSW 7 41,693,203 (GRCm39) missense probably damaging 1.00
R2249:Vmn2r59 UTSW 7 41,708,326 (GRCm39) missense probably benign 0.00
R2256:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2257:Vmn2r59 UTSW 7 41,661,669 (GRCm39) nonsense probably null
R2441:Vmn2r59 UTSW 7 41,695,570 (GRCm39) missense probably benign 0.00
R2511:Vmn2r59 UTSW 7 41,693,190 (GRCm39) missense probably damaging 1.00
R2860:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R2861:Vmn2r59 UTSW 7 41,696,427 (GRCm39) missense possibly damaging 0.79
R3690:Vmn2r59 UTSW 7 41,661,370 (GRCm39) missense possibly damaging 0.77
R3912:Vmn2r59 UTSW 7 41,695,744 (GRCm39) missense probably benign 0.00
R4167:Vmn2r59 UTSW 7 41,670,732 (GRCm39) intron probably benign
R4357:Vmn2r59 UTSW 7 41,661,644 (GRCm39) missense probably damaging 1.00
R4445:Vmn2r59 UTSW 7 41,691,874 (GRCm39) missense probably damaging 1.00
R4542:Vmn2r59 UTSW 7 41,695,497 (GRCm39) missense possibly damaging 0.93
R4587:Vmn2r59 UTSW 7 41,695,648 (GRCm39) missense probably benign 0.00
R4616:Vmn2r59 UTSW 7 41,661,862 (GRCm39) missense probably benign
R4653:Vmn2r59 UTSW 7 41,693,228 (GRCm39) missense probably benign 0.19
R4703:Vmn2r59 UTSW 7 41,661,686 (GRCm39) missense probably benign 0.01
R4910:Vmn2r59 UTSW 7 41,693,077 (GRCm39) missense probably benign
R5045:Vmn2r59 UTSW 7 41,695,496 (GRCm39) missense possibly damaging 0.93
R5105:Vmn2r59 UTSW 7 41,696,529 (GRCm39) missense probably benign 0.01
R5153:Vmn2r59 UTSW 7 41,691,834 (GRCm39) critical splice donor site probably null
R5566:Vmn2r59 UTSW 7 41,696,247 (GRCm39) missense possibly damaging 0.92
R5586:Vmn2r59 UTSW 7 41,695,105 (GRCm39) missense probably benign 0.12
R5606:Vmn2r59 UTSW 7 41,695,318 (GRCm39) missense probably benign 0.27
R5616:Vmn2r59 UTSW 7 41,708,191 (GRCm39) splice site probably null
R5625:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R5696:Vmn2r59 UTSW 7 41,695,468 (GRCm39) missense probably benign 0.00
R5982:Vmn2r59 UTSW 7 41,695,491 (GRCm39) missense probably benign 0.00
R6106:Vmn2r59 UTSW 7 41,661,749 (GRCm39) nonsense probably null
R6196:Vmn2r59 UTSW 7 41,661,679 (GRCm39) missense probably benign 0.36
R6228:Vmn2r59 UTSW 7 41,691,835 (GRCm39) critical splice donor site probably null
R6590:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6625:Vmn2r59 UTSW 7 41,693,177 (GRCm39) missense probably benign 0.02
R6690:Vmn2r59 UTSW 7 41,695,890 (GRCm39) missense probably damaging 1.00
R6768:Vmn2r59 UTSW 7 41,661,392 (GRCm39) missense probably benign 0.17
R6830:Vmn2r59 UTSW 7 41,693,171 (GRCm39) missense probably benign 0.10
R6859:Vmn2r59 UTSW 7 41,693,277 (GRCm39) missense probably damaging 1.00
R7034:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7036:Vmn2r59 UTSW 7 41,695,644 (GRCm39) missense probably benign 0.03
R7145:Vmn2r59 UTSW 7 41,695,188 (GRCm39) missense probably damaging 1.00
R7556:Vmn2r59 UTSW 7 41,695,233 (GRCm39) missense probably damaging 1.00
R7733:Vmn2r59 UTSW 7 41,661,443 (GRCm39) missense probably benign 0.17
R7770:Vmn2r59 UTSW 7 41,708,336 (GRCm39) missense probably damaging 1.00
R7812:Vmn2r59 UTSW 7 41,695,196 (GRCm39) nonsense probably null
R7867:Vmn2r59 UTSW 7 41,661,707 (GRCm39) missense probably damaging 1.00
R7975:Vmn2r59 UTSW 7 41,693,199 (GRCm39) missense probably damaging 1.00
R7999:Vmn2r59 UTSW 7 41,696,256 (GRCm39) missense probably damaging 1.00
R8267:Vmn2r59 UTSW 7 41,661,521 (GRCm39) missense probably damaging 0.97
R8367:Vmn2r59 UTSW 7 41,661,247 (GRCm39) missense probably benign 0.44
R9106:Vmn2r59 UTSW 7 41,695,884 (GRCm39) missense probably benign 0.03
R9135:Vmn2r59 UTSW 7 41,693,127 (GRCm39) missense
R9135:Vmn2r59 UTSW 7 41,693,125 (GRCm39) missense probably benign 0.33
R9234:Vmn2r59 UTSW 7 41,661,907 (GRCm39) missense possibly damaging 0.67
R9273:Vmn2r59 UTSW 7 41,695,286 (GRCm39) nonsense probably null
R9432:Vmn2r59 UTSW 7 41,696,254 (GRCm39) missense probably damaging 1.00
R9433:Vmn2r59 UTSW 7 41,695,590 (GRCm39) missense probably damaging 0.99
R9616:Vmn2r59 UTSW 7 41,661,299 (GRCm39) missense probably damaging 1.00
R9654:Vmn2r59 UTSW 7 41,693,217 (GRCm39) missense probably benign 0.10
R9741:Vmn2r59 UTSW 7 41,708,209 (GRCm39) missense probably damaging 0.99
X0025:Vmn2r59 UTSW 7 41,695,365 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r59 UTSW 7 41,661,838 (GRCm39) missense possibly damaging 0.85
Z1176:Vmn2r59 UTSW 7 41,691,941 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATTGCTTATTGACAGCATAGTC -3'
(R):5'- CACCACCGTGAAGAGATGGTTG -3'

Sequencing Primer
(F):5'- GACAGCATAGTCTAAAACATGTGATG -3'
(R):5'- TTTGTCCAAACAGTTAATCCCTAC -3'
Posted On 2016-03-17