Incidental Mutation 'R4356:Scfd1'
ID 377754
Institutional Source Beutler Lab
Gene Symbol Scfd1
Ensembl Gene ENSMUSG00000020952
Gene Name Sec1 family domain containing 1
Synonyms RA410, STXBP1L2, 3110021P21Rik
MMRRC Submission 041669-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.956) question?
Stock # R4356 (G1)
Quality Score 225
Status Validated
Chromosome 12
Chromosomal Location 51424296-51496887 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 51486068 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 541 (N541K)
Ref Sequence ENSEMBL: ENSMUSP00000021335 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021335]
AlphaFold Q8BRF7
Predicted Effect probably benign
Transcript: ENSMUST00000021335
AA Change: N541K

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000021335
Gene: ENSMUSG00000020952
AA Change: N541K

DomainStartEndE-ValueType
Pfam:Sec1 41 632 1.6e-109 PFAM
Predicted Effect unknown
Transcript: ENSMUST00000218138
AA Change: N122K
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219686
Meta Mutation Damage Score 0.0712 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (58/58)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm1 T A 3: 59,843,701 (GRCm39) Y132N probably damaging Het
Adam21 T C 12: 81,605,594 (GRCm39) T723A probably damaging Het
Alox5 C T 6: 116,397,219 (GRCm39) V322I probably benign Het
Alpk1 C T 3: 127,523,022 (GRCm39) V7M probably damaging Het
Ankhd1 A T 18: 36,776,096 (GRCm39) K1482* probably null Het
Cacna1e A C 1: 154,319,727 (GRCm39) D1324E probably damaging Het
Ccdc150 A G 1: 54,392,213 (GRCm39) D657G probably damaging Het
Celsr1 A G 15: 85,863,028 (GRCm39) S1335P probably damaging Het
Cfhr4 T A 1: 139,660,048 (GRCm39) K621N probably damaging Het
Cspg5 A G 9: 110,085,245 (GRCm39) D391G probably damaging Het
Defa30 A T 8: 21,624,821 (GRCm39) D48V possibly damaging Het
E2f7 T C 10: 110,595,712 (GRCm39) Y136H probably damaging Het
Fam3d A G 14: 8,349,314 (GRCm38) L212P probably damaging Het
Fbxw25 A T 9: 109,491,153 (GRCm39) C122S probably damaging Het
Fgg A T 3: 82,920,250 (GRCm39) D343V probably damaging Het
Flnb T A 14: 7,922,700 (GRCm38) M1712K probably benign Het
Fnbp4 T C 2: 90,588,683 (GRCm39) S485P probably damaging Het
Ftsj3 G A 11: 106,144,502 (GRCm39) A134V probably benign Het
Gast C A 11: 100,227,373 (GRCm39) S22Y probably damaging Het
Gm20834 T A Y: 10,322,962 (GRCm39) H158L possibly damaging Het
Ids C A X: 69,389,950 (GRCm39) G506C probably damaging Het
Ifna15 G T 4: 88,476,079 (GRCm39) T135N probably benign Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Impg2 C T 16: 56,080,527 (GRCm39) T777I probably damaging Het
Kif11 C A 19: 37,399,883 (GRCm39) T790K probably benign Het
Kif24 A G 4: 41,413,827 (GRCm39) probably null Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lrp10 C T 14: 54,705,823 (GRCm39) R338C probably damaging Het
Mib1 A G 18: 10,751,844 (GRCm39) N242S probably benign Het
Nectin1 A G 9: 43,703,802 (GRCm39) D264G probably benign Het
Nipsnap3a T C 4: 52,995,979 (GRCm39) probably null Het
Or10al3 G T 17: 38,011,790 (GRCm39) E76D probably damaging Het
Or5w14 G A 2: 87,542,229 (GRCm39) S7F possibly damaging Het
P3h4 A G 11: 100,304,452 (GRCm39) F263S probably damaging Het
Pcdhga4 C T 18: 37,820,664 (GRCm39) H738Y probably damaging Het
Prickle2 A T 6: 92,388,490 (GRCm39) I304K probably damaging Het
Ptprq A T 10: 107,444,225 (GRCm39) Y1460N probably damaging Het
Rbl2 A G 8: 91,833,735 (GRCm39) D812G probably damaging Het
Rbm19 A G 5: 120,278,427 (GRCm39) T737A possibly damaging Het
Rbsn G A 6: 92,184,029 (GRCm39) L95F possibly damaging Het
Sall4 T C 2: 168,597,400 (GRCm39) E480G probably benign Het
Scube3 G A 17: 28,383,283 (GRCm39) G442S probably benign Het
Slc15a4 A G 5: 127,681,600 (GRCm39) probably null Het
Smarcc1 A G 9: 110,025,324 (GRCm39) D667G probably damaging Het
Sned1 A T 1: 93,193,113 (GRCm39) probably null Het
Spsb1 T C 4: 149,991,232 (GRCm39) H112R probably damaging Het
Sun3 A G 11: 8,966,328 (GRCm39) V231A probably damaging Het
Vmn2r106 A T 17: 20,499,910 (GRCm39) D108E probably benign Het
Xdh A G 17: 74,222,685 (GRCm39) V560A probably benign Het
Zfp352 T A 4: 90,112,071 (GRCm39) H70Q possibly damaging Het
Zfp40 C A 17: 23,396,164 (GRCm39) C73F probably benign Het
Zfp975 A C 7: 42,311,251 (GRCm39) L454R probably damaging Het
Zik1 A T 7: 10,224,268 (GRCm39) C276* probably null Het
Other mutations in Scfd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00497:Scfd1 APN 12 51,474,652 (GRCm39) missense probably benign 0.01
IGL00640:Scfd1 APN 12 51,436,098 (GRCm39) missense probably benign 0.12
IGL01481:Scfd1 APN 12 51,430,903 (GRCm39) missense probably damaging 0.99
IGL01585:Scfd1 APN 12 51,462,336 (GRCm39) missense probably damaging 1.00
IGL01862:Scfd1 APN 12 51,492,494 (GRCm39) missense probably damaging 1.00
IGL02000:Scfd1 APN 12 51,460,900 (GRCm39) missense probably benign 0.03
IGL02226:Scfd1 APN 12 51,436,164 (GRCm39) splice site probably benign
IGL02327:Scfd1 APN 12 51,436,100 (GRCm39) missense possibly damaging 0.81
IGL02503:Scfd1 APN 12 51,469,704 (GRCm39) missense possibly damaging 0.90
IGL02585:Scfd1 APN 12 51,433,890 (GRCm39) missense probably damaging 0.97
IGL02732:Scfd1 APN 12 51,469,756 (GRCm39) missense probably benign 0.01
R0671:Scfd1 UTSW 12 51,459,411 (GRCm39) missense probably benign 0.01
R0707:Scfd1 UTSW 12 51,459,360 (GRCm39) missense probably damaging 0.98
R1467:Scfd1 UTSW 12 51,478,281 (GRCm39) missense possibly damaging 0.49
R1467:Scfd1 UTSW 12 51,478,281 (GRCm39) missense possibly damaging 0.49
R1962:Scfd1 UTSW 12 51,469,769 (GRCm39) missense probably benign 0.00
R2173:Scfd1 UTSW 12 51,433,862 (GRCm39) missense probably benign 0.22
R2249:Scfd1 UTSW 12 51,462,299 (GRCm39) missense possibly damaging 0.48
R3872:Scfd1 UTSW 12 51,438,979 (GRCm39) missense probably damaging 0.98
R4080:Scfd1 UTSW 12 51,478,302 (GRCm39) missense probably benign
R4841:Scfd1 UTSW 12 51,436,109 (GRCm39) missense probably damaging 0.96
R4842:Scfd1 UTSW 12 51,436,109 (GRCm39) missense probably damaging 0.96
R4909:Scfd1 UTSW 12 51,437,195 (GRCm39) missense probably benign 0.00
R5004:Scfd1 UTSW 12 51,491,777 (GRCm39) missense probably benign 0.03
R5275:Scfd1 UTSW 12 51,462,372 (GRCm39) missense probably benign 0.19
R5494:Scfd1 UTSW 12 51,443,522 (GRCm39) splice site probably null
R5779:Scfd1 UTSW 12 51,478,312 (GRCm39) missense probably benign
R6000:Scfd1 UTSW 12 51,492,457 (GRCm39) missense possibly damaging 0.55
R6017:Scfd1 UTSW 12 51,492,461 (GRCm39) missense probably damaging 1.00
R6522:Scfd1 UTSW 12 51,478,324 (GRCm39) missense probably benign 0.04
R6954:Scfd1 UTSW 12 51,474,729 (GRCm39) critical splice donor site probably null
R7748:Scfd1 UTSW 12 51,436,140 (GRCm39) missense probably benign 0.21
R7993:Scfd1 UTSW 12 51,492,490 (GRCm39) missense probably damaging 1.00
R8122:Scfd1 UTSW 12 51,480,052 (GRCm39) missense possibly damaging 0.95
R8353:Scfd1 UTSW 12 51,459,374 (GRCm39) missense possibly damaging 0.91
R8453:Scfd1 UTSW 12 51,459,374 (GRCm39) missense possibly damaging 0.91
R8890:Scfd1 UTSW 12 51,474,678 (GRCm39) missense probably benign
R9284:Scfd1 UTSW 12 51,439,024 (GRCm39) missense probably benign 0.00
R9294:Scfd1 UTSW 12 51,440,649 (GRCm39) missense possibly damaging 0.76
RF007:Scfd1 UTSW 12 51,469,756 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CTTGCCCTGGAAATGCTTTG -3'
(R):5'- TGCCACTGAGAACATGGACTC -3'

Sequencing Primer
(F):5'- CCCTGGAAATGCTTTGAATTTTGC -3'
(R):5'- CACTGAGAACATGGACTCTTTGC -3'
Posted On 2016-04-01