Incidental Mutation 'R0304:Fasn'
| ID |
37776 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Fasn
|
| Ensembl Gene |
ENSMUSG00000025153 |
| Gene Name |
fatty acid synthase |
| Synonyms |
A630082H08Rik, FAS |
| MMRRC Submission |
038515-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0304 (G1)
|
| Quality Score |
209 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
120696672-120715373 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 120710762 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 299
(V299A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000052872
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055655]
[ENSMUST00000205905]
[ENSMUST00000206589]
|
| AlphaFold |
P19096 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000055655
AA Change: V299A
PolyPhen 2
Score 0.849 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000052872
Gene: ENSMUSG00000025153
AA Change: V299A
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ketoacyl-synt
|
1 |
239 |
6.8e-73 |
PFAM |
|
Pfam:Ketoacyl-synt_C
|
243 |
360 |
3.7e-38 |
PFAM |
|
Pfam:KAsynt_C_assoc
|
362 |
474 |
8.2e-46 |
PFAM |
|
Pfam:Acyl_transf_1
|
493 |
810 |
9.5e-115 |
PFAM |
|
Pfam:PS-DH
|
853 |
1169 |
9.9e-24 |
PFAM |
|
low complexity region
|
1175 |
1204 |
N/A |
INTRINSIC |
|
Pfam:Methyltransf_12
|
1238 |
1337 |
2e-9 |
PFAM |
|
PKS_ER
|
1532 |
1847 |
1.44e-147 |
SMART |
|
PKS_KR
|
1878 |
2059 |
2.33e-42 |
SMART |
|
Pfam:PP-binding
|
2119 |
2185 |
1.1e-10 |
PFAM |
|
Pfam:Thioesterase
|
2235 |
2494 |
1.6e-62 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205905
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000206589
AA Change: V299A
PolyPhen 2
Score 0.578 (Sensitivity: 0.88; Specificity: 0.91)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000206637
|
| Meta Mutation Damage Score |
0.3462 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.2%
- 20x: 95.3%
|
| Validation Efficiency |
98% (95/97) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted mutation of this locus has implicated its product in embryogenesis as all homozygotes and most heterozygotes die prior to birth. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aadacl4fm1 |
C |
T |
4: 144,246,619 (GRCm39) |
T55I |
probably benign |
Het |
| Acod1 |
T |
A |
14: 103,292,418 (GRCm39) |
I314N |
probably damaging |
Het |
| Actl11 |
T |
A |
9: 107,806,967 (GRCm39) |
V430E |
probably damaging |
Het |
| Adam19 |
A |
C |
11: 46,018,219 (GRCm39) |
D427A |
possibly damaging |
Het |
| Adarb2 |
C |
T |
13: 8,802,606 (GRCm39) |
|
probably benign |
Het |
| Akap7 |
A |
T |
10: 25,147,450 (GRCm39) |
H93Q |
probably damaging |
Het |
| Ankrd36 |
C |
A |
11: 5,578,981 (GRCm39) |
R82S |
possibly damaging |
Het |
| Arhgap21 |
A |
T |
2: 20,864,612 (GRCm39) |
|
probably benign |
Het |
| Atm |
T |
A |
9: 53,427,644 (GRCm39) |
I489F |
probably benign |
Het |
| Carmil1 |
T |
C |
13: 24,323,324 (GRCm39) |
S243G |
probably damaging |
Het |
| Cdc42bpg |
T |
C |
19: 6,367,278 (GRCm39) |
V939A |
probably damaging |
Het |
| Cel |
A |
C |
2: 28,447,783 (GRCm39) |
L377R |
probably benign |
Het |
| Clock |
A |
G |
5: 76,374,832 (GRCm39) |
V779A |
unknown |
Het |
| Cluap1 |
G |
A |
16: 3,747,782 (GRCm39) |
|
probably benign |
Het |
| Ctif |
A |
T |
18: 75,654,889 (GRCm39) |
H212Q |
probably benign |
Het |
| Cyp4a29 |
T |
A |
4: 115,110,129 (GRCm39) |
|
probably benign |
Het |
| Cytip |
T |
C |
2: 58,038,258 (GRCm39) |
N101S |
possibly damaging |
Het |
| D130043K22Rik |
T |
C |
13: 25,048,798 (GRCm39) |
M434T |
probably benign |
Het |
| Ddx47 |
A |
G |
6: 134,994,183 (GRCm39) |
I154V |
possibly damaging |
Het |
| Dnah6 |
C |
T |
6: 73,136,098 (GRCm39) |
E1014K |
probably damaging |
Het |
| Dnajc27 |
T |
G |
12: 4,156,793 (GRCm39) |
|
probably benign |
Het |
| Drc7 |
A |
T |
8: 95,785,756 (GRCm39) |
D204V |
probably damaging |
Het |
| Dsc3 |
A |
G |
18: 20,114,298 (GRCm39) |
Y319H |
probably damaging |
Het |
| Eml6 |
T |
C |
11: 29,727,441 (GRCm39) |
Q1227R |
probably benign |
Het |
| Enpp2 |
A |
T |
15: 54,741,202 (GRCm39) |
D365E |
probably benign |
Het |
| Ercc2 |
T |
C |
7: 19,120,633 (GRCm39) |
I199T |
possibly damaging |
Het |
| Exd2 |
G |
A |
12: 80,538,014 (GRCm39) |
|
probably benign |
Het |
| F2 |
A |
T |
2: 91,463,578 (GRCm39) |
I128N |
probably damaging |
Het |
| Fam219b |
T |
C |
9: 57,446,159 (GRCm39) |
L123P |
probably damaging |
Het |
| Fastkd2 |
T |
C |
1: 63,791,559 (GRCm39) |
V689A |
possibly damaging |
Het |
| Fbxw13 |
C |
T |
9: 109,023,789 (GRCm39) |
R85Q |
probably benign |
Het |
| Fer1l6 |
A |
G |
15: 58,462,411 (GRCm39) |
Y822C |
probably benign |
Het |
| Fhl5 |
T |
C |
4: 25,207,241 (GRCm39) |
T176A |
probably benign |
Het |
| Gm20530 |
T |
G |
17: 36,405,118 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4787 |
A |
T |
12: 81,425,708 (GRCm39) |
I150N |
probably damaging |
Het |
| Grip1 |
G |
A |
10: 119,911,376 (GRCm39) |
S618N |
probably benign |
Het |
| Hdac9 |
T |
C |
12: 34,424,110 (GRCm39) |
K454E |
probably damaging |
Het |
| Iars2 |
T |
A |
1: 185,019,353 (GRCm39) |
I978F |
possibly damaging |
Het |
| Icosl |
A |
G |
10: 77,911,156 (GRCm39) |
Y299C |
probably benign |
Het |
| Idi1 |
T |
C |
13: 8,940,393 (GRCm39) |
Y192H |
probably damaging |
Het |
| Iqub |
T |
G |
6: 24,454,290 (GRCm39) |
Q531P |
probably damaging |
Het |
| Itih4 |
T |
A |
14: 30,612,051 (GRCm39) |
|
probably null |
Het |
| Izumo4 |
A |
T |
10: 80,538,770 (GRCm39) |
H71L |
probably damaging |
Het |
| Jcad |
A |
T |
18: 4,673,325 (GRCm39) |
E362D |
possibly damaging |
Het |
| Kif21a |
G |
T |
15: 90,860,724 (GRCm39) |
|
probably null |
Het |
| Kynu |
A |
T |
2: 43,569,893 (GRCm39) |
I392F |
probably damaging |
Het |
| Luc7l2 |
A |
G |
6: 38,569,711 (GRCm39) |
E223G |
probably damaging |
Het |
| Map3k8 |
A |
C |
18: 4,339,552 (GRCm39) |
L273R |
probably damaging |
Het |
| Max |
A |
G |
12: 76,985,361 (GRCm39) |
L119P |
probably benign |
Het |
| Mphosph9 |
T |
C |
5: 124,436,892 (GRCm39) |
N484S |
probably benign |
Het |
| Mrgprg |
A |
G |
7: 143,318,792 (GRCm39) |
Y107H |
probably damaging |
Het |
| Mrps31 |
A |
T |
8: 22,911,354 (GRCm39) |
I199F |
probably benign |
Het |
| Mtr |
C |
G |
13: 12,237,040 (GRCm39) |
|
probably null |
Het |
| Muc6 |
G |
A |
7: 141,218,313 (GRCm39) |
S2120F |
possibly damaging |
Het |
| Nkapd1 |
T |
C |
9: 50,519,222 (GRCm39) |
D130G |
probably damaging |
Het |
| Nptx2 |
A |
G |
5: 144,490,460 (GRCm39) |
|
probably benign |
Het |
| Nrip1 |
T |
C |
16: 76,089,595 (GRCm39) |
Q654R |
possibly damaging |
Het |
| Ocm |
A |
G |
5: 143,961,352 (GRCm39) |
F30L |
probably damaging |
Het |
| Oosp1 |
T |
C |
19: 11,668,333 (GRCm39) |
M17V |
probably benign |
Het |
| Or14c45 |
C |
T |
7: 86,176,195 (GRCm39) |
P77S |
probably damaging |
Het |
| Or4c111 |
G |
A |
2: 88,843,632 (GRCm39) |
R259W |
probably damaging |
Het |
| Or4c118 |
A |
C |
2: 88,975,108 (GRCm39) |
Y86* |
probably null |
Het |
| Or52ad1 |
G |
T |
7: 102,995,918 (GRCm39) |
D72E |
probably damaging |
Het |
| Pax1 |
A |
T |
2: 147,208,067 (GRCm39) |
Y225F |
probably benign |
Het |
| Pde4dip |
T |
A |
3: 97,751,028 (GRCm39) |
H62L |
probably benign |
Het |
| Pkd1 |
C |
A |
17: 24,804,920 (GRCm39) |
Q3190K |
probably damaging |
Het |
| Pkn1 |
A |
C |
8: 84,410,236 (GRCm39) |
|
probably benign |
Het |
| Plin5 |
T |
C |
17: 56,422,597 (GRCm39) |
D113G |
probably damaging |
Het |
| Ppfia1 |
A |
G |
7: 144,036,082 (GRCm39) |
V1141A |
probably damaging |
Het |
| Ppp4r1 |
T |
A |
17: 66,123,001 (GRCm39) |
D334E |
probably benign |
Het |
| Ptov1 |
A |
T |
7: 44,512,873 (GRCm39) |
|
probably null |
Het |
| Rab22a |
G |
A |
2: 173,503,252 (GRCm39) |
V22M |
probably damaging |
Het |
| Rictor |
T |
A |
15: 6,815,852 (GRCm39) |
|
probably null |
Het |
| Sart1 |
G |
T |
19: 5,430,559 (GRCm39) |
|
probably benign |
Het |
| Scn11a |
G |
A |
9: 119,648,928 (GRCm39) |
A45V |
probably benign |
Het |
| Serpina5 |
A |
G |
12: 104,069,459 (GRCm39) |
T224A |
possibly damaging |
Het |
| Siglecf |
G |
T |
7: 43,001,825 (GRCm39) |
G212C |
probably damaging |
Het |
| Slc38a4 |
A |
T |
15: 96,906,335 (GRCm39) |
M378K |
probably damaging |
Het |
| Spata22 |
T |
A |
11: 73,231,275 (GRCm39) |
C176* |
probably null |
Het |
| Tmc3 |
G |
A |
7: 83,245,347 (GRCm39) |
E131K |
probably damaging |
Het |
| Trappc10 |
A |
T |
10: 78,046,594 (GRCm39) |
|
probably benign |
Het |
| Uvrag |
A |
G |
7: 98,537,180 (GRCm39) |
F672L |
probably benign |
Het |
| Vmn1r121 |
A |
G |
7: 20,832,332 (GRCm39) |
V36A |
possibly damaging |
Het |
| Vmn1r13 |
A |
T |
6: 57,187,611 (GRCm39) |
M257L |
probably benign |
Het |
| Vmn1r58 |
C |
T |
7: 5,413,495 (GRCm39) |
C245Y |
probably damaging |
Het |
| Vmn1r86 |
C |
A |
7: 12,836,707 (GRCm39) |
M56I |
probably benign |
Het |
| Wdr62 |
T |
C |
7: 29,942,299 (GRCm39) |
Y1051C |
probably benign |
Het |
| Xpnpep3 |
A |
G |
15: 81,314,915 (GRCm39) |
D205G |
probably damaging |
Het |
| Zdhhc14 |
T |
C |
17: 5,775,611 (GRCm39) |
|
probably benign |
Het |
| Zfp607a |
A |
T |
7: 27,578,637 (GRCm39) |
D569V |
possibly damaging |
Het |
| Zfp609 |
C |
T |
9: 65,608,470 (GRCm39) |
E1137K |
possibly damaging |
Het |
| Zfp871 |
T |
C |
17: 32,993,408 (GRCm39) |
Y589C |
probably damaging |
Het |
| Zzef1 |
A |
T |
11: 72,771,450 (GRCm39) |
D1644V |
probably benign |
Het |
|
| Other mutations in Fasn |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00468:Fasn
|
APN |
11 |
120,711,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01014:Fasn
|
APN |
11 |
120,708,055 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01131:Fasn
|
APN |
11 |
120,705,445 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01603:Fasn
|
APN |
11 |
120,706,891 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01606:Fasn
|
APN |
11 |
120,699,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01897:Fasn
|
APN |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01899:Fasn
|
APN |
11 |
120,710,975 (GRCm39) |
splice site |
probably benign |
|
|
IGL01987:Fasn
|
APN |
11 |
120,708,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02103:Fasn
|
APN |
11 |
120,702,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02212:Fasn
|
APN |
11 |
120,698,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02294:Fasn
|
APN |
11 |
120,701,102 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02336:Fasn
|
APN |
11 |
120,704,562 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02417:Fasn
|
APN |
11 |
120,711,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02452:Fasn
|
APN |
11 |
120,699,006 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02559:Fasn
|
APN |
11 |
120,699,892 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02724:Fasn
|
APN |
11 |
120,700,659 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02862:Fasn
|
APN |
11 |
120,709,805 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02947:Fasn
|
APN |
11 |
120,706,502 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03025:Fasn
|
APN |
11 |
120,708,974 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03131:Fasn
|
APN |
11 |
120,701,550 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03157:Fasn
|
APN |
11 |
120,698,735 (GRCm39) |
missense |
probably benign |
0.12 |
|
IGL03182:Fasn
|
APN |
11 |
120,703,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03370:Fasn
|
APN |
11 |
120,703,621 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
BB007:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
BB017:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0019:Fasn
|
UTSW |
11 |
120,698,824 (GRCm39) |
splice site |
probably benign |
|
|
R0243:Fasn
|
UTSW |
11 |
120,706,141 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Fasn
|
UTSW |
11 |
120,707,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Fasn
|
UTSW |
11 |
120,701,894 (GRCm39) |
missense |
probably benign |
|
|
R0626:Fasn
|
UTSW |
11 |
120,702,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1037:Fasn
|
UTSW |
11 |
120,700,277 (GRCm39) |
missense |
probably benign |
|
|
R1061:Fasn
|
UTSW |
11 |
120,713,008 (GRCm39) |
splice site |
probably null |
|
|
R1109:Fasn
|
UTSW |
11 |
120,703,150 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1467:Fasn
|
UTSW |
11 |
120,701,866 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1498:Fasn
|
UTSW |
11 |
120,706,245 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1552:Fasn
|
UTSW |
11 |
120,709,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Fasn
|
UTSW |
11 |
120,704,075 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1624:Fasn
|
UTSW |
11 |
120,703,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1774:Fasn
|
UTSW |
11 |
120,707,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1826:Fasn
|
UTSW |
11 |
120,699,325 (GRCm39) |
splice site |
probably benign |
|
|
R1846:Fasn
|
UTSW |
11 |
120,704,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2298:Fasn
|
UTSW |
11 |
120,704,642 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2513:Fasn
|
UTSW |
11 |
120,705,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3001:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3002:Fasn
|
UTSW |
11 |
120,700,671 (GRCm39) |
missense |
probably benign |
|
|
R3154:Fasn
|
UTSW |
11 |
120,698,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3434:Fasn
|
UTSW |
11 |
120,713,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4794:Fasn
|
UTSW |
11 |
120,702,121 (GRCm39) |
missense |
probably benign |
0.36 |
|
R4840:Fasn
|
UTSW |
11 |
120,703,885 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4863:Fasn
|
UTSW |
11 |
120,699,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4876:Fasn
|
UTSW |
11 |
120,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4914:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4915:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4916:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4918:Fasn
|
UTSW |
11 |
120,707,472 (GRCm39) |
missense |
probably benign |
0.39 |
|
R4936:Fasn
|
UTSW |
11 |
120,706,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5025:Fasn
|
UTSW |
11 |
120,702,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5092:Fasn
|
UTSW |
11 |
120,705,862 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Fasn
|
UTSW |
11 |
120,702,217 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5175:Fasn
|
UTSW |
11 |
120,707,195 (GRCm39) |
missense |
probably benign |
0.14 |
|
R5183:Fasn
|
UTSW |
11 |
120,699,708 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5506:Fasn
|
UTSW |
11 |
120,700,336 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5557:Fasn
|
UTSW |
11 |
120,703,252 (GRCm39) |
missense |
probably benign |
0.10 |
|
R5614:Fasn
|
UTSW |
11 |
120,704,154 (GRCm39) |
missense |
probably benign |
|
|
R5728:Fasn
|
UTSW |
11 |
120,704,339 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5838:Fasn
|
UTSW |
11 |
120,706,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5959:Fasn
|
UTSW |
11 |
120,699,390 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6029:Fasn
|
UTSW |
11 |
120,711,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6134:Fasn
|
UTSW |
11 |
120,713,012 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6335:Fasn
|
UTSW |
11 |
120,706,185 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6452:Fasn
|
UTSW |
11 |
120,706,237 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6627:Fasn
|
UTSW |
11 |
120,709,753 (GRCm39) |
missense |
probably benign |
0.10 |
|
R6742:Fasn
|
UTSW |
11 |
120,701,279 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6767:Fasn
|
UTSW |
11 |
120,708,313 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R6927:Fasn
|
UTSW |
11 |
120,699,115 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6976:Fasn
|
UTSW |
11 |
120,710,693 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Fasn
|
UTSW |
11 |
120,710,946 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7157:Fasn
|
UTSW |
11 |
120,701,291 (GRCm39) |
nonsense |
probably null |
|
|
R7373:Fasn
|
UTSW |
11 |
120,704,802 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7575:Fasn
|
UTSW |
11 |
120,703,513 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7652:Fasn
|
UTSW |
11 |
120,707,154 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7670:Fasn
|
UTSW |
11 |
120,704,245 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7806:Fasn
|
UTSW |
11 |
120,700,821 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7930:Fasn
|
UTSW |
11 |
120,700,061 (GRCm39) |
missense |
probably benign |
|
|
R8007:Fasn
|
UTSW |
11 |
120,700,353 (GRCm39) |
missense |
probably benign |
|
|
R8012:Fasn
|
UTSW |
11 |
120,702,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8185:Fasn
|
UTSW |
11 |
120,702,969 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8557:Fasn
|
UTSW |
11 |
120,706,610 (GRCm39) |
missense |
probably benign |
0.23 |
|
R8711:Fasn
|
UTSW |
11 |
120,709,944 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8772:Fasn
|
UTSW |
11 |
120,711,362 (GRCm39) |
missense |
probably benign |
|
|
R8856:Fasn
|
UTSW |
11 |
120,708,979 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8875:Fasn
|
UTSW |
11 |
120,703,224 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9071:Fasn
|
UTSW |
11 |
120,708,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9153:Fasn
|
UTSW |
11 |
120,706,496 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9238:Fasn
|
UTSW |
11 |
120,705,871 (GRCm39) |
missense |
probably benign |
|
|
R9249:Fasn
|
UTSW |
11 |
120,703,915 (GRCm39) |
missense |
probably benign |
|
|
R9345:Fasn
|
UTSW |
11 |
120,706,735 (GRCm39) |
missense |
probably benign |
0.22 |
|
X0067:Fasn
|
UTSW |
11 |
120,707,129 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Fasn
|
UTSW |
11 |
120,706,297 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGCCCCAAGGTAGGCCAAGTAATG -3'
(R):5'- TCTATGCCACGATTCTGAATGCCG -3'
Sequencing Primer
(F):5'- AGGCCAAGTAATGGTTACACTAC -3'
(R):5'- ACCGTAGGTGTAACATTCCC -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation