Incidental Mutation 'R4552:Odf2l'
ID 377803
Institutional Source Beutler Lab
Gene Symbol Odf2l
Ensembl Gene ENSMUSG00000028256
Gene Name outer dense fiber of sperm tails 2-like
Synonyms 4733401D09Rik, 9630045K08Rik
MMRRC Submission 041783-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.171) question?
Stock # R4552 (G1)
Quality Score 225
Status Validated
Chromosome 3
Chromosomal Location 144824349-144859676 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 144856844 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 600 (T600S)
Ref Sequence ENSEMBL: ENSMUSP00000096140 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029920] [ENSMUST00000098538] [ENSMUST00000098539] [ENSMUST00000106192] [ENSMUST00000200353]
AlphaFold Q9D478
Predicted Effect probably benign
Transcript: ENSMUST00000029920
AA Change: T504S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000029920
Gene: ENSMUSG00000028256
AA Change: T504S

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
coiled coil region 85 183 N/A INTRINSIC
coiled coil region 206 367 N/A INTRINSIC
coiled coil region 388 508 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000098538
AA Change: T600S

PolyPhen 2 Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000096140
Gene: ENSMUSG00000028256
AA Change: T600S

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 604 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000098539
AA Change: T547S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000096141
Gene: ENSMUSG00000028256
AA Change: T547S

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 410 N/A INTRINSIC
coiled coil region 431 551 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000106192
AA Change: T547S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000101798
Gene: ENSMUSG00000028256
AA Change: T547S

DomainStartEndE-ValueType
coiled coil region 31 58 N/A INTRINSIC
low complexity region 77 88 N/A INTRINSIC
coiled coil region 128 226 N/A INTRINSIC
coiled coil region 249 410 N/A INTRINSIC
coiled coil region 431 551 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195926
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196426
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198808
Predicted Effect probably benign
Transcript: ENSMUST00000200353
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199045
Predicted Effect noncoding transcript
Transcript: ENSMUST00000200014
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency 97% (62/64)
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Arhgap33 A T 7: 30,218,533 (GRCm39) probably benign Het
Arid1a A C 4: 133,423,010 (GRCm39) probably benign Het
C4bp A G 1: 130,564,464 (GRCm39) Y407H possibly damaging Het
Camta1 T C 4: 151,876,959 (GRCm39) R79G probably damaging Het
Caskin1 G A 17: 24,725,602 (GRCm39) S1296N probably benign Het
Cep128 T C 12: 91,260,936 (GRCm39) E309G probably damaging Het
Chit1 A G 1: 134,071,789 (GRCm39) T100A probably benign Het
Dalrd3 A G 9: 108,449,429 (GRCm39) D454G possibly damaging Het
Ddx19a G A 8: 111,705,198 (GRCm39) Q308* probably null Het
Dmxl2 T C 9: 54,359,047 (GRCm39) N395S probably damaging Het
Dnah17 T C 11: 117,943,769 (GRCm39) D3125G possibly damaging Het
Dnah5 T C 15: 28,397,300 (GRCm39) V3331A probably benign Het
Dnah9 T C 11: 65,732,192 (GRCm39) E4238G probably damaging Het
Dner T C 1: 84,361,578 (GRCm39) Y677C probably damaging Het
Epgn A T 5: 91,175,421 (GRCm39) K14* probably null Het
Hid1 G A 11: 115,249,505 (GRCm39) T240M possibly damaging Het
Igbp1b T A 6: 138,635,112 (GRCm39) M111L probably benign Het
Kif26b T A 1: 178,711,600 (GRCm39) I740N probably damaging Het
Klk4 C A 7: 43,533,443 (GRCm39) H101N probably benign Het
Mrgpra2b C A 7: 47,113,754 (GRCm39) S300I probably benign Het
Mtss2 A G 8: 111,465,137 (GRCm39) T464A probably damaging Het
Nbas T C 12: 13,385,938 (GRCm39) probably null Het
Nif3l1 C T 1: 58,488,483 (GRCm39) probably benign Het
Noct T A 3: 51,157,589 (GRCm39) I309N probably benign Het
Obscn T C 11: 59,022,472 (GRCm39) R758G possibly damaging Het
Odf4 C T 11: 68,812,866 (GRCm39) S264N probably benign Het
Or13a17 A T 7: 140,271,655 (GRCm39) Y279F probably damaging Het
Or1m1 A G 9: 18,666,430 (GRCm39) V167A possibly damaging Het
Or2y1e A T 11: 49,218,777 (GRCm39) M180L probably benign Het
Or6c217 T C 10: 129,737,992 (GRCm39) M196V probably benign Het
Papolb T C 5: 142,514,933 (GRCm39) I237V probably benign Het
Parpbp T A 10: 87,929,564 (GRCm39) Q428L possibly damaging Het
Pclo T C 5: 14,719,285 (GRCm39) S1141P unknown Het
Plcb1 T C 2: 135,177,413 (GRCm39) S582P probably benign Het
Ppargc1a C T 5: 51,620,557 (GRCm39) probably benign Het
Ptchd4 A T 17: 42,813,346 (GRCm39) I416L probably benign Het
Rhpn1 G A 15: 75,585,968 (GRCm39) R627H probably benign Het
Ric8a G A 7: 140,441,250 (GRCm39) G182S probably damaging Het
Rims1 T C 1: 22,443,718 (GRCm39) D895G probably damaging Het
Rrp1b G A 17: 32,274,984 (GRCm39) probably benign Het
Rtf1 T A 2: 119,561,210 (GRCm39) D636E probably benign Het
Scn3a T C 2: 65,354,523 (GRCm39) D333G probably benign Het
Sema6a A G 18: 47,424,990 (GRCm39) L207P probably damaging Het
Shcbp1 A T 8: 4,799,779 (GRCm39) Y160* probably null Het
Slc27a1 A T 8: 72,032,710 (GRCm39) probably null Het
Ston2 C T 12: 91,608,646 (GRCm39) R818Q probably damaging Het
Tipin T A 9: 64,195,385 (GRCm39) probably null Het
Tjap1 A T 17: 46,570,953 (GRCm39) probably null Het
Vmn1r117 A T 7: 20,617,517 (GRCm39) F177Y probably damaging Het
Vmn1r57 A G 7: 5,223,667 (GRCm39) D64G possibly damaging Het
Vmn2r73 T A 7: 85,525,055 (GRCm39) D31V probably benign Het
Vmn2r-ps41 A T 7: 9,180,063 (GRCm39) noncoding transcript Het
Other mutations in Odf2l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00685:Odf2l APN 3 144,833,634 (GRCm39) missense possibly damaging 0.93
IGL00821:Odf2l APN 3 144,856,748 (GRCm39) missense probably damaging 1.00
IGL01984:Odf2l APN 3 144,845,590 (GRCm39) nonsense probably null
R0080:Odf2l UTSW 3 144,830,084 (GRCm39) missense possibly damaging 0.63
R0133:Odf2l UTSW 3 144,854,302 (GRCm39) missense probably damaging 0.96
R0436:Odf2l UTSW 3 144,831,877 (GRCm39) missense possibly damaging 0.91
R1218:Odf2l UTSW 3 144,854,693 (GRCm39) missense probably damaging 1.00
R1521:Odf2l UTSW 3 144,854,797 (GRCm39) missense possibly damaging 0.93
R1677:Odf2l UTSW 3 144,845,543 (GRCm39) critical splice acceptor site probably null
R1884:Odf2l UTSW 3 144,856,809 (GRCm39) missense probably damaging 1.00
R2151:Odf2l UTSW 3 144,854,785 (GRCm39) missense possibly damaging 0.86
R2910:Odf2l UTSW 3 144,830,084 (GRCm39) missense probably benign 0.00
R2911:Odf2l UTSW 3 144,830,084 (GRCm39) missense probably benign 0.00
R4640:Odf2l UTSW 3 144,834,706 (GRCm39) missense probably damaging 1.00
R4667:Odf2l UTSW 3 144,833,801 (GRCm39) missense probably benign 0.04
R5472:Odf2l UTSW 3 144,852,627 (GRCm39) missense probably benign 0.00
R5769:Odf2l UTSW 3 144,841,492 (GRCm39) missense possibly damaging 0.91
R5877:Odf2l UTSW 3 144,834,771 (GRCm39) splice site probably null
R6026:Odf2l UTSW 3 144,854,797 (GRCm39) missense possibly damaging 0.93
R6031:Odf2l UTSW 3 144,845,624 (GRCm39) missense probably damaging 1.00
R6031:Odf2l UTSW 3 144,845,624 (GRCm39) missense probably damaging 1.00
R6351:Odf2l UTSW 3 144,841,479 (GRCm39) missense probably benign 0.11
R6454:Odf2l UTSW 3 144,859,181 (GRCm39) missense possibly damaging 0.93
R6462:Odf2l UTSW 3 144,852,672 (GRCm39) missense probably damaging 1.00
R6888:Odf2l UTSW 3 144,854,379 (GRCm39) critical splice donor site probably null
R7008:Odf2l UTSW 3 144,838,495 (GRCm39) missense probably damaging 1.00
R7121:Odf2l UTSW 3 144,845,581 (GRCm39) missense possibly damaging 0.93
R7151:Odf2l UTSW 3 144,832,827 (GRCm39) missense probably benign 0.26
R7542:Odf2l UTSW 3 144,859,197 (GRCm39) missense probably damaging 0.99
R7664:Odf2l UTSW 3 144,854,345 (GRCm39) missense probably benign 0.41
R7811:Odf2l UTSW 3 144,859,148 (GRCm39) missense probably benign 0.00
R7816:Odf2l UTSW 3 144,856,776 (GRCm39) missense probably damaging 1.00
R7913:Odf2l UTSW 3 144,859,244 (GRCm39) nonsense probably null
R8090:Odf2l UTSW 3 144,832,796 (GRCm39) missense probably damaging 0.96
R8205:Odf2l UTSW 3 144,856,495 (GRCm39) critical splice acceptor site probably benign
R8222:Odf2l UTSW 3 144,833,799 (GRCm39) missense probably damaging 1.00
R8829:Odf2l UTSW 3 144,833,820 (GRCm39) missense probably benign 0.02
R8832:Odf2l UTSW 3 144,833,820 (GRCm39) missense probably benign 0.02
R8862:Odf2l UTSW 3 144,833,758 (GRCm39) unclassified probably benign
R9136:Odf2l UTSW 3 144,851,698 (GRCm39) missense
R9778:Odf2l UTSW 3 144,854,789 (GRCm39) missense possibly damaging 0.60
Predicted Primers PCR Primer
(F):5'- GTCATACCCAACTAATATCTACTTGGG -3'
(R):5'- TGACTGAAGCTGCACAGAG -3'

Sequencing Primer
(F):5'- ACTGTGACTATATCAGGGCTTC -3'
(R):5'- CACAGAGCAGGGTGATGAAAACTC -3'
Posted On 2016-04-06