Incidental Mutation 'R4904:Zfp955a'
ID378068
Institutional Source Beutler Lab
Gene Symbol Zfp955a
Ensembl Gene ENSMUSG00000094441
Gene Namezinc finger protein 955A
SynonymsAI842447
MMRRC Submission 042507-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.069) question?
Stock #R4904 (G1)
Quality Score225
Status Validated
Chromosome17
Chromosomal Location33241519-33255040 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) A to T at 33242188 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Stop codon at position 323 (C323*)
Ref Sequence ENSEMBL: ENSMUSP00000008830 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000008830]
Predicted Effect probably null
Transcript: ENSMUST00000008830
AA Change: C323*
SMART Domains Protein: ENSMUSP00000008830
Gene: ENSMUSG00000094441
AA Change: C323*

DomainStartEndE-ValueType
KRAB 10 71 7.08e-15 SMART
ZnF_C2H2 230 252 7.29e0 SMART
ZnF_C2H2 258 280 5.72e-1 SMART
ZnF_C2H2 290 312 6.57e-1 SMART
ZnF_C2HC 291 307 9.75e0 SMART
ZnF_C2H2 318 340 7.67e-2 SMART
ZnF_C2H2 346 368 3.16e-3 SMART
ZnF_C2H2 374 396 1.18e-2 SMART
ZnF_C2H2 402 424 2.99e-4 SMART
ZnF_C2H2 430 452 2.09e-3 SMART
ZnF_C2H2 458 480 6.57e-1 SMART
ZnF_C2HC 459 475 4.03e1 SMART
ZnF_C2H2 486 508 1.28e-3 SMART
ZnF_C2H2 514 536 2.36e-2 SMART
Meta Mutation Damage Score 0.9716 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.1%
Validation Efficiency 94% (82/87)
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 T G 4: 130,012,539 I920S possibly damaging Het
Afap1l1 A G 18: 61,738,715 I556T probably benign Het
Ankfy1 C A 11: 72,752,105 H665N probably benign Het
Aqp9 A C 9: 71,162,403 probably benign Het
Arhgap21 A G 2: 20,850,061 S1497P probably benign Het
Armc7 A G 11: 115,488,974 D166G probably damaging Het
Arrdc1 C A 2: 24,926,664 V167F possibly damaging Het
AW822073 T A 10: 58,223,487 R482* probably null Het
Col6a3 A T 1: 90,801,442 I1259N probably damaging Het
Coq8a C T 1: 180,178,603 R207Q probably damaging Het
Cybb C G X: 9,450,750 D246H probably benign Het
Dcbld1 C T 10: 52,319,970 Q425* probably null Het
Def8 A G 8: 123,461,480 N445D probably damaging Het
Dicer1 C T 12: 104,713,066 V551I probably benign Het
Dst A T 1: 34,169,798 T800S probably damaging Het
Dtl A T 1: 191,568,345 C136S probably damaging Het
Duox1 T A 2: 122,320,864 Y310N probably damaging Het
Ebf1 T C 11: 44,869,169 F211S probably damaging Het
Gm44501 A T 17: 40,578,993 I133F possibly damaging Het
Gm6625 T C 8: 89,146,751 noncoding transcript Het
Golgb1 A T 16: 36,893,386 D243V probably damaging Het
Gprc5c G T 11: 114,864,267 V257L possibly damaging Het
Gtf2a1l G A 17: 88,690,043 probably null Het
Herc2 T C 7: 56,157,486 F2471L probably damaging Het
Hfe A T 13: 23,708,054 I109N probably damaging Het
Hrg A G 16: 22,951,250 E43G probably benign Het
Hspa1a T C 17: 34,970,451 D492G probably damaging Het
Itgb8 T C 12: 119,170,871 D487G probably benign Het
Jag1 A G 2: 137,087,142 V798A probably damaging Het
Kcnq5 A G 1: 21,424,100 V501A probably damaging Het
Kntc1 T C 5: 123,778,333 V743A possibly damaging Het
Ly86 G T 13: 37,415,520 V126F possibly damaging Het
Med26 A T 8: 72,496,847 L136H probably damaging Het
Mpp3 T C 11: 102,000,587 D575G probably benign Het
Myoc G A 1: 162,639,425 M54I probably benign Het
Nlrp1c-ps A G 11: 71,242,628 noncoding transcript Het
Olfr111 A G 17: 37,530,631 Y218C probably damaging Het
Olfr1418 C T 19: 11,855,867 V29M possibly damaging Het
Olfr574 A G 7: 102,949,065 Y190C probably damaging Het
Pak7 A T 2: 136,083,347 D678E probably benign Het
Pcdhb12 T C 18: 37,437,856 V685A possibly damaging Het
Pcdhga2 A G 18: 37,669,879 T259A possibly damaging Het
Pde6a A T 18: 61,265,034 M702L probably benign Het
Pigq A G 17: 25,931,060 probably benign Het
Polrmt A G 10: 79,746,551 M1T probably null Het
Ptch1 A C 13: 63,523,004 I904S probably damaging Het
Rflnb A T 11: 76,022,138 C141* probably null Het
Rilpl1 C A 5: 124,514,744 probably null Het
Rpgrip1 T C 14: 52,121,087 S217P possibly damaging Het
Rpgrip1 A T 14: 52,160,129 I1292F probably damaging Het
Sema3a A C 5: 13,581,098 Y534S probably damaging Het
Sez6 A G 11: 77,975,254 Y736C probably damaging Het
Shank1 G T 7: 44,334,040 probably benign Het
Slc45a4 G A 15: 73,586,842 S294F probably benign Het
Slc9a8 A G 2: 167,471,396 I393V possibly damaging Het
Sod1 T A 16: 90,222,844 F46Y probably damaging Het
Sult1b1 T C 5: 87,535,053 D11G probably benign Het
Syn3 T G 10: 86,467,086 K68N possibly damaging Het
Taar8c C T 10: 24,101,249 V222I probably benign Het
Tbx20 T C 9: 24,758,833 K235E probably damaging Het
Tcaf3 C A 6: 42,593,997 E274* probably null Het
Tll1 A T 8: 64,070,199 M493K probably benign Het
Tmem236 T A 2: 14,195,992 S123T probably benign Het
Trim33 T C 3: 103,331,647 V647A possibly damaging Het
Tspear T A 10: 77,869,655 Y296N possibly damaging Het
Vps13d T C 4: 145,155,445 K1187E probably damaging Het
Xpot C T 10: 121,617,178 V52I probably benign Het
Zdhhc3 A T 9: 123,100,387 V61E probably damaging Het
Other mutations in Zfp955a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01115:Zfp955a APN 17 33242580 nonsense probably null
IGL01859:Zfp955a APN 17 33243719 missense probably benign 0.45
IGL02612:Zfp955a APN 17 33244065 missense probably damaging 0.99
IGL02894:Zfp955a APN 17 33242452 nonsense probably null
IGL02933:Zfp955a APN 17 33243709 splice site probably null
R0145:Zfp955a UTSW 17 33242456 missense probably damaging 0.98
R0577:Zfp955a UTSW 17 33242094 missense probably damaging 0.99
R0963:Zfp955a UTSW 17 33243752 missense probably benign 0.00
R1588:Zfp955a UTSW 17 33241817 missense probably benign 0.00
R1614:Zfp955a UTSW 17 33242332 missense possibly damaging 0.72
R1704:Zfp955a UTSW 17 33241725 nonsense probably null
R1994:Zfp955a UTSW 17 33241646 missense probably damaging 0.99
R2043:Zfp955a UTSW 17 33242553 missense possibly damaging 0.94
R2091:Zfp955a UTSW 17 33242757 nonsense probably null
R2091:Zfp955a UTSW 17 33242757 nonsense probably null
R4077:Zfp955a UTSW 17 33241701 missense probably benign 0.15
R4078:Zfp955a UTSW 17 33241701 missense probably benign 0.15
R4689:Zfp955a UTSW 17 33242066 missense probably damaging 1.00
R4735:Zfp955a UTSW 17 33241722 missense probably benign 0.09
R4870:Zfp955a UTSW 17 33241725 nonsense probably null
R5180:Zfp955a UTSW 17 33242618 missense probably benign 0.15
R6006:Zfp955a UTSW 17 33241686 missense probably damaging 1.00
R7132:Zfp955a UTSW 17 33241615 nonsense probably null
R7403:Zfp955a UTSW 17 33243746 missense probably benign 0.01
R7457:Zfp955a UTSW 17 33244051 nonsense probably null
R7547:Zfp955a UTSW 17 33242823 missense probably benign 0.05
X0062:Zfp955a UTSW 17 33242002 missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- TCATGGTTGGAACAGTTGCCC -3'
(R):5'- GTAGACACTGTGGTGAAACTTTCC -3'

Sequencing Primer
(F):5'- GTTGCCCTCACTGATAAAGGC -3'
(R):5'- GGTGAAACTTTCCTGTATTCCATGGC -3'
Posted On2016-04-15