Incidental Mutation 'R4905:Olfr1459'
ID 378145
Institutional Source Beutler Lab
Gene Symbol Olfr1459
Ensembl Gene ENSMUSG00000057503
Gene Name olfactory receptor 1459
Synonyms MOR202-17, GA_x6K02T2RE5P-3473421-3472498
Accession Numbers
Essential gene? Probably non essential (E-score: 0.133) question?
Stock # R4905 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 13138021-13149549 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 13146177 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Alanine to Serine at position 161 (A161S)
Ref Sequence ENSEMBL: ENSMUSP00000150886 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078299] [ENSMUST00000213493]
AlphaFold Q8VFV9
Predicted Effect probably benign
Transcript: ENSMUST00000078299
AA Change: A161S

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000077414
Gene: ENSMUSG00000057503
AA Change: A161S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 8e-50 PFAM
Pfam:7tm_1 39 288 1.5e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213493
AA Change: A161S

PolyPhen 2 Score 0.069 (Sensitivity: 0.94; Specificity: 0.84)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215405
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.0%
  • 20x: 87.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A T 10: 100,612,818 probably null Het
1700123L14Rik T A 6: 96,165,930 R44S possibly damaging Het
2700049A03Rik G T 12: 71,164,546 E685* probably null Het
2700049A03Rik A T 12: 71,164,547 E685V possibly damaging Het
9530053A07Rik A T 7: 28,156,983 K2065M possibly damaging Het
Abcc5 A G 16: 20,399,928 S235P probably damaging Het
Abcc6 T C 7: 45,995,225 N842S probably benign Het
Acbd6 G A 1: 155,624,923 V210I probably benign Het
Ahctf1 A T 1: 179,748,627 V2130D probably damaging Het
Akap5 A G 12: 76,328,433 E213G probably damaging Het
Alyref T G 11: 120,596,053 probably null Het
Anapc5 G T 5: 122,817,910 N152K probably benign Het
Atp8b2 A T 3: 89,949,008 D416E probably benign Het
AW551984 A T 9: 39,597,158 V354E probably damaging Het
Bag6 A G 17: 35,145,186 E844G probably damaging Het
Bmp1 C T 14: 70,491,362 R590H probably benign Het
Ccnh T C 13: 85,206,135 S233P possibly damaging Het
Cdca7 TGAAGAAGAAGAAGAAGAAGAAGAAGAAGAAGA TGAAGAAGAAGAAGAAGAAGAAGAAGAAGA 2: 72,481,861 probably benign Het
Col6a6 A G 9: 105,767,424 S1222P probably damaging Het
Dhfr G A 13: 92,365,774 G118S probably damaging Het
Dnah9 G A 11: 65,874,124 R1414* probably null Het
Dnaic1 A G 4: 41,614,269 D315G probably benign Het
Eogt T C 6: 97,142,831 R139G probably benign Het
Fh1 C T 1: 175,619,073 G79E probably damaging Het
Gabrg3 A G 7: 56,724,556 Y421H probably damaging Het
Glipr1 C A 10: 111,985,640 R219L probably damaging Het
Gm1123 T C 9: 99,009,316 D360G probably benign Het
Ift81 C T 5: 122,591,079 probably null Het
Itsn2 A G 12: 4,634,583 probably benign Het
Kri1 A T 9: 21,287,702 H55Q probably benign Het
Mcidas C A 13: 112,994,417 A92E possibly damaging Het
Mcidas C T 13: 112,997,504 T174M possibly damaging Het
Mmp25 C A 17: 23,644,048 G130* probably null Het
Myh11 G A 16: 14,250,523 T211M probably benign Het
Myo10 A G 15: 25,800,212 D1458G probably damaging Het
Ncf4 A G 15: 78,254,904 T154A probably damaging Het
Nfatc4 T C 14: 55,830,582 I620T probably benign Het
Nos3 A T 5: 24,367,331 Y134F probably benign Het
Olfr273 T C 4: 52,855,613 N300S probably damaging Het
Olfr575 A T 7: 102,955,514 I36N probably damaging Het
Olfr799 T A 10: 129,647,923 V265E possibly damaging Het
Pax9 G T 12: 56,696,626 R19S probably damaging Het
Pcdha9 T C 18: 36,998,892 I338T probably damaging Het
Plxnb2 G T 15: 89,157,411 T1730K probably damaging Het
Rac1 A G 5: 143,517,152 probably null Het
Samsn1 G T 16: 75,876,465 F174L possibly damaging Het
Scaf1 G A 7: 45,012,705 T86M probably damaging Het
Smc1b A G 15: 85,066,227 Y1199H probably damaging Het
Svep1 A G 4: 58,069,308 I2826T probably benign Het
Tex36 A G 7: 133,587,453 V130A probably damaging Het
Tigd5 A G 15: 75,911,403 H538R probably damaging Het
Tlr3 C A 8: 45,399,223 probably null Het
Tubb2b A T 13: 34,128,204 I202N probably damaging Het
Unc13c A G 9: 73,680,392 V1453A probably benign Het
Unc5c A T 3: 141,801,310 T608S probably benign Het
Vrk1 C A 12: 106,051,828 H119N probably damaging Het
Wdr53 T A 16: 32,256,658 M227K probably benign Het
Xpo4 T C 14: 57,638,289 D129G possibly damaging Het
Zcchc4 T C 5: 52,796,650 I224T probably damaging Het
Zdhhc1 T A 8: 105,483,694 E30D probably damaging Het
Zscan29 C G 2: 121,161,383 R540T possibly damaging Het
Other mutations in Olfr1459
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01371:Olfr1459 APN 19 13145828 missense possibly damaging 0.82
IGL01618:Olfr1459 APN 19 13146250 missense probably benign 0.00
IGL01800:Olfr1459 APN 19 13146629 missense probably damaging 1.00
IGL02224:Olfr1459 APN 19 13145756 missense probably damaging 1.00
BB009:Olfr1459 UTSW 19 13145981 missense probably benign 0.10
BB019:Olfr1459 UTSW 19 13145981 missense probably benign 0.10
PIT4651001:Olfr1459 UTSW 19 13146627 missense probably benign 0.02
R0617:Olfr1459 UTSW 19 13146363 missense probably benign 0.28
R2041:Olfr1459 UTSW 19 13146677 start gained probably benign
R2878:Olfr1459 UTSW 19 13146407 missense probably benign 0.38
R3742:Olfr1459 UTSW 19 13145894 missense probably damaging 0.98
R4914:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4915:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4916:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4917:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R4918:Olfr1459 UTSW 19 13145991 missense possibly damaging 0.64
R5367:Olfr1459 UTSW 19 13146501 missense probably damaging 0.98
R6242:Olfr1459 UTSW 19 13146086 missense probably benign 0.05
R6632:Olfr1459 UTSW 19 13146188 missense probably benign 0.02
R6893:Olfr1459 UTSW 19 13145742 missense probably benign 0.00
R7932:Olfr1459 UTSW 19 13145981 missense probably benign 0.10
R9572:Olfr1459 UTSW 19 13146564 missense possibly damaging 0.78
R9730:Olfr1459 UTSW 19 13146383 missense possibly damaging 0.80
Predicted Primers PCR Primer
(F):5'- CCTGAAGCTGAATGCATCTTTAG -3'
(R):5'- TACAATGCTTGTGCCTCTCAG -3'

Sequencing Primer
(F):5'- AGCTGAATGCATCTTTAGTATGTTG -3'
(R):5'- AATGCTTGTGCCTCTCAGATGTTC -3'
Posted On 2016-04-15