Mutagenetix > Incidental Mutation

Incidental Mutation 'R4906:Clasp1'

378155

Institutional Source

Beutler Lab

Gene Symbol

Clasp1

Ensembl Gene

ENSMUSG00000064302

Gene Name

CLIP associating protein 1

Synonyms

1700030C23Rik, B130045P17Rik, CLASP1, mCLASP1, 5730583A19Rik, CLASP1alpha

MMRRC Submission

042508-MU

Accession Numbers

Is this an essential gene?

Probably essential (E-score: 0.957) question?

Stock #

R4906 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

118389058-118612678 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 118508910 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Stop codon at position 308 (L308*)

Ref Sequence

ENSEMBL: ENSMUSP00000142203 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000049404] [ENSMUST00000070989] [ENSMUST00000165223] [ENSMUST00000178710] [ENSMUST00000185405] [ENSMUST00000186349] [ENSMUST00000187713] [ENSMUST00000188710] [ENSMUST00000189262] [ENSMUST00000189570] [ENSMUST00000189738] [ENSMUST00000190571] [ENSMUST00000191445] [ENSMUST00000191823] [ENSMUST00000190733]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000049404
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000042266
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	821	831	N/A	INTRINSIC
TOG	847	1085	3.23e-1	SMART
low complexity region	1096	1113	N/A	INTRINSIC
low complexity region	1134	1147	N/A	INTRINSIC
low complexity region	1225	1236	N/A	INTRINSIC
TOG	1287	1525	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000070989
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000067858
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	850	860	N/A	INTRINSIC
TOG	876	1114	3.23e-1	SMART
low complexity region	1125	1142	N/A	INTRINSIC
low complexity region	1215	1226	N/A	INTRINSIC
TOG	1277	1515	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000165223
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000128089
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	792	802	N/A	INTRINSIC
TOG	818	1056	3.23e-1	SMART
low complexity region	1067	1084	N/A	INTRINSIC
low complexity region	1157	1168	N/A	INTRINSIC
TOG	1219	1457	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000178710
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000137137
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	752	766	N/A	INTRINSIC
low complexity region	784	794	N/A	INTRINSIC
TOG	810	1047	6.55e-2	SMART
low complexity region	1058	1075	N/A	INTRINSIC
low complexity region	1148	1159	N/A	INTRINSIC
TOG	1210	1448	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000185405
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000139619
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	682	715	N/A	INTRINSIC
low complexity region	769	783	N/A	INTRINSIC
low complexity region	801	811	N/A	INTRINSIC
TOG	827	1065	1.6e-5	SMART
low complexity region	1076	1093	N/A	INTRINSIC
low complexity region	1166	1177	N/A	INTRINSIC
TOG	1228	1466	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000186349
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000141105
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	821	831	N/A	INTRINSIC
TOG	847	1085	3.23e-1	SMART
low complexity region	1096	1113	N/A	INTRINSIC
low complexity region	1134	1147	N/A	INTRINSIC
low complexity region	1225	1236	N/A	INTRINSIC
TOG	1287	1525	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000187713
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000139526
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	768	782	N/A	INTRINSIC
low complexity region	800	810	N/A	INTRINSIC
TOG	826	1064	1.6e-5	SMART
low complexity region	1075	1092	N/A	INTRINSIC
low complexity region	1165	1176	N/A	INTRINSIC
TOG	1227	1465	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000188710
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140593
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	751	763	N/A	INTRINSIC
low complexity region	818	832	N/A	INTRINSIC
low complexity region	850	860	N/A	INTRINSIC
TOG	876	1114	1.6e-5	SMART
low complexity region	1125	1142	N/A	INTRINSIC
low complexity region	1215	1226	N/A	INTRINSIC
TOG	1277	1515	2.3e-34	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000189216

Predicted Effect

probably null
Transcript: ENSMUST00000189262
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140860
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	776	786	N/A	INTRINSIC
TOG	802	1040	1.6e-5	SMART
low complexity region	1051	1068	N/A	INTRINSIC
low complexity region	1141	1152	N/A	INTRINSIC
TOG	1203	1441	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000189570
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140167
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	684	714	N/A	INTRINSIC
low complexity region	792	802	N/A	INTRINSIC
TOG	818	1055	3.2e-6	SMART
low complexity region	1066	1083	N/A	INTRINSIC
low complexity region	1156	1167	N/A	INTRINSIC
TOG	1218	1456	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000189738
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140665
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	7.31e-51	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	1.14e-11	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	668	698	N/A	INTRINSIC
low complexity region	752	766	N/A	INTRINSIC
low complexity region	784	794	N/A	INTRINSIC
TOG	810	1048	3.23e-1	SMART
low complexity region	1059	1076	N/A	INTRINSIC
low complexity region	1149	1160	N/A	INTRINSIC
TOG	1211	1449	4.96e-30	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000190571
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140019
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	682	715	N/A	INTRINSIC
low complexity region	759	771	N/A	INTRINSIC
low complexity region	805	819	N/A	INTRINSIC
low complexity region	837	847	N/A	INTRINSIC
TOG	863	1101	1.6e-5	SMART
low complexity region	1112	1129	N/A	INTRINSIC
low complexity region	1150	1163	N/A	INTRINSIC
low complexity region	1241	1252	N/A	INTRINSIC
TOG	1303	1541	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000191445
AA Change: L540*

SMART Domains

Protein: ENSMUSP00000140095
Gene: ENSMUSG00000064302
AA Change: L540*

Domain	Start	End	E-Value	Type
TOG	1	232	3.4e-55	SMART
low complexity region	252	266	N/A	INTRINSIC
low complexity region	280	296	N/A	INTRINSIC
TOG	319	551	5.5e-16	SMART
low complexity region	579	594	N/A	INTRINSIC
low complexity region	606	633	N/A	INTRINSIC
low complexity region	674	707	N/A	INTRINSIC
low complexity region	761	775	N/A	INTRINSIC
low complexity region	793	803	N/A	INTRINSIC
TOG	819	1056	3.2e-6	SMART
low complexity region	1067	1084	N/A	INTRINSIC
low complexity region	1157	1168	N/A	INTRINSIC
TOG	1219	1457	2.3e-34	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000191823
AA Change: L308*

SMART Domains

Protein: ENSMUSP00000142203
Gene: ENSMUSG00000064302
AA Change: L308*

Domain	Start	End	E-Value	Type
low complexity region	20	34	N/A	INTRINSIC
low complexity region	48	64	N/A	INTRINSIC
TOG	87	319	5.6e-16	SMART
low complexity region	347	362	N/A	INTRINSIC
low complexity region	374	401	N/A	INTRINSIC
low complexity region	450	483	N/A	INTRINSIC
low complexity region	537	551	N/A	INTRINSIC
low complexity region	568	578	N/A	INTRINSIC
TOG	594	832	1.6e-5	SMART
low complexity region	843	860	N/A	INTRINSIC
low complexity region	933	944	N/A	INTRINSIC
TOG	995	1233	2.4e-34	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205176

Predicted Effect

probably benign
Transcript: ENSMUST00000204904

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190135

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000203646

Predicted Effect

probably benign
Transcript: ENSMUST00000190733

Coding Region Coverage

1x: 98.9%
3x: 98.1%
10x: 95.7%
20x: 90.5%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5330417H12Rik	T	C	7: 107,624,690		probably benign	Het
Ablim2	C	T	5: 35,802,422	R73C	possibly damaging	Het
Adgrf2	T	C	17: 42,711,193	I247V	probably benign	Het
Adgrv1	A	G	13: 81,270,738		probably null	Het
Ankrd22	T	A	19: 34,149,352	K26I	possibly damaging	Het
Arhgap32	T	A	9: 32,245,256		probably null	Het
Armc10	A	G	5: 21,661,524	Y262C	probably damaging	Het
Arrb2	A	G	11: 70,439,899	D374G	probably benign	Het
Ascc3	C	T	10: 50,749,131	R1675C	probably damaging	Het
Atg5	T	C	10: 44,363,050	*276R	probably null	Het
Bcl11b	G	A	12: 107,916,709	T377M	probably damaging	Het
C1s2	C	A	6: 124,635,114	E104*	probably null	Het
Carf	A	T	1: 60,141,367	H316L	probably damaging	Het
Ccdc77	A	T	6: 120,334,835	I234N	probably damaging	Het
Cd300c2	A	T	11: 114,997,000	V192E	possibly damaging	Het
Cep72	G	A	13: 74,059,465	R62C	probably damaging	Het
Clec2g	A	G	6: 128,979,448	S25G	probably benign	Het
Cngb1	T	C	8: 95,251,973	M1046V	probably damaging	Het
Cobll1	A	T	2: 65,097,693	D1095E	probably benign	Het
Cpeb2	A	G	5: 43,244,662	H662R	possibly damaging	Het
Cps1	A	T	1: 67,139,763	T45S	probably benign	Het
Cspp1	A	G	1: 10,082,328	Q368R	possibly damaging	Het
Dcaf6	C	A	1: 165,411,463		probably null	Het
Dcst1	T	C	3: 89,350,507	Y652C	possibly damaging	Het
Elf5	T	G	2: 103,449,573	Y225*	probably null	Het
Ermap	A	C	4: 119,188,818		probably benign	Het
Fam186b	A	T	15: 99,271,321	V915D	probably damaging	Het
Fbxo34	C	A	14: 47,529,454	N90K	probably benign	Het
Flnc	A	G	6: 29,447,525	E1109G	probably damaging	Het
Flt1	C	A	5: 147,683,939	A132S	probably benign	Het
Gabpb2	A	G	3: 95,190,636	V242A	probably benign	Het
Gas2l3	CACTCGTCATACT	CACT	10: 89,430,958		probably benign	Het
Gm14409	T	C	2: 177,265,430	T92A	possibly damaging	Het
Gm21798	A	T	15: 64,817,883		probably benign	Het
Gm765	A	T	6: 98,238,119	M181K	probably damaging	Het
Gpr179	A	T	11: 97,346,661	S345T	possibly damaging	Het
Gusb	A	T	5: 129,998,118	F377L	probably damaging	Het
Hnrnpu	T	C	1: 178,329,373		probably benign	Het
Htr3b	C	T	9: 48,937,048		probably null	Het
Iqub	A	T	6: 24,501,369	V194D	probably damaging	Het
Itga2b	A	G	11: 102,461,159	V504A	probably benign	Het
Itga4	T	A	2: 79,288,248	F430L	probably damaging	Het
Jcad	C	A	18: 4,673,762	P508H	probably damaging	Het
Jph1	T	C	1: 17,091,611	T276A	probably damaging	Het
Kansl2	A	G	15: 98,531,890	F87S	possibly damaging	Het
Kdm1b	T	C	13: 47,063,144		probably null	Het
Kif5b	C	T	18: 6,220,930	D393N	probably benign	Het
Kmt2d	A	T	15: 98,849,539		probably benign	Het
Krt75	A	G	15: 101,570,239	I320T	probably damaging	Het
Lipo5	T	C	19: 33,465,948	N156S	unknown	Het
Mblac2	A	C	13: 81,711,587	Q19P	probably null	Het
Mfsd4b3	T	C	10: 39,948,060	H68R	probably damaging	Het
Mzb1	A	T	18: 35,647,953		probably null	Het
Nup210l	T	A	3: 90,170,030	I891N	probably benign	Het
Nwd1	G	A	8: 72,672,213	R667Q	probably damaging	Het
Oas1h	C	T	5: 120,867,109	Q207*	probably null	Het
Olfr159	A	T	4: 43,770,476	F178L	possibly damaging	Het
Pcdh15	C	T	10: 74,504,793	R1120*	probably null	Het
Pfkl	A	G	10: 77,988,310	L748P	probably damaging	Het
Phldb2	T	A	16: 45,751,395	K473N	probably damaging	Het
Rapgef6	G	A	11: 54,552,836	V82I	probably damaging	Het
Rfc3	A	T	5: 151,647,495	L112Q	probably damaging	Het
Rsph6a	T	A	7: 19,068,072	C349S	possibly damaging	Het
Sec16a	A	T	2: 26,441,967		probably benign	Het
Sept14	T	A	5: 129,692,966	Y222F	probably benign	Het
Skor2	T	C	18: 76,860,295	S571P	possibly damaging	Het
Slc13a5	T	A	11: 72,257,418	M264L	probably damaging	Het
Slc45a3	T	A	1: 131,981,577	V504E	probably damaging	Het
Smg1	C	T	7: 118,152,408		probably benign	Het
Smim20	A	G	5: 53,277,161	N45S	probably null	Het
Spp2	A	T	1: 88,412,269	S111C	probably damaging	Het
Sspo	A	G	6: 48,465,730		probably null	Het
Sycp2	C	T	2: 178,403,657		probably null	Het
Tas2r113	A	G	6: 132,893,558	N183S	possibly damaging	Het
Tcaf2	A	T	6: 42,629,745	M425K	probably benign	Het
Tdrp	A	G	8: 13,953,845	V164A	possibly damaging	Het
Tmbim1	A	G	1: 74,289,409	F298S	probably damaging	Het
Tmem211	T	A	5: 113,238,170	M161K	probably benign	Het
Tmem89	A	G	9: 108,914,761		probably benign	Het
Trpm2	G	T	10: 77,932,189	C825*	probably null	Het
Tsc1	A	G	2: 28,675,189	E421G	possibly damaging	Het
Usp24	T	C	4: 106,388,637	I1364T	probably benign	Het
Vmn1r52	G	A	6: 90,178,948	G78E	possibly damaging	Het
Vmn2r73	T	G	7: 85,857,621	I828L	probably damaging	Het
Vwa5b1	A	T	4: 138,610,747	D87E	probably benign	Het
Zfp451	A	T	1: 33,805,384	D47E	probably damaging	Het
Zfp821	A	G	8: 109,724,209	E278G	probably damaging	Het
Zfp930	A	T	8: 69,228,945	T430S	probably benign	Het
Zfp994	G	T	17: 22,200,467	Y500*	probably null	Het
Zmat3	A	T	3: 32,343,687	I142N	probably damaging	Het
Zzef1	T	A	11: 72,901,388	I2266N	probably damaging	Het

Other mutations in Clasp1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01785:Clasp1	APN	1	118497736	missense	possibly damaging	0.74
IGL01786:Clasp1	APN	1	118497736	missense	possibly damaging	0.74
IGL01871:Clasp1	APN	1	118570889	missense	probably damaging	1.00
IGL02066:Clasp1	APN	1	118565260	critical splice donor site	probably null
IGL02602:Clasp1	APN	1	118471785	missense	probably damaging	0.99
IGL02683:Clasp1	APN	1	118539266	missense	probably benign	0.33
IGL02728:Clasp1	APN	1	118602377	missense	probably damaging	1.00
IGL02820:Clasp1	APN	1	118551104	missense	possibly damaging	0.77
IGL02874:Clasp1	APN	1	118552043	missense	possibly damaging	0.86
IGL02975:Clasp1	APN	1	118462547	missense	probably damaging	1.00
IGL03100:Clasp1	APN	1	118467896	missense	possibly damaging	0.79
IGL03115:Clasp1	APN	1	118501323	nonsense	probably null
IGL03122:Clasp1	APN	1	118510277	missense	probably damaging	1.00
IGL03180:Clasp1	APN	1	118505525	missense	probably benign	0.33
IGL03248:Clasp1	APN	1	118602476	missense	probably benign	0.01
IGL03388:Clasp1	APN	1	118505503	missense	possibly damaging	0.95
F5770:Clasp1	UTSW	1	118581348	missense	probably damaging	1.00
I2288:Clasp1	UTSW	1	118565229	missense	probably benign	0.09
PIT4585001:Clasp1	UTSW	1	118462555	missense	probably damaging	0.99
R0079:Clasp1	UTSW	1	118543304	missense	probably damaging	1.00
R0395:Clasp1	UTSW	1	118539331	missense	possibly damaging	0.48
R0960:Clasp1	UTSW	1	118552026	missense	probably benign	0.39
R1448:Clasp1	UTSW	1	118508916	missense	probably benign	0.01
R1497:Clasp1	UTSW	1	118552058	missense	probably benign	0.42
R1607:Clasp1	UTSW	1	118504959	missense	probably damaging	0.98
R1722:Clasp1	UTSW	1	118590464	missense	probably damaging	1.00
R1758:Clasp1	UTSW	1	118548025	missense	probably damaging	1.00
R1765:Clasp1	UTSW	1	118505531	missense	probably damaging	0.99
R1855:Clasp1	UTSW	1	118508894	missense	probably damaging	1.00
R1861:Clasp1	UTSW	1	118570931	missense	possibly damaging	0.93
R1874:Clasp1	UTSW	1	118600585	critical splice donor site	probably null
R1942:Clasp1	UTSW	1	118501348	missense	possibly damaging	0.94
R2025:Clasp1	UTSW	1	118504899	missense	probably damaging	1.00
R2174:Clasp1	UTSW	1	118560095	missense	probably damaging	1.00
R2280:Clasp1	UTSW	1	118565183	missense	probably benign	0.05
R2288:Clasp1	UTSW	1	118578878	missense	probably benign
R2895:Clasp1	UTSW	1	118459838	missense	probably damaging	1.00
R3958:Clasp1	UTSW	1	118467881	missense	probably damaging	0.99
R4073:Clasp1	UTSW	1	118503848	missense	probably damaging	1.00
R4206:Clasp1	UTSW	1	118578906	missense	probably damaging	1.00
R4465:Clasp1	UTSW	1	118561078	missense	probably damaging	1.00
R4609:Clasp1	UTSW	1	118503035	intron	probably benign
R4679:Clasp1	UTSW	1	118543271	missense	probably damaging	0.99
R4707:Clasp1	UTSW	1	118543197	nonsense	probably null
R4809:Clasp1	UTSW	1	118461250	missense	probably benign	0.00
R5048:Clasp1	UTSW	1	118547610	intron	probably benign
R5298:Clasp1	UTSW	1	118547920	missense	possibly damaging	0.71
R5485:Clasp1	UTSW	1	118467913	missense	possibly damaging	0.95
R5516:Clasp1	UTSW	1	118497721	missense	probably damaging	1.00
R5821:Clasp1	UTSW	1	118590484	missense	probably damaging	1.00
R5911:Clasp1	UTSW	1	118506908	unclassified	probably benign
R6092:Clasp1	UTSW	1	118510298	missense	probably damaging	0.97
R6181:Clasp1	UTSW	1	118419817	missense	probably benign	0.18
R6478:Clasp1	UTSW	1	118512180	nonsense	probably null
R7090:Clasp1	UTSW	1	118482086	missense	probably benign	0.45
R7216:Clasp1	UTSW	1	118547918	missense	probably benign	0.00
R7508:Clasp1	UTSW	1	118545434	missense	probably benign	0.30
R7541:Clasp1	UTSW	1	118542997	splice site	probably null
R7644:Clasp1	UTSW	1	118512750	splice site	probably null
R7825:Clasp1	UTSW	1	118545393	missense	probably benign	0.00
R7910:Clasp1	UTSW	1	118602414	nonsense	probably null
R7971:Clasp1	UTSW	1	118521829	missense	probably damaging	0.99
R8074:Clasp1	UTSW	1	118462483	missense	probably benign
R8344:Clasp1	UTSW	1	118503899	missense	probably damaging	1.00
R8847:Clasp1	UTSW	1	118578975	missense	probably damaging	1.00
R9035:Clasp1	UTSW	1	118503853	missense	probably damaging	1.00
R9073:Clasp1	UTSW	1	118462463	splice site	probably null
R9161:Clasp1	UTSW	1	118546921	missense	probably damaging	0.98
R9184:Clasp1	UTSW	1	118543178	missense	probably benign	0.17
R9379:Clasp1	UTSW	1	118581427	utr 3 prime	probably benign
R9379:Clasp1	UTSW	1	118581438	utr 3 prime	probably benign
R9422:Clasp1	UTSW	1	118462527	missense	possibly damaging	0.46
R9516:Clasp1	UTSW	1	118503830	missense	possibly damaging	0.88
R9566:Clasp1	UTSW	1	118552071	missense	probably benign	0.01
R9776:Clasp1	UTSW	1	118581378	missense	possibly damaging	0.89
V7581:Clasp1	UTSW	1	118581348	missense	probably damaging	1.00
X0028:Clasp1	UTSW	1	118551125	missense	possibly damaging	0.93

Predicted Primers

PCR Primer
(F):5'- CTCAAAGATGCTGTGTGGCG -3'
(R):5'- ACCTCCTGAGTGAGCAGTATCC -3'

Sequencing Primer
(F):5'- CAAAGATGCTGTGTGGCGTACTG -3'
(R):5'- AGACTATACCTTGACCTCTGGGGAG -3'

Posted On

2016-04-15