Incidental Mutation 'R4917:Syne1'
ID 378303
Institutional Source Beutler Lab
Gene Symbol Syne1
Ensembl Gene ENSMUSG00000096054
Gene Name spectrin repeat containing, nuclear envelope 1
Synonyms C130039F11Rik, enaptin165, SYNE-1, nesprin-1, A330049M09Rik
MMRRC Submission 042519-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4917 (G1)
Quality Score 204
Status Validated
Chromosome 10
Chromosomal Location 4970917-5501482 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 5007909 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 7932 (C7932Y)
Ref Sequence ENSEMBL: ENSMUSP00000150262 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095899] [ENSMUST00000215295]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000095899
AA Change: C105Y

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000093587
Gene: ENSMUSG00000096054
AA Change: C105Y

DomainStartEndE-ValueType
SPEC 43 150 6.95e-13 SMART
SPEC 157 259 1.55e-10 SMART
SPEC 266 366 3.4e-16 SMART
low complexity region 372 386 N/A INTRINSIC
low complexity region 403 421 N/A INTRINSIC
low complexity region 459 468 N/A INTRINSIC
coiled coil region 483 505 N/A INTRINSIC
SPEC 595 698 6.9e-17 SMART
SPEC 705 809 8.82e-1 SMART
low complexity region 811 826 N/A INTRINSIC
low complexity region 869 882 N/A INTRINSIC
KASH 892 949 5.15e-31 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000215295
AA Change: C7932Y

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Meta Mutation Damage Score 0.9541 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.3%
  • 10x: 96.1%
  • 20x: 91.7%
Validation Efficiency 97% (111/114)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for an allele lacking the KASH domain exhibit neonatal and postnatal lethality, progressive muscular dystrophy, and limb weakness. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 92 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 C T 13: 81,658,996 (GRCm39) V2783I probably benign Het
Ago4 A C 4: 126,400,635 (GRCm39) C693G probably damaging Het
Apobec2 T C 17: 48,730,153 (GRCm39) E171G probably benign Het
Arfgef3 T A 10: 18,492,638 (GRCm39) I1258F probably damaging Het
Arhgef40 A G 14: 52,227,556 (GRCm39) E434G probably damaging Het
Bcas1 T C 2: 170,220,806 (GRCm39) D324G probably damaging Het
Bdp1 A T 13: 100,191,713 (GRCm39) V1422E probably damaging Het
Bfsp1 C T 2: 143,669,391 (GRCm39) R396Q probably benign Het
Bpifb9b T A 2: 154,156,026 (GRCm39) probably null Het
Cacna1s T A 1: 136,029,302 (GRCm39) probably null Het
Casp8 T C 1: 58,866,377 (GRCm39) F126S probably damaging Het
Cdh26 T C 2: 178,091,614 (GRCm39) S58P probably benign Het
Cds2 A G 2: 132,140,398 (GRCm39) T182A probably damaging Het
Cfap157 C T 2: 32,669,965 (GRCm39) R206H probably benign Het
Col7a1 G A 9: 108,795,532 (GRCm39) G1529E unknown Het
Crybg3 A G 16: 59,350,782 (GRCm39) F2567L probably benign Het
Cyp2e1 T C 7: 140,354,527 (GRCm39) S393P possibly damaging Het
D5Ertd579e A G 5: 36,773,160 (GRCm39) Y412H probably damaging Het
Dclk2 A T 3: 86,732,049 (GRCm39) probably null Het
Ddx50 A T 10: 62,463,450 (GRCm39) C414* probably null Het
Dip2c T A 13: 9,671,905 (GRCm39) probably null Het
Dmtn G T 14: 70,843,159 (GRCm39) P283Q probably damaging Het
Dspp C A 5: 104,325,789 (GRCm39) D717E unknown Het
Efcab11 T C 12: 99,685,321 (GRCm39) D151G probably damaging Het
Egfem1 T C 3: 29,206,042 (GRCm39) V93A probably damaging Het
Ehbp1 T C 11: 22,096,592 (GRCm39) D299G probably benign Het
Erlec1 A G 11: 30,884,710 (GRCm39) Y448H possibly damaging Het
Fer1l4 T C 2: 155,873,220 (GRCm39) K1287E probably benign Het
Fn1 A T 1: 71,634,968 (GRCm39) probably null Het
Fut8 G T 12: 77,521,818 (GRCm39) A486S probably damaging Het
Gfra1 A T 19: 58,255,522 (GRCm39) S308R probably damaging Het
Gm10764 A G 10: 87,126,579 (GRCm39) noncoding transcript Het
Gm5958 C A 14: 100,073,189 (GRCm39) noncoding transcript Het
Gm6788 C T 19: 28,740,664 (GRCm39) noncoding transcript Het
Gsdmd A G 15: 75,736,241 (GRCm39) I123M probably benign Het
H2bc13 A T 13: 21,900,189 (GRCm39) V42E probably damaging Het
Hsf4 A G 8: 105,999,367 (GRCm39) E235G probably benign Het
Ighv1-83 T C 12: 115,927,580 (GRCm39) I57V probably benign Het
Inhca A C 9: 103,129,054 (GRCm39) Y235* probably null Het
Inpp5f A T 7: 128,286,840 (GRCm39) D573V probably damaging Het
Kcnj1 T A 9: 32,308,056 (GRCm39) L160Q probably damaging Het
Kcnmb3 A T 3: 32,526,653 (GRCm39) C179* probably null Het
Lrig1 A G 6: 94,586,700 (GRCm39) F659L probably damaging Het
Lrrc3 T C 10: 77,737,253 (GRCm39) D61G probably benign Het
Marchf4 T G 1: 72,467,938 (GRCm39) S365R probably benign Het
Mccc1 A G 3: 36,051,703 (GRCm39) L32S probably benign Het
Mei4 A G 9: 81,772,216 (GRCm39) T10A probably benign Het
Meis1 T C 11: 18,959,222 (GRCm39) probably benign Het
Mllt1 T C 17: 57,206,813 (GRCm39) T344A probably benign Het
Mmp11 C T 10: 75,761,419 (GRCm39) A31T probably damaging Het
Mrps28 A G 3: 8,947,614 (GRCm39) probably benign Het
Mthfsl A C 9: 88,597,550 (GRCm39) L67V probably damaging Het
Ncaph2 A G 15: 89,244,574 (GRCm39) I11V probably damaging Het
Ncdn G A 4: 126,643,731 (GRCm39) L364F possibly damaging Het
Nfat5 T A 8: 108,051,284 (GRCm39) D47E probably damaging Het
Or51g2 A T 7: 102,622,614 (GRCm39) I195N possibly damaging Het
Or5b106 T A 19: 13,123,355 (GRCm39) I223L possibly damaging Het
Or5bw2 C T 7: 6,573,643 (GRCm39) L218F possibly damaging Het
Pcdhb3 A T 18: 37,435,452 (GRCm39) I473F probably damaging Het
Pcdhgb8 A T 18: 37,897,191 (GRCm39) N754Y probably damaging Het
Pgbd5 C A 8: 125,097,305 (GRCm39) K408N probably benign Het
Pnisr A G 4: 21,859,330 (GRCm39) probably benign Het
Poldip3 A T 15: 83,016,776 (GRCm39) probably null Het
Ppfia2 G C 10: 106,597,978 (GRCm39) L180F probably damaging Het
Psmc3 A G 2: 90,896,317 (GRCm39) probably benign Het
Rab3gap1 T A 1: 127,816,914 (GRCm39) W58R possibly damaging Het
Rere T A 4: 150,703,601 (GRCm39) W1528R probably damaging Het
Rhot1 A G 11: 80,100,027 (GRCm39) probably benign Het
Rsf1 T C 7: 97,311,612 (GRCm39) S781P probably damaging Het
Rtraf T C 14: 19,873,784 (GRCm39) K5R probably damaging Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Ryr2 A G 13: 11,609,872 (GRCm39) V753A probably damaging Het
Ryr3 T C 2: 112,661,530 (GRCm39) H1820R probably damaging Het
Schip1 A T 3: 68,315,818 (GRCm39) probably benign Het
Scin T A 12: 40,119,373 (GRCm39) I552F possibly damaging Het
Selp A C 1: 163,972,475 (GRCm39) T705P probably damaging Het
Sh3rf3 A T 10: 58,842,925 (GRCm39) D297V probably damaging Het
Slc24a4 T A 12: 102,231,203 (GRCm39) probably null Het
Slc2a9 C A 5: 38,574,603 (GRCm39) L224F probably benign Het
Slc35e2 C A 4: 155,700,693 (GRCm39) P272Q probably damaging Het
Slf2 T G 19: 44,960,100 (GRCm39) D1022E probably damaging Het
Tc2n A G 12: 101,631,954 (GRCm39) L301P probably damaging Het
Tchhl1 A G 3: 93,377,623 (GRCm39) D109G possibly damaging Het
Thoc7 T C 14: 13,953,154 (GRCm38) I83V probably damaging Het
Tm4sf1 C T 3: 57,200,448 (GRCm39) G85S probably damaging Het
Tmem63a T A 1: 180,794,086 (GRCm39) I541N probably benign Het
Tmpo A G 10: 90,985,411 (GRCm39) V357A probably damaging Het
Unc80 T C 1: 66,685,709 (GRCm39) Y2278H possibly damaging Het
Vmn1r26 A G 6: 57,985,808 (GRCm39) F127S probably damaging Het
Vmn2r8 A T 5: 108,945,264 (GRCm39) M781K probably damaging Het
Vps36 T G 8: 22,708,280 (GRCm39) M348R possibly damaging Het
Vps45 T C 3: 95,926,943 (GRCm39) T535A probably damaging Het
Other mutations in Syne1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00684:Syne1 APN 10 5,342,167 (GRCm38) synonymous probably benign
IGL00725:Syne1 APN 10 5,344,922 (GRCm38) missense possibly damaging 0.48
IGL00799:Syne1 APN 10 5,347,878 (GRCm38) missense probably benign 0.00
IGL01087:Syne1 APN 10 5,375,708 (GRCm39) missense probably damaging 1.00
IGL01123:Syne1 APN 10 5,294,921 (GRCm39) nonsense probably null
IGL01147:Syne1 APN 10 5,002,691 (GRCm39) nonsense probably null
IGL01150:Syne1 APN 10 5,393,154 (GRCm39) missense probably damaging 1.00
IGL01154:Syne1 APN 10 5,310,848 (GRCm39) missense probably damaging 1.00
IGL01727:Syne1 APN 10 4,997,842 (GRCm39) missense probably damaging 0.99
IGL01761:Syne1 APN 10 5,355,456 (GRCm39) missense probably damaging 1.00
IGL01793:Syne1 APN 10 5,302,191 (GRCm39) missense possibly damaging 0.67
IGL01961:Syne1 APN 10 4,993,723 (GRCm39) missense possibly damaging 0.94
IGL01975:Syne1 APN 10 5,018,908 (GRCm39) intron probably benign
IGL02152:Syne1 APN 10 5,374,382 (GRCm39) missense probably damaging 1.00
IGL02423:Syne1 APN 10 5,318,295 (GRCm39) missense probably benign 0.00
IGL02457:Syne1 APN 10 5,292,167 (GRCm39) missense probably damaging 1.00
IGL02543:Syne1 APN 10 4,993,618 (GRCm39) missense probably damaging 0.97
IGL02836:Syne1 APN 10 5,359,875 (GRCm39) splice site probably benign
IGL03141:Syne1 APN 10 5,374,261 (GRCm39) missense probably damaging 1.00
FR4548:Syne1 UTSW 10 4,982,969 (GRCm39) missense probably benign 0.09
IGL02799:Syne1 UTSW 10 5,309,059 (GRCm39) missense probably damaging 1.00
PIT4305001:Syne1 UTSW 10 5,283,023 (GRCm39) missense probably damaging 1.00
PIT4687001:Syne1 UTSW 10 5,308,390 (GRCm39) missense possibly damaging 0.87
R0004:Syne1 UTSW 10 5,393,132 (GRCm39) splice site probably benign
R0110:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0165:Syne1 UTSW 10 4,983,096 (GRCm39) missense probably benign 0.28
R0194:Syne1 UTSW 10 5,374,311 (GRCm39) missense probably benign
R0311:Syne1 UTSW 10 5,298,943 (GRCm39) missense possibly damaging 0.92
R0328:Syne1 UTSW 10 5,298,945 (GRCm39) missense possibly damaging 0.62
R0379:Syne1 UTSW 10 5,491,989 (GRCm39) missense probably damaging 1.00
R0387:Syne1 UTSW 10 5,301,029 (GRCm39) missense probably benign
R0452:Syne1 UTSW 10 5,355,435 (GRCm39) missense probably damaging 0.98
R0456:Syne1 UTSW 10 5,292,252 (GRCm39) missense probably benign 0.04
R0457:Syne1 UTSW 10 4,972,041 (GRCm39) missense probably damaging 1.00
R0469:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0510:Syne1 UTSW 10 5,317,600 (GRCm39) missense probably damaging 1.00
R0533:Syne1 UTSW 10 5,308,438 (GRCm39) missense probably benign 0.00
R0617:Syne1 UTSW 10 5,300,933 (GRCm39) missense probably damaging 1.00
R0690:Syne1 UTSW 10 4,983,138 (GRCm39) splice site probably benign
R0964:Syne1 UTSW 10 4,993,652 (GRCm39) missense possibly damaging 0.95
R1133:Syne1 UTSW 10 5,299,044 (GRCm39) missense possibly damaging 0.77
R1327:Syne1 UTSW 10 4,998,925 (GRCm39) splice site probably benign
R1339:Syne1 UTSW 10 5,317,571 (GRCm39) missense probably damaging 1.00
R1531:Syne1 UTSW 10 5,297,875 (GRCm39) nonsense probably null
R1558:Syne1 UTSW 10 5,299,280 (GRCm39) nonsense probably null
R1633:Syne1 UTSW 10 5,299,388 (GRCm39) missense probably damaging 1.00
R1642:Syne1 UTSW 10 5,298,694 (GRCm39) missense possibly damaging 0.94
R1658:Syne1 UTSW 10 5,317,616 (GRCm39) missense probably benign 0.03
R1753:Syne1 UTSW 10 5,317,621 (GRCm39) missense probably benign 0.28
R1759:Syne1 UTSW 10 5,299,369 (GRCm39) missense probably damaging 1.00
R1792:Syne1 UTSW 10 4,990,975 (GRCm39) missense probably damaging 1.00
R2076:Syne1 UTSW 10 4,990,897 (GRCm39) missense probably damaging 0.99
R2079:Syne1 UTSW 10 5,311,502 (GRCm39) missense probably benign 0.01
R2102:Syne1 UTSW 10 5,006,514 (GRCm39) missense probably damaging 1.00
R2233:Syne1 UTSW 10 4,991,484 (GRCm39) missense probably benign 0.01
R2305:Syne1 UTSW 10 4,997,573 (GRCm39) missense probably damaging 0.97
R3435:Syne1 UTSW 10 5,298,565 (GRCm39) missense probably damaging 1.00
R3749:Syne1 UTSW 10 5,002,267 (GRCm39) splice site probably benign
R3876:Syne1 UTSW 10 5,002,345 (GRCm39) missense possibly damaging 0.57
R3895:Syne1 UTSW 10 5,355,456 (GRCm39) missense probably damaging 0.98
R3974:Syne1 UTSW 10 4,993,630 (GRCm39) missense probably benign 0.06
R4042:Syne1 UTSW 10 4,991,584 (GRCm39) missense probably benign 0.21
R4120:Syne1 UTSW 10 5,359,798 (GRCm39) missense probably damaging 1.00
R4201:Syne1 UTSW 10 5,297,870 (GRCm39) missense probably benign
R4364:Syne1 UTSW 10 5,303,987 (GRCm39) missense probably damaging 0.96
R4498:Syne1 UTSW 10 4,981,768 (GRCm39) missense probably benign 0.00
R4767:Syne1 UTSW 10 5,294,866 (GRCm39) nonsense probably null
R4804:Syne1 UTSW 10 5,299,310 (GRCm39) missense possibly damaging 0.95
R4930:Syne1 UTSW 10 5,002,777 (GRCm39) missense probably damaging 0.99
R5081:Syne1 UTSW 10 4,997,767 (GRCm39) missense probably benign 0.04
R5089:Syne1 UTSW 10 5,355,444 (GRCm39) nonsense probably null
R5174:Syne1 UTSW 10 4,991,490 (GRCm39) missense probably damaging 0.99
R5205:Syne1 UTSW 10 5,002,295 (GRCm39) missense probably benign 0.05
R5303:Syne1 UTSW 10 5,370,464 (GRCm39) missense probably benign 0.00
R5384:Syne1 UTSW 10 4,991,494 (GRCm39) missense probably benign 0.00
R5385:Syne1 UTSW 10 4,991,494 (GRCm39) missense probably benign 0.00
R5392:Syne1 UTSW 10 5,298,661 (GRCm39) missense probably damaging 1.00
R5442:Syne1 UTSW 10 5,293,473 (GRCm39) missense probably benign 0.09
R5750:Syne1 UTSW 10 5,289,209 (GRCm39) missense probably benign 0.01
R5935:Syne1 UTSW 10 5,310,706 (GRCm39) splice site probably null
R6015:Syne1 UTSW 10 5,296,819 (GRCm39) critical splice donor site probably null
R6023:Syne1 UTSW 10 5,393,223 (GRCm39) missense probably benign 0.09
R6049:Syne1 UTSW 10 5,297,926 (GRCm39) missense possibly damaging 0.79
R6084:Syne1 UTSW 10 5,298,994 (GRCm39) missense probably damaging 1.00
R6145:Syne1 UTSW 10 5,002,750 (GRCm39) missense probably damaging 1.00
R6164:Syne1 UTSW 10 5,011,429 (GRCm39) missense probably damaging 1.00
R6165:Syne1 UTSW 10 5,375,678 (GRCm39) missense probably damaging 1.00
R6198:Syne1 UTSW 10 5,252,269 (GRCm39) missense probably damaging 0.99
R6217:Syne1 UTSW 10 5,243,761 (GRCm39) missense probably benign 0.00
R6247:Syne1 UTSW 10 5,299,071 (GRCm39) missense probably damaging 0.98
R6271:Syne1 UTSW 10 5,184,652 (GRCm39) missense probably damaging 1.00
R6338:Syne1 UTSW 10 5,205,475 (GRCm39) missense probably benign 0.00
R6344:Syne1 UTSW 10 4,972,212 (GRCm39) missense probably benign 0.08
R6434:Syne1 UTSW 10 5,268,422 (GRCm39) missense probably benign 0.01
R6476:Syne1 UTSW 10 5,104,531 (GRCm39) missense possibly damaging 0.88
R6479:Syne1 UTSW 10 5,406,826 (GRCm39) missense probably damaging 1.00
R6479:Syne1 UTSW 10 5,181,679 (GRCm39) nonsense probably null
R6546:Syne1 UTSW 10 5,168,645 (GRCm39) nonsense probably null
R6578:Syne1 UTSW 10 5,355,454 (GRCm39) nonsense probably null
R6611:Syne1 UTSW 10 4,995,273 (GRCm39) missense probably benign 0.01
R6615:Syne1 UTSW 10 5,251,340 (GRCm39) missense probably damaging 0.98
R6632:Syne1 UTSW 10 5,165,667 (GRCm39) critical splice donor site probably null
R6662:Syne1 UTSW 10 5,078,416 (GRCm39) missense probably damaging 1.00
R6677:Syne1 UTSW 10 4,990,942 (GRCm39) missense possibly damaging 0.82
R6764:Syne1 UTSW 10 5,179,011 (GRCm39) nonsense probably null
R6765:Syne1 UTSW 10 5,093,285 (GRCm39) splice site probably null
R6778:Syne1 UTSW 10 5,052,406 (GRCm39) missense probably damaging 0.97
R6851:Syne1 UTSW 10 5,212,703 (GRCm39) nonsense probably null
R6878:Syne1 UTSW 10 5,370,388 (GRCm39) missense possibly damaging 0.78
R6883:Syne1 UTSW 10 5,181,704 (GRCm39) nonsense probably null
R6910:Syne1 UTSW 10 4,998,887 (GRCm39) missense probably benign 0.01
R6916:Syne1 UTSW 10 5,177,912 (GRCm39) missense probably benign 0.00
R6925:Syne1 UTSW 10 5,076,682 (GRCm39) missense probably benign 0.00
R6943:Syne1 UTSW 10 5,033,940 (GRCm39) missense probably benign
R6947:Syne1 UTSW 10 5,125,789 (GRCm39) missense probably damaging 1.00
R6965:Syne1 UTSW 10 5,179,120 (GRCm39) missense possibly damaging 0.66
R6968:Syne1 UTSW 10 5,067,041 (GRCm39) missense probably benign 0.09
R7043:Syne1 UTSW 10 5,022,193 (GRCm39) missense possibly damaging 0.77
R7059:Syne1 UTSW 10 5,296,859 (GRCm39) missense probably damaging 1.00
R7067:Syne1 UTSW 10 5,184,586 (GRCm39) missense probably damaging 1.00
R7087:Syne1 UTSW 10 5,492,024 (GRCm39) start gained probably benign
R7099:Syne1 UTSW 10 5,073,744 (GRCm39) missense probably benign 0.43
R7107:Syne1 UTSW 10 5,082,078 (GRCm39) missense probably damaging 1.00
R7120:Syne1 UTSW 10 5,243,971 (GRCm39) missense probably benign
R7127:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7128:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7131:Syne1 UTSW 10 5,178,221 (GRCm39) missense probably damaging 1.00
R7132:Syne1 UTSW 10 5,193,180 (GRCm39) missense probably damaging 1.00
R7133:Syne1 UTSW 10 5,181,592 (GRCm39) missense probably damaging 1.00
R7135:Syne1 UTSW 10 5,183,409 (GRCm39) missense probably benign 0.01
R7147:Syne1 UTSW 10 5,199,340 (GRCm39) missense probably damaging 1.00
R7158:Syne1 UTSW 10 5,007,931 (GRCm39) missense probably damaging 1.00
R7189:Syne1 UTSW 10 5,374,295 (GRCm39) missense probably benign 0.03
R7193:Syne1 UTSW 10 5,183,406 (GRCm39) missense probably damaging 1.00
R7194:Syne1 UTSW 10 5,060,859 (GRCm39) missense probably damaging 1.00
R7233:Syne1 UTSW 10 5,252,160 (GRCm39) missense probably damaging 1.00
R7255:Syne1 UTSW 10 5,283,446 (GRCm39) missense probably damaging 0.98
R7267:Syne1 UTSW 10 5,178,218 (GRCm39) missense probably damaging 1.00
R7294:Syne1 UTSW 10 5,047,483 (GRCm39) critical splice donor site probably null
R7303:Syne1 UTSW 10 5,206,805 (GRCm39) missense probably benign 0.04
R7313:Syne1 UTSW 10 4,997,635 (GRCm39) missense probably damaging 1.00
R7330:Syne1 UTSW 10 5,078,434 (GRCm39) missense probably benign 0.00
R7334:Syne1 UTSW 10 5,007,886 (GRCm39) missense probably damaging 1.00
R7363:Syne1 UTSW 10 5,090,970 (GRCm39) missense possibly damaging 0.45
R7400:Syne1 UTSW 10 5,168,580 (GRCm39) missense probably benign 0.12
R7425:Syne1 UTSW 10 5,375,760 (GRCm39) missense probably damaging 1.00
R7427:Syne1 UTSW 10 5,223,718 (GRCm39) missense probably damaging 0.98
R7446:Syne1 UTSW 10 5,172,266 (GRCm39) missense probably benign 0.00
R7462:Syne1 UTSW 10 5,002,793 (GRCm39) missense possibly damaging 0.87
R7502:Syne1 UTSW 10 5,283,446 (GRCm39) missense probably damaging 0.98
R7525:Syne1 UTSW 10 5,135,559 (GRCm39) critical splice acceptor site probably null
R7529:Syne1 UTSW 10 5,374,382 (GRCm39) missense probably damaging 1.00
R7577:Syne1 UTSW 10 5,074,820 (GRCm39) missense probably damaging 1.00
R7579:Syne1 UTSW 10 5,299,324 (GRCm39) missense probably damaging 1.00
R7594:Syne1 UTSW 10 5,165,190 (GRCm39) critical splice donor site probably null
R7646:Syne1 UTSW 10 5,122,949 (GRCm39) missense probably damaging 1.00
R7651:Syne1 UTSW 10 5,293,416 (GRCm39) missense probably damaging 1.00
R7651:Syne1 UTSW 10 5,155,074 (GRCm39) missense probably benign 0.38
R7669:Syne1 UTSW 10 5,011,531 (GRCm39) missense probably damaging 1.00
R7672:Syne1 UTSW 10 5,168,527 (GRCm39) missense probably benign 0.02
R7682:Syne1 UTSW 10 5,112,461 (GRCm39) missense probably benign
R7702:Syne1 UTSW 10 5,195,835 (GRCm39) missense probably damaging 1.00
R7767:Syne1 UTSW 10 5,283,632 (GRCm39) missense possibly damaging 0.49
R7767:Syne1 UTSW 10 5,283,560 (GRCm39) missense possibly damaging 0.60
R7829:Syne1 UTSW 10 5,292,293 (GRCm39) missense probably damaging 0.96
R7840:Syne1 UTSW 10 5,082,078 (GRCm39) missense probably damaging 1.00
R7859:Syne1 UTSW 10 5,107,683 (GRCm39) missense possibly damaging 0.80
R7899:Syne1 UTSW 10 5,177,956 (GRCm39) nonsense probably null
R7918:Syne1 UTSW 10 5,309,078 (GRCm39) missense possibly damaging 0.50
R7923:Syne1 UTSW 10 5,214,738 (GRCm39) missense probably damaging 1.00
R7946:Syne1 UTSW 10 5,200,919 (GRCm39) missense possibly damaging 0.92
R7966:Syne1 UTSW 10 5,066,965 (GRCm39) critical splice donor site probably null
R7975:Syne1 UTSW 10 4,981,786 (GRCm39) missense probably benign 0.00
R7981:Syne1 UTSW 10 5,179,248 (GRCm39) missense probably benign 0.04
R8053:Syne1 UTSW 10 5,002,658 (GRCm39) nonsense probably null
R8054:Syne1 UTSW 10 5,220,970 (GRCm39) missense probably benign 0.22
R8062:Syne1 UTSW 10 5,135,394 (GRCm39) critical splice donor site probably null
R8085:Syne1 UTSW 10 5,178,021 (GRCm39) missense possibly damaging 0.78
R8087:Syne1 UTSW 10 5,283,034 (GRCm39) missense probably benign
R8094:Syne1 UTSW 10 5,067,031 (GRCm39) missense probably damaging 0.98
R8310:Syne1 UTSW 10 5,297,829 (GRCm39) missense probably benign
R8325:Syne1 UTSW 10 5,096,257 (GRCm39) missense probably benign 0.15
R8342:Syne1 UTSW 10 5,058,622 (GRCm39) missense probably benign 0.18
R8353:Syne1 UTSW 10 5,300,983 (GRCm39) missense probably damaging 1.00
R8376:Syne1 UTSW 10 4,993,615 (GRCm39) missense probably benign 0.09
R8398:Syne1 UTSW 10 5,074,923 (GRCm39) missense probably damaging 1.00
R8434:Syne1 UTSW 10 5,073,057 (GRCm39) missense probably benign 0.00
R8436:Syne1 UTSW 10 5,178,659 (GRCm39) missense probably benign 0.26
R8459:Syne1 UTSW 10 5,374,277 (GRCm39) nonsense probably null
R8461:Syne1 UTSW 10 5,011,463 (GRCm39) missense probably benign 0.34
R8496:Syne1 UTSW 10 5,268,441 (GRCm39) missense probably damaging 0.99
R8496:Syne1 UTSW 10 5,178,896 (GRCm39) missense probably damaging 0.99
R8693:Syne1 UTSW 10 5,090,928 (GRCm39) missense possibly damaging 0.60
R8698:Syne1 UTSW 10 5,179,229 (GRCm39) missense probably damaging 1.00
R8701:Syne1 UTSW 10 5,155,026 (GRCm39) nonsense probably null
R8713:Syne1 UTSW 10 5,266,040 (GRCm39) missense probably damaging 1.00
R8724:Syne1 UTSW 10 5,033,861 (GRCm39) missense possibly damaging 0.77
R8729:Syne1 UTSW 10 5,179,275 (GRCm39) missense probably benign 0.00
R8742:Syne1 UTSW 10 5,058,661 (GRCm39) missense probably benign 0.09
R8757:Syne1 UTSW 10 5,144,618 (GRCm39) missense probably damaging 1.00
R8776:Syne1 UTSW 10 5,181,783 (GRCm39) missense possibly damaging 0.81
R8776-TAIL:Syne1 UTSW 10 5,181,783 (GRCm39) missense possibly damaging 0.81
R8778:Syne1 UTSW 10 5,309,066 (GRCm39) missense probably benign 0.00
R8801:Syne1 UTSW 10 5,308,335 (GRCm39) missense probably damaging 1.00
R8803:Syne1 UTSW 10 5,311,535 (GRCm39) missense probably damaging 1.00
R8808:Syne1 UTSW 10 5,309,074 (GRCm39) missense probably damaging 1.00
R8829:Syne1 UTSW 10 5,058,685 (GRCm39) missense probably benign
R8843:Syne1 UTSW 10 5,143,040 (GRCm39) missense possibly damaging 0.88
R8843:Syne1 UTSW 10 5,280,204 (GRCm39) missense probably benign 0.01
R8854:Syne1 UTSW 10 5,078,503 (GRCm39) missense probably benign 0.00
R8863:Syne1 UTSW 10 5,049,527 (GRCm39) missense probably damaging 1.00
R8864:Syne1 UTSW 10 5,370,473 (GRCm39) missense probably benign 0.01
R8881:Syne1 UTSW 10 5,223,639 (GRCm39) missense probably damaging 1.00
R8884:Syne1 UTSW 10 5,181,822 (GRCm39) missense possibly damaging 0.93
R8893:Syne1 UTSW 10 5,299,020 (GRCm39) nonsense probably null
R8958:Syne1 UTSW 10 5,181,768 (GRCm39) missense probably benign
R8964:Syne1 UTSW 10 5,060,872 (GRCm39) missense
R8975:Syne1 UTSW 10 5,161,945 (GRCm39) missense probably benign 0.04
R8987:Syne1 UTSW 10 5,177,579 (GRCm39) missense possibly damaging 0.92
R8992:Syne1 UTSW 10 5,135,508 (GRCm39) missense probably benign 0.01
R9005:Syne1 UTSW 10 5,155,406 (GRCm39) missense probably benign
R9084:Syne1 UTSW 10 5,289,240 (GRCm39) missense probably benign 0.01
R9117:Syne1 UTSW 10 5,053,667 (GRCm39) missense probably damaging 0.96
R9128:Syne1 UTSW 10 5,058,556 (GRCm39) missense probably benign 0.38
R9181:Syne1 UTSW 10 5,063,994 (GRCm39) missense probably damaging 0.99
R9189:Syne1 UTSW 10 5,172,289 (GRCm39) missense probably benign 0.00
R9189:Syne1 UTSW 10 5,123,008 (GRCm39) missense probably damaging 1.00
R9205:Syne1 UTSW 10 5,152,013 (GRCm39) nonsense probably null
R9217:Syne1 UTSW 10 5,299,324 (GRCm39) missense probably damaging 1.00
R9246:Syne1 UTSW 10 5,255,706 (GRCm39) missense probably benign 0.00
R9264:Syne1 UTSW 10 5,212,793 (GRCm39) missense probably damaging 1.00
R9273:Syne1 UTSW 10 4,990,901 (GRCm39) missense probably benign 0.16
R9315:Syne1 UTSW 10 5,283,553 (GRCm39) missense possibly damaging 0.79
R9331:Syne1 UTSW 10 5,073,666 (GRCm39) missense probably benign 0.45
R9355:Syne1 UTSW 10 5,318,255 (GRCm39) missense probably damaging 1.00
R9378:Syne1 UTSW 10 5,200,954 (GRCm39) missense probably damaging 0.96
R9389:Syne1 UTSW 10 5,179,193 (GRCm39) missense possibly damaging 0.65
R9395:Syne1 UTSW 10 5,261,728 (GRCm39) missense probably damaging 1.00
R9405:Syne1 UTSW 10 5,152,030 (GRCm39) missense probably damaging 1.00
R9417:Syne1 UTSW 10 5,082,021 (GRCm39) missense probably benign
R9419:Syne1 UTSW 10 5,155,071 (GRCm39) missense probably benign 0.01
R9473:Syne1 UTSW 10 5,198,258 (GRCm39) missense probably benign 0.00
R9484:Syne1 UTSW 10 5,170,359 (GRCm39) missense probably damaging 1.00
R9505:Syne1 UTSW 10 4,980,394 (GRCm39) missense probably benign 0.00
R9509:Syne1 UTSW 10 5,298,927 (GRCm39) critical splice donor site probably null
R9546:Syne1 UTSW 10 5,193,123 (GRCm39) missense probably damaging 1.00
R9567:Syne1 UTSW 10 5,196,386 (GRCm39) missense possibly damaging 0.54
R9601:Syne1 UTSW 10 5,209,270 (GRCm39) missense probably benign 0.23
R9619:Syne1 UTSW 10 5,090,909 (GRCm39) missense probably benign 0.03
R9621:Syne1 UTSW 10 5,273,887 (GRCm39) missense probably benign 0.01
R9623:Syne1 UTSW 10 5,152,009 (GRCm39) missense probably damaging 1.00
R9646:Syne1 UTSW 10 5,179,187 (GRCm39) missense possibly damaging 0.95
R9666:Syne1 UTSW 10 4,984,937 (GRCm39) missense probably damaging 1.00
R9677:Syne1 UTSW 10 5,215,125 (GRCm39) missense probably damaging 1.00
R9695:Syne1 UTSW 10 5,268,461 (GRCm39) missense probably benign 0.03
R9696:Syne1 UTSW 10 5,297,847 (GRCm39) missense probably benign 0.00
R9719:Syne1 UTSW 10 5,276,601 (GRCm39) missense possibly damaging 0.47
R9744:Syne1 UTSW 10 5,274,184 (GRCm39) missense probably benign 0.01
R9761:Syne1 UTSW 10 5,318,190 (GRCm39) critical splice donor site probably null
R9763:Syne1 UTSW 10 5,007,858 (GRCm39) missense probably benign 0.31
RF010:Syne1 UTSW 10 5,196,386 (GRCm39) missense possibly damaging 0.89
RF015:Syne1 UTSW 10 5,252,248 (GRCm39) missense probably benign 0.01
RF023:Syne1 UTSW 10 5,205,482 (GRCm39) missense probably damaging 1.00
X0017:Syne1 UTSW 10 5,296,917 (GRCm39) missense probably damaging 1.00
X0025:Syne1 UTSW 10 5,308,973 (GRCm39) nonsense probably null
X0063:Syne1 UTSW 10 5,002,354 (GRCm39) missense probably damaging 1.00
Z1176:Syne1 UTSW 10 5,280,251 (GRCm39) missense probably benign 0.10
Z1176:Syne1 UTSW 10 5,209,280 (GRCm39) missense probably benign
Z1176:Syne1 UTSW 10 5,198,364 (GRCm39) missense probably damaging 0.96
Z1177:Syne1 UTSW 10 5,209,349 (GRCm39) missense probably damaging 1.00
Z1177:Syne1 UTSW 10 5,093,230 (GRCm39) missense possibly damaging 0.78
Predicted Primers PCR Primer
(F):5'- TACAGTGACTGGGAAGCTGG -3'
(R):5'- ATCCAGGAAAGTGAACCACTGTC -3'

Sequencing Primer
(F):5'- CTGGGAAGCTGGCTGGAG -3'
(R):5'- CCAGTATGGCATATCAGTCCGTGAG -3'
Posted On 2016-04-15