Incidental Mutation 'R4921:Fer1l6'
ID 378634
Institutional Source Beutler Lab
Gene Symbol Fer1l6
Ensembl Gene ENSMUSG00000037106
Gene Name fer-1 like family member 6
Synonyms EG631797
MMRRC Submission 042523-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R4921 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 58381897-58536936 bp(+) (GRCm39)
Type of Mutation critical splice acceptor site
DNA Base Change (assembly) G to T at 58472160 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161028] [ENSMUST00000161028]
AlphaFold E0CZ42
Predicted Effect probably null
Transcript: ENSMUST00000161028
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000161028
SMART Domains Protein: ENSMUSP00000125718
Gene: ENSMUSG00000037106

DomainStartEndE-ValueType
low complexity region 4 20 N/A INTRINSIC
C2 83 179 4.09e-12 SMART
FerI 165 235 2.06e-36 SMART
C2 243 354 5.19e-14 SMART
low complexity region 412 449 N/A INTRINSIC
FerB 714 787 2.53e-45 SMART
C2 829 936 8.84e-8 SMART
C2 1000 1099 3.05e0 SMART
low complexity region 1189 1203 N/A INTRINSIC
low complexity region 1256 1270 N/A INTRINSIC
C2 1361 1460 5.78e-12 SMART
low complexity region 1518 1529 N/A INTRINSIC
C2 1601 1731 1.01e-2 SMART
Pfam:Ferlin_C 1765 1857 2.3e-40 PFAM
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.7%
  • 20x: 90.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 98 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A T 5: 109,885,662 (GRCm39) N65K probably benign Het
Abcc9 T C 6: 142,536,162 (GRCm39) Y1524C probably benign Het
Acap1 A G 11: 69,778,019 (GRCm39) I102T probably damaging Het
Acvr2a T C 2: 48,783,553 (GRCm39) V284A possibly damaging Het
Adam3 T C 8: 25,174,630 (GRCm39) M712V probably benign Het
Adck1 T C 12: 88,407,908 (GRCm39) V213A probably benign Het
Adgrl3 G T 5: 81,659,957 (GRCm39) W242L probably damaging Het
Alk T C 17: 72,211,310 (GRCm39) T857A probably benign Het
Alms1 A G 6: 85,605,528 (GRCm39) T2393A probably benign Het
Ank3 C T 10: 69,837,939 (GRCm39) P240L probably damaging Het
Ankrd35 C A 3: 96,592,140 (GRCm39) L809M possibly damaging Het
Birc6 T A 17: 74,957,094 (GRCm39) L3690Q probably damaging Het
Bmp3 C A 5: 99,019,920 (GRCm39) F114L probably damaging Het
Cage1 G A 13: 38,203,184 (GRCm39) H627Y probably benign Het
Cars1 T C 7: 143,123,212 (GRCm39) D468G probably damaging Het
Ccdc148 T C 2: 58,719,814 (GRCm39) E487G probably damaging Het
Ccdc80 A T 16: 44,938,530 (GRCm39) I746F probably damaging Het
Ccl25 A G 8: 4,403,913 (GRCm39) Q119R possibly damaging Het
Cdh24 C T 14: 54,870,672 (GRCm39) D178N probably damaging Het
Cdk12 A T 11: 98,113,513 (GRCm39) T766S unknown Het
Chst15 T A 7: 131,849,613 (GRCm39) T443S probably benign Het
Cnbp T C 6: 87,822,128 (GRCm39) D125G possibly damaging Het
Cntn2 A T 1: 132,443,770 (GRCm39) V1003E possibly damaging Het
Crct1 A G 3: 92,922,132 (GRCm39) probably benign Het
Dand5 C T 8: 85,543,113 (GRCm39) C121Y probably damaging Het
Dmkn A T 7: 30,470,658 (GRCm39) D382V probably damaging Het
Dnase2b T A 3: 146,299,196 (GRCm39) T86S probably damaging Het
Dusp8 GCCACCACCACCACCACCACCACC GCCACCACCACCACCACCACC 7: 141,635,891 (GRCm39) probably benign Het
Eef1akmt1 C T 14: 57,788,089 (GRCm39) V90M probably damaging Het
Egfl7 G T 2: 26,480,992 (GRCm39) W168L probably benign Het
Ep400 A G 5: 110,813,676 (GRCm39) C2908R probably damaging Het
Espl1 A G 15: 102,223,676 (GRCm39) K1076E probably damaging Het
Exoc4 A G 6: 33,887,452 (GRCm39) N747D probably benign Het
Fancm T C 12: 65,123,915 (GRCm39) V191A probably benign Het
Fbxo17 A G 7: 28,432,214 (GRCm39) D97G probably benign Het
Flt4 T C 11: 49,517,970 (GRCm39) W337R probably damaging Het
Fpr-rs7 T C 17: 20,334,082 (GRCm39) H136R possibly damaging Het
Frem3 T A 8: 81,339,765 (GRCm39) I686N possibly damaging Het
Galnt9 A G 5: 110,725,315 (GRCm39) K84R probably damaging Het
Gfm2 T A 13: 97,312,184 (GRCm39) M760K probably damaging Het
Glis3 T C 19: 28,643,504 (GRCm39) T13A probably damaging Het
H2-K2 A G 17: 34,216,050 (GRCm39) V323A possibly damaging Het
Hbb-bs G A 7: 103,475,927 (GRCm39) A130V probably damaging Het
Herc2 T A 7: 55,879,438 (GRCm39) H4685Q probably benign Het
Ighv5-9-1 C T 12: 113,699,914 (GRCm39) R56H possibly damaging Het
Itgb4 A G 11: 115,897,431 (GRCm39) N1548S probably benign Het
Itpr3 T C 17: 27,316,979 (GRCm39) Y745H probably damaging Het
Kank3 G T 17: 34,036,174 (GRCm39) G14V probably damaging Het
Kif24 G T 4: 41,394,329 (GRCm39) S982Y probably damaging Het
Kifc5b C T 17: 27,139,997 (GRCm39) R53W probably damaging Het
Krt39 A G 11: 99,405,575 (GRCm39) S442P possibly damaging Het
Lcat G A 8: 106,669,074 (GRCm39) P67L possibly damaging Het
Maml2 T C 9: 13,532,471 (GRCm39) S562P probably damaging Het
Map3k8 G A 18: 4,349,124 (GRCm39) R65W possibly damaging Het
Mbd3 G T 10: 80,231,410 (GRCm39) R12S probably damaging Het
Msr1 T C 8: 40,077,292 (GRCm39) E106G possibly damaging Het
Myh4 T A 11: 67,144,854 (GRCm39) L1256Q probably damaging Het
Mypn G A 10: 62,983,715 (GRCm39) T511M possibly damaging Het
Nub1 A T 5: 24,906,467 (GRCm39) N331I probably benign Het
Nup107 A G 10: 117,606,416 (GRCm39) V440A possibly damaging Het
Ofcc1 A G 13: 40,367,993 (GRCm39) F174L probably benign Het
Or10d5 A C 9: 39,861,521 (GRCm39) V182G probably damaging Het
Or52ab2 A T 7: 102,969,750 (GRCm39) N44I probably damaging Het
Or9q2 T C 19: 13,772,829 (GRCm39) I49V probably benign Het
Parp2 C A 14: 51,056,725 (GRCm39) L310I probably damaging Het
Pcdh20 A G 14: 88,707,162 (GRCm39) V46A probably benign Het
Pcdhgb6 A G 18: 37,876,525 (GRCm39) D411G probably damaging Het
Pkd1l2 T C 8: 117,781,624 (GRCm39) E807G probably benign Het
Pkd1l2 A T 8: 117,799,288 (GRCm39) N267K probably damaging Het
Pramel24 A T 4: 143,454,896 (GRCm39) K398M possibly damaging Het
Rell1 C A 5: 64,093,376 (GRCm39) M126I probably damaging Het
Robo4 G A 9: 37,313,856 (GRCm39) E36K probably benign Het
Rpgrip1l T C 8: 91,987,637 (GRCm39) S807G probably benign Het
Rpl10a T C 17: 28,549,826 (GRCm39) V169A probably benign Het
Rubcn C T 16: 32,667,664 (GRCm39) V166I probably damaging Het
Sall2 T C 14: 52,552,850 (GRCm39) E113G possibly damaging Het
Sars2 T C 7: 28,451,863 (GRCm39) S423P possibly damaging Het
Scaper A G 9: 55,799,519 (GRCm39) I182T probably benign Het
Selp A G 1: 163,968,966 (GRCm39) D522G possibly damaging Het
Sema4b T A 7: 79,848,504 (GRCm39) I35N possibly damaging Het
Sgce A T 6: 4,694,153 (GRCm39) F268I probably damaging Het
Slc14a2 G T 18: 78,235,403 (GRCm39) A258E probably damaging Het
Slc17a9 T C 2: 180,377,742 (GRCm39) Y213H probably benign Het
Slc22a7 T G 17: 46,747,859 (GRCm39) I233L probably benign Het
Slc35f1 A G 10: 52,938,698 (GRCm39) Q210R probably damaging Het
Slc6a21 A G 7: 44,937,734 (GRCm39) E350G possibly damaging Het
Spata21 A T 4: 140,839,402 (GRCm39) D639V probably damaging Het
Svil A G 18: 5,108,631 (GRCm39) D1519G probably damaging Het
Tbccd1 T C 16: 22,660,649 (GRCm39) T56A probably benign Het
Tigit A T 16: 43,482,380 (GRCm39) I118N probably damaging Het
Tlr11 A T 14: 50,600,342 (GRCm39) Q776L possibly damaging Het
Tspan12 A C 6: 21,835,448 (GRCm39) I9S possibly damaging Het
Unc5c T A 3: 141,494,727 (GRCm39) Y347N probably damaging Het
Unk A G 11: 115,945,771 (GRCm39) T481A probably benign Het
Vmn1r192 A C 13: 22,371,650 (GRCm39) V190G probably damaging Het
Vnn3 A T 10: 23,740,473 (GRCm39) M259L probably benign Het
Zan T C 5: 137,406,632 (GRCm39) probably benign Het
Zdhhc6 T C 19: 55,301,642 (GRCm39) H113R probably damaging Het
Other mutations in Fer1l6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0009:Fer1l6 UTSW 15 58,534,636 (GRCm39) missense probably damaging 1.00
R0141:Fer1l6 UTSW 15 58,430,251 (GRCm39) missense probably damaging 1.00
R0178:Fer1l6 UTSW 15 58,509,763 (GRCm39) splice site probably null
R0304:Fer1l6 UTSW 15 58,462,411 (GRCm39) missense probably benign 0.08
R0379:Fer1l6 UTSW 15 58,420,187 (GRCm39) missense probably benign 0.05
R0457:Fer1l6 UTSW 15 58,509,943 (GRCm39) critical splice donor site probably null
R0546:Fer1l6 UTSW 15 58,430,257 (GRCm39) splice site probably null
R0602:Fer1l6 UTSW 15 58,449,794 (GRCm39) missense probably damaging 0.98
R0619:Fer1l6 UTSW 15 58,534,784 (GRCm39) splice site probably null
R0669:Fer1l6 UTSW 15 58,425,573 (GRCm39) splice site probably null
R0854:Fer1l6 UTSW 15 58,431,037 (GRCm39) missense probably benign 0.00
R0948:Fer1l6 UTSW 15 58,435,924 (GRCm39) missense probably benign 0.00
R1180:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R1483:Fer1l6 UTSW 15 58,509,819 (GRCm39) missense possibly damaging 0.84
R1627:Fer1l6 UTSW 15 58,513,728 (GRCm39) missense probably benign 0.41
R1635:Fer1l6 UTSW 15 58,518,930 (GRCm39) missense probably damaging 1.00
R1834:Fer1l6 UTSW 15 58,429,718 (GRCm39) missense possibly damaging 0.58
R1921:Fer1l6 UTSW 15 58,497,080 (GRCm39) missense probably damaging 1.00
R2000:Fer1l6 UTSW 15 58,474,160 (GRCm39) splice site probably benign
R2041:Fer1l6 UTSW 15 58,430,155 (GRCm39) missense probably damaging 1.00
R2144:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2145:Fer1l6 UTSW 15 58,499,383 (GRCm39) missense probably benign
R2981:Fer1l6 UTSW 15 58,435,926 (GRCm39) missense probably damaging 0.99
R4164:Fer1l6 UTSW 15 58,431,087 (GRCm39) missense possibly damaging 0.83
R4192:Fer1l6 UTSW 15 58,518,998 (GRCm39) missense probably damaging 1.00
R4273:Fer1l6 UTSW 15 58,499,371 (GRCm39) missense probably benign 0.41
R4573:Fer1l6 UTSW 15 58,498,129 (GRCm39) critical splice donor site probably null
R4581:Fer1l6 UTSW 15 58,512,075 (GRCm39) missense probably damaging 1.00
R4624:Fer1l6 UTSW 15 58,425,554 (GRCm39) missense probably damaging 1.00
R4755:Fer1l6 UTSW 15 58,512,060 (GRCm39) missense probably benign 0.09
R4774:Fer1l6 UTSW 15 58,449,798 (GRCm39) missense probably damaging 0.99
R4894:Fer1l6 UTSW 15 58,490,751 (GRCm39) missense probably damaging 1.00
R4896:Fer1l6 UTSW 15 58,509,869 (GRCm39) missense probably damaging 1.00
R4962:Fer1l6 UTSW 15 58,443,250 (GRCm39) missense probably benign 0.03
R5029:Fer1l6 UTSW 15 58,515,769 (GRCm39) missense probably benign 0.00
R5134:Fer1l6 UTSW 15 58,512,003 (GRCm39) missense probably damaging 1.00
R5175:Fer1l6 UTSW 15 58,422,126 (GRCm39) missense probably damaging 1.00
R5227:Fer1l6 UTSW 15 58,453,752 (GRCm39) nonsense probably null
R5561:Fer1l6 UTSW 15 58,532,674 (GRCm39) missense probably damaging 0.97
R5621:Fer1l6 UTSW 15 58,430,175 (GRCm39) missense probably damaging 1.00
R5670:Fer1l6 UTSW 15 58,494,331 (GRCm39) missense probably benign 0.00
R5745:Fer1l6 UTSW 15 58,443,238 (GRCm39) missense probably benign 0.01
R5807:Fer1l6 UTSW 15 58,462,399 (GRCm39) nonsense probably null
R5823:Fer1l6 UTSW 15 58,462,352 (GRCm39) nonsense probably null
R5892:Fer1l6 UTSW 15 58,435,917 (GRCm39) missense probably benign
R6006:Fer1l6 UTSW 15 58,518,893 (GRCm39) missense probably damaging 1.00
R6137:Fer1l6 UTSW 15 58,431,055 (GRCm39) missense probably damaging 0.97
R6195:Fer1l6 UTSW 15 58,509,806 (GRCm39) missense probably damaging 1.00
R6234:Fer1l6 UTSW 15 58,432,488 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,509,855 (GRCm39) missense probably damaging 1.00
R6237:Fer1l6 UTSW 15 58,497,026 (GRCm39) nonsense probably null
R6271:Fer1l6 UTSW 15 58,513,767 (GRCm39) missense probably benign 0.01
R6336:Fer1l6 UTSW 15 58,431,081 (GRCm39) nonsense probably null
R6784:Fer1l6 UTSW 15 58,443,275 (GRCm39) missense possibly damaging 0.63
R6852:Fer1l6 UTSW 15 58,466,727 (GRCm39) missense probably damaging 1.00
R7030:Fer1l6 UTSW 15 58,501,227 (GRCm39) missense probably damaging 1.00
R7088:Fer1l6 UTSW 15 58,435,899 (GRCm39) missense possibly damaging 0.69
R7181:Fer1l6 UTSW 15 58,447,146 (GRCm39) missense probably benign 0.00
R7226:Fer1l6 UTSW 15 58,462,384 (GRCm39) missense probably benign 0.00
R7266:Fer1l6 UTSW 15 58,499,446 (GRCm39) missense probably benign
R7463:Fer1l6 UTSW 15 58,445,450 (GRCm39) nonsense probably null
R7464:Fer1l6 UTSW 15 58,445,096 (GRCm39) splice site probably null
R7469:Fer1l6 UTSW 15 58,462,419 (GRCm39) splice site probably null
R7483:Fer1l6 UTSW 15 58,513,794 (GRCm39) missense possibly damaging 0.83
R7491:Fer1l6 UTSW 15 58,472,281 (GRCm39) missense probably damaging 1.00
R7534:Fer1l6 UTSW 15 58,509,875 (GRCm39) missense probably damaging 1.00
R7562:Fer1l6 UTSW 15 58,432,331 (GRCm39) missense probably benign 0.00
R7580:Fer1l6 UTSW 15 58,430,245 (GRCm39) missense probably benign 0.41
R7599:Fer1l6 UTSW 15 58,499,438 (GRCm39) missense probably benign
R7607:Fer1l6 UTSW 15 58,534,581 (GRCm39) nonsense probably null
R7677:Fer1l6 UTSW 15 58,474,139 (GRCm39) missense probably benign 0.00
R8202:Fer1l6 UTSW 15 58,502,486 (GRCm39) missense probably damaging 1.00
R8261:Fer1l6 UTSW 15 58,432,345 (GRCm39) missense possibly damaging 0.84
R8847:Fer1l6 UTSW 15 58,414,012 (GRCm39) missense possibly damaging 0.72
R9022:Fer1l6 UTSW 15 58,455,329 (GRCm39) missense probably damaging 0.99
R9030:Fer1l6 UTSW 15 58,502,594 (GRCm39) missense probably damaging 1.00
R9160:Fer1l6 UTSW 15 58,515,715 (GRCm39) missense possibly damaging 0.94
R9180:Fer1l6 UTSW 15 58,494,230 (GRCm39) missense probably benign 0.19
R9289:Fer1l6 UTSW 15 58,490,766 (GRCm39) missense probably damaging 1.00
R9559:Fer1l6 UTSW 15 58,429,759 (GRCm39) missense possibly damaging 0.88
R9562:Fer1l6 UTSW 15 58,490,370 (GRCm39) missense possibly damaging 0.70
R9682:Fer1l6 UTSW 15 58,422,113 (GRCm39) missense probably benign 0.03
R9775:Fer1l6 UTSW 15 58,497,098 (GRCm39) missense probably benign
X0021:Fer1l6 UTSW 15 58,441,051 (GRCm39) nonsense probably null
X0027:Fer1l6 UTSW 15 58,501,189 (GRCm39) missense probably damaging 1.00
X0063:Fer1l6 UTSW 15 58,490,423 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CGCAAATTATCTGTGCAAATAGGTC -3'
(R):5'- CAGCGTCAGAATTCTATTGATGTTCC -3'

Sequencing Primer
(F):5'- GCAAATAGGTCATTAAGTGGTACTCC -3'
(R):5'- GATGTTCCAATAAAGGCAGTTCATG -3'
Posted On 2016-04-15