Mutagenetix > Incidental Mutation

Incidental Mutation 'R4921:Birc6'

378649

Institutional Source

Beutler Lab

Gene Symbol

Birc6

Ensembl Gene

ENSMUSG00000024073

Gene Name

baculoviral IAP repeat-containing 6

Synonyms

D630005A10Rik, A430032G04Rik, apollon, Bruce, A430040A19Rik

MMRRC Submission

042523-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4921 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

74835290-75010351 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 74957094 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Glutamine at position 3690 (L3690Q)

Ref Sequence

ENSEMBL: ENSMUSP00000138693 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000180037] [ENSMUST00000182133] [ENSMUST00000182597] [ENSMUST00000182817] [ENSMUST00000182944] [ENSMUST00000183224]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000180037
AA Change: L3696Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000136329
Gene: ENSMUSG00000024073
AA Change: L3696Q

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2253	2266	N/A	INTRINSIC
low complexity region	2491	2505	N/A	INTRINSIC
low complexity region	2671	2688	N/A	INTRINSIC
low complexity region	2893	2905	N/A	INTRINSIC
low complexity region	2958	2970	N/A	INTRINSIC
Pfam:DUF3643	3477	3632	1e-69	PFAM
low complexity region	3747	3772	N/A	INTRINSIC
low complexity region	3900	3919	N/A	INTRINSIC
low complexity region	3940	3958	N/A	INTRINSIC
low complexity region	3963	3972	N/A	INTRINSIC
low complexity region	4146	4157	N/A	INTRINSIC
low complexity region	4307	4318	N/A	INTRINSIC
low complexity region	4433	4444	N/A	INTRINSIC
UBCc	4592	4756	1.04e-25	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182133
AA Change: L3690Q

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000138693
Gene: ENSMUSG00000024073
AA Change: L3690Q

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2055	N/A	INTRINSIC
low complexity region	2136	2157	N/A	INTRINSIC
low complexity region	2247	2260	N/A	INTRINSIC
low complexity region	2485	2499	N/A	INTRINSIC
low complexity region	2665	2682	N/A	INTRINSIC
low complexity region	2887	2899	N/A	INTRINSIC
low complexity region	2952	2964	N/A	INTRINSIC
Pfam:DUF3643	3470	3626	2.1e-71	PFAM
low complexity region	3741	3766	N/A	INTRINSIC
low complexity region	3894	3913	N/A	INTRINSIC
low complexity region	3934	3952	N/A	INTRINSIC
low complexity region	3957	3966	N/A	INTRINSIC
low complexity region	4140	4151	N/A	INTRINSIC
low complexity region	4301	4312	N/A	INTRINSIC
low complexity region	4427	4438	N/A	INTRINSIC
UBCc	4586	4750	1.04e-25	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000182597
AA Change: L3705Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138333
Gene: ENSMUSG00000024073
AA Change: L3705Q

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1620	1675	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1993	1998	N/A	INTRINSIC
low complexity region	2044	2059	N/A	INTRINSIC
low complexity region	2142	2163	N/A	INTRINSIC
low complexity region	2262	2275	N/A	INTRINSIC
low complexity region	2500	2514	N/A	INTRINSIC
low complexity region	2680	2697	N/A	INTRINSIC
low complexity region	2902	2914	N/A	INTRINSIC
low complexity region	2967	2979	N/A	INTRINSIC
Pfam:DUF3643	3485	3641	2.2e-71	PFAM
low complexity region	3756	3781	N/A	INTRINSIC
low complexity region	3909	3928	N/A	INTRINSIC
low complexity region	3949	3967	N/A	INTRINSIC
low complexity region	3972	3981	N/A	INTRINSIC
low complexity region	4155	4166	N/A	INTRINSIC
low complexity region	4316	4327	N/A	INTRINSIC
low complexity region	4442	4453	N/A	INTRINSIC
UBCc	4601	4765	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000182817

SMART Domains

Protein: ENSMUSP00000138349
Gene: ENSMUSG00000024073

Domain	Start	End	E-Value	Type
low complexity region	63	82	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000182944
AA Change: L3692Q

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138732
Gene: ENSMUSG00000024073
AA Change: L3692Q

Domain	Start	End	E-Value	Type
low complexity region	24	54	N/A	INTRINSIC
BIR	287	363	2.87e-24	SMART
low complexity region	472	493	N/A	INTRINSIC
low complexity region	624	635	N/A	INTRINSIC
low complexity region	674	685	N/A	INTRINSIC
low complexity region	769	781	N/A	INTRINSIC
low complexity region	1054	1071	N/A	INTRINSIC
low complexity region	1369	1380	N/A	INTRINSIC
coiled coil region	1616	1671	N/A	INTRINSIC
low complexity region	1705	1722	N/A	INTRINSIC
low complexity region	1989	1994	N/A	INTRINSIC
low complexity region	2040	2055	N/A	INTRINSIC
low complexity region	2138	2159	N/A	INTRINSIC
low complexity region	2249	2262	N/A	INTRINSIC
low complexity region	2487	2501	N/A	INTRINSIC
low complexity region	2667	2684	N/A	INTRINSIC
low complexity region	2889	2901	N/A	INTRINSIC
low complexity region	2954	2966	N/A	INTRINSIC
Pfam:DUF3643	3472	3628	3.2e-71	PFAM
low complexity region	3743	3768	N/A	INTRINSIC
low complexity region	3896	3915	N/A	INTRINSIC
low complexity region	3936	3954	N/A	INTRINSIC
low complexity region	3959	3968	N/A	INTRINSIC
low complexity region	4142	4153	N/A	INTRINSIC
low complexity region	4303	4314	N/A	INTRINSIC
low complexity region	4429	4440	N/A	INTRINSIC
UBCc	4588	4752	1.04e-25	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000183010

Predicted Effect

probably damaging
Transcript: ENSMUST00000183224
AA Change: L3676Q

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138270
Gene: ENSMUSG00000024073
AA Change: L3676Q

Domain	Start	End	E-Value	Type
low complexity region	2	26	N/A	INTRINSIC
BIR	259	335	2.87e-24	SMART
low complexity region	444	465	N/A	INTRINSIC
low complexity region	596	607	N/A	INTRINSIC
low complexity region	646	657	N/A	INTRINSIC
low complexity region	741	753	N/A	INTRINSIC
low complexity region	1026	1043	N/A	INTRINSIC
low complexity region	1355	1366	N/A	INTRINSIC
coiled coil region	1606	1661	N/A	INTRINSIC
low complexity region	1695	1712	N/A	INTRINSIC
low complexity region	1979	1984	N/A	INTRINSIC
low complexity region	2030	2041	N/A	INTRINSIC
low complexity region	2122	2143	N/A	INTRINSIC
low complexity region	2233	2246	N/A	INTRINSIC
low complexity region	2471	2485	N/A	INTRINSIC
low complexity region	2651	2668	N/A	INTRINSIC
low complexity region	2873	2885	N/A	INTRINSIC
low complexity region	2938	2950	N/A	INTRINSIC
Pfam:DUF3643	3456	3612	3.2e-71	PFAM
low complexity region	3727	3752	N/A	INTRINSIC
low complexity region	3880	3899	N/A	INTRINSIC
low complexity region	3920	3938	N/A	INTRINSIC
low complexity region	3943	3952	N/A	INTRINSIC
low complexity region	4126	4137	N/A	INTRINSIC
low complexity region	4287	4298	N/A	INTRINSIC
low complexity region	4413	4424	N/A	INTRINSIC
UBCc	4572	4736	1.04e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000183249

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.7%
20x: 90.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice exhibit perinatal lethality and exhibit placental defects. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 98 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930522L14Rik	A	T	5: 109,885,662 (GRCm39)	N65K	probably benign	Het
Abcc9	T	C	6: 142,536,162 (GRCm39)	Y1524C	probably benign	Het
Acap1	A	G	11: 69,778,019 (GRCm39)	I102T	probably damaging	Het
Acvr2a	T	C	2: 48,783,553 (GRCm39)	V284A	possibly damaging	Het
Adam3	T	C	8: 25,174,630 (GRCm39)	M712V	probably benign	Het
Adck1	T	C	12: 88,407,908 (GRCm39)	V213A	probably benign	Het
Adgrl3	G	T	5: 81,659,957 (GRCm39)	W242L	probably damaging	Het
Alk	T	C	17: 72,211,310 (GRCm39)	T857A	probably benign	Het
Alms1	A	G	6: 85,605,528 (GRCm39)	T2393A	probably benign	Het
Ank3	C	T	10: 69,837,939 (GRCm39)	P240L	probably damaging	Het
Ankrd35	C	A	3: 96,592,140 (GRCm39)	L809M	possibly damaging	Het
Bmp3	C	A	5: 99,019,920 (GRCm39)	F114L	probably damaging	Het
Cage1	G	A	13: 38,203,184 (GRCm39)	H627Y	probably benign	Het
Cars1	T	C	7: 143,123,212 (GRCm39)	D468G	probably damaging	Het
Ccdc148	T	C	2: 58,719,814 (GRCm39)	E487G	probably damaging	Het
Ccdc80	A	T	16: 44,938,530 (GRCm39)	I746F	probably damaging	Het
Ccl25	A	G	8: 4,403,913 (GRCm39)	Q119R	possibly damaging	Het
Cdh24	C	T	14: 54,870,672 (GRCm39)	D178N	probably damaging	Het
Cdk12	A	T	11: 98,113,513 (GRCm39)	T766S	unknown	Het
Chst15	T	A	7: 131,849,613 (GRCm39)	T443S	probably benign	Het
Cnbp	T	C	6: 87,822,128 (GRCm39)	D125G	possibly damaging	Het
Cntn2	A	T	1: 132,443,770 (GRCm39)	V1003E	possibly damaging	Het
Crct1	A	G	3: 92,922,132 (GRCm39)		probably benign	Het
Dand5	C	T	8: 85,543,113 (GRCm39)	C121Y	probably damaging	Het
Dmkn	A	T	7: 30,470,658 (GRCm39)	D382V	probably damaging	Het
Dnase2b	T	A	3: 146,299,196 (GRCm39)	T86S	probably damaging	Het
Dusp8	GCCACCACCACCACCACCACCACC	GCCACCACCACCACCACCACC	7: 141,635,891 (GRCm39)		probably benign	Het
Eef1akmt1	C	T	14: 57,788,089 (GRCm39)	V90M	probably damaging	Het
Egfl7	G	T	2: 26,480,992 (GRCm39)	W168L	probably benign	Het
Ep400	A	G	5: 110,813,676 (GRCm39)	C2908R	probably damaging	Het
Espl1	A	G	15: 102,223,676 (GRCm39)	K1076E	probably damaging	Het
Exoc4	A	G	6: 33,887,452 (GRCm39)	N747D	probably benign	Het
Fancm	T	C	12: 65,123,915 (GRCm39)	V191A	probably benign	Het
Fbxo17	A	G	7: 28,432,214 (GRCm39)	D97G	probably benign	Het
Fer1l6	G	T	15: 58,472,160 (GRCm39)		probably null	Het
Flt4	T	C	11: 49,517,970 (GRCm39)	W337R	probably damaging	Het
Fpr-rs7	T	C	17: 20,334,082 (GRCm39)	H136R	possibly damaging	Het
Frem3	T	A	8: 81,339,765 (GRCm39)	I686N	possibly damaging	Het
Galnt9	A	G	5: 110,725,315 (GRCm39)	K84R	probably damaging	Het
Gfm2	T	A	13: 97,312,184 (GRCm39)	M760K	probably damaging	Het
Glis3	T	C	19: 28,643,504 (GRCm39)	T13A	probably damaging	Het
H2-K2	A	G	17: 34,216,050 (GRCm39)	V323A	possibly damaging	Het
Hbb-bs	G	A	7: 103,475,927 (GRCm39)	A130V	probably damaging	Het
Herc2	T	A	7: 55,879,438 (GRCm39)	H4685Q	probably benign	Het
Ighv5-9-1	C	T	12: 113,699,914 (GRCm39)	R56H	possibly damaging	Het
Itgb4	A	G	11: 115,897,431 (GRCm39)	N1548S	probably benign	Het
Itpr3	T	C	17: 27,316,979 (GRCm39)	Y745H	probably damaging	Het
Kank3	G	T	17: 34,036,174 (GRCm39)	G14V	probably damaging	Het
Kif24	G	T	4: 41,394,329 (GRCm39)	S982Y	probably damaging	Het
Kifc5b	C	T	17: 27,139,997 (GRCm39)	R53W	probably damaging	Het
Krt39	A	G	11: 99,405,575 (GRCm39)	S442P	possibly damaging	Het
Lcat	G	A	8: 106,669,074 (GRCm39)	P67L	possibly damaging	Het
Maml2	T	C	9: 13,532,471 (GRCm39)	S562P	probably damaging	Het
Map3k8	G	A	18: 4,349,124 (GRCm39)	R65W	possibly damaging	Het
Mbd3	G	T	10: 80,231,410 (GRCm39)	R12S	probably damaging	Het
Msr1	T	C	8: 40,077,292 (GRCm39)	E106G	possibly damaging	Het
Myh4	T	A	11: 67,144,854 (GRCm39)	L1256Q	probably damaging	Het
Mypn	G	A	10: 62,983,715 (GRCm39)	T511M	possibly damaging	Het
Nub1	A	T	5: 24,906,467 (GRCm39)	N331I	probably benign	Het
Nup107	A	G	10: 117,606,416 (GRCm39)	V440A	possibly damaging	Het
Ofcc1	A	G	13: 40,367,993 (GRCm39)	F174L	probably benign	Het
Or10d5	A	C	9: 39,861,521 (GRCm39)	V182G	probably damaging	Het
Or52ab2	A	T	7: 102,969,750 (GRCm39)	N44I	probably damaging	Het
Or9q2	T	C	19: 13,772,829 (GRCm39)	I49V	probably benign	Het
Parp2	C	A	14: 51,056,725 (GRCm39)	L310I	probably damaging	Het
Pcdh20	A	G	14: 88,707,162 (GRCm39)	V46A	probably benign	Het
Pcdhgb6	A	G	18: 37,876,525 (GRCm39)	D411G	probably damaging	Het
Pkd1l2	T	C	8: 117,781,624 (GRCm39)	E807G	probably benign	Het
Pkd1l2	A	T	8: 117,799,288 (GRCm39)	N267K	probably damaging	Het
Pramel24	A	T	4: 143,454,896 (GRCm39)	K398M	possibly damaging	Het
Rell1	C	A	5: 64,093,376 (GRCm39)	M126I	probably damaging	Het
Robo4	G	A	9: 37,313,856 (GRCm39)	E36K	probably benign	Het
Rpgrip1l	T	C	8: 91,987,637 (GRCm39)	S807G	probably benign	Het
Rpl10a	T	C	17: 28,549,826 (GRCm39)	V169A	probably benign	Het
Rubcn	C	T	16: 32,667,664 (GRCm39)	V166I	probably damaging	Het
Sall2	T	C	14: 52,552,850 (GRCm39)	E113G	possibly damaging	Het
Sars2	T	C	7: 28,451,863 (GRCm39)	S423P	possibly damaging	Het
Scaper	A	G	9: 55,799,519 (GRCm39)	I182T	probably benign	Het
Selp	A	G	1: 163,968,966 (GRCm39)	D522G	possibly damaging	Het
Sema4b	T	A	7: 79,848,504 (GRCm39)	I35N	possibly damaging	Het
Sgce	A	T	6: 4,694,153 (GRCm39)	F268I	probably damaging	Het
Slc14a2	G	T	18: 78,235,403 (GRCm39)	A258E	probably damaging	Het
Slc17a9	T	C	2: 180,377,742 (GRCm39)	Y213H	probably benign	Het
Slc22a7	T	G	17: 46,747,859 (GRCm39)	I233L	probably benign	Het
Slc35f1	A	G	10: 52,938,698 (GRCm39)	Q210R	probably damaging	Het
Slc6a21	A	G	7: 44,937,734 (GRCm39)	E350G	possibly damaging	Het
Spata21	A	T	4: 140,839,402 (GRCm39)	D639V	probably damaging	Het
Svil	A	G	18: 5,108,631 (GRCm39)	D1519G	probably damaging	Het
Tbccd1	T	C	16: 22,660,649 (GRCm39)	T56A	probably benign	Het
Tigit	A	T	16: 43,482,380 (GRCm39)	I118N	probably damaging	Het
Tlr11	A	T	14: 50,600,342 (GRCm39)	Q776L	possibly damaging	Het
Tspan12	A	C	6: 21,835,448 (GRCm39)	I9S	possibly damaging	Het
Unc5c	T	A	3: 141,494,727 (GRCm39)	Y347N	probably damaging	Het
Unk	A	G	11: 115,945,771 (GRCm39)	T481A	probably benign	Het
Vmn1r192	A	C	13: 22,371,650 (GRCm39)	V190G	probably damaging	Het
Vnn3	A	T	10: 23,740,473 (GRCm39)	M259L	probably benign	Het
Zan	T	C	5: 137,406,632 (GRCm39)		probably benign	Het
Zdhhc6	T	C	19: 55,301,642 (GRCm39)	H113R	probably damaging	Het

Other mutations in Birc6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00402:Birc6	APN	17	74,880,558 (GRCm39)	splice site	probably benign
IGL00542:Birc6	APN	17	74,930,766 (GRCm39)	splice site	probably null
IGL00659:Birc6	APN	17	74,967,648 (GRCm39)	missense	probably damaging	1.00
IGL00710:Birc6	APN	17	74,916,084 (GRCm39)	missense	probably benign	0.37
IGL00806:Birc6	APN	17	74,918,524 (GRCm39)	missense	possibly damaging	0.85
IGL00848:Birc6	APN	17	75,003,388 (GRCm39)	nonsense	probably null
IGL01071:Birc6	APN	17	74,873,127 (GRCm39)	missense	possibly damaging	0.84
IGL01071:Birc6	APN	17	74,938,696 (GRCm39)	missense	probably damaging	1.00
IGL01121:Birc6	APN	17	74,938,033 (GRCm39)	missense	probably benign	0.08
IGL01132:Birc6	APN	17	74,910,055 (GRCm39)	missense	probably damaging	1.00
IGL01323:Birc6	APN	17	74,929,920 (GRCm39)	missense	probably damaging	1.00
IGL01444:Birc6	APN	17	74,938,682 (GRCm39)	missense	probably damaging	1.00
IGL01511:Birc6	APN	17	74,933,998 (GRCm39)	nonsense	probably null
IGL01576:Birc6	APN	17	74,984,365 (GRCm39)	missense	possibly damaging	0.80
IGL01578:Birc6	APN	17	74,955,192 (GRCm39)	missense	probably benign	0.08
IGL01649:Birc6	APN	17	74,911,541 (GRCm39)	missense	probably benign	0.03
IGL01657:Birc6	APN	17	74,967,606 (GRCm39)	missense	probably damaging	1.00
IGL01739:Birc6	APN	17	74,966,216 (GRCm39)	missense	probably benign
IGL01756:Birc6	APN	17	74,947,203 (GRCm39)	missense	probably benign	0.00
IGL01807:Birc6	APN	17	74,938,032 (GRCm39)	missense	probably benign
IGL01885:Birc6	APN	17	74,911,511 (GRCm39)	missense	possibly damaging	0.51
IGL01906:Birc6	APN	17	74,945,353 (GRCm39)	missense	probably damaging	1.00
IGL01915:Birc6	APN	17	74,938,715 (GRCm39)	missense	probably benign	0.34
IGL01998:Birc6	APN	17	74,886,880 (GRCm39)	missense	probably benign	0.06
IGL02084:Birc6	APN	17	74,915,277 (GRCm39)	missense	probably benign	0.45
IGL02086:Birc6	APN	17	74,946,822 (GRCm39)	missense	probably damaging	1.00
IGL02161:Birc6	APN	17	74,855,832 (GRCm39)	missense	probably damaging	0.99
IGL02195:Birc6	APN	17	75,004,376 (GRCm39)	splice site	probably benign
IGL02283:Birc6	APN	17	74,906,935 (GRCm39)	missense	probably benign
IGL02476:Birc6	APN	17	75,003,386 (GRCm39)	missense	possibly damaging	0.81
IGL02493:Birc6	APN	17	74,959,054 (GRCm39)	unclassified	probably benign
IGL02547:Birc6	APN	17	74,886,640 (GRCm39)	missense	probably benign	0.21
IGL02678:Birc6	APN	17	74,956,898 (GRCm39)	missense	probably damaging	1.00
IGL02713:Birc6	APN	17	74,886,319 (GRCm39)	missense	probably benign
IGL02851:Birc6	APN	17	74,916,184 (GRCm39)	missense	probably damaging	1.00
IGL02875:Birc6	APN	17	74,896,713 (GRCm39)	missense	probably damaging	1.00
IGL02985:Birc6	APN	17	74,947,185 (GRCm39)	missense	probably benign	0.00
IGL03004:Birc6	APN	17	74,919,180 (GRCm39)	missense	probably benign	0.10
IGL03053:Birc6	APN	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
IGL03085:Birc6	APN	17	74,903,945 (GRCm39)	missense	probably damaging	0.97
IGL03109:Birc6	APN	17	74,886,329 (GRCm39)	missense	possibly damaging	0.71
IGL03143:Birc6	APN	17	74,905,994 (GRCm39)	missense	possibly damaging	0.89
IGL03180:Birc6	APN	17	74,966,226 (GRCm39)	missense	probably benign
IGL03221:Birc6	APN	17	74,934,002 (GRCm39)	missense	probably benign	0.00
IGL03230:Birc6	APN	17	74,918,065 (GRCm39)	missense	probably damaging	1.00
IGL03294:Birc6	APN	17	74,956,881 (GRCm39)	missense	probably benign	0.02
IGL03399:Birc6	APN	17	74,901,368 (GRCm39)	missense	probably benign	0.01
Badlands	UTSW	17	74,910,031 (GRCm39)	missense	probably damaging	1.00
Big_sky	UTSW	17	74,835,533 (GRCm39)	missense	probably null	0.33
bitterroot	UTSW	17	74,956,691 (GRCm39)	missense	probably damaging	1.00
Black_hills	UTSW	17	74,999,327 (GRCm39)	missense	probably damaging	1.00
bottomlands	UTSW	17	74,916,654 (GRCm39)	missense	probably damaging	1.00
Chai	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
Dakota	UTSW	17	74,932,099 (GRCm39)	critical splice acceptor site	probably null
Sempervirens	UTSW	17	74,949,499 (GRCm39)	missense	probably damaging	1.00
E0370:Birc6	UTSW	17	74,984,352 (GRCm39)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,905,039 (GRCm39)	missense	probably damaging	1.00
G1citation:Birc6	UTSW	17	74,887,377 (GRCm39)	missense	possibly damaging	0.82
PIT4494001:Birc6	UTSW	17	74,933,975 (GRCm39)	missense	probably damaging	1.00
R0081:Birc6	UTSW	17	74,950,436 (GRCm39)	missense	probably benign	0.01
R0086:Birc6	UTSW	17	74,900,161 (GRCm39)	missense	possibly damaging	0.54
R0089:Birc6	UTSW	17	74,945,371 (GRCm39)	missense	possibly damaging	0.90
R0116:Birc6	UTSW	17	74,930,741 (GRCm39)	splice site	probably benign
R0129:Birc6	UTSW	17	74,835,755 (GRCm39)	missense	probably benign	0.05
R0196:Birc6	UTSW	17	74,887,282 (GRCm39)	missense	possibly damaging	0.57
R0201:Birc6	UTSW	17	74,916,322 (GRCm39)	missense	possibly damaging	0.92
R0207:Birc6	UTSW	17	74,969,827 (GRCm39)	splice site	probably benign
R0295:Birc6	UTSW	17	74,920,357 (GRCm39)	intron	probably benign
R0386:Birc6	UTSW	17	74,906,335 (GRCm39)	missense	probably damaging	0.99
R0423:Birc6	UTSW	17	75,003,292 (GRCm39)	missense	probably damaging	1.00
R0449:Birc6	UTSW	17	74,999,290 (GRCm39)	missense	probably damaging	1.00
R0453:Birc6	UTSW	17	74,956,749 (GRCm39)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,969,620 (GRCm39)	missense	probably damaging	1.00
R0457:Birc6	UTSW	17	74,959,023 (GRCm39)	missense	probably benign
R0564:Birc6	UTSW	17	74,932,238 (GRCm39)	splice site	probably benign
R0575:Birc6	UTSW	17	74,996,232 (GRCm39)	missense	probably damaging	1.00
R0582:Birc6	UTSW	17	74,950,332 (GRCm39)	missense	probably damaging	1.00
R0624:Birc6	UTSW	17	74,887,344 (GRCm39)	missense	probably benign	0.20
R0973:Birc6	UTSW	17	74,872,856 (GRCm39)	missense	probably damaging	0.99
R1061:Birc6	UTSW	17	74,996,307 (GRCm39)	missense	probably damaging	1.00
R1378:Birc6	UTSW	17	74,967,450 (GRCm39)	missense	probably damaging	1.00
R1402:Birc6	UTSW	17	75,004,528 (GRCm39)	splice site	probably benign
R1436:Birc6	UTSW	17	74,959,700 (GRCm39)	missense	probably damaging	1.00
R1456:Birc6	UTSW	17	74,916,285 (GRCm39)	missense	probably benign	0.35
R1465:Birc6	UTSW	17	74,930,853 (GRCm39)	missense	probably benign	0.03
R1465:Birc6	UTSW	17	74,930,853 (GRCm39)	missense	probably benign	0.03
R1474:Birc6	UTSW	17	74,886,673 (GRCm39)	missense	probably damaging	0.98
R1479:Birc6	UTSW	17	74,941,848 (GRCm39)	missense	probably damaging	1.00
R1486:Birc6	UTSW	17	74,946,815 (GRCm39)	missense	probably damaging	1.00
R1499:Birc6	UTSW	17	74,919,314 (GRCm39)	missense	probably damaging	1.00
R1515:Birc6	UTSW	17	74,835,631 (GRCm39)	nonsense	probably null
R1549:Birc6	UTSW	17	74,969,737 (GRCm39)	missense	probably damaging	1.00
R1559:Birc6	UTSW	17	74,999,232 (GRCm39)	missense	probably damaging	1.00
R1573:Birc6	UTSW	17	74,967,685 (GRCm39)	splice site	probably benign
R1615:Birc6	UTSW	17	74,916,404 (GRCm39)	splice site	probably null
R1621:Birc6	UTSW	17	74,977,245 (GRCm39)	missense	probably benign
R1680:Birc6	UTSW	17	74,855,741 (GRCm39)	missense	probably benign	0.01
R1743:Birc6	UTSW	17	74,886,751 (GRCm39)	missense	possibly damaging	0.95
R1774:Birc6	UTSW	17	74,947,008 (GRCm39)	missense	probably damaging	1.00
R1775:Birc6	UTSW	17	74,919,281 (GRCm39)	missense	probably damaging	1.00
R1818:Birc6	UTSW	17	74,956,844 (GRCm39)	missense	probably damaging	1.00
R1836:Birc6	UTSW	17	74,921,385 (GRCm39)	missense	probably benign	0.41
R1931:Birc6	UTSW	17	74,872,977 (GRCm39)	missense	probably damaging	0.99
R1939:Birc6	UTSW	17	74,977,332 (GRCm39)	missense	probably damaging	1.00
R1964:Birc6	UTSW	17	74,941,880 (GRCm39)	missense	possibly damaging	0.94
R1994:Birc6	UTSW	17	74,905,057 (GRCm39)	missense	probably benign	0.01
R2000:Birc6	UTSW	17	74,911,614 (GRCm39)	missense	possibly damaging	0.46
R2042:Birc6	UTSW	17	74,916,654 (GRCm39)	missense	probably damaging	1.00
R2090:Birc6	UTSW	17	74,969,791 (GRCm39)	missense	probably benign
R2130:Birc6	UTSW	17	74,966,149 (GRCm39)	splice site	probably benign
R2144:Birc6	UTSW	17	74,967,408 (GRCm39)	missense	possibly damaging	0.71
R2145:Birc6	UTSW	17	74,967,408 (GRCm39)	missense	possibly damaging	0.71
R2166:Birc6	UTSW	17	74,942,790 (GRCm39)	missense	probably benign	0.02
R2180:Birc6	UTSW	17	74,919,146 (GRCm39)	missense	probably benign	0.03
R2271:Birc6	UTSW	17	74,909,966 (GRCm39)	missense	probably benign	0.06
R2272:Birc6	UTSW	17	74,909,966 (GRCm39)	missense	probably benign	0.06
R2416:Birc6	UTSW	17	74,915,214 (GRCm39)	missense	possibly damaging	0.83
R2420:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2421:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2422:Birc6	UTSW	17	74,967,609 (GRCm39)	missense	probably damaging	1.00
R2513:Birc6	UTSW	17	74,954,724 (GRCm39)	missense	probably damaging	0.97
R2912:Birc6	UTSW	17	74,999,201 (GRCm39)	missense	probably damaging	1.00
R3024:Birc6	UTSW	17	74,915,214 (GRCm39)	missense	possibly damaging	0.83
R3771:Birc6	UTSW	17	74,925,424 (GRCm39)	splice site	probably benign
R3772:Birc6	UTSW	17	74,925,424 (GRCm39)	splice site	probably benign
R3829:Birc6	UTSW	17	74,962,173 (GRCm39)	missense	probably damaging	1.00
R3913:Birc6	UTSW	17	74,880,608 (GRCm39)	nonsense	probably null
R3915:Birc6	UTSW	17	74,886,603 (GRCm39)	missense	probably benign	0.12
R3921:Birc6	UTSW	17	74,934,014 (GRCm39)	missense	probably damaging	0.98
R3928:Birc6	UTSW	17	74,945,404 (GRCm39)	missense	probably damaging	1.00
R3928:Birc6	UTSW	17	74,918,170 (GRCm39)	missense	possibly damaging	0.91
R4111:Birc6	UTSW	17	74,873,010 (GRCm39)	missense	probably damaging	1.00
R4155:Birc6	UTSW	17	74,903,934 (GRCm39)	missense	probably benign	0.00
R4163:Birc6	UTSW	17	74,933,975 (GRCm39)	missense	probably damaging	1.00
R4226:Birc6	UTSW	17	74,926,835 (GRCm39)	critical splice donor site	probably null
R4227:Birc6	UTSW	17	74,926,835 (GRCm39)	critical splice donor site	probably null
R4358:Birc6	UTSW	17	74,926,663 (GRCm39)	splice site	probably null
R4524:Birc6	UTSW	17	74,948,772 (GRCm39)	missense	probably damaging	1.00
R4605:Birc6	UTSW	17	74,946,929 (GRCm39)	missense	probably damaging	1.00
R4619:Birc6	UTSW	17	74,947,145 (GRCm39)	missense	probably benign	0.18
R4620:Birc6	UTSW	17	74,947,145 (GRCm39)	missense	probably benign	0.18
R4762:Birc6	UTSW	17	74,936,484 (GRCm39)	missense	probably damaging	1.00
R4814:Birc6	UTSW	17	74,956,667 (GRCm39)	missense	probably damaging	1.00
R4849:Birc6	UTSW	17	74,954,383 (GRCm39)	missense	probably damaging	0.99
R4869:Birc6	UTSW	17	74,893,007 (GRCm39)	missense	probably benign	0.05
R4912:Birc6	UTSW	17	74,872,900 (GRCm39)	missense	probably damaging	1.00
R4942:Birc6	UTSW	17	74,930,045 (GRCm39)	missense	probably damaging	1.00
R4954:Birc6	UTSW	17	74,919,026 (GRCm39)	missense	probably damaging	1.00
R4992:Birc6	UTSW	17	74,996,251 (GRCm39)	missense	probably benign	0.44
R4994:Birc6	UTSW	17	74,901,319 (GRCm39)	intron	probably benign
R5018:Birc6	UTSW	17	74,947,054 (GRCm39)	missense	probably damaging	1.00
R5022:Birc6	UTSW	17	74,999,327 (GRCm39)	missense	probably damaging	1.00
R5054:Birc6	UTSW	17	74,962,320 (GRCm39)	missense	probably damaging	1.00
R5068:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5069:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5070:Birc6	UTSW	17	74,872,967 (GRCm39)	missense	probably damaging	1.00
R5196:Birc6	UTSW	17	74,913,136 (GRCm39)	splice site	probably benign
R5209:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5212:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5216:Birc6	UTSW	17	74,920,465 (GRCm39)	missense	probably damaging	1.00
R5279:Birc6	UTSW	17	74,957,042 (GRCm39)	missense	probably damaging	0.98
R5286:Birc6	UTSW	17	74,977,242 (GRCm39)	missense	probably damaging	1.00
R5399:Birc6	UTSW	17	74,911,573 (GRCm39)	missense	possibly damaging	0.75
R5482:Birc6	UTSW	17	74,969,685 (GRCm39)	missense	probably damaging	1.00
R5482:Birc6	UTSW	17	74,948,777 (GRCm39)	missense	possibly damaging	0.86
R5492:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5504:Birc6	UTSW	17	74,962,208 (GRCm39)	missense	probably damaging	1.00
R5519:Birc6	UTSW	17	74,887,173 (GRCm39)	missense	probably benign
R5544:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5608:Birc6	UTSW	17	74,920,539 (GRCm39)	missense	probably damaging	0.99
R5623:Birc6	UTSW	17	74,835,651 (GRCm39)	missense	probably damaging	0.99
R5701:Birc6	UTSW	17	75,004,420 (GRCm39)	missense	possibly damaging	0.59
R5707:Birc6	UTSW	17	75,003,399 (GRCm39)	missense	probably damaging	1.00
R5715:Birc6	UTSW	17	74,938,615 (GRCm39)	missense	probably damaging	1.00
R5734:Birc6	UTSW	17	74,925,419 (GRCm39)	splice site	probably benign
R5792:Birc6	UTSW	17	74,938,048 (GRCm39)	missense	probably benign	0.05
R5809:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5810:Birc6	UTSW	17	74,977,369 (GRCm39)	missense	probably damaging	1.00
R5813:Birc6	UTSW	17	74,953,497 (GRCm39)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,906,232 (GRCm39)	missense	probably damaging	1.00
R5933:Birc6	UTSW	17	74,906,233 (GRCm39)	missense	probably damaging	0.98
R5960:Birc6	UTSW	17	74,835,760 (GRCm39)	missense	probably damaging	0.97
R5961:Birc6	UTSW	17	74,953,596 (GRCm39)	missense	probably damaging	1.00
R5967:Birc6	UTSW	17	74,967,434 (GRCm39)	missense	probably damaging	0.99
R5970:Birc6	UTSW	17	74,925,497 (GRCm39)	missense	possibly damaging	0.95
R5977:Birc6	UTSW	17	74,910,031 (GRCm39)	missense	probably damaging	1.00
R5982:Birc6	UTSW	17	74,955,153 (GRCm39)	missense	probably benign
R6023:Birc6	UTSW	17	74,961,372 (GRCm39)	missense	probably benign	0.24
R6034:Birc6	UTSW	17	74,922,278 (GRCm39)	missense	probably damaging	1.00
R6034:Birc6	UTSW	17	74,922,278 (GRCm39)	missense	probably damaging	1.00
R6243:Birc6	UTSW	17	74,916,382 (GRCm39)	missense	probably damaging	0.96
R6294:Birc6	UTSW	17	74,996,252 (GRCm39)	missense	probably benign	0.00
R6327:Birc6	UTSW	17	74,969,774 (GRCm39)	missense	probably damaging	1.00
R6501:Birc6	UTSW	17	74,886,276 (GRCm39)	missense	probably damaging	1.00
R6810:Birc6	UTSW	17	74,919,215 (GRCm39)	missense	possibly damaging	0.63
R6822:Birc6	UTSW	17	74,905,039 (GRCm39)	missense	probably damaging	1.00
R6822:Birc6	UTSW	17	74,887,377 (GRCm39)	missense	possibly damaging	0.82
R6835:Birc6	UTSW	17	74,949,499 (GRCm39)	missense	probably damaging	1.00
R6945:Birc6	UTSW	17	74,886,526 (GRCm39)	missense	probably benign	0.04
R6957:Birc6	UTSW	17	74,886,486 (GRCm39)	missense	probably benign
R6989:Birc6	UTSW	17	74,937,984 (GRCm39)	missense	probably benign	0.18
R6991:Birc6	UTSW	17	74,869,090 (GRCm39)	missense	probably damaging	1.00
R7019:Birc6	UTSW	17	74,916,340 (GRCm39)	missense	probably benign	0.01
R7092:Birc6	UTSW	17	74,953,740 (GRCm39)	missense	probably damaging	1.00
R7158:Birc6	UTSW	17	74,901,371 (GRCm39)	missense	probably benign	0.25
R7204:Birc6	UTSW	17	74,947,103 (GRCm39)	missense	probably damaging	1.00
R7267:Birc6	UTSW	17	74,892,980 (GRCm39)	missense	probably benign	0.00
R7316:Birc6	UTSW	17	74,911,489 (GRCm39)	missense	probably damaging	0.99
R7341:Birc6	UTSW	17	74,919,069 (GRCm39)	missense	probably damaging	1.00
R7404:Birc6	UTSW	17	74,946,789 (GRCm39)	missense	possibly damaging	0.73
R7449:Birc6	UTSW	17	75,009,336 (GRCm39)	missense	probably benign
R7498:Birc6	UTSW	17	74,967,465 (GRCm39)	missense	probably damaging	1.00
R7539:Birc6	UTSW	17	74,956,691 (GRCm39)	missense	probably damaging	1.00
R7569:Birc6	UTSW	17	74,905,077 (GRCm39)	missense	possibly damaging	0.71
R7574:Birc6	UTSW	17	74,886,879 (GRCm39)	missense	probably benign
R7611:Birc6	UTSW	17	74,969,713 (GRCm39)	missense	probably damaging	0.98
R7653:Birc6	UTSW	17	74,954,729 (GRCm39)	missense	possibly damaging	0.91
R7716:Birc6	UTSW	17	74,869,056 (GRCm39)	missense	probably damaging	0.99
R7728:Birc6	UTSW	17	74,929,100 (GRCm39)	missense	probably benign	0.01
R7810:Birc6	UTSW	17	74,855,815 (GRCm39)	missense	probably damaging	0.98
R7828:Birc6	UTSW	17	74,886,501 (GRCm39)	missense	probably damaging	0.97
R7881:Birc6	UTSW	17	74,948,666 (GRCm39)	missense	probably damaging	0.99
R7896:Birc6	UTSW	17	74,929,077 (GRCm39)	missense	probably damaging	0.99
R7950:Birc6	UTSW	17	74,900,095 (GRCm39)	missense	probably damaging	1.00
R7988:Birc6	UTSW	17	74,906,368 (GRCm39)	splice site	probably null
R8073:Birc6	UTSW	17	74,910,080 (GRCm39)	missense	probably damaging	1.00
R8128:Birc6	UTSW	17	74,916,253 (GRCm39)	missense	probably damaging	1.00
R8167:Birc6	UTSW	17	74,950,389 (GRCm39)	missense	probably damaging	1.00
R8236:Birc6	UTSW	17	74,918,126 (GRCm39)	missense	probably damaging	1.00
R8237:Birc6	UTSW	17	74,918,126 (GRCm39)	missense	probably damaging	1.00
R8255:Birc6	UTSW	17	74,969,775 (GRCm39)	missense	probably damaging	0.99
R8259:Birc6	UTSW	17	74,905,073 (GRCm39)	missense	probably benign	0.01
R8297:Birc6	UTSW	17	74,932,099 (GRCm39)	critical splice acceptor site	probably null
R8376:Birc6	UTSW	17	74,896,635 (GRCm39)	missense	probably benign	0.18
R8413:Birc6	UTSW	17	74,853,388 (GRCm39)	missense	possibly damaging	0.54
R8503:Birc6	UTSW	17	74,999,239 (GRCm39)	missense	probably damaging	1.00
R8504:Birc6	UTSW	17	74,959,000 (GRCm39)	missense	probably damaging	0.98
R8543:Birc6	UTSW	17	74,872,860 (GRCm39)	missense	probably damaging	1.00
R8550:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8551:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8556:Birc6	UTSW	17	74,864,949 (GRCm39)	missense	probably benign	0.37
R8683:Birc6	UTSW	17	74,916,114 (GRCm39)	missense	possibly damaging	0.74
R8751:Birc6	UTSW	17	74,955,135 (GRCm39)	missense	probably damaging	0.98
R8803:Birc6	UTSW	17	74,959,033 (GRCm39)	missense	probably damaging	0.99
R8806:Birc6	UTSW	17	74,949,311 (GRCm39)	missense	probably damaging	1.00
R8825:Birc6	UTSW	17	74,920,500 (GRCm39)	missense	probably damaging	0.99
R8888:Birc6	UTSW	17	74,835,533 (GRCm39)	missense	probably null	0.33
R8972:Birc6	UTSW	17	75,009,313 (GRCm39)	missense	probably benign	0.05
R9069:Birc6	UTSW	17	74,868,260 (GRCm39)	splice site	probably benign
R9111:Birc6	UTSW	17	74,966,340 (GRCm39)	missense	probably damaging	0.99
R9130:Birc6	UTSW	17	74,919,146 (GRCm39)	missense
R9352:Birc6	UTSW	17	74,965,347 (GRCm39)	critical splice donor site	probably null
R9354:Birc6	UTSW	17	74,921,401 (GRCm39)	missense	probably benign
R9432:Birc6	UTSW	17	74,966,216 (GRCm39)	missense	probably benign
R9446:Birc6	UTSW	17	74,925,491 (GRCm39)	missense	probably damaging	1.00
R9485:Birc6	UTSW	17	74,945,398 (GRCm39)	missense	probably damaging	1.00
R9499:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9551:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9552:Birc6	UTSW	17	74,916,064 (GRCm39)	missense	probably benign	0.05
R9585:Birc6	UTSW	17	74,916,265 (GRCm39)	missense	probably damaging	1.00
R9647:Birc6	UTSW	17	74,999,305 (GRCm39)	missense	probably damaging	1.00
R9648:Birc6	UTSW	17	74,938,696 (GRCm39)	missense	probably damaging	1.00
R9667:Birc6	UTSW	17	75,004,420 (GRCm39)	missense	possibly damaging	0.59
R9696:Birc6	UTSW	17	74,947,292 (GRCm39)	missense	probably damaging	0.99
RF016:Birc6	UTSW	17	74,996,319 (GRCm39)	missense	probably damaging	1.00
Z1088:Birc6	UTSW	17	74,918,537 (GRCm39)	missense	probably damaging	0.99
Z1177:Birc6	UTSW	17	74,954,275 (GRCm39)	missense	probably benign	0.10

Predicted Primers

PCR Primer
(F):5'- TGAATCCCACTTGGCAACTC -3'
(R):5'- AAGCTGACCTTGTGCTGCTC -3'

Sequencing Primer
(F):5'- GCTATCAAACAGTTGCTAGACTCGG -3'
(R):5'- CTGCTGTGCCCCTAAATTATG -3'

Posted On

2016-04-15