Incidental Mutation 'R4922:Sgo2b'
ID 378698
Institutional Source Beutler Lab
Gene Symbol Sgo2b
Ensembl Gene ENSMUSG00000094443
Gene Name shugoshin 2B
Synonyms Gm4975, Sgol2b
MMRRC Submission 042524-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R4922 (G1)
Quality Score 225
Status Validated
Chromosome 8
Chromosomal Location 64377728-64405204 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 64379664 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1056 (M1056K)
Ref Sequence ENSEMBL: ENSMUSP00000136323 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000179944]
AlphaFold J3QMK1
Predicted Effect possibly damaging
Transcript: ENSMUST00000179944
AA Change: M1056K

PolyPhen 2 Score 0.663 (Sensitivity: 0.86; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000136323
Gene: ENSMUSG00000094443
AA Change: M1056K

DomainStartEndE-ValueType
coiled coil region 54 113 N/A INTRINSIC
low complexity region 122 135 N/A INTRINSIC
low complexity region 163 172 N/A INTRINSIC
low complexity region 400 414 N/A INTRINSIC
internal_repeat_1 528 618 9.12e-8 PROSPERO
internal_repeat_1 713 809 9.12e-8 PROSPERO
low complexity region 1009 1024 N/A INTRINSIC
low complexity region 1059 1081 N/A INTRINSIC
low complexity region 1112 1126 N/A INTRINSIC
low complexity region 1130 1148 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210915
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency 97% (76/78)
Allele List at MGI
Other mutations in this stock
Total: 69 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrb2 G T 4: 129,901,645 (GRCm39) C423F probably damaging Het
Akap11 A T 14: 78,750,220 (GRCm39) Y722* probably null Het
Albfm1 A G 5: 90,727,570 (GRCm39) H396R possibly damaging Het
Anxa3 A T 5: 96,968,288 (GRCm39) I114F probably damaging Het
Arfgef3 T A 10: 18,467,934 (GRCm39) R1755S probably damaging Het
Atf7ip A T 6: 136,537,039 (GRCm39) T91S possibly damaging Het
Bcl2 C A 1: 106,640,376 (GRCm39) A79S probably benign Het
Bltp1 T A 3: 37,041,314 (GRCm39) I2564K probably damaging Het
Bmerb1 A G 16: 13,804,683 (GRCm39) H10R possibly damaging Het
Bmp10 C T 6: 87,410,557 (GRCm39) P117S probably benign Het
Bmpr2 A G 1: 59,906,583 (GRCm39) T559A probably benign Het
Cd200r1 A T 16: 44,610,039 (GRCm39) Y86F probably damaging Het
Cemip T A 7: 83,596,308 (GRCm39) probably benign Het
Cfap251 T C 5: 123,394,116 (GRCm39) V335A probably benign Het
Cfap52 A G 11: 67,822,548 (GRCm39) probably null Het
Chml T C 1: 175,514,712 (GRCm39) H60R possibly damaging Het
Cic TCCCCC TCCCCCCCC 7: 24,991,095 (GRCm39) probably benign Het
Clec12a A G 6: 129,336,441 (GRCm39) Y201C probably damaging Het
Col15a1 T C 4: 47,258,719 (GRCm39) V370A probably benign Het
Cpsf3 T C 12: 21,351,538 (GRCm39) I353T probably damaging Het
Csf2rb T A 15: 78,230,667 (GRCm39) V470E probably benign Het
Cyp4a10 C A 4: 115,378,291 (GRCm39) Q126K probably benign Het
Dennd1b T C 1: 139,013,652 (GRCm39) S249P probably damaging Het
Dnase2a A G 8: 85,635,625 (GRCm39) probably null Het
Dpp10 T C 1: 123,305,882 (GRCm39) N490S probably benign Het
Drgx A T 14: 32,330,363 (GRCm39) N160I probably damaging Het
Enc1 C T 13: 97,382,243 (GRCm39) A251V probably benign Het
Fancd2 T C 6: 113,562,434 (GRCm39) V1258A probably benign Het
Fancm G A 12: 65,153,666 (GRCm39) probably null Het
Fbxo16 C T 14: 65,536,657 (GRCm39) T177I probably benign Het
Gm1965 T C 6: 89,123,525 (GRCm39) noncoding transcript Het
Hal A T 10: 93,339,401 (GRCm39) M497L probably damaging Het
Hectd4 T C 5: 121,497,378 (GRCm39) L3936S possibly damaging Het
Hs3st4 G T 7: 123,996,410 (GRCm39) G359W probably damaging Het
Il6st C T 13: 112,639,399 (GRCm39) P608L probably damaging Het
Kctd18 A C 1: 58,004,707 (GRCm39) probably benign Het
Kntc1 T A 5: 123,940,309 (GRCm39) S1636T probably damaging Het
Lrrn1 A T 6: 107,545,311 (GRCm39) S370C probably damaging Het
Mtcl1 A C 17: 66,655,474 (GRCm39) C968G probably benign Het
Mylip G A 13: 45,562,238 (GRCm39) A347T probably damaging Het
Naip2 T C 13: 100,291,468 (GRCm39) S1157G probably benign Het
Ncoa4-ps A G 12: 119,226,252 (GRCm39) noncoding transcript Het
Neu4 T A 1: 93,950,200 (GRCm39) V53E probably damaging Het
Nxpe3 T C 16: 55,680,687 (GRCm39) I302V probably benign Het
Or11i1 A T 3: 106,729,576 (GRCm39) C100S probably damaging Het
Or4c15b A T 2: 89,112,811 (GRCm39) L243Q possibly damaging Het
Otos T C 1: 92,572,090 (GRCm39) T79A probably damaging Het
Pde4a T C 9: 21,122,009 (GRCm39) I578T probably damaging Het
Pramel17 T A 4: 101,692,729 (GRCm39) M424L probably benign Het
Prex2 C T 1: 11,240,164 (GRCm39) P927S probably damaging Het
Prune2 A T 19: 17,100,116 (GRCm39) K1873N probably benign Het
Ptk7 C A 17: 46,887,417 (GRCm39) probably null Het
Reln T A 5: 22,200,585 (GRCm39) probably null Het
Rgl2 A G 17: 34,151,749 (GRCm39) probably benign Het
Rnf145 T A 11: 44,448,063 (GRCm39) probably benign Het
Ryr2 T C 13: 11,724,849 (GRCm39) E2488G probably damaging Het
Snapc4 A G 2: 26,259,245 (GRCm39) V635A probably benign Het
Snx19 T A 9: 30,348,763 (GRCm39) Y101N probably benign Het
Sorl1 C A 9: 41,925,746 (GRCm39) probably null Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Speer4a2 A T 5: 26,289,791 (GRCm39) I212N probably damaging Het
Tmem30b G A 12: 73,592,488 (GRCm39) P209L probably damaging Het
Trbv12-2 G T 6: 41,096,081 (GRCm39) C52F probably damaging Het
Tsc2 T A 17: 24,819,343 (GRCm39) D1304V probably benign Het
Ugt2b36 T C 5: 87,214,183 (GRCm39) Y487C probably damaging Het
Vmn1r10 T A 6: 57,090,811 (GRCm39) N134K probably damaging Het
Wdr27 C A 17: 15,141,016 (GRCm39) probably null Het
Wdr75 T C 1: 45,855,638 (GRCm39) F430L probably damaging Het
Zfp629 A G 7: 127,211,299 (GRCm39) I170T probably damaging Het
Other mutations in Sgo2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01017:Sgo2b APN 8 64,379,557 (GRCm39) missense probably benign
IGL01343:Sgo2b APN 8 64,380,349 (GRCm39) nonsense probably null
IGL02027:Sgo2b APN 8 64,379,863 (GRCm39) missense probably benign
IGL02090:Sgo2b APN 8 64,380,123 (GRCm39) missense probably damaging 0.99
IGL02121:Sgo2b APN 8 64,384,316 (GRCm39) missense possibly damaging 0.94
IGL02206:Sgo2b APN 8 64,394,118 (GRCm39) missense possibly damaging 0.94
IGL02554:Sgo2b APN 8 64,379,571 (GRCm39) missense probably damaging 0.96
IGL02663:Sgo2b APN 8 64,396,148 (GRCm39) missense probably damaging 0.97
IGL03149:Sgo2b APN 8 64,379,617 (GRCm39) missense probably benign 0.14
floater UTSW 8 64,391,451 (GRCm39) nonsense probably null
R0164:Sgo2b UTSW 8 64,391,417 (GRCm39) missense possibly damaging 0.92
R0164:Sgo2b UTSW 8 64,391,417 (GRCm39) missense possibly damaging 0.92
R0201:Sgo2b UTSW 8 64,379,670 (GRCm39) missense probably benign
R0285:Sgo2b UTSW 8 64,381,823 (GRCm39) nonsense probably null
R0325:Sgo2b UTSW 8 64,381,410 (GRCm39) missense probably benign 0.20
R0727:Sgo2b UTSW 8 64,380,816 (GRCm39) missense probably damaging 0.98
R0943:Sgo2b UTSW 8 64,384,369 (GRCm39) missense possibly damaging 0.82
R1148:Sgo2b UTSW 8 64,379,889 (GRCm39) missense probably damaging 0.99
R1266:Sgo2b UTSW 8 64,381,455 (GRCm39) missense probably benign 0.00
R1484:Sgo2b UTSW 8 64,384,507 (GRCm39) missense possibly damaging 0.77
R1493:Sgo2b UTSW 8 64,379,889 (GRCm39) missense probably damaging 0.99
R1537:Sgo2b UTSW 8 64,379,536 (GRCm39) missense possibly damaging 0.94
R1630:Sgo2b UTSW 8 64,380,831 (GRCm39) missense possibly damaging 0.90
R1803:Sgo2b UTSW 8 64,380,426 (GRCm39) missense probably benign 0.01
R1912:Sgo2b UTSW 8 64,384,503 (GRCm39) missense probably damaging 0.98
R1993:Sgo2b UTSW 8 64,379,867 (GRCm39) missense probably benign 0.36
R2042:Sgo2b UTSW 8 64,381,561 (GRCm39) missense probably benign
R2130:Sgo2b UTSW 8 64,380,181 (GRCm39) missense probably benign 0.09
R2146:Sgo2b UTSW 8 64,381,057 (GRCm39) missense probably benign 0.00
R2881:Sgo2b UTSW 8 64,380,570 (GRCm39) missense probably damaging 0.99
R3686:Sgo2b UTSW 8 64,384,361 (GRCm39) missense probably benign 0.20
R3706:Sgo2b UTSW 8 64,381,179 (GRCm39) missense probably damaging 0.98
R3889:Sgo2b UTSW 8 64,380,777 (GRCm39) missense possibly damaging 0.82
R3894:Sgo2b UTSW 8 64,381,767 (GRCm39) missense possibly damaging 0.91
R3895:Sgo2b UTSW 8 64,381,767 (GRCm39) missense possibly damaging 0.91
R4058:Sgo2b UTSW 8 64,379,981 (GRCm39) missense probably damaging 0.98
R4259:Sgo2b UTSW 8 64,381,330 (GRCm39) missense probably benign 0.06
R4260:Sgo2b UTSW 8 64,381,330 (GRCm39) missense probably benign 0.06
R4704:Sgo2b UTSW 8 64,380,824 (GRCm39) missense probably damaging 0.98
R4815:Sgo2b UTSW 8 64,384,448 (GRCm39) missense probably benign
R5232:Sgo2b UTSW 8 64,381,636 (GRCm39) missense possibly damaging 0.55
R5262:Sgo2b UTSW 8 64,396,171 (GRCm39) missense probably damaging 0.99
R5444:Sgo2b UTSW 8 64,379,590 (GRCm39) missense possibly damaging 0.90
R5677:Sgo2b UTSW 8 64,380,008 (GRCm39) missense possibly damaging 0.77
R5959:Sgo2b UTSW 8 64,380,322 (GRCm39) missense probably benign 0.01
R6004:Sgo2b UTSW 8 64,379,707 (GRCm39) nonsense probably null
R6267:Sgo2b UTSW 8 64,380,827 (GRCm39) missense probably benign
R6296:Sgo2b UTSW 8 64,380,827 (GRCm39) missense probably benign
R6328:Sgo2b UTSW 8 64,381,345 (GRCm39) nonsense probably null
R6517:Sgo2b UTSW 8 64,384,528 (GRCm39) missense probably damaging 0.99
R6523:Sgo2b UTSW 8 64,380,538 (GRCm39) missense probably benign 0.11
R6726:Sgo2b UTSW 8 64,380,769 (GRCm39) nonsense probably null
R6957:Sgo2b UTSW 8 64,384,489 (GRCm39) small deletion probably benign
R7031:Sgo2b UTSW 8 64,393,078 (GRCm39) missense possibly damaging 0.94
R7034:Sgo2b UTSW 8 64,379,868 (GRCm39) missense probably benign 0.36
R7145:Sgo2b UTSW 8 64,381,218 (GRCm39) missense probably damaging 1.00
R7289:Sgo2b UTSW 8 64,394,192 (GRCm39) missense probably damaging 0.97
R7366:Sgo2b UTSW 8 64,391,451 (GRCm39) nonsense probably null
R7660:Sgo2b UTSW 8 64,393,108 (GRCm39) missense probably benign 0.27
R7761:Sgo2b UTSW 8 64,379,946 (GRCm39) missense probably benign
R7762:Sgo2b UTSW 8 64,379,531 (GRCm39) missense probably benign 0.03
R7822:Sgo2b UTSW 8 64,380,318 (GRCm39) missense probably damaging 0.98
R8111:Sgo2b UTSW 8 64,396,138 (GRCm39) missense probably damaging 0.98
R8129:Sgo2b UTSW 8 64,381,834 (GRCm39) missense possibly damaging 0.90
R8273:Sgo2b UTSW 8 64,377,735 (GRCm39) missense unknown
R8856:Sgo2b UTSW 8 64,393,091 (GRCm39) missense probably null 0.99
R9249:Sgo2b UTSW 8 64,391,407 (GRCm39) nonsense probably null
R9428:Sgo2b UTSW 8 64,393,067 (GRCm39) missense probably damaging 0.99
R9616:Sgo2b UTSW 8 64,380,274 (GRCm39) missense probably benign
R9621:Sgo2b UTSW 8 64,380,651 (GRCm39) missense probably damaging 0.99
RF014:Sgo2b UTSW 8 64,384,439 (GRCm39) missense possibly damaging 0.94
RF055:Sgo2b UTSW 8 64,396,203 (GRCm39) missense probably damaging 1.00
Z1088:Sgo2b UTSW 8 64,381,456 (GRCm39) missense possibly damaging 0.61
Z1088:Sgo2b UTSW 8 64,380,039 (GRCm39) missense probably damaging 1.00
Z1177:Sgo2b UTSW 8 64,381,419 (GRCm39) missense possibly damaging 0.82
Z1177:Sgo2b UTSW 8 64,380,473 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AAACTCTGGCCTACCTGGTCTAG -3'
(R):5'- TTGTTCTCCTGAAACCCATGGAC -3'

Sequencing Primer
(F):5'- GGCCTACCTGGTCTAGACTTTTG -3'
(R):5'- CTGAAACCCATGGACCAGTGG -3'
Posted On 2016-04-15