Incidental Mutation 'R4924:Kdm5b'
| ID |
378837 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kdm5b
|
| Ensembl Gene |
ENSMUSG00000042207 |
| Gene Name |
lysine (K)-specific demethylase 5B |
| Synonyms |
Jarid1b, Plu1, Rb-Bp2, 2210016I17Rik, 2010009J12Rik, PLU-1, D1Ertd202e |
| MMRRC Submission |
042526-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.268)
|
| Stock # |
R4924 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
134560171-134635285 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 134631351 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Glutamic Acid
at position 1538
(K1538E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000038138
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047714]
[ENSMUST00000112198]
|
| AlphaFold |
Q80Y84 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047714
AA Change: K1538E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000038138
Gene: ENSMUSG00000042207
AA Change: K1538E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
744 |
2.2e-17 |
PFAM |
|
Pfam:PLU-1
|
757 |
1088 |
5.6e-92 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
PHD
|
1486 |
1536 |
1.18e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000112198
|
| SMART Domains |
Protein: ENSMUSP00000107817
Gene: ENSMUSG00000042207
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
7 |
30 |
N/A |
INTRINSIC |
|
JmjN
|
31 |
72 |
2.87e-20 |
SMART |
|
ARID
|
94 |
183 |
7.39e-32 |
SMART |
|
BRIGHT
|
98 |
188 |
1.51e-35 |
SMART |
|
low complexity region
|
228 |
239 |
N/A |
INTRINSIC |
|
PHD
|
311 |
357 |
6.15e-14 |
SMART |
|
JmjC
|
453 |
619 |
2.33e-67 |
SMART |
|
Pfam:zf-C5HC2
|
692 |
745 |
6.7e-21 |
PFAM |
|
Pfam:PLU-1
|
756 |
1088 |
6e-94 |
PFAM |
|
low complexity region
|
1097 |
1109 |
N/A |
INTRINSIC |
|
PHD
|
1178 |
1222 |
6.2e-10 |
SMART |
|
low complexity region
|
1225 |
1236 |
N/A |
INTRINSIC |
|
low complexity region
|
1406 |
1417 |
N/A |
INTRINSIC |
|
low complexity region
|
1470 |
1484 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000191572
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 96.0%
- 20x: 91.6%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Homozygous mutant mice display decreased body weight, decreased female fertility, lower uterine weight, and a delay in mammary development. Knockout of this gene has also been associated with embryonic lethality. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit decreased body weight, background-sensitive premature mortality, decreased female fertility, delayed mammary gland development, decreased serum estradiol levels, and reduced mammary epithelial cell proliferation in early puberty. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 76 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aatk |
G |
A |
11: 120,011,525 (GRCm38) |
H625Y |
probably damaging |
Het |
| Adamts4 |
C |
T |
1: 171,259,074 (GRCm38) |
R812W |
probably damaging |
Het |
| Ajuba |
A |
C |
14: 54,571,599 (GRCm38) |
|
probably null |
Het |
| Aox2 |
T |
A |
1: 58,305,344 (GRCm38) |
V532D |
probably damaging |
Het |
| Arpc1b |
G |
A |
5: 145,126,815 (GRCm38) |
S295N |
probably benign |
Het |
| Baiap2 |
A |
G |
11: 119,997,024 (GRCm38) |
S335G |
probably damaging |
Het |
| BC051142 |
C |
T |
17: 34,459,977 (GRCm38) |
P221L |
probably damaging |
Het |
| Brap |
T |
G |
5: 121,665,255 (GRCm38) |
N155K |
probably damaging |
Het |
| Btn1a1 |
A |
G |
13: 23,464,226 (GRCm38) |
|
probably benign |
Het |
| Ccl12 |
G |
A |
11: 82,102,649 (GRCm38) |
V38I |
probably benign |
Het |
| Cemip |
T |
C |
7: 83,952,938 (GRCm38) |
Y881C |
probably damaging |
Het |
| Cep128 |
T |
C |
12: 91,022,400 (GRCm38) |
|
silent |
Het |
| Chd5 |
A |
C |
4: 152,366,429 (GRCm38) |
D670A |
possibly damaging |
Het |
| Cmip |
T |
C |
8: 117,257,255 (GRCm38) |
Y52H |
probably benign |
Het |
| Dmtn |
A |
G |
14: 70,617,959 (GRCm38) |
I30T |
probably benign |
Het |
| Dscaml1 |
T |
A |
9: 45,745,189 (GRCm38) |
M1609K |
probably damaging |
Het |
| Edar |
C |
A |
10: 58,629,375 (GRCm38) |
E55D |
probably damaging |
Het |
| Ehmt1 |
A |
T |
2: 24,839,722 (GRCm38) |
I601N |
probably damaging |
Het |
| Fam120a |
A |
T |
13: 48,902,096 (GRCm38) |
N705K |
probably benign |
Het |
| Gm21718 |
G |
T |
14: 51,312,835 (GRCm38) |
|
noncoding transcript |
Het |
| Gnaz |
A |
G |
10: 74,991,713 (GRCm38) |
D99G |
probably benign |
Het |
| Helz |
G |
A |
11: 107,602,339 (GRCm38) |
G196D |
probably damaging |
Het |
| Hif1a |
T |
C |
12: 73,939,557 (GRCm38) |
S341P |
probably damaging |
Het |
| Hivep1 |
G |
T |
13: 42,158,316 (GRCm38) |
S1344I |
probably benign |
Het |
| Hspa1l |
T |
A |
17: 34,977,856 (GRCm38) |
Y290* |
probably null |
Het |
| Ift81 |
A |
G |
5: 122,594,616 (GRCm38) |
L285S |
possibly damaging |
Het |
| Inpp4b |
T |
A |
8: 82,122,624 (GRCm38) |
N891K |
probably damaging |
Het |
| Irx6 |
C |
T |
8: 92,678,353 (GRCm38) |
T283M |
probably benign |
Het |
| Kif13a |
A |
G |
13: 46,929,599 (GRCm38) |
V8A |
probably damaging |
Het |
| Krtap15 |
T |
A |
16: 88,829,148 (GRCm38) |
N34K |
probably damaging |
Het |
| Lama2 |
T |
G |
10: 27,369,141 (GRCm38) |
I215L |
probably damaging |
Het |
| Ldlrad3 |
C |
T |
2: 102,069,983 (GRCm38) |
R58H |
possibly damaging |
Het |
| Lvrn |
C |
T |
18: 46,894,725 (GRCm38) |
P869L |
probably damaging |
Het |
| Myo1d |
A |
G |
11: 80,674,678 (GRCm38) |
F411S |
probably damaging |
Het |
| Myo5b |
T |
A |
18: 74,695,384 (GRCm38) |
H702Q |
probably benign |
Het |
| Nat8f4 |
G |
T |
6: 85,901,419 (GRCm38) |
Q41K |
probably benign |
Het |
| Nckap5 |
C |
A |
1: 126,027,028 (GRCm38) |
E596* |
probably null |
Het |
| Nek10 |
T |
A |
14: 14,846,594 (GRCm38) |
|
probably null |
Het |
| Notch3 |
T |
C |
17: 32,144,731 (GRCm38) |
Y1145C |
probably damaging |
Het |
| Nr4a2 |
A |
T |
2: 57,112,023 (GRCm38) |
H76Q |
probably benign |
Het |
| Nup98 |
T |
C |
7: 102,134,978 (GRCm38) |
Q1049R |
probably damaging |
Het |
| Olfr1080 |
A |
T |
2: 86,553,509 (GRCm38) |
F205Y |
probably damaging |
Het |
| Olfr1298 |
A |
T |
2: 111,645,776 (GRCm38) |
S74T |
possibly damaging |
Het |
| Olfr172 |
T |
A |
16: 58,760,619 (GRCm38) |
R186* |
probably null |
Het |
| Pepd |
T |
C |
7: 35,020,984 (GRCm38) |
Y231H |
probably benign |
Het |
| Plagl1 |
G |
T |
10: 13,127,557 (GRCm38) |
A190S |
possibly damaging |
Het |
| Plat |
T |
A |
8: 22,778,253 (GRCm38) |
I345N |
probably damaging |
Het |
| Pnmt |
A |
G |
11: 98,387,460 (GRCm38) |
E120G |
probably damaging |
Het |
| Prkrip1 |
C |
A |
5: 136,198,943 (GRCm38) |
|
probably null |
Het |
| Pygm |
G |
A |
19: 6,393,724 (GRCm38) |
A572T |
probably damaging |
Het |
| Rbm4b |
T |
C |
19: 4,757,372 (GRCm38) |
F39L |
probably damaging |
Het |
| Rpe65 |
A |
G |
3: 159,622,631 (GRCm38) |
H388R |
probably benign |
Het |
| Scn4a |
G |
T |
11: 106,320,088 (GRCm38) |
A1701E |
possibly damaging |
Het |
| Sdk2 |
C |
A |
11: 113,857,758 (GRCm38) |
W616L |
probably damaging |
Het |
| Serpina3m |
T |
A |
12: 104,391,470 (GRCm38) |
S218T |
probably benign |
Het |
| Siglece |
C |
T |
7: 43,659,873 (GRCm38) |
R87H |
probably damaging |
Het |
| Sim1 |
C |
A |
10: 50,909,902 (GRCm38) |
L284M |
probably damaging |
Het |
| Smok3c |
G |
T |
5: 138,065,582 (GRCm38) |
E444* |
probably null |
Het |
| Snx4 |
T |
C |
16: 33,294,730 (GRCm38) |
V427A |
probably benign |
Het |
| Srp68 |
A |
T |
11: 116,260,858 (GRCm38) |
V304E |
probably damaging |
Het |
| Stag1 |
A |
T |
9: 100,796,755 (GRCm38) |
H243L |
possibly damaging |
Het |
| Stx6 |
T |
C |
1: 155,173,991 (GRCm38) |
V14A |
probably damaging |
Het |
| Sv2b |
T |
A |
7: 75,136,421 (GRCm38) |
Y417F |
probably benign |
Het |
| Tas2r103 |
A |
G |
6: 133,036,198 (GRCm38) |
Y302H |
probably benign |
Het |
| Thop1 |
T |
C |
10: 81,080,194 (GRCm38) |
S404P |
probably benign |
Het |
| Trp53bp1 |
G |
T |
2: 121,221,220 (GRCm38) |
C988* |
probably null |
Het |
| Ube3c |
A |
G |
5: 29,631,271 (GRCm38) |
E630G |
possibly damaging |
Het |
| Usf3 |
T |
C |
16: 44,217,355 (GRCm38) |
S733P |
probably benign |
Het |
| Vmn1r195 |
A |
G |
13: 22,279,019 (GRCm38) |
T220A |
probably benign |
Het |
| Vmn1r201 |
A |
T |
13: 22,474,712 (GRCm38) |
H32L |
probably benign |
Het |
| Wnt2 |
A |
G |
6: 18,023,240 (GRCm38) |
C137R |
probably damaging |
Het |
| Ythdc2 |
T |
C |
18: 44,847,804 (GRCm38) |
S489P |
probably damaging |
Het |
| Zfp248 |
A |
G |
6: 118,429,072 (GRCm38) |
C418R |
probably damaging |
Het |
| Zfp946 |
T |
G |
17: 22,455,521 (GRCm38) |
F419V |
probably damaging |
Het |
| Zfp994 |
C |
T |
17: 22,200,757 (GRCm38) |
E404K |
probably damaging |
Het |
| Zfpm1 |
T |
C |
8: 122,334,608 (GRCm38) |
V304A |
possibly damaging |
Het |
|
| Other mutations in Kdm5b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00230:Kdm5b
|
APN |
1 |
134,620,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01458:Kdm5b
|
APN |
1 |
134,621,986 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
IGL01567:Kdm5b
|
APN |
1 |
134,602,540 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01625:Kdm5b
|
APN |
1 |
134,617,968 (GRCm38) |
missense |
possibly damaging |
0.74 |
|
IGL01970:Kdm5b
|
APN |
1 |
134,600,727 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02183:Kdm5b
|
APN |
1 |
134,624,931 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02592:Kdm5b
|
APN |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02695:Kdm5b
|
APN |
1 |
134,604,485 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
IGL02697:Kdm5b
|
APN |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
IGL03036:Kdm5b
|
APN |
1 |
134,608,937 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03056:Kdm5b
|
APN |
1 |
134,587,979 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03206:Kdm5b
|
APN |
1 |
134,627,317 (GRCm38) |
missense |
probably benign |
|
|
IGL03342:Kdm5b
|
APN |
1 |
134,602,576 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL03388:Kdm5b
|
APN |
1 |
134,627,322 (GRCm38) |
missense |
probably benign |
|
|
amaryllis
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
PIT4486001:Kdm5b
|
UTSW |
1 |
134,628,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0233:Kdm5b
|
UTSW |
1 |
134,604,634 (GRCm38) |
splice site |
probably benign |
|
|
R0334:Kdm5b
|
UTSW |
1 |
134,604,522 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0504:Kdm5b
|
UTSW |
1 |
134,621,023 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0505:Kdm5b
|
UTSW |
1 |
134,602,571 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R0521:Kdm5b
|
UTSW |
1 |
134,618,033 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R1004:Kdm5b
|
UTSW |
1 |
134,588,904 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R1087:Kdm5b
|
UTSW |
1 |
134,600,637 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1126:Kdm5b
|
UTSW |
1 |
134,613,991 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R1221:Kdm5b
|
UTSW |
1 |
134,599,091 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1230:Kdm5b
|
UTSW |
1 |
134,613,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1345:Kdm5b
|
UTSW |
1 |
134,630,550 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R1482:Kdm5b
|
UTSW |
1 |
134,624,897 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Kdm5b
|
UTSW |
1 |
134,624,853 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1653:Kdm5b
|
UTSW |
1 |
134,602,481 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1693:Kdm5b
|
UTSW |
1 |
134,597,576 (GRCm38) |
splice site |
probably benign |
|
|
R1721:Kdm5b
|
UTSW |
1 |
134,613,181 (GRCm38) |
splice site |
probably benign |
|
|
R1741:Kdm5b
|
UTSW |
1 |
134,618,017 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1762:Kdm5b
|
UTSW |
1 |
134,604,467 (GRCm38) |
nonsense |
probably null |
|
|
R1820:Kdm5b
|
UTSW |
1 |
134,597,670 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R1872:Kdm5b
|
UTSW |
1 |
134,624,994 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1966:Kdm5b
|
UTSW |
1 |
134,613,873 (GRCm38) |
splice site |
probably null |
|
|
R2056:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2059:Kdm5b
|
UTSW |
1 |
134,613,214 (GRCm38) |
missense |
probably benign |
0.05 |
|
R2405:Kdm5b
|
UTSW |
1 |
134,609,016 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3417:Kdm5b
|
UTSW |
1 |
134,587,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Kdm5b
|
UTSW |
1 |
134,613,345 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3783:Kdm5b
|
UTSW |
1 |
134,630,542 (GRCm38) |
missense |
probably benign |
|
|
R3803:Kdm5b
|
UTSW |
1 |
134,615,941 (GRCm38) |
missense |
probably benign |
0.07 |
|
R3980:Kdm5b
|
UTSW |
1 |
134,619,670 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3983:Kdm5b
|
UTSW |
1 |
134,631,304 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R4013:Kdm5b
|
UTSW |
1 |
134,627,329 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R4162:Kdm5b
|
UTSW |
1 |
134,625,161 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4701:Kdm5b
|
UTSW |
1 |
134,606,012 (GRCm38) |
intron |
probably benign |
|
|
R4791:Kdm5b
|
UTSW |
1 |
134,630,800 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4836:Kdm5b
|
UTSW |
1 |
134,593,315 (GRCm38) |
splice site |
probably null |
|
|
R5135:Kdm5b
|
UTSW |
1 |
134,588,746 (GRCm38) |
intron |
probably benign |
|
|
R5248:Kdm5b
|
UTSW |
1 |
134,620,997 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5290:Kdm5b
|
UTSW |
1 |
134,622,099 (GRCm38) |
splice site |
probably null |
|
|
R5358:Kdm5b
|
UTSW |
1 |
134,607,694 (GRCm38) |
nonsense |
probably null |
|
|
R5388:Kdm5b
|
UTSW |
1 |
134,608,897 (GRCm38) |
nonsense |
probably null |
|
|
R5396:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5397:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5398:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5399:Kdm5b
|
UTSW |
1 |
134,622,098 (GRCm38) |
splice site |
probably null |
|
|
R5529:Kdm5b
|
UTSW |
1 |
134,588,003 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5540:Kdm5b
|
UTSW |
1 |
134,631,241 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5661:Kdm5b
|
UTSW |
1 |
134,599,073 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5663:Kdm5b
|
UTSW |
1 |
134,630,635 (GRCm38) |
missense |
probably benign |
|
|
R5822:Kdm5b
|
UTSW |
1 |
134,588,773 (GRCm38) |
splice site |
probably benign |
|
|
R6226:Kdm5b
|
UTSW |
1 |
134,608,878 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6368:Kdm5b
|
UTSW |
1 |
134,599,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6681:Kdm5b
|
UTSW |
1 |
134,613,269 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R6715:Kdm5b
|
UTSW |
1 |
134,609,061 (GRCm38) |
critical splice donor site |
probably null |
|
|
R7132:Kdm5b
|
UTSW |
1 |
134,599,106 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7202:Kdm5b
|
UTSW |
1 |
134,624,759 (GRCm38) |
missense |
probably benign |
|
|
R7258:Kdm5b
|
UTSW |
1 |
134,621,021 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7335:Kdm5b
|
UTSW |
1 |
134,560,439 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7420:Kdm5b
|
UTSW |
1 |
134,604,497 (GRCm38) |
missense |
probably benign |
0.14 |
|
R7426:Kdm5b
|
UTSW |
1 |
134,595,833 (GRCm38) |
missense |
probably benign |
0.02 |
|
R7452:Kdm5b
|
UTSW |
1 |
134,624,948 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7595:Kdm5b
|
UTSW |
1 |
134,608,966 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7612:Kdm5b
|
UTSW |
1 |
134,624,918 (GRCm38) |
nonsense |
probably null |
|
|
R7704:Kdm5b
|
UTSW |
1 |
134,587,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7846:Kdm5b
|
UTSW |
1 |
134,617,840 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8115:Kdm5b
|
UTSW |
1 |
134,619,673 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8146:Kdm5b
|
UTSW |
1 |
134,625,126 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8160:Kdm5b
|
UTSW |
1 |
134,613,919 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8527:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8542:Kdm5b
|
UTSW |
1 |
134,605,774 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R8930:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8932:Kdm5b
|
UTSW |
1 |
134,616,272 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8950:Kdm5b
|
UTSW |
1 |
134,613,926 (GRCm38) |
missense |
possibly damaging |
0.84 |
|
R9089:Kdm5b
|
UTSW |
1 |
134,607,768 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9109:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9133:Kdm5b
|
UTSW |
1 |
134,602,585 (GRCm38) |
missense |
probably benign |
|
|
R9298:Kdm5b
|
UTSW |
1 |
134,600,755 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9423:Kdm5b
|
UTSW |
1 |
134,587,967 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9630:Kdm5b
|
UTSW |
1 |
134,585,233 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9670:Kdm5b
|
UTSW |
1 |
134,630,502 (GRCm38) |
nonsense |
probably null |
|
|
X0063:Kdm5b
|
UTSW |
1 |
134,588,876 (GRCm38) |
missense |
probably benign |
0.07 |
|
Z1176:Kdm5b
|
UTSW |
1 |
134,625,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Kdm5b
|
UTSW |
1 |
134,595,798 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CCCGATTTTGAATGGCATTGTTTC -3'
(R):5'- TCGTAATCAGTAGAGACCCCTG -3'
Sequencing Primer
(F):5'- GAATGGCATTGTTTCCTCTGAAC -3'
(R):5'- GTCAGCATTTTAAACTTCAACAACC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation