Incidental Mutation 'R4924:Nat8f4'
ID 378858
Institutional Source Beutler Lab
Gene Symbol Nat8f4
Ensembl Gene ENSMUSG00000068299
Gene Name N-acetyltransferase 8 (GCN5-related) family member 4
Synonyms 1700019G17Rik
MMRRC Submission 042526-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R4924 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 85876033-85881866 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 85878401 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 41 (Q41K)
Ref Sequence ENSEMBL: ENSMUSP00000124071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095757] [ENSMUST00000159755]
AlphaFold G5E8L3
Predicted Effect probably benign
Transcript: ENSMUST00000095757
AA Change: Q41K

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000093430
Gene: ENSMUSG00000068299
AA Change: Q41K

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
Pfam:Acetyltransf_10 75 192 2.5e-11 PFAM
Pfam:Acetyltransf_8 83 200 2.1e-11 PFAM
Pfam:Acetyltransf_7 104 194 3.3e-14 PFAM
Pfam:Acetyltransf_1 111 193 6.3e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000159755
AA Change: Q41K

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000124071
Gene: ENSMUSG00000068299
AA Change: Q41K

DomainStartEndE-ValueType
transmembrane domain 33 55 N/A INTRINSIC
transmembrane domain 60 82 N/A INTRINSIC
low complexity region 117 130 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 96.0%
  • 20x: 91.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk G A 11: 119,902,351 (GRCm39) H625Y probably damaging Het
Adamts4 C T 1: 171,086,643 (GRCm39) R812W probably damaging Het
Ajuba A C 14: 54,809,056 (GRCm39) probably null Het
Aox1 T A 1: 58,344,503 (GRCm39) V532D probably damaging Het
Arpc1b G A 5: 145,063,625 (GRCm39) S295N probably benign Het
Baiap2 A G 11: 119,887,850 (GRCm39) S335G probably damaging Het
Brap T G 5: 121,803,318 (GRCm39) N155K probably damaging Het
Btn1a1 A G 13: 23,648,396 (GRCm39) probably benign Het
Ccl12 G A 11: 81,993,475 (GRCm39) V38I probably benign Het
Cemip T C 7: 83,602,146 (GRCm39) Y881C probably damaging Het
Cep128 T C 12: 90,989,174 (GRCm39) silent Het
Chd5 A C 4: 152,450,886 (GRCm39) D670A possibly damaging Het
Cmip T C 8: 117,983,994 (GRCm39) Y52H probably benign Het
Dmtn A G 14: 70,855,399 (GRCm39) I30T probably benign Het
Dscaml1 T A 9: 45,656,487 (GRCm39) M1609K probably damaging Het
Edar C A 10: 58,465,197 (GRCm39) E55D probably damaging Het
Ehmt1 A T 2: 24,729,734 (GRCm39) I601N probably damaging Het
Fam120a A T 13: 49,055,572 (GRCm39) N705K probably benign Het
Gm21718 G T 14: 51,550,292 (GRCm39) noncoding transcript Het
Gnaz A G 10: 74,827,545 (GRCm39) D99G probably benign Het
Helz G A 11: 107,493,165 (GRCm39) G196D probably damaging Het
Hif1a T C 12: 73,986,331 (GRCm39) S341P probably damaging Het
Hivep1 G T 13: 42,311,792 (GRCm39) S1344I probably benign Het
Hspa1l T A 17: 35,196,832 (GRCm39) Y290* probably null Het
Ift81 A G 5: 122,732,679 (GRCm39) L285S possibly damaging Het
Inpp4b T A 8: 82,849,253 (GRCm39) N891K probably damaging Het
Irx6 C T 8: 93,404,981 (GRCm39) T283M probably benign Het
Kdm5b A G 1: 134,559,089 (GRCm39) K1538E probably benign Het
Kif13a A G 13: 47,083,075 (GRCm39) V8A probably damaging Het
Krtap15-1 T A 16: 88,626,036 (GRCm39) N34K probably damaging Het
Lama2 T G 10: 27,245,137 (GRCm39) I215L probably damaging Het
Ldlrad3 C T 2: 101,900,328 (GRCm39) R58H possibly damaging Het
Lvrn C T 18: 47,027,792 (GRCm39) P869L probably damaging Het
Myo1d A G 11: 80,565,504 (GRCm39) F411S probably damaging Het
Myo5b T A 18: 74,828,455 (GRCm39) H702Q probably benign Het
Nckap5 C A 1: 125,954,765 (GRCm39) E596* probably null Het
Nek10 T A 14: 14,846,594 (GRCm38) probably null Het
Notch3 T C 17: 32,363,705 (GRCm39) Y1145C probably damaging Het
Nr4a2 A T 2: 57,002,035 (GRCm39) H76Q probably benign Het
Nup98 T C 7: 101,784,185 (GRCm39) Q1049R probably damaging Het
Or4k48 A T 2: 111,476,121 (GRCm39) S74T possibly damaging Het
Or5k1b T A 16: 58,580,982 (GRCm39) R186* probably null Het
Or8k33 A T 2: 86,383,853 (GRCm39) F205Y probably damaging Het
Pepd T C 7: 34,720,409 (GRCm39) Y231H probably benign Het
Plagl1 G T 10: 13,003,301 (GRCm39) A190S possibly damaging Het
Plat T A 8: 23,268,269 (GRCm39) I345N probably damaging Het
Pnmt A G 11: 98,278,286 (GRCm39) E120G probably damaging Het
Prkrip1 C A 5: 136,227,797 (GRCm39) probably null Het
Pygm G A 19: 6,443,754 (GRCm39) A572T probably damaging Het
Rbm4b T C 19: 4,807,400 (GRCm39) F39L probably damaging Het
Rpe65 A G 3: 159,328,268 (GRCm39) H388R probably benign Het
Scn4a G T 11: 106,210,914 (GRCm39) A1701E possibly damaging Het
Sdk2 C A 11: 113,748,584 (GRCm39) W616L probably damaging Het
Serpina3m T A 12: 104,357,729 (GRCm39) S218T probably benign Het
Siglece C T 7: 43,309,297 (GRCm39) R87H probably damaging Het
Sim1 C A 10: 50,785,998 (GRCm39) L284M probably damaging Het
Smok3c G T 5: 138,063,844 (GRCm39) E444* probably null Het
Snx4 T C 16: 33,115,100 (GRCm39) V427A probably benign Het
Srp68 A T 11: 116,151,684 (GRCm39) V304E probably damaging Het
Stag1 A T 9: 100,678,808 (GRCm39) H243L possibly damaging Het
Stx6 T C 1: 155,049,737 (GRCm39) V14A probably damaging Het
Sv2b T A 7: 74,786,169 (GRCm39) Y417F probably benign Het
Tas2r103 A G 6: 133,013,161 (GRCm39) Y302H probably benign Het
Thop1 T C 10: 80,916,028 (GRCm39) S404P probably benign Het
Trp53bp1 G T 2: 121,051,701 (GRCm39) C988* probably null Het
Tsbp1 C T 17: 34,678,951 (GRCm39) P221L probably damaging Het
Ube3c A G 5: 29,836,269 (GRCm39) E630G possibly damaging Het
Usf3 T C 16: 44,037,718 (GRCm39) S733P probably benign Het
Vmn1r195 A G 13: 22,463,189 (GRCm39) T220A probably benign Het
Vmn1r201 A T 13: 22,658,882 (GRCm39) H32L probably benign Het
Wnt2 A G 6: 18,023,239 (GRCm39) C137R probably damaging Het
Ythdc2 T C 18: 44,980,871 (GRCm39) S489P probably damaging Het
Zfp248 A G 6: 118,406,033 (GRCm39) C418R probably damaging Het
Zfp946 T G 17: 22,674,502 (GRCm39) F419V probably damaging Het
Zfp994 C T 17: 22,419,738 (GRCm39) E404K probably damaging Het
Zfpm1 T C 8: 123,061,347 (GRCm39) V304A possibly damaging Het
Other mutations in Nat8f4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00158:Nat8f4 APN 6 85,877,969 (GRCm39) missense probably benign 0.05
IGL03072:Nat8f4 APN 6 85,877,836 (GRCm39) intron probably benign
R1341:Nat8f4 UTSW 6 85,878,406 (GRCm39) missense probably damaging 0.96
R1725:Nat8f4 UTSW 6 85,878,080 (GRCm39) nonsense probably null
R1923:Nat8f4 UTSW 6 85,878,497 (GRCm39) missense probably damaging 1.00
R2258:Nat8f4 UTSW 6 85,878,207 (GRCm39) missense possibly damaging 0.84
R3975:Nat8f4 UTSW 6 85,878,052 (GRCm39) missense possibly damaging 0.62
R4697:Nat8f4 UTSW 6 85,878,368 (GRCm39) missense probably benign 0.01
R4784:Nat8f4 UTSW 6 85,878,481 (GRCm39) missense probably benign 0.03
R4991:Nat8f4 UTSW 6 85,878,122 (GRCm39) missense probably benign 0.30
R6074:Nat8f4 UTSW 6 85,878,169 (GRCm39) missense probably damaging 0.98
R7058:Nat8f4 UTSW 6 85,878,271 (GRCm39) missense possibly damaging 0.73
R7790:Nat8f4 UTSW 6 85,877,873 (GRCm39) missense probably benign 0.00
R8079:Nat8f4 UTSW 6 85,877,976 (GRCm39) missense probably benign 0.25
R9782:Nat8f4 UTSW 6 85,878,052 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATGCCAACTACCTGGTCTCC -3'
(R):5'- TCTGGATGTCCCTTGTGATCAC -3'

Sequencing Primer
(F):5'- CCATGTGCATTCAGGTAAGACTTG -3'
(R):5'- CTGATACTTGAGAGCCAGAAGTCTC -3'
Posted On 2016-04-15