Incidental Mutation 'R4925:Or1e23'
ID 378978
Institutional Source Beutler Lab
Gene Symbol Or1e23
Ensembl Gene ENSMUSG00000095312
Gene Name olfactory receptor family 1 subfamily E member 23
Synonyms MOR135-31_p, MOR135-14, Olfr382, GA_x6K02T2P1NL-3676608-3675670
Accession Numbers
Essential gene? Probably non essential (E-score: 0.215) question?
Stock # R4925 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 73407085-73408023 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73407998 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 9 (I9N)
Ref Sequence ENSEMBL: ENSMUSP00000091575 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092921]
AlphaFold Q8VF79
Predicted Effect possibly damaging
Transcript: ENSMUST00000092921
AA Change: I9N

PolyPhen 2 Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000091575
Gene: ENSMUSG00000095312
AA Change: I9N

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 5.6e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.9e-10 PFAM
Pfam:7tm_1 41 290 1.2e-24 PFAM
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.0%
  • 20x: 87.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810065E05Rik T A 11: 58,316,540 (GRCm39) C173* probably null Het
3425401B19Rik T A 14: 32,385,137 (GRCm39) H276L possibly damaging Het
Adam21 T G 12: 81,607,163 (GRCm39) M200L probably benign Het
Adamts3 A T 5: 89,832,182 (GRCm39) S974T probably benign Het
Adamtsl3 T A 7: 82,251,507 (GRCm39) probably null Het
Atp8b2 A G 3: 89,853,930 (GRCm39) probably null Het
Brd8 T C 18: 34,740,388 (GRCm39) T552A probably benign Het
Btaf1 A G 19: 36,988,733 (GRCm39) S1826G probably benign Het
Ccdc163 A G 4: 116,568,528 (GRCm39) E77G possibly damaging Het
Ces2g A G 8: 105,691,526 (GRCm39) R194G probably benign Het
Cip2a T C 16: 48,836,726 (GRCm39) probably null Het
Cln8 A G 8: 14,945,004 (GRCm39) H106R possibly damaging Het
Col12a1 T G 9: 79,582,077 (GRCm39) L1391F probably damaging Het
Col16a1 G A 4: 129,947,969 (GRCm39) D230N probably damaging Het
Crhbp C A 13: 95,580,318 (GRCm39) G87V possibly damaging Het
Cyp3a16 C T 5: 145,389,644 (GRCm39) M240I probably benign Het
Cyp4a14 A T 4: 115,353,133 (GRCm39) W60R possibly damaging Het
Fam47e A G 5: 92,733,149 (GRCm39) Y304C probably damaging Het
Fgfbp1 A T 5: 44,136,634 (GRCm39) D219E probably damaging Het
Fgfr2 A T 7: 129,787,002 (GRCm39) Y485N probably damaging Het
Fhdc1 C T 3: 84,360,840 (GRCm39) V363M probably damaging Het
Foxb1 T A 9: 69,667,437 (GRCm39) E31V probably damaging Het
Galnt9 T C 5: 110,692,605 (GRCm39) V13A possibly damaging Het
Ghrl T C 6: 113,693,218 (GRCm39) D77G probably damaging Het
Gpr85 A G 6: 13,835,977 (GRCm39) V309A probably benign Het
Greb1 T C 12: 16,731,472 (GRCm39) Y1622C probably damaging Het
Greb1l T A 18: 10,547,447 (GRCm39) M1555K possibly damaging Het
Grin2a T A 16: 9,487,687 (GRCm39) N404Y probably damaging Het
Gtpbp1 A C 15: 79,600,169 (GRCm39) I399L probably benign Het
Hectd4 T C 5: 121,460,753 (GRCm39) S911P possibly damaging Het
Igkc A T 6: 70,703,520 (GRCm39) K34* probably null Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Iqgap1 T A 7: 80,415,065 (GRCm39) I149F probably damaging Het
Lama1 C T 17: 68,101,309 (GRCm39) A1934V probably benign Het
Lrp1 C A 10: 127,410,944 (GRCm39) E1415* probably null Het
Lypd8l T A 11: 58,501,513 (GRCm39) T157S probably damaging Het
Macf1 A C 4: 123,420,445 (GRCm39) C270G probably benign Het
Marveld3 A G 8: 110,674,943 (GRCm39) V291A probably benign Het
Med23 T C 10: 24,786,645 (GRCm39) F917S probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Ncan A T 8: 70,562,604 (GRCm39) D551E probably benign Het
Or4x6 T A 2: 89,949,121 (GRCm39) T274S probably damaging Het
Or52h2 T C 7: 103,839,387 (GRCm39) Y9C possibly damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pla2g12a T C 3: 129,672,467 (GRCm39) W34R probably damaging Het
Plekha7 A G 7: 115,757,363 (GRCm39) F529S probably damaging Het
Potefam1 T C 2: 111,048,961 (GRCm39) K273E probably benign Het
Ppl T A 16: 4,922,846 (GRCm39) D215V probably damaging Het
Pramel15 A T 4: 144,104,502 (GRCm39) M1K probably null Het
Prdm1 T A 10: 44,316,165 (GRCm39) Y690F probably damaging Het
Prkcd T A 14: 30,329,570 (GRCm39) D124V probably damaging Het
Ptprc C A 1: 138,027,235 (GRCm39) D538Y probably benign Het
Rasl10b G A 11: 83,303,505 (GRCm39) V21M probably damaging Het
Rgsl1 T A 1: 153,688,023 (GRCm39) Y657F probably benign Het
Rrn3 T C 16: 13,617,836 (GRCm39) C360R probably damaging Het
Scarb1 T C 5: 125,374,363 (GRCm39) T257A probably damaging Het
Serpinb2 T A 1: 107,443,219 (GRCm39) M6K probably benign Het
Slco4a1 T C 2: 180,113,849 (GRCm39) Y429H probably benign Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Taar3 T A 10: 23,826,441 (GRCm39) F329Y probably damaging Het
Tardbp A T 4: 148,703,108 (GRCm39) N285K probably benign Het
Tcstv7b A G 13: 120,702,384 (GRCm39) Y60C probably damaging Het
Tnni2 A T 7: 141,996,430 (GRCm39) E4V probably benign Het
Tnpo2 A T 8: 85,776,654 (GRCm39) I454F probably damaging Het
Tpr T G 1: 150,308,316 (GRCm39) H1690Q probably benign Het
Trav18 T C 14: 54,068,577 (GRCm39) S6P probably benign Het
Trf T C 9: 103,096,445 (GRCm39) N25S probably benign Het
Vmn1r59 T C 7: 5,457,115 (GRCm39) N215S probably benign Het
Vmn2r2 T C 3: 64,044,892 (GRCm39) M1V probably null Het
Wdr64 T C 1: 175,552,268 (GRCm39) probably null Het
Wdr73 T C 7: 80,542,943 (GRCm39) S222G probably benign Het
Other mutations in Or1e23
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00235:Or1e23 APN 11 73,407,236 (GRCm39) missense possibly damaging 0.59
IGL00896:Or1e23 APN 11 73,407,167 (GRCm39) missense probably damaging 1.00
IGL01723:Or1e23 APN 11 73,407,452 (GRCm39) missense probably damaging 1.00
IGL01734:Or1e23 APN 11 73,407,462 (GRCm39) missense probably benign 0.39
IGL02267:Or1e23 APN 11 73,407,375 (GRCm39) missense probably benign 0.44
IGL02681:Or1e23 APN 11 73,407,356 (GRCm39) missense probably benign
IGL03165:Or1e23 APN 11 73,407,710 (GRCm39) nonsense probably null
BB009:Or1e23 UTSW 11 73,407,983 (GRCm39) missense probably damaging 1.00
BB019:Or1e23 UTSW 11 73,407,983 (GRCm39) missense probably damaging 1.00
IGL03134:Or1e23 UTSW 11 73,407,941 (GRCm39) missense probably benign 0.02
R0320:Or1e23 UTSW 11 73,407,750 (GRCm39) missense probably damaging 1.00
R0633:Or1e23 UTSW 11 73,407,753 (GRCm39) missense probably benign 0.23
R0638:Or1e23 UTSW 11 73,407,750 (GRCm39) missense probably damaging 1.00
R0691:Or1e23 UTSW 11 73,407,670 (GRCm39) missense possibly damaging 0.55
R1630:Or1e23 UTSW 11 73,407,546 (GRCm39) missense probably damaging 1.00
R2269:Or1e23 UTSW 11 73,407,309 (GRCm39) missense probably damaging 1.00
R4001:Or1e23 UTSW 11 73,407,812 (GRCm39) missense probably damaging 1.00
R5707:Or1e23 UTSW 11 73,407,451 (GRCm39) missense probably damaging 1.00
R5911:Or1e23 UTSW 11 73,407,351 (GRCm39) missense probably damaging 1.00
R6225:Or1e23 UTSW 11 73,407,831 (GRCm39) missense probably damaging 0.99
R6251:Or1e23 UTSW 11 73,407,534 (GRCm39) missense probably benign 0.00
R6332:Or1e23 UTSW 11 73,408,001 (GRCm39) missense probably benign 0.00
R7013:Or1e23 UTSW 11 73,407,247 (GRCm39) nonsense probably null
R7196:Or1e23 UTSW 11 73,407,957 (GRCm39) missense probably benign
R7443:Or1e23 UTSW 11 73,407,674 (GRCm39) missense possibly damaging 0.89
R7932:Or1e23 UTSW 11 73,407,983 (GRCm39) missense probably damaging 1.00
R8201:Or1e23 UTSW 11 73,407,899 (GRCm39) missense probably damaging 1.00
R8257:Or1e23 UTSW 11 73,407,203 (GRCm39) missense probably benign 0.28
R8547:Or1e23 UTSW 11 73,407,440 (GRCm39) missense probably damaging 1.00
R9219:Or1e23 UTSW 11 73,407,801 (GRCm39) missense probably damaging 0.98
R9526:Or1e23 UTSW 11 73,407,351 (GRCm39) missense probably damaging 1.00
R9638:Or1e23 UTSW 11 73,407,875 (GRCm39) missense probably benign 0.00
Z1177:Or1e23 UTSW 11 73,407,861 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGCAACTTGGGCATTGTGAC -3'
(R):5'- CAGGAACTTGGATGCCTGAG -3'

Sequencing Primer
(F):5'- CAACTTGGGCATTGTGACAGAGG -3'
(R):5'- CTTGAATTTTAAGGGACATGGA -3'
Posted On 2016-04-15