Incidental Mutation 'R4926:Corin'
| ID |
379020 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Corin
|
| Ensembl Gene |
ENSMUSG00000005220 |
| Gene Name |
corin, serine peptidase |
| Synonyms |
Lrp4 |
| MMRRC Submission |
042527-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.237)
|
| Stock # |
R4926 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
72457368-72661816 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 72529525 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Arginine
at position 212
(C212R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135511
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005352]
[ENSMUST00000167460]
[ENSMUST00000175766]
[ENSMUST00000176974]
[ENSMUST00000177290]
|
| AlphaFold |
Q9Z319 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000005352
AA Change: C345R
PolyPhen 2
Score 0.945 (Sensitivity: 0.80; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000005352
Gene: ENSMUSG00000005220
AA Change: C345R
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
15 |
N/A |
INTRINSIC |
|
transmembrane domain
|
113 |
135 |
N/A |
INTRINSIC |
|
FRI
|
205 |
318 |
6.15e-11 |
SMART |
|
LDLa
|
336 |
372 |
1.31e-8 |
SMART |
|
LDLa
|
373 |
408 |
1.5e-8 |
SMART |
|
LDLa
|
409 |
447 |
5.47e-11 |
SMART |
|
LDLa
|
448 |
484 |
1.22e-8 |
SMART |
|
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
|
FRI
|
522 |
643 |
2.75e-31 |
SMART |
|
LDLa
|
647 |
684 |
2.19e-10 |
SMART |
|
LDLa
|
685 |
722 |
1.76e-5 |
SMART |
|
LDLa
|
723 |
759 |
4.18e-7 |
SMART |
|
SR
|
758 |
853 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
868 |
1097 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000167460
AA Change: C279R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000127389
Gene: ENSMUSG00000005220
AA Change: C279R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
342 |
1.5e-8 |
SMART |
|
LDLa
|
343 |
381 |
5.47e-11 |
SMART |
|
LDLa
|
382 |
418 |
1.22e-8 |
SMART |
|
low complexity region
|
442 |
455 |
N/A |
INTRINSIC |
|
FRI
|
456 |
577 |
2.75e-31 |
SMART |
|
LDLa
|
581 |
618 |
2.19e-10 |
SMART |
|
LDLa
|
619 |
656 |
1.76e-5 |
SMART |
|
LDLa
|
657 |
693 |
4.18e-7 |
SMART |
|
SR
|
692 |
787 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
802 |
1031 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000175766
AA Change: C277R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135889
Gene: ENSMUSG00000005220
AA Change: C277R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
45 |
67 |
N/A |
INTRINSIC |
|
FRI
|
137 |
250 |
6.15e-11 |
SMART |
|
LDLa
|
268 |
304 |
1.31e-8 |
SMART |
|
LDLa
|
305 |
343 |
2.07e-11 |
SMART |
|
low complexity region
|
367 |
380 |
N/A |
INTRINSIC |
|
FRI
|
381 |
502 |
2.75e-31 |
SMART |
|
LDLa
|
506 |
543 |
2.19e-10 |
SMART |
|
LDLa
|
544 |
581 |
1.76e-5 |
SMART |
|
LDLa
|
582 |
618 |
4.18e-7 |
SMART |
|
SR
|
617 |
712 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
727 |
956 |
5.45e-76 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176396
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000176439
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000176974
AA Change: C279R
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000135722
Gene: ENSMUSG00000005220
AA Change: C279R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
139 |
252 |
6.15e-11 |
SMART |
|
LDLa
|
270 |
306 |
1.31e-8 |
SMART |
|
LDLa
|
307 |
344 |
3.86e-11 |
SMART |
|
LDLa
|
345 |
381 |
1.22e-8 |
SMART |
|
low complexity region
|
405 |
418 |
N/A |
INTRINSIC |
|
FRI
|
419 |
540 |
2.75e-31 |
SMART |
|
LDLa
|
544 |
581 |
2.19e-10 |
SMART |
|
LDLa
|
582 |
619 |
1.76e-5 |
SMART |
|
LDLa
|
620 |
656 |
4.18e-7 |
SMART |
|
SR
|
655 |
750 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
765 |
994 |
5.45e-76 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000177290
AA Change: C212R
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000135511
Gene: ENSMUSG00000005220
AA Change: C212R
| Domain | Start | End | E-Value | Type |
|---|
|
transmembrane domain
|
47 |
69 |
N/A |
INTRINSIC |
|
FRI
|
72 |
185 |
6.15e-11 |
SMART |
|
LDLa
|
203 |
239 |
1.31e-8 |
SMART |
|
LDLa
|
240 |
275 |
1.5e-8 |
SMART |
|
LDLa
|
276 |
314 |
5.47e-11 |
SMART |
|
LDLa
|
315 |
351 |
1.22e-8 |
SMART |
|
low complexity region
|
375 |
388 |
N/A |
INTRINSIC |
|
FRI
|
389 |
510 |
2.75e-31 |
SMART |
|
LDLa
|
514 |
551 |
2.19e-10 |
SMART |
|
LDLa
|
552 |
589 |
1.76e-5 |
SMART |
|
LDLa
|
590 |
626 |
4.18e-7 |
SMART |
|
SR
|
625 |
720 |
3.99e-10 |
SMART |
|
Tryp_SPc
|
735 |
964 |
5.45e-76 |
SMART |
|
| Meta Mutation Damage Score |
0.9689 |
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.3%
|
| Validation Efficiency |
99% (87/88) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
PHENOTYPE: Homozygous null mice display hypertension that is enhanced by high-salt diet and pregnancy, increased body weight, and cardiac hypertrophy. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700102P08Rik |
A |
T |
9: 108,272,498 (GRCm39) |
D136V |
probably damaging |
Het |
| Ankrd17 |
G |
A |
5: 90,447,891 (GRCm39) |
R217W |
probably damaging |
Het |
| Ankrd23 |
A |
T |
1: 36,571,068 (GRCm39) |
H102Q |
probably damaging |
Het |
| Arfip2 |
G |
T |
7: 105,287,151 (GRCm39) |
R138S |
probably damaging |
Het |
| Arhgap27 |
A |
T |
11: 103,229,949 (GRCm39) |
|
probably null |
Het |
| Atg2a |
T |
C |
19: 6,307,563 (GRCm39) |
L1499P |
probably damaging |
Het |
| Bnc2 |
A |
G |
4: 84,194,416 (GRCm39) |
S110P |
probably damaging |
Het |
| Ccdc171 |
T |
C |
4: 83,476,829 (GRCm39) |
|
probably benign |
Het |
| Ccdc7a |
A |
G |
8: 129,706,535 (GRCm39) |
|
probably benign |
Het |
| Chd5 |
T |
C |
4: 152,467,768 (GRCm39) |
S1689P |
probably benign |
Het |
| Cyp2c65 |
A |
G |
19: 39,049,597 (GRCm39) |
I42V |
probably benign |
Het |
| Cyp3a25 |
G |
A |
5: 145,928,266 (GRCm39) |
R260C |
probably damaging |
Het |
| Dock6 |
T |
C |
9: 21,757,087 (GRCm39) |
Y116C |
probably damaging |
Het |
| Eif3a |
A |
G |
19: 60,751,656 (GRCm39) |
|
probably benign |
Het |
| Epop |
T |
C |
11: 97,519,143 (GRCm39) |
D322G |
probably damaging |
Het |
| Eps8l3 |
T |
A |
3: 107,798,004 (GRCm39) |
|
probably benign |
Het |
| Exph5 |
T |
C |
9: 53,287,925 (GRCm39) |
S1669P |
possibly damaging |
Het |
| Faah |
A |
T |
4: 115,856,823 (GRCm39) |
|
probably benign |
Het |
| Fanca |
A |
G |
8: 124,030,724 (GRCm39) |
C453R |
probably benign |
Het |
| Fcgbp |
T |
A |
7: 27,785,660 (GRCm39) |
C366S |
probably damaging |
Het |
| Fmn2 |
A |
G |
1: 174,329,981 (GRCm39) |
T124A |
unknown |
Het |
| Foxi3 |
C |
T |
6: 70,933,996 (GRCm39) |
S161L |
probably damaging |
Het |
| Foxo3 |
A |
T |
10: 42,073,020 (GRCm39) |
V499E |
probably damaging |
Het |
| Gas2l3 |
CACTCGTCATACT |
CACT |
10: 89,266,820 (GRCm39) |
|
probably benign |
Het |
| Gbgt1 |
T |
C |
2: 28,393,182 (GRCm39) |
V90A |
probably damaging |
Het |
| Gm839 |
A |
C |
6: 89,189,581 (GRCm39) |
|
noncoding transcript |
Het |
| Gtf3c2 |
T |
C |
5: 31,326,467 (GRCm39) |
E348G |
possibly damaging |
Het |
| Hnrnpm |
G |
T |
17: 33,868,775 (GRCm39) |
R551S |
probably damaging |
Het |
| Hspa1l |
A |
G |
17: 35,197,199 (GRCm39) |
T413A |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,269,841 (GRCm39) |
Y2297H |
probably damaging |
Het |
| Ighv1-81 |
T |
A |
12: 115,884,093 (GRCm39) |
I53L |
probably benign |
Het |
| Kcnj11 |
C |
T |
7: 45,748,544 (GRCm39) |
V260I |
probably benign |
Het |
| Krt84 |
A |
G |
15: 101,438,689 (GRCm39) |
V266A |
probably benign |
Het |
| Lgals3bp |
T |
C |
11: 118,284,781 (GRCm39) |
Y266C |
probably damaging |
Het |
| Lrrc41 |
T |
C |
4: 115,946,521 (GRCm39) |
V412A |
possibly damaging |
Het |
| Map4k4 |
A |
T |
1: 40,056,385 (GRCm39) |
E1023D |
probably damaging |
Het |
| Mark3 |
T |
A |
12: 111,584,758 (GRCm39) |
L118* |
probably null |
Het |
| Mrgpra9 |
T |
A |
7: 46,884,759 (GRCm39) |
T303S |
possibly damaging |
Het |
| Mterf4 |
T |
C |
1: 93,232,647 (GRCm39) |
E68G |
probably benign |
Het |
| Nckap5 |
A |
C |
1: 126,456,378 (GRCm39) |
|
probably benign |
Het |
| Nox3 |
T |
A |
17: 3,720,169 (GRCm39) |
T339S |
probably damaging |
Het |
| Nrip2 |
A |
C |
6: 128,385,337 (GRCm39) |
H256P |
probably benign |
Het |
| Oas1d |
T |
C |
5: 121,053,831 (GRCm39) |
V97A |
probably benign |
Het |
| Obox2 |
T |
A |
7: 15,131,102 (GRCm39) |
|
probably null |
Het |
| Opa1 |
T |
C |
16: 29,467,791 (GRCm39) |
F989S |
possibly damaging |
Het |
| Or10g9 |
T |
C |
9: 39,912,319 (GRCm39) |
|
probably null |
Het |
| Padi1 |
T |
A |
4: 140,552,158 (GRCm39) |
I429F |
probably damaging |
Het |
| Paics |
A |
G |
5: 77,109,051 (GRCm39) |
D163G |
probably damaging |
Het |
| Pik3c2b |
G |
T |
1: 133,027,364 (GRCm39) |
E1288* |
probably null |
Het |
| Prdm16 |
A |
T |
4: 154,426,009 (GRCm39) |
V593D |
possibly damaging |
Het |
| Prpf39 |
A |
G |
12: 65,090,830 (GRCm39) |
I165M |
possibly damaging |
Het |
| Pth2r |
A |
G |
1: 65,361,143 (GRCm39) |
T26A |
probably benign |
Het |
| Ptpn21 |
T |
C |
12: 98,681,454 (GRCm39) |
|
probably null |
Het |
| Rab44 |
C |
T |
17: 29,358,529 (GRCm39) |
A239V |
probably benign |
Het |
| Rtcb |
T |
C |
10: 85,791,600 (GRCm39) |
N52S |
probably benign |
Het |
| Sapcd2 |
T |
A |
2: 25,263,578 (GRCm39) |
|
probably null |
Het |
| Scaf11 |
T |
C |
15: 96,316,123 (GRCm39) |
E1147G |
possibly damaging |
Het |
| Selenoo |
T |
C |
15: 88,983,881 (GRCm39) |
Y595H |
probably damaging |
Het |
| Slc2a5 |
G |
T |
4: 150,205,199 (GRCm39) |
E3* |
probably null |
Het |
| Snw1 |
A |
G |
12: 87,499,428 (GRCm39) |
V391A |
probably benign |
Het |
| Sorbs2 |
A |
G |
8: 46,249,254 (GRCm39) |
K755R |
probably benign |
Het |
| Sorbs3 |
G |
T |
14: 70,424,394 (GRCm39) |
P513T |
probably damaging |
Het |
| Sowaha |
T |
A |
11: 53,370,337 (GRCm39) |
E133V |
possibly damaging |
Het |
| Srsf5 |
T |
C |
12: 80,994,075 (GRCm39) |
|
probably benign |
Het |
| St8sia5 |
T |
A |
18: 77,342,478 (GRCm39) |
M396K |
possibly damaging |
Het |
| Tcp11l1 |
T |
C |
2: 104,512,130 (GRCm39) |
I501V |
probably benign |
Het |
| Tert |
A |
G |
13: 73,796,508 (GRCm39) |
K1080E |
possibly damaging |
Het |
| Tescl |
T |
A |
7: 24,033,323 (GRCm39) |
M1L |
possibly damaging |
Het |
| Thop1 |
T |
A |
10: 80,909,201 (GRCm39) |
|
probably null |
Het |
| Tmtc4 |
T |
C |
14: 123,210,618 (GRCm39) |
H80R |
probably damaging |
Het |
| Toe1 |
C |
T |
4: 116,661,729 (GRCm39) |
S480N |
probably damaging |
Het |
| Trap1 |
C |
A |
16: 3,863,352 (GRCm39) |
V557F |
probably benign |
Het |
| Trim30d |
T |
C |
7: 104,132,564 (GRCm39) |
E91G |
probably benign |
Het |
| Ttf1 |
C |
T |
2: 28,954,668 (GRCm39) |
H11Y |
possibly damaging |
Het |
| Ttll8 |
C |
A |
15: 88,798,368 (GRCm39) |
G789V |
probably damaging |
Het |
| Ulk4 |
A |
G |
9: 121,087,798 (GRCm39) |
F298S |
probably benign |
Het |
| Wwc1 |
C |
T |
11: 35,780,227 (GRCm39) |
A243T |
probably benign |
Het |
| Zfp248 |
A |
C |
6: 118,406,787 (GRCm39) |
H267Q |
possibly damaging |
Het |
| Zfyve26 |
T |
A |
12: 79,321,785 (GRCm39) |
M945L |
probably benign |
Het |
| Zup1 |
T |
C |
10: 33,825,434 (GRCm39) |
D16G |
probably damaging |
Het |
|
| Other mutations in Corin |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Corin
|
APN |
5 |
72,462,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01114:Corin
|
APN |
5 |
72,462,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01351:Corin
|
APN |
5 |
72,496,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01516:Corin
|
APN |
5 |
72,611,830 (GRCm39) |
nonsense |
probably null |
|
|
IGL01785:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01786:Corin
|
APN |
5 |
72,497,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01845:Corin
|
APN |
5 |
72,511,282 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Corin
|
APN |
5 |
72,529,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02629:Corin
|
APN |
5 |
72,490,016 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Corin
|
APN |
5 |
72,511,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03120:Corin
|
APN |
5 |
72,518,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03150:Corin
|
APN |
5 |
72,460,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03183:Corin
|
APN |
5 |
72,458,929 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03185:Corin
|
APN |
5 |
72,490,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03408:Corin
|
APN |
5 |
72,500,304 (GRCm39) |
missense |
probably benign |
0.40 |
|
alpaca
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0078:Corin
|
UTSW |
5 |
72,611,816 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0724:Corin
|
UTSW |
5 |
72,490,138 (GRCm39) |
splice site |
probably benign |
|
|
R1065:Corin
|
UTSW |
5 |
72,458,993 (GRCm39) |
nonsense |
probably null |
|
|
R1301:Corin
|
UTSW |
5 |
72,462,276 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1466:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1520:Corin
|
UTSW |
5 |
72,488,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1584:Corin
|
UTSW |
5 |
72,460,133 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1617:Corin
|
UTSW |
5 |
72,661,295 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1912:Corin
|
UTSW |
5 |
72,515,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2059:Corin
|
UTSW |
5 |
72,473,394 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R2173:Corin
|
UTSW |
5 |
72,661,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2242:Corin
|
UTSW |
5 |
72,490,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2373:Corin
|
UTSW |
5 |
72,496,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2850:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3683:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3684:Corin
|
UTSW |
5 |
72,488,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3790:Corin
|
UTSW |
5 |
72,592,641 (GRCm39) |
missense |
probably benign |
0.38 |
|
R3847:Corin
|
UTSW |
5 |
72,579,508 (GRCm39) |
missense |
probably benign |
0.13 |
|
R3926:Corin
|
UTSW |
5 |
72,529,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3939:Corin
|
UTSW |
5 |
72,497,222 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R3945:Corin
|
UTSW |
5 |
72,515,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4079:Corin
|
UTSW |
5 |
72,661,226 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4224:Corin
|
UTSW |
5 |
72,500,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4473:Corin
|
UTSW |
5 |
72,496,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4586:Corin
|
UTSW |
5 |
72,487,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Corin
|
UTSW |
5 |
72,460,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Corin
|
UTSW |
5 |
72,511,194 (GRCm39) |
intron |
probably benign |
|
|
R5138:Corin
|
UTSW |
5 |
72,496,402 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5262:Corin
|
UTSW |
5 |
72,462,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5268:Corin
|
UTSW |
5 |
72,500,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5302:Corin
|
UTSW |
5 |
72,473,441 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5307:Corin
|
UTSW |
5 |
72,514,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5324:Corin
|
UTSW |
5 |
72,592,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5352:Corin
|
UTSW |
5 |
72,462,376 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5373:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5374:Corin
|
UTSW |
5 |
72,462,296 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Corin
|
UTSW |
5 |
72,515,827 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5502:Corin
|
UTSW |
5 |
72,473,449 (GRCm39) |
nonsense |
probably null |
|
|
R5544:Corin
|
UTSW |
5 |
72,462,357 (GRCm39) |
nonsense |
probably null |
|
|
R5682:Corin
|
UTSW |
5 |
72,579,497 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5818:Corin
|
UTSW |
5 |
72,592,738 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5992:Corin
|
UTSW |
5 |
72,473,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6115:Corin
|
UTSW |
5 |
72,518,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Corin
|
UTSW |
5 |
72,529,439 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6317:Corin
|
UTSW |
5 |
72,496,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7053:Corin
|
UTSW |
5 |
72,458,870 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7242:Corin
|
UTSW |
5 |
72,462,398 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7452:Corin
|
UTSW |
5 |
72,592,590 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7783:Corin
|
UTSW |
5 |
72,458,967 (GRCm39) |
missense |
probably benign |
0.26 |
|
R7903:Corin
|
UTSW |
5 |
72,458,843 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7956:Corin
|
UTSW |
5 |
72,579,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8007:Corin
|
UTSW |
5 |
72,473,446 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8125:Corin
|
UTSW |
5 |
72,515,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8215:Corin
|
UTSW |
5 |
72,462,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Corin
|
UTSW |
5 |
72,514,269 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Corin
|
UTSW |
5 |
72,462,274 (GRCm39) |
missense |
probably benign |
|
|
R8505:Corin
|
UTSW |
5 |
72,592,750 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8746:Corin
|
UTSW |
5 |
72,592,695 (GRCm39) |
missense |
probably benign |
0.31 |
|
R8887:Corin
|
UTSW |
5 |
72,486,953 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9484:Corin
|
UTSW |
5 |
72,497,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Corin
|
UTSW |
5 |
72,592,597 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Corin
|
UTSW |
5 |
72,611,836 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTACTAATGGCCAGGCTGG -3'
(R):5'- CTACCGTGAGCATTCCAGAGTC -3'
Sequencing Primer
(F):5'- CAGGCTGGCTGTCAGTATC -3'
(R):5'- CGTGAGCATTCCAGAGTCCAATG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation