Incidental Mutation 'R4926:Mrgpra9'
ID 379033
Institutional Source Beutler Lab
Gene Symbol Mrgpra9
Ensembl Gene ENSMUSG00000074111
Gene Name MAS-related GPR, member A9
Synonyms MrgA9, EG668725
MMRRC Submission 042527-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.049) question?
Stock # R4926 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 46884667-46902627 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 46884759 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 303 (T303S)
Ref Sequence ENSEMBL: ENSMUSP00000136396 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098436] [ENSMUST00000179005]
AlphaFold A0A140T8U8
Predicted Effect possibly damaging
Transcript: ENSMUST00000098436
AA Change: T302S

PolyPhen 2 Score 0.476 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000096035
Gene: ENSMUSG00000074111
AA Change: T302S

DomainStartEndE-ValueType
low complexity region 37 48 N/A INTRINSIC
Pfam:7tm_1 56 225 1.5e-11 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000179005
AA Change: T303S

PolyPhen 2 Score 0.618 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000136396
Gene: ENSMUSG00000074111
AA Change: T303S

DomainStartEndE-ValueType
Pfam:7tm_1 12 178 3.4e-9 PFAM
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.3%
Validation Efficiency 99% (87/88)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700102P08Rik A T 9: 108,272,498 (GRCm39) D136V probably damaging Het
Ankrd17 G A 5: 90,447,891 (GRCm39) R217W probably damaging Het
Ankrd23 A T 1: 36,571,068 (GRCm39) H102Q probably damaging Het
Arfip2 G T 7: 105,287,151 (GRCm39) R138S probably damaging Het
Arhgap27 A T 11: 103,229,949 (GRCm39) probably null Het
Atg2a T C 19: 6,307,563 (GRCm39) L1499P probably damaging Het
Bnc2 A G 4: 84,194,416 (GRCm39) S110P probably damaging Het
Ccdc171 T C 4: 83,476,829 (GRCm39) probably benign Het
Ccdc7a A G 8: 129,706,535 (GRCm39) probably benign Het
Chd5 T C 4: 152,467,768 (GRCm39) S1689P probably benign Het
Corin A G 5: 72,529,525 (GRCm39) C212R probably damaging Het
Cyp2c65 A G 19: 39,049,597 (GRCm39) I42V probably benign Het
Cyp3a25 G A 5: 145,928,266 (GRCm39) R260C probably damaging Het
Dock6 T C 9: 21,757,087 (GRCm39) Y116C probably damaging Het
Eif3a A G 19: 60,751,656 (GRCm39) probably benign Het
Epop T C 11: 97,519,143 (GRCm39) D322G probably damaging Het
Eps8l3 T A 3: 107,798,004 (GRCm39) probably benign Het
Exph5 T C 9: 53,287,925 (GRCm39) S1669P possibly damaging Het
Faah A T 4: 115,856,823 (GRCm39) probably benign Het
Fanca A G 8: 124,030,724 (GRCm39) C453R probably benign Het
Fcgbp T A 7: 27,785,660 (GRCm39) C366S probably damaging Het
Fmn2 A G 1: 174,329,981 (GRCm39) T124A unknown Het
Foxi3 C T 6: 70,933,996 (GRCm39) S161L probably damaging Het
Foxo3 A T 10: 42,073,020 (GRCm39) V499E probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gbgt1 T C 2: 28,393,182 (GRCm39) V90A probably damaging Het
Gm839 A C 6: 89,189,581 (GRCm39) noncoding transcript Het
Gtf3c2 T C 5: 31,326,467 (GRCm39) E348G possibly damaging Het
Hnrnpm G T 17: 33,868,775 (GRCm39) R551S probably damaging Het
Hspa1l A G 17: 35,197,199 (GRCm39) T413A possibly damaging Het
Hspg2 T C 4: 137,269,841 (GRCm39) Y2297H probably damaging Het
Ighv1-81 T A 12: 115,884,093 (GRCm39) I53L probably benign Het
Kcnj11 C T 7: 45,748,544 (GRCm39) V260I probably benign Het
Krt84 A G 15: 101,438,689 (GRCm39) V266A probably benign Het
Lgals3bp T C 11: 118,284,781 (GRCm39) Y266C probably damaging Het
Lrrc41 T C 4: 115,946,521 (GRCm39) V412A possibly damaging Het
Map4k4 A T 1: 40,056,385 (GRCm39) E1023D probably damaging Het
Mark3 T A 12: 111,584,758 (GRCm39) L118* probably null Het
Mterf4 T C 1: 93,232,647 (GRCm39) E68G probably benign Het
Nckap5 A C 1: 126,456,378 (GRCm39) probably benign Het
Nox3 T A 17: 3,720,169 (GRCm39) T339S probably damaging Het
Nrip2 A C 6: 128,385,337 (GRCm39) H256P probably benign Het
Oas1d T C 5: 121,053,831 (GRCm39) V97A probably benign Het
Obox2 T A 7: 15,131,102 (GRCm39) probably null Het
Opa1 T C 16: 29,467,791 (GRCm39) F989S possibly damaging Het
Or10g9 T C 9: 39,912,319 (GRCm39) probably null Het
Padi1 T A 4: 140,552,158 (GRCm39) I429F probably damaging Het
Paics A G 5: 77,109,051 (GRCm39) D163G probably damaging Het
Pik3c2b G T 1: 133,027,364 (GRCm39) E1288* probably null Het
Prdm16 A T 4: 154,426,009 (GRCm39) V593D possibly damaging Het
Prpf39 A G 12: 65,090,830 (GRCm39) I165M possibly damaging Het
Pth2r A G 1: 65,361,143 (GRCm39) T26A probably benign Het
Ptpn21 T C 12: 98,681,454 (GRCm39) probably null Het
Rab44 C T 17: 29,358,529 (GRCm39) A239V probably benign Het
Rtcb T C 10: 85,791,600 (GRCm39) N52S probably benign Het
Sapcd2 T A 2: 25,263,578 (GRCm39) probably null Het
Scaf11 T C 15: 96,316,123 (GRCm39) E1147G possibly damaging Het
Selenoo T C 15: 88,983,881 (GRCm39) Y595H probably damaging Het
Slc2a5 G T 4: 150,205,199 (GRCm39) E3* probably null Het
Snw1 A G 12: 87,499,428 (GRCm39) V391A probably benign Het
Sorbs2 A G 8: 46,249,254 (GRCm39) K755R probably benign Het
Sorbs3 G T 14: 70,424,394 (GRCm39) P513T probably damaging Het
Sowaha T A 11: 53,370,337 (GRCm39) E133V possibly damaging Het
Srsf5 T C 12: 80,994,075 (GRCm39) probably benign Het
St8sia5 T A 18: 77,342,478 (GRCm39) M396K possibly damaging Het
Tcp11l1 T C 2: 104,512,130 (GRCm39) I501V probably benign Het
Tert A G 13: 73,796,508 (GRCm39) K1080E possibly damaging Het
Tescl T A 7: 24,033,323 (GRCm39) M1L possibly damaging Het
Thop1 T A 10: 80,909,201 (GRCm39) probably null Het
Tmtc4 T C 14: 123,210,618 (GRCm39) H80R probably damaging Het
Toe1 C T 4: 116,661,729 (GRCm39) S480N probably damaging Het
Trap1 C A 16: 3,863,352 (GRCm39) V557F probably benign Het
Trim30d T C 7: 104,132,564 (GRCm39) E91G probably benign Het
Ttf1 C T 2: 28,954,668 (GRCm39) H11Y possibly damaging Het
Ttll8 C A 15: 88,798,368 (GRCm39) G789V probably damaging Het
Ulk4 A G 9: 121,087,798 (GRCm39) F298S probably benign Het
Wwc1 C T 11: 35,780,227 (GRCm39) A243T probably benign Het
Zfp248 A C 6: 118,406,787 (GRCm39) H267Q possibly damaging Het
Zfyve26 T A 12: 79,321,785 (GRCm39) M945L probably benign Het
Zup1 T C 10: 33,825,434 (GRCm39) D16G probably damaging Het
Other mutations in Mrgpra9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Mrgpra9 APN 7 46,884,839 (GRCm39) missense possibly damaging 0.85
IGL00575:Mrgpra9 APN 7 46,885,053 (GRCm39) missense possibly damaging 0.76
IGL01649:Mrgpra9 APN 7 46,884,900 (GRCm39) missense probably benign 0.22
IGL03207:Mrgpra9 APN 7 46,885,385 (GRCm39) missense possibly damaging 0.68
R0388:Mrgpra9 UTSW 7 46,902,542 (GRCm39) start codon destroyed probably null 0.08
R0972:Mrgpra9 UTSW 7 46,885,203 (GRCm39) missense probably damaging 0.99
R1270:Mrgpra9 UTSW 7 46,902,531 (GRCm39) critical splice donor site probably null
R1381:Mrgpra9 UTSW 7 46,885,050 (GRCm39) missense possibly damaging 0.75
R1403:Mrgpra9 UTSW 7 46,885,386 (GRCm39) missense probably benign 0.24
R1403:Mrgpra9 UTSW 7 46,885,386 (GRCm39) missense probably benign 0.24
R1448:Mrgpra9 UTSW 7 46,885,561 (GRCm39) missense probably benign 0.02
R2045:Mrgpra9 UTSW 7 46,885,583 (GRCm39) missense probably benign
R2144:Mrgpra9 UTSW 7 46,885,211 (GRCm39) missense probably benign 0.31
R2187:Mrgpra9 UTSW 7 46,884,797 (GRCm39) missense probably damaging 1.00
R2507:Mrgpra9 UTSW 7 46,885,242 (GRCm39) missense possibly damaging 0.63
R2913:Mrgpra9 UTSW 7 46,884,828 (GRCm39) missense probably benign
R3810:Mrgpra9 UTSW 7 46,885,527 (GRCm39) missense probably damaging 0.98
R4177:Mrgpra9 UTSW 7 46,885,302 (GRCm39) missense probably damaging 1.00
R4521:Mrgpra9 UTSW 7 46,884,938 (GRCm39) missense probably damaging 1.00
R4781:Mrgpra9 UTSW 7 46,884,795 (GRCm39) missense possibly damaging 0.88
R6469:Mrgpra9 UTSW 7 46,884,854 (GRCm39) missense probably benign 0.02
R6505:Mrgpra9 UTSW 7 46,884,884 (GRCm39) missense probably benign 0.00
R6724:Mrgpra9 UTSW 7 46,884,786 (GRCm39) missense probably damaging 1.00
R7398:Mrgpra9 UTSW 7 46,885,385 (GRCm39) missense possibly damaging 0.68
R8737:Mrgpra9 UTSW 7 46,885,624 (GRCm39) missense probably benign 0.00
R8824:Mrgpra9 UTSW 7 46,885,041 (GRCm39) missense probably benign 0.06
R8881:Mrgpra9 UTSW 7 46,885,242 (GRCm39) missense possibly damaging 0.63
R9320:Mrgpra9 UTSW 7 46,885,392 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GAGGCATGTTGAGTCAGTAAGC -3'
(R):5'- ACCATCATGCTGACCATTTTGG -3'

Sequencing Primer
(F):5'- TCAGTAAGCTGAGAGGAGAGTG -3'
(R):5'- TCTCCTCTGCGGGTTGC -3'
Posted On 2016-04-15