Incidental Mutation 'R4908:Cd84'
ID 379155
Institutional Source Beutler Lab
Gene Symbol Cd84
Ensembl Gene ENSMUSG00000038147
Gene Name CD84 antigen
Synonyms SLAMF5, CDw84, A130013D22Rik
MMRRC Submission 042510-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4908 (G1)
Quality Score 225
Status Not validated
Chromosome 1
Chromosomal Location 171667265-171718285 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 171700432 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 183 (D183G)
Ref Sequence ENSEMBL: ENSMUSP00000120881 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042302] [ENSMUST00000136479] [ENSMUST00000155802]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000042302
AA Change: D183G

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000047024
Gene: ENSMUSG00000038147
AA Change: D183G

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 26 126 3.16e-1 SMART
IG_like 137 208 1.02e1 SMART
transmembrane domain 220 242 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128189
Predicted Effect probably damaging
Transcript: ENSMUST00000136479
AA Change: D183G

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000122951
Gene: ENSMUSG00000038147
AA Change: D183G

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 26 126 3.16e-1 SMART
IG_like 137 208 1.02e1 SMART
transmembrane domain 220 242 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000155802
AA Change: D183G

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000120881
Gene: ENSMUSG00000038147
AA Change: D183G

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
IG 26 126 3.16e-1 SMART
IG_like 137 208 1.02e1 SMART
transmembrane domain 220 242 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.3%
  • 10x: 96.2%
  • 20x: 92.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane glycoprotein that is a member of the signaling lymphocyte activation molecule (SLAM) family. This family forms a subset of the larger CD2 cell-surface receptor Ig superfamily. The encoded protein is a homophilic adhesion molecule that is expressed in numerous immune cells types and is involved in regulating receptor-mediated signaling in those cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a knock-out allele of this gene show defects in T follicular helper function and germinal center formation. Mice homozygous for a different knock-out allele display normal platelet physiology and thrombus formation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 99 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110059G10Rik T A 9: 122,778,008 (GRCm39) I79L probably benign Het
Ablim2 C T 5: 35,959,766 (GRCm39) R73C possibly damaging Het
Acaa1a G A 9: 119,177,772 (GRCm39) S218N probably benign Het
Acsm5 A T 7: 119,137,314 (GRCm39) I377F probably damaging Het
Ahnak2 T C 12: 112,741,706 (GRCm39) T789A probably benign Het
Ak9 A T 10: 41,296,678 (GRCm39) T1475S unknown Het
AU040320 A T 4: 126,747,081 (GRCm39) N1028Y probably damaging Het
Bahcc1 T A 11: 120,178,580 (GRCm39) S2380T probably benign Het
Cadps A G 14: 12,536,386 (GRCm38) Y525H probably damaging Het
Casp8ap2 A G 4: 32,639,905 (GRCm39) T320A possibly damaging Het
Ccdc138 A G 10: 58,380,817 (GRCm39) N483D possibly damaging Het
Ccdc39 G A 3: 33,893,242 (GRCm39) probably null Het
Cd300c2 T C 11: 114,887,772 (GRCm39) N210S probably damaging Het
Cep95 C T 11: 106,702,172 (GRCm39) P390S probably damaging Het
Chd9 A T 8: 91,741,877 (GRCm39) H1622L possibly damaging Het
Cilp C A 9: 65,185,302 (GRCm39) Q466K probably benign Het
Cinp T A 12: 110,850,487 (GRCm39) T5S probably damaging Het
Clec4a2 T C 6: 123,119,462 (GRCm39) L238S probably damaging Het
Cntrob T C 11: 69,211,732 (GRCm39) Y164C probably damaging Het
Col6a3 A G 1: 90,735,246 (GRCm39) L1408P probably damaging Het
Cul3 G A 1: 80,258,632 (GRCm39) S468L possibly damaging Het
Dnah11 T A 12: 118,090,618 (GRCm39) D1081V probably benign Het
Dnah2 C A 11: 69,411,973 (GRCm39) V263L probably benign Het
Efna3 C G 3: 89,222,805 (GRCm39) R185P probably damaging Het
F5 A T 1: 164,039,389 (GRCm39) I2000F probably damaging Het
Fancm G A 12: 65,141,645 (GRCm39) G422E probably benign Het
Gcnt2 A T 13: 41,014,210 (GRCm39) D127V probably damaging Het
Gm21798 G T 15: 64,689,618 (GRCm39) probably benign Het
Gramd1a A C 7: 30,838,292 (GRCm39) S320R probably benign Het
Grn T C 11: 102,327,344 (GRCm39) probably benign Het
Helq A T 5: 100,910,507 (GRCm39) probably null Het
Herc2 A G 7: 55,827,660 (GRCm39) I2914V probably benign Het
Hnrnph1 T C 11: 50,269,237 (GRCm39) V27A probably damaging Het
Hs1bp3 G T 12: 8,374,007 (GRCm39) G182C probably damaging Het
Idnk C T 13: 58,311,267 (GRCm39) P78L probably benign Het
Il10ra T C 9: 45,166,919 (GRCm39) D544G probably benign Het
Inpp5e T C 2: 26,290,918 (GRCm39) D383G probably damaging Het
Jak1 A T 4: 101,036,911 (GRCm39) V243D probably damaging Het
Kcnma1 A T 14: 23,359,220 (GRCm39) S1036T probably damaging Het
Kif26a G A 12: 112,123,776 (GRCm39) C127Y probably damaging Het
Kif2c T C 4: 117,023,608 (GRCm39) E368G probably damaging Het
Lasp1 T A 11: 97,724,530 (GRCm39) probably null Het
Lcor T A 19: 41,572,601 (GRCm39) V452D probably benign Het
Lrrtm1 C G 6: 77,221,661 (GRCm39) H373D probably benign Het
Matr3 T A 18: 35,705,754 (GRCm39) D226E probably damaging Het
Mmp17 G A 5: 129,682,730 (GRCm39) W456* probably null Het
Mpp4 T C 1: 59,164,748 (GRCm39) E463G probably damaging Het
Myh6 A C 14: 55,194,419 (GRCm39) F737V probably damaging Het
Nars2 T A 7: 96,672,948 (GRCm39) D271E probably benign Het
Nav2 A G 7: 49,254,258 (GRCm39) E2352G probably damaging Het
Nckap1 A G 2: 80,353,718 (GRCm39) probably null Het
Nckap5 A T 1: 125,955,324 (GRCm39) S477R probably damaging Het
Nek11 T G 9: 105,175,488 (GRCm39) I319L probably benign Het
Neto2 A G 8: 86,396,393 (GRCm39) I84T probably damaging Het
Nlrp9a A T 7: 26,250,369 (GRCm39) I45F probably damaging Het
Numa1 G A 7: 101,662,012 (GRCm39) R548H probably damaging Het
Or10a5 A C 7: 106,635,364 (GRCm39) M1L probably benign Het
Or14c39 A C 7: 86,344,395 (GRCm39) I244L probably benign Het
Or2ag1b A T 7: 106,288,740 (GRCm39) L66H probably damaging Het
Or4c10 A T 2: 89,760,923 (GRCm39) M257L probably benign Het
Or4c100 T A 2: 88,356,254 (GRCm39) I109N probably damaging Het
Or4k36 T A 2: 111,146,574 (GRCm39) F250Y probably benign Het
Or7g25 A G 9: 19,160,149 (GRCm39) V182A probably benign Het
Or9m1 A T 2: 87,733,533 (GRCm39) N162K probably damaging Het
Pcdhb16 T A 18: 37,612,894 (GRCm39) probably null Het
Pdcd10 T C 3: 75,448,553 (GRCm39) T4A probably damaging Het
Pgc A T 17: 48,039,819 (GRCm39) Y71F probably damaging Het
Phlpp1 G A 1: 106,317,481 (GRCm39) G1234E probably damaging Het
Prr27 T C 5: 87,990,888 (GRCm39) F167L probably benign Het
Prrc2b T A 2: 32,116,330 (GRCm39) S1421T possibly damaging Het
Pxmp2 A G 5: 110,431,518 (GRCm39) V75A probably benign Het
Pygl A T 12: 70,243,807 (GRCm39) M545K probably null Het
Ranbp9 A G 13: 43,574,733 (GRCm39) Y412H possibly damaging Het
Rcc1 A G 4: 132,065,064 (GRCm39) V140A probably damaging Het
Reln A G 5: 22,184,718 (GRCm39) V1599A probably benign Het
Rhebl1 A T 15: 98,776,903 (GRCm39) D122E probably damaging Het
Rock2 C T 12: 17,009,492 (GRCm39) L676F probably benign Het
Scn9a A T 2: 66,357,087 (GRCm39) D1062E probably benign Het
Sec63 T C 10: 42,681,186 (GRCm39) I390T probably damaging Het
Slc10a6 T C 5: 103,754,493 (GRCm39) E346G probably benign Het
Slc12a3 G A 8: 95,075,216 (GRCm39) V737M possibly damaging Het
Slc12a8 T C 16: 33,426,629 (GRCm39) probably null Het
Slc25a38 T A 9: 119,949,354 (GRCm39) I102N probably damaging Het
Spg7 T A 8: 123,807,394 (GRCm39) V390E probably damaging Het
Tbc1d20 T C 2: 152,144,228 (GRCm39) V75A probably benign Het
Tesk1 T A 4: 43,445,555 (GRCm39) C243* probably null Het
Ttk T A 9: 83,725,739 (GRCm39) N220K possibly damaging Het
Ttll5 A G 12: 85,965,948 (GRCm39) E651G probably benign Het
Tubd1 T C 11: 86,457,879 (GRCm39) Y426H probably damaging Het
Uba6 T C 5: 86,288,293 (GRCm39) silent Het
Ube2ql1 G A 13: 69,852,289 (GRCm39) R263W probably damaging Het
Vmn2r117 C T 17: 23,678,812 (GRCm39) G804D probably damaging Het
Vmn2r25 C T 6: 123,805,406 (GRCm39) E484K probably benign Het
Vmn2r4 T A 3: 64,296,476 (GRCm39) I770F possibly damaging Het
Vmn2r82 G A 10: 79,214,589 (GRCm39) V191M probably benign Het
Zbtb45 C T 7: 12,742,037 (GRCm39) V74M probably damaging Het
Zfp366 T C 13: 99,370,609 (GRCm39) V443A possibly damaging Het
Zfyve1 A T 12: 83,598,345 (GRCm39) C628S probably damaging Het
Zfyve26 A T 12: 79,296,469 (GRCm39) probably null Het
Other mutations in Cd84
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Cd84 APN 1 171,679,704 (GRCm39) critical splice donor site probably null
IGL01371:Cd84 APN 1 171,713,937 (GRCm39) missense probably benign 0.36
IGL03035:Cd84 APN 1 171,679,601 (GRCm39) missense probably damaging 0.99
IGL03098:Cd84 APN 1 171,700,267 (GRCm39) missense possibly damaging 0.78
R0511:Cd84 UTSW 1 171,700,494 (GRCm39) missense probably benign 0.00
R1244:Cd84 UTSW 1 171,679,397 (GRCm39) missense probably damaging 0.99
R1438:Cd84 UTSW 1 171,679,685 (GRCm39) missense probably damaging 1.00
R1459:Cd84 UTSW 1 171,679,510 (GRCm39) missense probably benign 0.02
R1654:Cd84 UTSW 1 171,712,173 (GRCm39) missense possibly damaging 0.69
R1658:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1659:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1765:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1771:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1776:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1799:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1815:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1816:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R1982:Cd84 UTSW 1 171,712,152 (GRCm39) splice site probably null
R1990:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R2056:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R2057:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R2058:Cd84 UTSW 1 171,700,317 (GRCm39) missense possibly damaging 0.78
R2098:Cd84 UTSW 1 171,713,148 (GRCm39) missense probably benign 0.07
R4674:Cd84 UTSW 1 171,700,887 (GRCm39) missense possibly damaging 0.82
R4675:Cd84 UTSW 1 171,700,887 (GRCm39) missense possibly damaging 0.82
R4806:Cd84 UTSW 1 171,679,688 (GRCm39) missense probably benign 0.00
R4828:Cd84 UTSW 1 171,700,315 (GRCm39) missense probably damaging 0.97
R5366:Cd84 UTSW 1 171,700,872 (GRCm39) missense probably damaging 1.00
R5725:Cd84 UTSW 1 171,700,928 (GRCm39) missense probably benign 0.00
R5883:Cd84 UTSW 1 171,700,405 (GRCm39) missense possibly damaging 0.58
R6722:Cd84 UTSW 1 171,700,344 (GRCm39) missense probably damaging 0.98
R6966:Cd84 UTSW 1 171,713,976 (GRCm39) missense possibly damaging 0.93
R7513:Cd84 UTSW 1 171,712,185 (GRCm39) missense probably benign 0.01
R7733:Cd84 UTSW 1 171,668,226 (GRCm39) start codon destroyed probably null 1.00
R9123:Cd84 UTSW 1 171,712,153 (GRCm39) critical splice acceptor site probably null
R9134:Cd84 UTSW 1 171,679,413 (GRCm39) missense probably damaging 1.00
R9441:Cd84 UTSW 1 171,713,994 (GRCm39) critical splice donor site probably null
R9702:Cd84 UTSW 1 171,700,498 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- AGGCTCATATGTTTTCCCCTTATAGG -3'
(R):5'- ACACCCAGTGCTAGTCTCAC -3'

Sequencing Primer
(F):5'- TCCCCTTATAGGTCGACTTAAAAC -3'
(R):5'- GCTAGTCTCACTTTAAAGGAGGCAC -3'
Posted On 2016-04-15