Mutagenetix > Incidental Mutation

Incidental Mutation 'R4911:Hydin'

379538

Institutional Source

Beutler Lab

Gene Symbol

Hydin

Ensembl Gene

ENSMUSG00000059854

Gene Name

HYDIN, axonemal central pair apparatus protein

Synonyms

hy-3, hyrh, hy3, 1700034M11Rik, 4930545D19Rik

MMRRC Submission

042513-MU

Accession Numbers

Ncbi RefSeq: NM_172916; MGI: 2389007

Essential gene?

Probably essential (E-score: 0.784) question?

Stock #

R4911 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110266977-110610253 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 110595438 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 4574 (Y4574C)

Ref Sequence

ENSEMBL: ENSMUSP00000046204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043141]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000043141
AA Change: Y4574C

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)

SMART Domains

Protein: ENSMUSP00000046204
Gene: ENSMUSG00000059854
AA Change: Y4574C

Domain	Start	End	E-Value	Type
Pfam:Motile_Sperm	246	325	5.6e-8	PFAM
Pfam:ASH	559	659	9.4e-17	PFAM
low complexity region	788	798	N/A	INTRINSIC
Pfam:PapD-like	848	906	1.2e-6	PFAM
low complexity region	998	1024	N/A	INTRINSIC
low complexity region	1279	1292	N/A	INTRINSIC
internal_repeat_6	1317	1549	5.96e-5	PROSPERO
internal_repeat_5	1355	1502	3.23e-5	PROSPERO
low complexity region	1574	1590	N/A	INTRINSIC
internal_repeat_4	1712	1940	5.14e-6	PROSPERO
coiled coil region	1947	1977	N/A	INTRINSIC
low complexity region	2009	2020	N/A	INTRINSIC
low complexity region	2034	2049	N/A	INTRINSIC
SCOP:d1eq1a_	2305	2403	3e-4	SMART
low complexity region	2404	2419	N/A	INTRINSIC
coiled coil region	2543	2588	N/A	INTRINSIC
low complexity region	2636	2656	N/A	INTRINSIC
internal_repeat_7	2772	3008	8.1e-5	PROSPERO
low complexity region	3660	3670	N/A	INTRINSIC
low complexity region	3919	3934	N/A	INTRINSIC
internal_repeat_5	4046	4190	3.23e-5	PROSPERO
internal_repeat_2	4106	4251	6.03e-7	PROSPERO
internal_repeat_4	4317	4532	5.14e-6	PROSPERO
internal_repeat_3	4403	4689	2.05e-6	PROSPERO
internal_repeat_2	4549	4697	6.03e-7	PROSPERO
low complexity region	4951	4964	N/A	INTRINSIC

Meta Mutation Damage Score

0.0754

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.5%
20x: 89.7%

Validation Efficiency

97% (149/153)

MGI Phenotype

Strain: 1856913; 3801608
Lethality: D28-D42
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted(1) Gene trapped(3) Transgenic(1) Spontaneous(2)

Other mutations in this stock

Total: 132 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	A	T	13: 63,170,939		probably null	Het
4430402I18Rik	G	A	19: 28,897,503		probably benign	Het
Aacs	A	G	5: 125,506,160	D260G	possibly damaging	Het
Aadacl4	T	A	4: 144,613,792	L29H	probably damaging	Het
Abca7	T	C	10: 80,012,188		probably null	Het
Adgre1	G	A	17: 57,447,832	M643I	possibly damaging	Het
Adgrl2	A	T	3: 148,890,463	M79K	probably damaging	Het
Ankrd55	T	A	13: 112,323,039		probably null	Het
Arhgap21	A	G	2: 20,858,989	I1257T	probably damaging	Het
Arhgap26	T	A	18: 38,993,637		probably benign	Het
Arhgap39	A	G	15: 76,737,805	S199P	probably damaging	Het
Arhgef5	A	G	6: 43,272,828	D171G	probably benign	Het
Atp7a	T	C	X: 106,120,374	V1305A	probably damaging	Het
B3gnt3	T	A	8: 71,692,934	R263S	probably benign	Het
B9d1	A	C	11: 61,507,671	D59A	probably benign	Het
Bag2	A	T	1: 33,748,276	I55N	probably benign	Het
Bank1	T	C	3: 136,284,243	I29V	probably benign	Het
Bbs2	A	T	8: 94,089,115	D174E	probably damaging	Het
Bmp8b	T	C	4: 123,115,237	W203R	probably damaging	Het
Cacnb2	A	T	2: 14,981,340	E359D	possibly damaging	Het
Camp	T	A	9: 109,847,583		probably null	Het
Casp4	C	T	9: 5,328,580		probably benign	Het
Ccdc110	A	T	8: 45,942,907	T612S	probably benign	Het
Cd209b	T	A	8: 3,926,640		probably null	Het
Cemip	T	C	7: 83,983,253	D367G	probably damaging	Het
Cers5	T	A	15: 99,747,079	N131I	probably damaging	Het
Chd5	T	G	4: 152,360,672	V370G	probably damaging	Het
Cipc	C	A	12: 86,952,757	Q20K	probably benign	Het
Cnr2	T	A	4: 135,917,201	F197I	possibly damaging	Het
Col7a1	G	A	9: 108,975,219	G2233S	unknown	Het
Dcdc2b	T	A	4: 129,611,267	I125F	possibly damaging	Het
Ddi2	A	G	4: 141,684,402	S400P	probably benign	Het
Ddx31	C	A	2: 28,904,684	T664K	probably benign	Het
Dhx30	C	A	9: 110,100,924	G35C	probably damaging	Het
Dmxl2	G	A	9: 54,411,653	T1576I	probably damaging	Het
Dnah1	T	C	14: 31,295,323	Y1510C	probably damaging	Het
Dnah2	C	T	11: 69,499,104		probably null	Het
Dock10	C	A	1: 80,606,236	G163C	probably damaging	Het
Edar	T	C	10: 58,621,324	N144S	probably benign	Het
Elavl2	T	A	4: 91,308,678	E54D	possibly damaging	Het
Enam	T	G	5: 88,502,314	S561A	probably benign	Het
Ercc5	C	A	1: 44,166,871	H315N	possibly damaging	Het
Esp31	A	G	17: 38,644,661	E65G	possibly damaging	Het
Faap100	T	C	11: 120,372,113	I806M	probably benign	Het
Fam159a	T	C	4: 108,377,461	T70A	probably benign	Het
Fbxw21	T	C	9: 109,145,663	Y263C	probably damaging	Het
Fsip2	T	A	2: 82,981,493	S2719T	possibly damaging	Het
Fv1	T	C	4: 147,869,418	V147A	probably benign	Het
Gal	T	C	19: 3,411,590	E65G	probably benign	Het
Galnt6	T	C	15: 100,716,178	T81A	probably benign	Het
Gcc2	A	G	10: 58,270,439	E399G	probably damaging	Het
Gfi1b	A	T	2: 28,610,102	C306S	probably damaging	Het
Gm10654	T	A	8: 70,931,852		noncoding transcript	Het
Gm20388	A	G	8: 123,080,604		probably benign	Het
Gm4788	T	G	1: 139,774,563	D61A	probably damaging	Het
Gm4953	T	A	1: 159,168,359		noncoding transcript	Het
Gorasp2	T	C	2: 70,688,339		probably benign	Het
Gse1	T	C	8: 120,568,466		probably benign	Het
H2-D1	A	G	17: 35,265,997	E278G	probably damaging	Het
Herc2	T	C	7: 56,227,892	L4569P	probably damaging	Het
Hgs	T	A	11: 120,477,202	S246T	probably damaging	Het
Hs2st1	T	C	3: 144,465,082	T110A	probably benign	Het
Ighv1-23	C	A	12: 114,764,752	V17F	possibly damaging	Het
Ighv8-14	A	T	12: 115,808,565		noncoding transcript	Het
Igsf21	C	T	4: 140,034,623	R248H	probably benign	Het
Il23r	T	C	6: 67,423,561	N595S	probably benign	Het
Il5ra	G	T	6: 106,715,668	P372Q	probably damaging	Het
Iltifb	T	C	10: 118,294,989	M1V	probably null	Het
Inppl1	A	G	7: 101,832,309	V222A	possibly damaging	Het
Ints10	T	C	8: 68,827,312	V697A	probably damaging	Het
Isg15	T	A	4: 156,199,760	T104S	probably benign	Het
Kif11	A	G	19: 37,417,937	T983A	probably benign	Het
Kif3b	A	T	2: 153,317,292	K338*	probably null	Het
Kpna2	T	A	11: 106,990,719	I362F	probably damaging	Het
Lama2	G	A	10: 27,138,927	T1595M	probably damaging	Het
Lrrc36	A	G	8: 105,426,935	T126A	probably benign	Het
Lrrk1	T	A	7: 66,295,454	D604V	probably damaging	Het
Map7d1	T	C	4: 126,236,691	K409E	probably damaging	Het
Mast2	T	C	4: 116,353,057	T110A	probably benign	Het
Micall2	G	A	5: 139,716,825	T221M	probably damaging	Het
Morc2b	T	A	17: 33,137,377	N474Y	probably damaging	Het
Myo1e	T	A	9: 70,343,096	M528K	probably benign	Het
Nlrp1c-ps	G	T	11: 71,260,369		noncoding transcript	Het
Nostrin	T	C	2: 69,161,142	S160P	possibly damaging	Het
Nup133	T	C	8: 123,927,131	R530G	possibly damaging	Het
Olfr452	T	A	6: 42,790,204	L55H	probably damaging	Het
Olfr488	T	C	7: 108,256,037	I34V	possibly damaging	Het
Olfr894	A	G	9: 38,219,096	E91G	probably damaging	Het
Pabpc4l	A	T	3: 46,446,162	M349K	possibly damaging	Het
Pah	G	A	10: 87,570,267	G256S	probably benign	Het
Park2	G	T	17: 10,840,472		probably benign	Het
Pigk	T	C	3: 152,740,204	S151P	probably damaging	Het
Plcd4	A	C	1: 74,564,413	T658P	possibly damaging	Het
Pld4	A	T	12: 112,764,517	S178C	probably benign	Het
Polr1a	G	A	6: 71,909,229	E23K	possibly damaging	Het
Pomt1	T	C	2: 32,241,679	S127P	probably damaging	Het
Pon2	A	G	6: 5,269,029	V215A	possibly damaging	Het
Ppp3cb	A	T	14: 20,509,440	M416K	probably damaging	Het
Prdm1	A	T	10: 44,442,052	N273K	possibly damaging	Het
Prg4	T	A	1: 150,455,823		probably benign	Het
Ptch1	G	A	13: 63,523,052	T888M	probably damaging	Het
Pusl1	T	G	4: 155,891,442		probably benign	Het
Rapgef6	A	T	11: 54,622,317	E122D	probably damaging	Het
Rif1	C	T	2: 52,110,518	T1328I	probably damaging	Het
Rngtt	T	G	4: 33,500,292		probably null	Het
Runx2	G	A	17: 44,814,192	P80L	probably damaging	Het
Samd1	A	G	8: 83,998,989		probably benign	Het
Scamp5	A	T	9: 57,451,452	F14I	probably damaging	Het
Shank3	C	T	15: 89,504,344	R380C	probably damaging	Het
Slc1a4	C	A	11: 20,332,166	A103S	probably damaging	Het
Slc39a14	A	G	14: 70,309,922	V325A	probably benign	Het
Slc5a9	C	A	4: 111,891,744		probably null	Het
Spta1	T	A	1: 174,185,647	S375T	probably damaging	Het
Sval1	A	G	6: 41,955,444	N76S	probably benign	Het
Synpo	C	T	18: 60,629,864		probably benign	Het
Sytl5	C	T	X: 9,915,602	P181L	possibly damaging	Het
Tacc1	A	G	8: 25,182,606	M111T	possibly damaging	Het
Tec	T	C	5: 72,756,351	D613G	probably benign	Het
Tecpr2	C	T	12: 110,931,487	T391I	possibly damaging	Het
Thop1	G	A	10: 81,073,291	G52D	probably damaging	Het
Tmco5	T	A	2: 116,892,208	V270D	possibly damaging	Het
Ttn	C	T	2: 76,726,629	E28265K	possibly damaging	Het
Tuft1	T	C	3: 94,635,443	D72G	probably damaging	Het
Tyrp1	C	T	4: 80,850,907		probably benign	Het
Usp9y	T	C	Y: 1,308,041	D2265G	probably damaging	Het
Vmn2r104	G	A	17: 20,030,026	A661V	probably benign	Het
Vwa5a	A	T	9: 38,737,972	N672I	probably benign	Het
Wdr95	A	T	5: 149,611,692	K772*	probably null	Het
Ybx1	T	C	4: 119,282,813	T106A	probably benign	Het
Ypel3	T	C	7: 126,777,789	S14P	probably benign	Het
Zfp518a	T	A	19: 40,915,528	S1300R	probably benign	Het
Zscan5b	A	T	7: 6,239,190	*469Y	probably null	Het

Other mutations in Hydin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Hydin	APN	8	110569802	missense	possibly damaging	0.69
IGL00432:Hydin	APN	8	110601252	missense	probably damaging	0.98
IGL01025:Hydin	APN	8	110326401	missense	probably benign	0.38
IGL01140:Hydin	APN	8	110398062	missense	probably benign	0.14
IGL01317:Hydin	APN	8	110326446	missense	probably damaging	0.98
IGL01473:Hydin	APN	8	110312160	missense	probably benign	0.08
IGL01473:Hydin	APN	8	110354953	missense	probably damaging	1.00
IGL01610:Hydin	APN	8	110557713	missense	probably benign	0.00
IGL01685:Hydin	APN	8	110355033	nonsense	probably null
IGL01734:Hydin	APN	8	110490789	nonsense	probably null
IGL01743:Hydin	APN	8	110592776	missense	possibly damaging	0.94
IGL01829:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL01919:Hydin	APN	8	110519174	missense	possibly damaging	0.89
IGL01946:Hydin	APN	8	110490718	missense	possibly damaging	0.91
IGL01983:Hydin	APN	8	110514895	missense	probably benign	0.02
IGL02122:Hydin	APN	8	110494415	missense	possibly damaging	0.86
IGL02140:Hydin	APN	8	110566938	missense	probably benign
IGL02158:Hydin	APN	8	110609966	missense	possibly damaging	0.89
IGL02167:Hydin	APN	8	110418423	missense	possibly damaging	0.96
IGL02171:Hydin	APN	8	110451958	nonsense	probably null
IGL02185:Hydin	APN	8	110506476	missense	possibly damaging	0.86
IGL02517:Hydin	APN	8	110566972	missense	probably benign	0.01
IGL02639:Hydin	APN	8	110538449	missense	probably benign	0.01
IGL02644:Hydin	APN	8	110538468	missense	probably damaging	1.00
IGL02652:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL02658:Hydin	APN	8	110413276	missense	possibly damaging	0.86
IGL02706:Hydin	APN	8	110410566	missense	probably damaging	0.99
IGL02892:Hydin	APN	8	110598959	missense	possibly damaging	0.89
IGL02947:Hydin	APN	8	110418462	missense	probably damaging	0.96
IGL03136:Hydin	APN	8	110418524	missense	probably benign	0.22
IGL03248:Hydin	APN	8	110595289	missense	probably damaging	0.97
IGL03251:Hydin	APN	8	110490596	missense	probably damaging	1.00
IGL03350:Hydin	APN	8	110312224	missense	possibly damaging	0.86
IGL03366:Hydin	APN	8	110267363	missense	unknown
IGL03404:Hydin	APN	8	110569777	missense	probably benign	0.06
Franz_joseph	UTSW	8	110601318	missense	probably damaging	1.00
jahreszeiten	UTSW	8	110569359	missense	probably damaging	1.00
maria	UTSW	8	110509127	splice site	probably benign
schoepfung	UTSW	8	110600245	missense	possibly damaging	0.68
surprise	UTSW	8	110528016	missense	probably benign
teresa	UTSW	8	110609671	missense	possibly damaging	0.79
BB001:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB004:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
BB011:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB014:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
P0005:Hydin	UTSW	8	110494289	critical splice acceptor site	probably null
R0099:Hydin	UTSW	8	110589561	missense	probably damaging	1.00
R0125:Hydin	UTSW	8	110462531	missense	probably benign	0.12
R0157:Hydin	UTSW	8	110300010	missense	possibly damaging	0.86
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0255:Hydin	UTSW	8	110565018	missense	probably benign	0.00
R0352:Hydin	UTSW	8	110569901	critical splice donor site	probably null
R0379:Hydin	UTSW	8	110509127	splice site	probably benign
R0468:Hydin	UTSW	8	110413223	missense	possibly damaging	0.96
R0477:Hydin	UTSW	8	110418498	missense	probably damaging	1.00
R0479:Hydin	UTSW	8	110599088	missense	probably damaging	1.00
R0539:Hydin	UTSW	8	110523072	missense	probably benign
R0550:Hydin	UTSW	8	110587775	missense	probably benign	0.01
R0571:Hydin	UTSW	8	110514103	splice site	probably null
R0606:Hydin	UTSW	8	110549798	splice site	probably benign
R0789:Hydin	UTSW	8	110566971	missense	possibly damaging	0.53
R0849:Hydin	UTSW	8	110598984	missense	probably damaging	1.00
R0946:Hydin	UTSW	8	110531053	missense	probably benign	0.25
R1201:Hydin	UTSW	8	110569855	missense	probably benign	0.01
R1375:Hydin	UTSW	8	110506222	critical splice donor site	probably null
R1385:Hydin	UTSW	8	110523204	missense	probably benign	0.40
R1411:Hydin	UTSW	8	110575031	missense	probably benign	0.04
R1437:Hydin	UTSW	8	110581985	nonsense	probably null
R1447:Hydin	UTSW	8	110523166	missense	probably damaging	1.00
R1448:Hydin	UTSW	8	110446585	missense	probably benign	0.27
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1523:Hydin	UTSW	8	110533271	missense	probably benign	0.05
R1544:Hydin	UTSW	8	110574854	missense	probably benign	0.30
R1581:Hydin	UTSW	8	110410460	missense	probably benign
R1584:Hydin	UTSW	8	110580815	missense	probably benign	0.27
R1598:Hydin	UTSW	8	110410674	missense	possibly damaging	0.96
R1633:Hydin	UTSW	8	110506982	missense	probably benign	0.10
R1777:Hydin	UTSW	8	110589571	missense	probably benign	0.14
R1817:Hydin	UTSW	8	110532827	missense	probably benign	0.00
R1828:Hydin	UTSW	8	110510894	missense	probably benign	0.03
R1837:Hydin	UTSW	8	110569625	missense	probably benign	0.20
R1848:Hydin	UTSW	8	110569808	missense	probably benign	0.19
R1869:Hydin	UTSW	8	110500705	missense	possibly damaging	0.94
R1909:Hydin	UTSW	8	110587772	missense	probably damaging	1.00
R1928:Hydin	UTSW	8	110502947	missense	possibly damaging	0.93
R1950:Hydin	UTSW	8	110609987	missense	possibly damaging	0.64
R2095:Hydin	UTSW	8	110462657	missense	probably damaging	0.96
R2172:Hydin	UTSW	8	110582049	missense	probably benign	0.42
R2217:Hydin	UTSW	8	110418506	missense	probably benign
R2248:Hydin	UTSW	8	110578203	missense	probably benign	0.09
R2272:Hydin	UTSW	8	110309132	missense	probably benign	0.01
R2294:Hydin	UTSW	8	110299959	missense	probably damaging	0.99
R2315:Hydin	UTSW	8	110398044	missense	probably benign	0.01
R2330:Hydin	UTSW	8	110565009	missense	probably benign	0.01
R2374:Hydin	UTSW	8	110565148	missense	probably damaging	1.00
R2446:Hydin	UTSW	8	110587715	missense	possibly damaging	0.82
R2484:Hydin	UTSW	8	110513115	missense	possibly damaging	0.76
R2698:Hydin	UTSW	8	110609929	missense	possibly damaging	0.70
R2843:Hydin	UTSW	8	110519114	missense	probably benign
R2844:Hydin	UTSW	8	110519114	missense	probably benign
R2846:Hydin	UTSW	8	110519114	missense	probably benign
R2882:Hydin	UTSW	8	110566923	missense	possibly damaging	0.92
R2937:Hydin	UTSW	8	110404295	missense	possibly damaging	0.88
R3031:Hydin	UTSW	8	110603216	missense	possibly damaging	0.83
R3038:Hydin	UTSW	8	110582689	missense	probably damaging	1.00
R3121:Hydin	UTSW	8	110506506	missense	probably benign
R3157:Hydin	UTSW	8	110267373	missense	unknown
R3547:Hydin	UTSW	8	110582067	missense	possibly damaging	0.85
R3696:Hydin	UTSW	8	110603279	missense	probably damaging	1.00
R3850:Hydin	UTSW	8	110563929	missense	probably damaging	0.99
R3896:Hydin	UTSW	8	110509079	missense	possibly damaging	0.93
R3983:Hydin	UTSW	8	110392325	missense	probably damaging	1.00
R4031:Hydin	UTSW	8	110610047	missense	probably benign	0.30
R4072:Hydin	UTSW	8	110505256	missense	possibly damaging	0.68
R4095:Hydin	UTSW	8	110541547	missense	probably damaging	0.98
R4176:Hydin	UTSW	8	110593820	missense	probably benign	0.00
R4213:Hydin	UTSW	8	110456507	missense	possibly damaging	0.91
R4412:Hydin	UTSW	8	110415736	missense	probably damaging	0.99
R4471:Hydin	UTSW	8	110587132	missense	probably damaging	1.00
R4474:Hydin	UTSW	8	110563865	missense	probably benign	0.11
R4495:Hydin	UTSW	8	110595402	missense	probably damaging	0.99
R4508:Hydin	UTSW	8	110519254	missense	possibly damaging	0.91
R4578:Hydin	UTSW	8	110267339	missense	unknown
R4583:Hydin	UTSW	8	110595225	missense	probably benign	0.36
R4600:Hydin	UTSW	8	110566950	missense	probably benign	0.04
R4681:Hydin	UTSW	8	110506471	missense	possibly damaging	0.85
R4685:Hydin	UTSW	8	110462522	missense	probably damaging	0.99
R4689:Hydin	UTSW	8	110595414	missense	probably benign	0.18
R4735:Hydin	UTSW	8	110555632	critical splice donor site	probably null
R4736:Hydin	UTSW	8	110523208	missense	probably benign	0.02
R4740:Hydin	UTSW	8	110446439	missense	probably benign	0.06
R4771:Hydin	UTSW	8	110532883	missense	probably benign
R4777:Hydin	UTSW	8	110410464	missense	probably damaging	0.98
R4859:Hydin	UTSW	8	110506494	missense	possibly damaging	0.93
R4964:Hydin	UTSW	8	110490673	missense	possibly damaging	0.86
R4965:Hydin	UTSW	8	110398095	missense	probably benign
R4989:Hydin	UTSW	8	110563922	missense	possibly damaging	0.84
R4995:Hydin	UTSW	8	110569642	missense	probably damaging	0.97
R5059:Hydin	UTSW	8	110505769	missense	probably damaging	0.96
R5071:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5073:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5092:Hydin	UTSW	8	110582668	missense	probably benign	0.16
R5156:Hydin	UTSW	8	110609701	missense	probably benign	0.00
R5166:Hydin	UTSW	8	110523142	missense	possibly damaging	0.89
R5189:Hydin	UTSW	8	110413211	critical splice acceptor site	probably null
R5243:Hydin	UTSW	8	110505748	missense	possibly damaging	0.92
R5244:Hydin	UTSW	8	110532819	missense	possibly damaging	0.77
R5256:Hydin	UTSW	8	110587223	missense	possibly damaging	0.92
R5266:Hydin	UTSW	8	110334784	missense	possibly damaging	0.87
R5283:Hydin	UTSW	8	110451980	missense	possibly damaging	0.96
R5343:Hydin	UTSW	8	110485419	missense	probably benign	0.40
R5359:Hydin	UTSW	8	110538372	missense	probably benign	0.00
R5390:Hydin	UTSW	8	110595467	missense	probably benign
R5394:Hydin	UTSW	8	110539842	splice site	probably null
R5441:Hydin	UTSW	8	110565109	missense	possibly damaging	0.72
R5461:Hydin	UTSW	8	110519231	missense	probably damaging	0.96
R5662:Hydin	UTSW	8	110580709	missense	probably benign	0.02
R5695:Hydin	UTSW	8	110535283	missense	probably benign	0.35
R5732:Hydin	UTSW	8	110452058	missense	probably benign	0.03
R5774:Hydin	UTSW	8	110571915	nonsense	probably null
R5780:Hydin	UTSW	8	110586080	missense	probably damaging	1.00
R5787:Hydin	UTSW	8	110326353	missense	probably damaging	0.99
R5802:Hydin	UTSW	8	110452060	missense	possibly damaging	0.86
R5841:Hydin	UTSW	8	110533214	missense	possibly damaging	0.76
R5856:Hydin	UTSW	8	110541842	missense	probably damaging	0.99
R5893:Hydin	UTSW	8	110490676	missense	probably benign	0.12
R5963:Hydin	UTSW	8	110494294	missense	possibly damaging	0.93
R6008:Hydin	UTSW	8	110599085	missense	probably benign	0.02
R6019:Hydin	UTSW	8	110566620	missense	probably benign
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6133:Hydin	UTSW	8	110601276	missense	probably benign	0.00
R6135:Hydin	UTSW	8	110462660	missense	possibly damaging	0.85
R6157:Hydin	UTSW	8	110528016	missense	probably benign
R6209:Hydin	UTSW	8	110593802	missense	probably benign	0.05
R6238:Hydin	UTSW	8	110392111	splice site	probably null
R6293:Hydin	UTSW	8	110597911	missense	possibly damaging	0.83
R6340:Hydin	UTSW	8	110354942	splice site	probably null
R6349:Hydin	UTSW	8	110418459	nonsense	probably null
R6357:Hydin	UTSW	8	110541657	missense	possibly damaging	0.86
R6385:Hydin	UTSW	8	110312224	missense	possibly damaging	0.86
R6396:Hydin	UTSW	8	110506889	missense	probably damaging	0.96
R6466:Hydin	UTSW	8	110506968	missense	possibly damaging	0.85
R6648:Hydin	UTSW	8	110525667	splice site	probably null
R6671:Hydin	UTSW	8	110601318	missense	probably damaging	1.00
R6695:Hydin	UTSW	8	110326460	missense	probably benign	0.05
R6800:Hydin	UTSW	8	110597971	missense	probably benign	0.09
R6841:Hydin	UTSW	8	110538375	missense	probably benign	0.09
R6867:Hydin	UTSW	8	110539802	missense	probably benign	0.08
R6889:Hydin	UTSW	8	110532856	missense	possibly damaging	0.79
R6895:Hydin	UTSW	8	110312251	missense	probably benign	0.00
R6940:Hydin	UTSW	8	110490611	missense	probably damaging	1.00
R6951:Hydin	UTSW	8	110398125	missense	probably benign
R6980:Hydin	UTSW	8	110413284	missense	possibly damaging	0.91
R6981:Hydin	UTSW	8	110531072	missense	possibly damaging	0.89
R7061:Hydin	UTSW	8	110603288	missense	possibly damaging	0.90
R7085:Hydin	UTSW	8	110603330	missense	probably benign	0.03
R7086:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R7110:Hydin	UTSW	8	110354951	critical splice acceptor site	probably null
R7158:Hydin	UTSW	8	110609671	missense	possibly damaging	0.79
R7163:Hydin	UTSW	8	110603336	missense	probably benign	0.25
R7209:Hydin	UTSW	8	110489792	nonsense	probably null
R7244:Hydin	UTSW	8	110549675	missense	probably damaging	0.98
R7347:Hydin	UTSW	8	110600362	missense	probably benign	0.06
R7349:Hydin	UTSW	8	110398171	splice site	probably null
R7359:Hydin	UTSW	8	110506101	missense	probably damaging	0.98
R7365:Hydin	UTSW	8	110557662	missense	probably damaging	0.99
R7365:Hydin	UTSW	8	110601273	missense	probably damaging	1.00
R7436:Hydin	UTSW	8	110583914	missense	probably damaging	0.96
R7528:Hydin	UTSW	8	110380572	nonsense	probably null
R7544:Hydin	UTSW	8	110589525	missense	probably benign	0.35
R7625:Hydin	UTSW	8	110541844	missense	probably benign	0.01
R7713:Hydin	UTSW	8	110593812	missense	possibly damaging	0.69
R7763:Hydin	UTSW	8	110505843	missense	possibly damaging	0.92
R7771:Hydin	UTSW	8	110565085	missense	probably damaging	0.97
R7794:Hydin	UTSW	8	110509083	missense	probably damaging	1.00
R7833:Hydin	UTSW	8	110589460	missense	probably damaging	0.99
R7894:Hydin	UTSW	8	110513010	missense	possibly damaging	0.88
R7899:Hydin	UTSW	8	110587748	missense	probably benign	0.00
R7908:Hydin	UTSW	8	110510867	missense	probably benign	0.01
R7912:Hydin	UTSW	8	110555607	missense	possibly damaging	0.68
R7919:Hydin	UTSW	8	110267339	missense	unknown
R7924:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
R7927:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
R7970:Hydin	UTSW	8	110309091	missense	probably damaging	0.99
R7993:Hydin	UTSW	8	110579632	missense	probably benign
R8011:Hydin	UTSW	8	110583909	missense	probably damaging	1.00
R8041:Hydin	UTSW	8	110574994	missense	probably benign	0.02
R8080:Hydin	UTSW	8	110535231	missense	probably benign	0.32
R8081:Hydin	UTSW	8	110365469	missense	possibly damaging	0.93
R8095:Hydin	UTSW	8	110569359	missense	probably damaging	1.00
R8157:Hydin	UTSW	8	110452036	missense	probably benign	0.33
R8186:Hydin	UTSW	8	110609645	missense	probably benign	0.14
R8205:Hydin	UTSW	8	110592638	missense	possibly damaging	0.57
R8263:Hydin	UTSW	8	110452073	missense	probably benign	0.00
R8288:Hydin	UTSW	8	110507029	missense	probably damaging	0.96
R8298:Hydin	UTSW	8	110600383	missense	probably damaging	1.00
R8309:Hydin	UTSW	8	110607902	missense	probably benign	0.18
R8348:Hydin	UTSW	8	110603246	missense	possibly damaging	0.68
R8356:Hydin	UTSW	8	110533124	missense	possibly damaging	0.67
R8406:Hydin	UTSW	8	110609911	missense	possibly damaging	0.94
R8415:Hydin	UTSW	8	110451994	missense	probably damaging	1.00
R8417:Hydin	UTSW	8	110569392	missense	probably benign	0.28
R8432:Hydin	UTSW	8	110597951	missense	probably benign	0.02
R8437:Hydin	UTSW	8	110462735	missense	probably damaging	0.96
R8463:Hydin	UTSW	8	110510921	missense	probably benign	0.22
R8508:Hydin	UTSW	8	110582018	missense	probably benign	0.00
R8510:Hydin	UTSW	8	110506570	missense	probably damaging	1.00
R8560:Hydin	UTSW	8	110538474	missense	probably benign	0.09
R8682:Hydin	UTSW	8	110309166	missense	probably damaging	0.96
R8697:Hydin	UTSW	8	110532883	missense	probably benign
R8857:Hydin	UTSW	8	110571955	critical splice donor site	probably null
R8866:Hydin	UTSW	8	110582147	missense	possibly damaging	0.89
R8878:Hydin	UTSW	8	110309088	missense	probably benign	0.12
R8897:Hydin	UTSW	8	110589480	missense	probably benign
R8987:Hydin	UTSW	8	110513134	nonsense	probably null
R9072:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9073:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9102:Hydin	UTSW	8	110508914	missense	probably benign	0.33
R9224:Hydin	UTSW	8	110532884	missense	probably benign
R9255:Hydin	UTSW	8	110535340	missense	probably benign	0.23
R9257:Hydin	UTSW	8	110575016	missense	probably damaging	0.99
R9261:Hydin	UTSW	8	110267415	missense	unknown
R9273:Hydin	UTSW	8	110506948	missense	probably damaging	0.98
R9376:Hydin	UTSW	8	110398063	missense	possibly damaging	0.70
R9380:Hydin	UTSW	8	110563872	missense	probably benign	0.07
R9386:Hydin	UTSW	8	110587730	missense	probably benign
R9406:Hydin	UTSW	8	110587780	missense	probably null	0.96
R9492:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R9513:Hydin	UTSW	8	110595482	missense	probably damaging	0.99
R9562:Hydin	UTSW	8	110586154	missense	probably benign	0.11
R9664:Hydin	UTSW	8	110494333	missense	probably benign	0.01
R9733:Hydin	UTSW	8	110535379	missense	probably benign
R9753:Hydin	UTSW	8	110490766	missense	possibly damaging	0.85
X0063:Hydin	UTSW	8	110551319	missense	probably damaging	1.00
Z1088:Hydin	UTSW	8	110299973	missense	probably benign	0.12
Z1088:Hydin	UTSW	8	110586048	missense	probably benign	0.00
Z1088:Hydin	UTSW	8	110592791	frame shift	probably null
Z1176:Hydin	UTSW	8	110541600	missense	possibly damaging	0.65
Z1177:Hydin	UTSW	8	110380610	missense	probably damaging	1.00
Z1177:Hydin	UTSW	8	110450232	missense	possibly damaging	0.47
Z1177:Hydin	UTSW	8	110587142	frame shift	probably null
Z1177:Hydin	UTSW	8	110609989	missense	probably benign	0.10
Z1188:Hydin	UTSW	8	110415787	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- TTTCTGACCAGGTCATCACC -3'
(R):5'- GGGCATATACTAGGCACACACC -3'

Sequencing Primer
(F):5'- TCACCATGAAGCCTAAAGAAGTCTG -3'
(R):5'- GGCACACACCAATATTCTTTTTCATG -3'

Posted On

2016-04-15