Incidental Mutation 'R4916:Megf8'
| ID |
380062 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Megf8
|
| Ensembl Gene |
ENSMUSG00000045039 |
| Gene Name |
multiple EGF-like-domains 8 |
| Synonyms |
m687Ddg, b2b1702Clo, Egfl4, b2b288Clo |
| MMRRC Submission |
042518-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.952)
|
| Stock # |
R4916 (G1)
|
| Quality Score |
214 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
25016589-25065342 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 25039089 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 900
(L900P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000122192
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000128119]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000128119
AA Change: L900P
PolyPhen 2
Score 0.240 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000122192
Gene: ENSMUSG00000045039
AA Change: L900P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
27 |
N/A |
INTRINSIC |
|
CUB
|
33 |
140 |
1.24e-15 |
SMART |
|
EGF
|
141 |
170 |
4.26e0 |
SMART |
|
EGF
|
173 |
203 |
2.43e1 |
SMART |
|
Pfam:Kelch_4
|
227 |
277 |
1.3e-11 |
PFAM |
|
Pfam:Kelch_3
|
240 |
287 |
1.6e-7 |
PFAM |
|
low complexity region
|
320 |
341 |
N/A |
INTRINSIC |
|
low complexity region
|
517 |
531 |
N/A |
INTRINSIC |
|
low complexity region
|
728 |
738 |
N/A |
INTRINSIC |
|
PSI
|
847 |
899 |
1.37e0 |
SMART |
|
low complexity region
|
932 |
938 |
N/A |
INTRINSIC |
|
PSI
|
949 |
991 |
2.11e-2 |
SMART |
|
PSI
|
1005 |
1073 |
7.82e-1 |
SMART |
|
EGF_CA
|
1074 |
1115 |
2.62e-9 |
SMART |
|
EGF
|
1117 |
1160 |
5.4e-2 |
SMART |
|
EGF_like
|
1163 |
1208 |
4e-1 |
SMART |
|
EGF_Lam
|
1211 |
1259 |
1.03e-7 |
SMART |
|
Blast:CUB
|
1263 |
1401 |
1e-30 |
BLAST |
|
EGF_like
|
1406 |
1445 |
3.29e1 |
SMART |
|
Pfam:Kelch_4
|
1509 |
1564 |
6.5e-12 |
PFAM |
|
Pfam:Kelch_3
|
1520 |
1574 |
1.2e-10 |
PFAM |
|
PSI
|
1868 |
1923 |
2.75e-1 |
SMART |
|
PSI
|
2004 |
2062 |
1.6e0 |
SMART |
|
PSI
|
2064 |
2121 |
1.68e-5 |
SMART |
|
EGF
|
2125 |
2164 |
1.08e-1 |
SMART |
|
EGF
|
2166 |
2194 |
4.26e0 |
SMART |
|
EGF
|
2204 |
2244 |
2.2e1 |
SMART |
|
EGF_like
|
2248 |
2321 |
6.37e-1 |
SMART |
|
low complexity region
|
2493 |
2504 |
N/A |
INTRINSIC |
|
low complexity region
|
2530 |
2541 |
N/A |
INTRINSIC |
|
transmembrane domain
|
2592 |
2614 |
N/A |
INTRINSIC |
|
low complexity region
|
2649 |
2668 |
N/A |
INTRINSIC |
|
low complexity region
|
2674 |
2702 |
N/A |
INTRINSIC |
|
low complexity region
|
2759 |
2774 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.0%
- 3x: 98.2%
- 10x: 95.9%
- 20x: 91.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a single-pass type I membrane protein of unknown function that contains several EGF-like domains, Kelch repeats, and PSI domains. Defects in this gene are a cause of Carpenter syndrome 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for an ENU mutation exhibit varying degrees of heterotaxia and congenital heart defects. Mice homozygous for another ENU-induced mutation exhibit abnormal development and patterning of the peripheral nervous system. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 106 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930595D18Rik |
G |
A |
12: 111,141,369 (GRCm39) |
Q19* |
probably null |
Het |
| 6030468B19Rik |
T |
A |
11: 117,697,092 (GRCm39) |
C230* |
probably null |
Het |
| Adcy10 |
A |
G |
1: 165,345,815 (GRCm39) |
E288G |
probably damaging |
Het |
| Adnp |
T |
A |
2: 168,029,537 (GRCm39) |
T51S |
possibly damaging |
Het |
| Agap3 |
C |
A |
5: 24,683,011 (GRCm39) |
A464D |
probably damaging |
Het |
| Ago4 |
A |
C |
4: 126,400,635 (GRCm39) |
C693G |
probably damaging |
Het |
| Ahi1 |
A |
G |
10: 20,860,303 (GRCm39) |
R675G |
probably damaging |
Het |
| Amigo1 |
T |
A |
3: 108,094,981 (GRCm39) |
L160Q |
probably damaging |
Het |
| Ankrd35 |
T |
C |
3: 96,591,438 (GRCm39) |
S575P |
probably benign |
Het |
| Ano3 |
T |
A |
2: 110,601,365 (GRCm39) |
T298S |
possibly damaging |
Het |
| Ap2b1 |
T |
G |
11: 83,281,532 (GRCm39) |
F813V |
probably damaging |
Het |
| Aplnr |
T |
G |
2: 84,967,261 (GRCm39) |
F95L |
probably damaging |
Het |
| Apobec2 |
T |
C |
17: 48,730,153 (GRCm39) |
E171G |
probably benign |
Het |
| Ascc1 |
A |
G |
10: 59,840,684 (GRCm39) |
N15S |
probably benign |
Het |
| AY358078 |
T |
A |
14: 52,040,108 (GRCm39) |
Y73N |
unknown |
Het |
| B3gnt8 |
C |
A |
7: 25,328,308 (GRCm39) |
P246Q |
probably damaging |
Het |
| C2cd2l |
T |
C |
9: 44,227,857 (GRCm39) |
Q250R |
probably damaging |
Het |
| Camk2d |
T |
C |
3: 126,577,624 (GRCm39) |
Y180H |
probably damaging |
Het |
| Ccdc170 |
A |
G |
10: 4,468,971 (GRCm39) |
E167G |
probably damaging |
Het |
| Cdcp3 |
T |
A |
7: 130,776,206 (GRCm39) |
|
probably null |
Het |
| Cdyl2 |
A |
G |
8: 117,305,926 (GRCm39) |
M445T |
probably damaging |
Het |
| Clca3a1 |
T |
C |
3: 144,721,605 (GRCm39) |
D322G |
probably benign |
Het |
| Cnot10 |
C |
T |
9: 114,458,202 (GRCm39) |
M101I |
possibly damaging |
Het |
| Cntrl |
C |
T |
2: 35,055,694 (GRCm39) |
T1196M |
probably benign |
Het |
| Cybb |
C |
G |
X: 9,316,989 (GRCm39) |
D246H |
probably benign |
Het |
| Dcaf6 |
T |
C |
1: 165,247,774 (GRCm39) |
D153G |
probably damaging |
Het |
| Dennd2c |
G |
A |
3: 103,039,140 (GRCm39) |
G96E |
probably benign |
Het |
| Dhrs9 |
T |
C |
2: 69,231,752 (GRCm39) |
F304S |
probably damaging |
Het |
| Dmxl1 |
T |
C |
18: 50,010,764 (GRCm39) |
S974P |
probably damaging |
Het |
| Dnah6 |
T |
C |
6: 73,169,659 (GRCm39) |
|
probably benign |
Het |
| Dnah7c |
T |
C |
1: 46,634,168 (GRCm39) |
L1049P |
probably damaging |
Het |
| Dnajc2 |
T |
C |
5: 21,962,338 (GRCm39) |
K621E |
probably damaging |
Het |
| Ehbp1 |
T |
C |
11: 22,096,592 (GRCm39) |
D299G |
probably benign |
Het |
| Erap1 |
A |
G |
13: 74,794,647 (GRCm39) |
E102G |
probably benign |
Het |
| Fasn |
T |
G |
11: 120,707,472 (GRCm39) |
N799T |
probably benign |
Het |
| Fbxl20 |
T |
C |
11: 98,019,186 (GRCm39) |
D22G |
probably damaging |
Het |
| Fgfr1 |
T |
C |
8: 26,053,542 (GRCm39) |
|
probably null |
Het |
| Frzb |
A |
T |
2: 80,276,871 (GRCm39) |
I105N |
probably damaging |
Het |
| Gabrb1 |
T |
A |
5: 72,026,764 (GRCm39) |
F55Y |
probably damaging |
Het |
| Gatd1 |
G |
T |
7: 140,989,010 (GRCm39) |
C216* |
probably null |
Het |
| Gnl2 |
A |
C |
4: 124,937,485 (GRCm39) |
N255T |
probably damaging |
Het |
| Golgb1 |
A |
T |
16: 36,736,480 (GRCm39) |
Q1909L |
probably benign |
Het |
| Gpnmb |
T |
C |
6: 49,028,904 (GRCm39) |
L474P |
probably damaging |
Het |
| H60b |
T |
C |
10: 22,163,115 (GRCm39) |
V230A |
possibly damaging |
Het |
| Hmcn2 |
T |
A |
2: 31,250,992 (GRCm39) |
V818D |
probably damaging |
Het |
| Irag2 |
C |
A |
6: 145,111,027 (GRCm39) |
S277R |
probably damaging |
Het |
| Itprid1 |
C |
T |
6: 55,955,175 (GRCm39) |
P928S |
possibly damaging |
Het |
| Jade2 |
G |
T |
11: 51,707,909 (GRCm39) |
T768K |
probably benign |
Het |
| Kif28 |
T |
C |
1: 179,530,085 (GRCm39) |
H692R |
probably benign |
Het |
| Kmt2b |
T |
C |
7: 30,277,942 (GRCm39) |
N1634S |
probably damaging |
Het |
| Knop1 |
A |
G |
7: 118,445,299 (GRCm39) |
W222R |
probably damaging |
Het |
| Map1b |
T |
C |
13: 99,569,808 (GRCm39) |
D971G |
unknown |
Het |
| Mapk7 |
G |
T |
11: 61,384,475 (GRCm39) |
T77K |
probably damaging |
Het |
| Mcm6 |
A |
G |
1: 128,276,714 (GRCm39) |
L292P |
probably damaging |
Het |
| Meis1 |
G |
A |
11: 18,831,776 (GRCm39) |
H421Y |
possibly damaging |
Het |
| Minar2 |
A |
T |
18: 59,205,277 (GRCm39) |
I22F |
probably damaging |
Het |
| Mllt1 |
T |
C |
17: 57,206,813 (GRCm39) |
T344A |
probably benign |
Het |
| Mta1 |
T |
A |
12: 113,100,160 (GRCm39) |
S657T |
probably benign |
Het |
| Mtus1 |
C |
A |
8: 41,453,838 (GRCm39) |
K998N |
probably damaging |
Het |
| Ncdn |
G |
A |
4: 126,643,731 (GRCm39) |
L364F |
possibly damaging |
Het |
| Ndufb7 |
T |
C |
8: 84,297,534 (GRCm39) |
L63P |
probably damaging |
Het |
| Nfix |
T |
C |
8: 85,498,458 (GRCm39) |
I172V |
probably benign |
Het |
| Nos1 |
T |
C |
5: 118,085,635 (GRCm39) |
|
probably null |
Het |
| Nrp1 |
C |
A |
8: 129,229,285 (GRCm39) |
S921* |
probably null |
Het |
| Oma1 |
T |
C |
4: 103,176,727 (GRCm39) |
|
probably null |
Het |
| Or3a1b |
A |
T |
11: 74,012,705 (GRCm39) |
I197F |
probably benign |
Het |
| Or5b106 |
T |
A |
19: 13,123,355 (GRCm39) |
I223L |
possibly damaging |
Het |
| Pcp2 |
T |
A |
8: 3,675,534 (GRCm39) |
|
probably benign |
Het |
| Pdk4 |
T |
A |
6: 5,489,157 (GRCm39) |
H250L |
possibly damaging |
Het |
| Phldb3 |
A |
G |
7: 24,323,716 (GRCm39) |
H449R |
probably benign |
Het |
| Pip4k2c |
T |
C |
10: 127,035,196 (GRCm39) |
T391A |
possibly damaging |
Het |
| Polrmt |
A |
G |
10: 79,582,385 (GRCm39) |
M1T |
probably null |
Het |
| Ppfia2 |
G |
C |
10: 106,597,978 (GRCm39) |
L180F |
probably damaging |
Het |
| Prkcg |
T |
G |
7: 3,378,781 (GRCm39) |
Y624* |
probably null |
Het |
| Psmg2 |
A |
G |
18: 67,781,926 (GRCm39) |
E164G |
probably damaging |
Het |
| Rb1 |
A |
T |
14: 73,454,131 (GRCm39) |
L589H |
probably damaging |
Het |
| Rcvrn |
A |
T |
11: 67,586,591 (GRCm39) |
I117F |
probably damaging |
Het |
| Rere |
T |
A |
4: 150,703,601 (GRCm39) |
W1528R |
probably damaging |
Het |
| Robo2 |
A |
G |
16: 73,695,803 (GRCm39) |
S1447P |
possibly damaging |
Het |
| Scfd2 |
C |
A |
5: 74,623,319 (GRCm39) |
G405W |
probably damaging |
Het |
| Scin |
T |
A |
12: 40,119,373 (GRCm39) |
I552F |
possibly damaging |
Het |
| Serpina3k |
G |
A |
12: 104,309,269 (GRCm39) |
V238M |
probably damaging |
Het |
| Slc1a6 |
G |
A |
10: 78,632,085 (GRCm39) |
V304M |
probably damaging |
Het |
| Slc20a2 |
C |
T |
8: 23,051,020 (GRCm39) |
S351L |
probably damaging |
Het |
| Slc31a2 |
T |
C |
4: 62,215,325 (GRCm39) |
V124A |
probably damaging |
Het |
| Slc38a3 |
T |
C |
9: 107,533,426 (GRCm39) |
N244S |
probably benign |
Het |
| Slc4a1 |
A |
G |
11: 102,243,279 (GRCm39) |
V784A |
probably damaging |
Het |
| Slc6a5 |
T |
C |
7: 49,598,004 (GRCm39) |
F623L |
probably benign |
Het |
| Slf2 |
T |
G |
19: 44,960,100 (GRCm39) |
D1022E |
probably damaging |
Het |
| Slfn8 |
G |
A |
11: 82,907,704 (GRCm39) |
H280Y |
probably damaging |
Het |
| Smpdl3a |
A |
T |
10: 57,677,127 (GRCm39) |
D45V |
probably damaging |
Het |
| Ssh3 |
T |
C |
19: 4,315,170 (GRCm39) |
E342G |
probably damaging |
Het |
| Tacr1 |
A |
T |
6: 82,531,922 (GRCm39) |
I273F |
probably benign |
Het |
| Tfg |
T |
A |
16: 56,514,759 (GRCm39) |
|
probably null |
Het |
| Tmem179 |
A |
G |
12: 112,468,268 (GRCm39) |
L71P |
probably damaging |
Het |
| Tmem63a |
T |
A |
1: 180,794,086 (GRCm39) |
I541N |
probably benign |
Het |
| Traj20 |
G |
A |
14: 54,436,924 (GRCm39) |
|
probably benign |
Het |
| Trappc13 |
A |
T |
13: 104,290,802 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
T |
2: 76,641,587 (GRCm39) |
L5176Q |
possibly damaging |
Het |
| Tulp1 |
A |
G |
17: 28,578,109 (GRCm39) |
L310P |
probably damaging |
Het |
| Ube3d |
A |
G |
9: 86,304,925 (GRCm39) |
Y306H |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,580,216 (GRCm39) |
V649E |
probably damaging |
Het |
| Vps13d |
A |
G |
4: 144,709,963 (GRCm39) |
L4211P |
probably damaging |
Het |
| Vwa5b1 |
T |
A |
4: 138,321,573 (GRCm39) |
I407F |
possibly damaging |
Het |
| Vwce |
G |
T |
19: 10,624,243 (GRCm39) |
C378F |
probably damaging |
Het |
| Zfp791 |
T |
A |
8: 85,837,580 (GRCm39) |
I95L |
probably benign |
Het |
|
| Other mutations in Megf8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00639:Megf8
|
APN |
7 |
25,043,109 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL00696:Megf8
|
APN |
7 |
25,041,817 (GRCm39) |
missense |
probably benign |
|
|
IGL01021:Megf8
|
APN |
7 |
25,037,799 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01290:Megf8
|
APN |
7 |
25,049,083 (GRCm39) |
nonsense |
probably null |
|
|
IGL01392:Megf8
|
APN |
7 |
25,063,174 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01410:Megf8
|
APN |
7 |
25,059,296 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01634:Megf8
|
APN |
7 |
25,058,206 (GRCm39) |
splice site |
probably benign |
|
|
IGL01648:Megf8
|
APN |
7 |
25,026,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01930:Megf8
|
APN |
7 |
25,034,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01954:Megf8
|
APN |
7 |
25,048,439 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02150:Megf8
|
APN |
7 |
25,045,842 (GRCm39) |
splice site |
probably null |
|
|
IGL02192:Megf8
|
APN |
7 |
25,053,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02250:Megf8
|
APN |
7 |
25,042,000 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02301:Megf8
|
APN |
7 |
25,037,325 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02317:Megf8
|
APN |
7 |
25,063,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02324:Megf8
|
APN |
7 |
25,039,873 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02503:Megf8
|
APN |
7 |
25,062,988 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
IGL02583:Megf8
|
APN |
7 |
25,055,218 (GRCm39) |
missense |
probably benign |
|
|
IGL02636:Megf8
|
APN |
7 |
25,057,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02704:Megf8
|
APN |
7 |
25,059,207 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02898:Megf8
|
APN |
7 |
25,045,933 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL03082:Megf8
|
APN |
7 |
25,029,661 (GRCm39) |
missense |
probably benign |
|
|
IGL03182:Megf8
|
APN |
7 |
25,046,773 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
megatherium
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
PIT4810001:Megf8
|
UTSW |
7 |
25,041,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0076:Megf8
|
UTSW |
7 |
25,053,383 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0217:Megf8
|
UTSW |
7 |
25,063,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0514:Megf8
|
UTSW |
7 |
25,063,728 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R0561:Megf8
|
UTSW |
7 |
25,028,257 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0563:Megf8
|
UTSW |
7 |
25,041,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0601:Megf8
|
UTSW |
7 |
25,027,965 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0879:Megf8
|
UTSW |
7 |
25,037,896 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1323:Megf8
|
UTSW |
7 |
25,059,527 (GRCm39) |
splice site |
probably null |
|
|
R1430:Megf8
|
UTSW |
7 |
25,063,768 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1445:Megf8
|
UTSW |
7 |
25,042,081 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1533:Megf8
|
UTSW |
7 |
25,034,280 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1606:Megf8
|
UTSW |
7 |
25,058,120 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1635:Megf8
|
UTSW |
7 |
25,046,172 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1654:Megf8
|
UTSW |
7 |
25,037,911 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R1661:Megf8
|
UTSW |
7 |
25,063,272 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1880:Megf8
|
UTSW |
7 |
25,034,285 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1962:Megf8
|
UTSW |
7 |
25,062,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2077:Megf8
|
UTSW |
7 |
25,053,163 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2127:Megf8
|
UTSW |
7 |
25,064,007 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2129:Megf8
|
UTSW |
7 |
25,030,140 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2199:Megf8
|
UTSW |
7 |
25,039,039 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R2201:Megf8
|
UTSW |
7 |
25,040,170 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2205:Megf8
|
UTSW |
7 |
25,041,173 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2207:Megf8
|
UTSW |
7 |
25,049,222 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2361:Megf8
|
UTSW |
7 |
25,048,379 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2680:Megf8
|
UTSW |
7 |
25,016,981 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3085:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3086:Megf8
|
UTSW |
7 |
25,048,444 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3433:Megf8
|
UTSW |
7 |
25,059,549 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3939:Megf8
|
UTSW |
7 |
25,058,627 (GRCm39) |
missense |
probably benign |
0.07 |
|
R4022:Megf8
|
UTSW |
7 |
25,037,200 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4214:Megf8
|
UTSW |
7 |
25,054,793 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4357:Megf8
|
UTSW |
7 |
25,055,174 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4521:Megf8
|
UTSW |
7 |
25,042,126 (GRCm39) |
missense |
probably benign |
0.19 |
|
R4620:Megf8
|
UTSW |
7 |
25,054,523 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4700:Megf8
|
UTSW |
7 |
25,062,940 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4940:Megf8
|
UTSW |
7 |
25,060,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5048:Megf8
|
UTSW |
7 |
25,030,517 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5258:Megf8
|
UTSW |
7 |
25,047,751 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R5271:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5390:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5391:Megf8
|
UTSW |
7 |
25,039,714 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5708:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5752:Megf8
|
UTSW |
7 |
25,054,539 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5930:Megf8
|
UTSW |
7 |
25,025,866 (GRCm39) |
nonsense |
probably null |
|
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Megf8
|
UTSW |
7 |
25,063,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6153:Megf8
|
UTSW |
7 |
25,046,796 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6210:Megf8
|
UTSW |
7 |
25,043,145 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6457:Megf8
|
UTSW |
7 |
25,049,120 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6659:Megf8
|
UTSW |
7 |
25,058,159 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6867:Megf8
|
UTSW |
7 |
25,030,460 (GRCm39) |
missense |
probably benign |
0.42 |
|
R6896:Megf8
|
UTSW |
7 |
25,029,357 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6899:Megf8
|
UTSW |
7 |
25,060,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6905:Megf8
|
UTSW |
7 |
25,037,357 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7099:Megf8
|
UTSW |
7 |
25,045,945 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7172:Megf8
|
UTSW |
7 |
25,043,092 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7378:Megf8
|
UTSW |
7 |
25,048,367 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Megf8
|
UTSW |
7 |
25,037,796 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7492:Megf8
|
UTSW |
7 |
25,053,273 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7699:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7700:Megf8
|
UTSW |
7 |
25,029,353 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7756:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7758:Megf8
|
UTSW |
7 |
25,041,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7786:Megf8
|
UTSW |
7 |
25,017,120 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7797:Megf8
|
UTSW |
7 |
25,034,022 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7881:Megf8
|
UTSW |
7 |
25,040,060 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8165:Megf8
|
UTSW |
7 |
25,053,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8258:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8259:Megf8
|
UTSW |
7 |
25,057,848 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8328:Megf8
|
UTSW |
7 |
25,046,917 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8362:Megf8
|
UTSW |
7 |
25,039,943 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8680:Megf8
|
UTSW |
7 |
25,059,166 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9080:Megf8
|
UTSW |
7 |
25,041,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9297:Megf8
|
UTSW |
7 |
25,030,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9314:Megf8
|
UTSW |
7 |
25,029,297 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9378:Megf8
|
UTSW |
7 |
25,039,840 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9530:Megf8
|
UTSW |
7 |
25,030,124 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9557:Megf8
|
UTSW |
7 |
25,058,511 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9592:Megf8
|
UTSW |
7 |
25,028,228 (GRCm39) |
missense |
probably benign |
0.29 |
|
R9612:Megf8
|
UTSW |
7 |
25,054,488 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9629:Megf8
|
UTSW |
7 |
25,043,194 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R9643:Megf8
|
UTSW |
7 |
25,046,907 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9666:Megf8
|
UTSW |
7 |
25,030,166 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9745:Megf8
|
UTSW |
7 |
25,058,133 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Z1088:Megf8
|
UTSW |
7 |
25,039,094 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Megf8
|
UTSW |
7 |
25,046,794 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Megf8
|
UTSW |
7 |
25,045,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACCTAACTCCTGTCCTACG -3'
(R):5'- TGCAGGTCACAGGAACAAAC -3'
Sequencing Primer
(F):5'- GGAGATCTCCTTCTTCTTCCTGGAG -3'
(R):5'- GGTCACAGGAACAAACTCTGAC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation