Incidental Mutation 'R4935:Acp6'
ID 380285
Institutional Source Beutler Lab
Gene Symbol Acp6
Ensembl Gene ENSMUSG00000028093
Gene Name acid phosphatase 6, lysophosphatidic
Synonyms 5730559A09Rik, ACPL1, mPACPL1
MMRRC Submission 042535-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.115) question?
Stock # R4935 (G1)
Quality Score 225
Status Not validated
Chromosome 3
Chromosomal Location 97066070-97083892 bp(+) (GRCm39)
Type of Mutation critical splice donor site (2 bp from exon)
DNA Base Change (assembly) T to C at 97079060 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000088263 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090759] [ENSMUST00000090759] [ENSMUST00000090759]
AlphaFold Q8BP40
Predicted Effect probably null
Transcript: ENSMUST00000090759
SMART Domains Protein: ENSMUSP00000088263
Gene: ENSMUSG00000028093

DomainStartEndE-ValueType
Pfam:His_Phos_2 42 228 4.6e-20 PFAM
Pfam:His_Phos_2 245 371 8e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000090759
SMART Domains Protein: ENSMUSP00000088263
Gene: ENSMUSG00000028093

DomainStartEndE-ValueType
Pfam:His_Phos_2 42 228 4.6e-20 PFAM
Pfam:His_Phos_2 245 371 8e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000090759
SMART Domains Protein: ENSMUSP00000088263
Gene: ENSMUSG00000028093

DomainStartEndE-ValueType
Pfam:His_Phos_2 42 228 4.6e-20 PFAM
Pfam:His_Phos_2 245 371 8e-9 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126438
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133965
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139898
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143234
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146143
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149900
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198329
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 97.9%
  • 10x: 94.8%
  • 20x: 86.9%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the histidine acid phosphatase protein family. The encoded protein hydrolyzes lysophosphatidic acid, which is involved in G protein-coupled receptor signaling, lipid raft modulation, and in balancing lipid composition within the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2016]
PHENOTYPE: Phenotypic analysis of mice homozygous for a gene trap allele indicates this mutation has no notable phenotype in any parameter tested. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A730071L15Rik A G 11: 6,150,442 (GRCm39) *138W probably null Het
Abcb1a T A 5: 8,787,773 (GRCm39) probably null Het
Adcyap1 A T 17: 93,511,541 (GRCm39) I172L probably benign Het
Adgrf1 A C 17: 43,606,130 (GRCm39) I85L probably benign Het
Afdn A T 17: 14,111,228 (GRCm39) T1604S probably benign Het
Angpt2 T C 8: 18,742,131 (GRCm39) Y475C probably damaging Het
Ank2 A G 3: 126,749,713 (GRCm39) S439P probably damaging Het
Ank3 T A 10: 69,812,033 (GRCm39) N366K probably damaging Het
Ankrd11 A G 8: 123,626,922 (GRCm39) S87P probably benign Het
Ano7 T A 1: 93,323,036 (GRCm39) S459T possibly damaging Het
Asxl3 G A 18: 22,656,369 (GRCm39) V1460M probably benign Het
Atg16l1 A C 1: 87,694,764 (GRCm39) N147T possibly damaging Het
Atp10a T C 7: 58,463,512 (GRCm39) V1015A probably damaging Het
Atxn7 T A 14: 14,100,401 (GRCm38) S696T probably benign Het
Babam1 C T 8: 71,852,446 (GRCm39) T184I probably benign Het
Blk A G 14: 63,618,711 (GRCm39) S175P possibly damaging Het
Col5a1 T A 2: 27,914,754 (GRCm39) F123L probably damaging Het
Csmd3 T C 15: 48,024,480 (GRCm39) Y496C probably damaging Het
Dnah3 A T 7: 119,615,700 (GRCm39) Y1676* probably null Het
Fdxacb1 T A 9: 50,683,243 (GRCm39) M402K probably benign Het
Frmd5 A G 2: 121,393,405 (GRCm39) V141A possibly damaging Het
Gapvd1 G A 2: 34,594,504 (GRCm39) R685* probably null Het
Grik2 A G 10: 49,116,826 (GRCm39) L645P probably damaging Het
H2aj T A 6: 136,785,681 (GRCm39) V115E possibly damaging Het
Hrh3 T C 2: 179,743,061 (GRCm39) Y189C probably damaging Het
Kcnc2 A G 10: 112,108,133 (GRCm39) T175A probably benign Het
Kcnv2 A G 19: 27,300,332 (GRCm39) Y61C probably damaging Het
Kif24 T C 4: 41,394,939 (GRCm39) R645G probably damaging Het
Knl1 A G 2: 118,899,438 (GRCm39) I380V possibly damaging Het
Lamb2 A G 9: 108,364,700 (GRCm39) I1151M possibly damaging Het
Leo1 A G 9: 75,353,159 (GRCm39) D234G probably benign Het
Lrp1b T G 2: 41,388,405 (GRCm39) N407H probably benign Het
Matn2 T C 15: 34,428,831 (GRCm39) S732P probably damaging Het
Mrps30 A T 13: 118,523,431 (GRCm39) F114I possibly damaging Het
Or1l8 T C 2: 36,817,713 (GRCm39) N138D probably benign Het
Or4f17-ps1 G A 2: 111,357,793 (GRCm39) V45I probably damaging Het
Or5b123 T C 19: 13,597,066 (GRCm39) I180T probably benign Het
Oxr1 T C 15: 41,676,980 (GRCm39) V179A probably benign Het
Plaur A T 7: 24,166,141 (GRCm39) S71C possibly damaging Het
Plbd2 T C 5: 120,624,786 (GRCm39) N461D possibly damaging Het
Plcb2 T A 2: 118,549,396 (GRCm39) Y322F probably damaging Het
Prkab2 T C 3: 97,569,671 (GRCm39) V79A probably damaging Het
Ptpn3 A T 4: 57,197,568 (GRCm39) C774S probably damaging Het
Ring1 A C 17: 34,242,016 (GRCm39) L131R probably benign Het
Rxfp2 G A 5: 149,975,097 (GRCm39) probably null Het
Selenbp1 A T 3: 94,845,269 (GRCm39) I122F probably benign Het
Septin7 A G 9: 25,217,468 (GRCm39) H394R probably benign Het
Slc1a7 G A 4: 107,864,758 (GRCm39) V266I probably damaging Het
Slc2a10 A G 2: 165,359,578 (GRCm39) T481A probably benign Het
Spmap2l T C 5: 77,185,200 (GRCm39) probably null Het
Tapbp A G 17: 34,144,596 (GRCm39) M231V probably benign Het
Tbxas1 A T 6: 38,999,981 (GRCm39) N256I probably benign Het
Uimc1 A G 13: 55,240,998 (GRCm39) I30T probably damaging Het
Usp48 C A 4: 137,377,669 (GRCm39) N231K probably benign Het
Zfhx3 T G 8: 109,674,482 (GRCm39) V1844G possibly damaging Het
Znrf3 A T 11: 5,233,422 (GRCm39) C212S probably damaging Het
Other mutations in Acp6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Acp6 APN 3 97,083,737 (GRCm39) missense possibly damaging 0.94
IGL01610:Acp6 APN 3 97,083,036 (GRCm39) missense possibly damaging 0.81
IGL01655:Acp6 APN 3 97,073,288 (GRCm39) critical splice donor site probably null
IGL01788:Acp6 APN 3 97,073,198 (GRCm39) missense probably damaging 1.00
IGL01845:Acp6 APN 3 97,081,123 (GRCm39) missense probably benign 0.00
IGL02978:Acp6 APN 3 97,073,875 (GRCm39) missense probably benign 0.30
IGL03180:Acp6 APN 3 97,082,951 (GRCm39) missense probably benign 0.15
R0144:Acp6 UTSW 3 97,073,145 (GRCm39) splice site probably benign
R0471:Acp6 UTSW 3 97,075,891 (GRCm39) critical splice donor site probably null
R1458:Acp6 UTSW 3 97,081,104 (GRCm39) splice site probably benign
R1889:Acp6 UTSW 3 97,073,201 (GRCm39) missense probably damaging 0.98
R1990:Acp6 UTSW 3 97,083,054 (GRCm39) missense probably damaging 1.00
R2051:Acp6 UTSW 3 97,075,333 (GRCm39) missense probably benign 0.00
R3786:Acp6 UTSW 3 97,066,605 (GRCm39) missense probably damaging 0.98
R3933:Acp6 UTSW 3 97,073,499 (GRCm39) missense probably benign 0.00
R4271:Acp6 UTSW 3 97,073,934 (GRCm39) critical splice donor site probably null
R4604:Acp6 UTSW 3 97,083,075 (GRCm39) missense probably benign 0.23
R4864:Acp6 UTSW 3 97,066,683 (GRCm39) critical splice donor site probably null
R5076:Acp6 UTSW 3 97,075,305 (GRCm39) missense probably benign 0.01
R5255:Acp6 UTSW 3 97,075,312 (GRCm39) missense probably benign 0.11
R5896:Acp6 UTSW 3 97,075,810 (GRCm39) missense probably benign 0.03
R5959:Acp6 UTSW 3 97,073,888 (GRCm39) missense probably damaging 1.00
R6004:Acp6 UTSW 3 97,082,997 (GRCm39) missense probably benign 0.11
R6938:Acp6 UTSW 3 97,082,949 (GRCm39) missense probably benign 0.04
R7593:Acp6 UTSW 3 97,073,266 (GRCm39) missense probably benign 0.30
R8485:Acp6 UTSW 3 97,066,302 (GRCm39) start gained probably benign
R8796:Acp6 UTSW 3 97,066,509 (GRCm39) missense probably benign 0.01
R8971:Acp6 UTSW 3 97,078,961 (GRCm39) missense probably damaging 1.00
X0067:Acp6 UTSW 3 97,073,273 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCCGCCCCTATGGTTTAATAG -3'
(R):5'- TGACACTCTGGACTCTGTGTAAC -3'

Sequencing Primer
(F):5'- TAGAAGCTAATTGGCGCCCTTAG -3'
(R):5'- GGACAGAGATACAGGTTCCTACC -3'
Posted On 2016-04-15