Incidental Mutation 'R0399:Or9g3'
ID 38036
Institutional Source Beutler Lab
Gene Symbol Or9g3
Ensembl Gene ENSMUSG00000075210
Gene Name olfactory receptor family 9 subfamily G member 3
Synonyms MOR213-6, Olfr1012, GA_x6K02T2Q125-47239120-47238185
MMRRC Submission 038604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.076) question?
Stock # R0399 (G1)
Quality Score 221
Status Validated
Chromosome 2
Chromosomal Location 85589783-85590718 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 85590248 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Methionine at position 157 (I157M)
Ref Sequence ENSEMBL: ENSMUSP00000148952 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099916] [ENSMUST00000214255] [ENSMUST00000214958]
AlphaFold Q8VFJ7
Predicted Effect possibly damaging
Transcript: ENSMUST00000099916
AA Change: I157M

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000097500
Gene: ENSMUSG00000075210
AA Change: I157M

DomainStartEndE-ValueType
Pfam:7tm_4 30 306 1.7e-47 PFAM
Pfam:7tm_1 40 289 8e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000214255
AA Change: I157M

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
Predicted Effect possibly damaging
Transcript: ENSMUST00000214958
AA Change: I157M

PolyPhen 2 Score 0.532 (Sensitivity: 0.88; Specificity: 0.90)
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.4%
Validation Efficiency 99% (71/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030452D12Rik T C 8: 107,231,174 (GRCm39) M120T unknown Het
Actr1a A T 19: 46,373,450 (GRCm39) probably null Het
Anapc5 A T 5: 122,929,816 (GRCm39) V555D probably damaging Het
Aox1 A G 1: 58,108,008 (GRCm39) probably null Het
Arhgap30 A G 1: 171,232,384 (GRCm39) E343G probably damaging Het
Asap2 C T 12: 21,267,998 (GRCm39) T291I possibly damaging Het
Atp5f1a T A 18: 77,869,536 (GRCm39) Y439* probably null Het
Auts2 A T 5: 131,469,362 (GRCm39) S428T probably benign Het
B3gnt7 T A 1: 86,233,433 (GRCm39) C109* probably null Het
C4b C A 17: 34,947,843 (GRCm39) Q1657H probably damaging Het
Cadm2 A T 16: 66,544,225 (GRCm39) L268* probably null Het
Cep290 G A 10: 100,390,262 (GRCm39) probably benign Het
Cep68 T G 11: 20,180,571 (GRCm39) I687L probably benign Het
Chd6 T A 2: 160,894,608 (GRCm39) D84V probably damaging Het
Clpx A G 9: 65,230,051 (GRCm39) T514A probably benign Het
Cox18 A T 5: 90,362,887 (GRCm39) C324S probably benign Het
Cryzl2 T C 1: 157,289,586 (GRCm39) Y75H probably damaging Het
Cxcr6 C T 9: 123,640,016 (GRCm39) A339V possibly damaging Het
Dock1 T C 7: 134,765,171 (GRCm39) L1721P probably benign Het
Dstyk T C 1: 132,380,818 (GRCm39) probably benign Het
Ecpas T C 4: 58,827,047 (GRCm39) T1029A possibly damaging Het
Ehf A G 2: 103,097,215 (GRCm39) Y246H probably damaging Het
Epas1 T C 17: 87,112,621 (GRCm39) V73A probably benign Het
Filip1 A G 9: 79,725,592 (GRCm39) I1009T possibly damaging Het
Glis3 A T 19: 28,276,168 (GRCm39) probably benign Het
Gm17333 A T 16: 77,649,678 (GRCm39) noncoding transcript Het
Gpc1 G A 1: 92,785,031 (GRCm39) R358H possibly damaging Het
Gpr155 A T 2: 73,200,346 (GRCm39) I387N possibly damaging Het
Gria1 A G 11: 57,076,853 (GRCm39) D83G probably damaging Het
Grid2 A G 6: 64,643,036 (GRCm39) I933V probably benign Het
Hhatl C T 9: 121,617,828 (GRCm39) A254T probably benign Het
Hook2 A G 8: 85,720,196 (GRCm39) probably benign Het
Ift140 T A 17: 25,269,314 (GRCm39) S656R possibly damaging Het
Il11ra1 A T 4: 41,766,185 (GRCm39) T241S probably benign Het
Kank1 A G 19: 25,388,606 (GRCm39) I760V probably benign Het
Kansl1 T C 11: 104,314,958 (GRCm39) E360G possibly damaging Het
Klf9 A T 19: 23,119,446 (GRCm39) S110C probably damaging Het
Klhl31 A G 9: 77,557,935 (GRCm39) N217S probably benign Het
Lct T C 1: 128,228,262 (GRCm39) Y1077C probably damaging Het
Lrrc49 A T 9: 60,517,529 (GRCm39) probably benign Het
Lrrn1 T A 6: 107,546,081 (GRCm39) H626Q probably benign Het
Mmp28 A T 11: 83,342,558 (GRCm39) L40Q probably damaging Het
Mroh1 C T 15: 76,336,299 (GRCm39) A1530V probably benign Het
Myo1e A G 9: 70,209,075 (GRCm39) probably benign Het
Naa25 A T 5: 121,573,553 (GRCm39) M761L probably benign Het
Ncln G A 10: 81,324,131 (GRCm39) A465V probably damaging Het
Nktr A G 9: 121,560,550 (GRCm39) N98S probably damaging Het
Or52h9 T A 7: 104,202,576 (GRCm39) V150E probably benign Het
Or5a1 G C 19: 12,097,734 (GRCm39) A114G possibly damaging Het
Or6d15 C A 6: 116,559,742 (GRCm39) S55I probably benign Het
Or8b4 G T 9: 37,830,849 (GRCm39) A304S possibly damaging Het
Pacsin2 T C 15: 83,270,983 (GRCm39) Y222C probably damaging Het
Pcdhb15 C T 18: 37,607,221 (GRCm39) T151M possibly damaging Het
Plcz1 C A 6: 139,968,956 (GRCm39) V161L possibly damaging Het
Ppp6c G A 2: 39,090,136 (GRCm39) probably benign Het
Relch A G 1: 105,678,684 (GRCm39) probably benign Het
Rhbdf2 T A 11: 116,494,818 (GRCm39) Y286F probably benign Het
Rtn3 A T 19: 7,435,241 (GRCm39) D231E probably damaging Het
Slc35c2 A C 2: 165,122,815 (GRCm39) Y156* probably null Het
Spata46 A G 1: 170,139,106 (GRCm39) D35G probably damaging Het
Tmed3 A G 9: 89,584,926 (GRCm39) F110L possibly damaging Het
Tmem104 T G 11: 115,092,134 (GRCm39) probably benign Het
Tpbg T A 9: 85,726,991 (GRCm39) V320E possibly damaging Het
Trib2 T C 12: 15,843,664 (GRCm39) D190G probably damaging Het
Tspan2 A G 3: 102,666,701 (GRCm39) T26A probably damaging Het
Usp17lb A C 7: 104,490,358 (GRCm39) Y190D possibly damaging Het
Utp18 C T 11: 93,770,973 (GRCm39) probably benign Het
Utp20 A T 10: 88,656,841 (GRCm39) D121E probably damaging Het
Vmn1r80 T A 7: 11,927,244 (GRCm39) M118K possibly damaging Het
Vmn1r84 T C 7: 12,095,794 (GRCm39) S300G probably benign Het
Other mutations in Or9g3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01799:Or9g3 APN 2 85,589,986 (GRCm39) missense probably benign 0.30
IGL02334:Or9g3 APN 2 85,590,503 (GRCm39) nonsense probably null
IGL03050:Or9g3 UTSW 2 85,589,785 (GRCm39) makesense probably null
R1730:Or9g3 UTSW 2 85,590,586 (GRCm39) missense possibly damaging 0.91
R2142:Or9g3 UTSW 2 85,590,021 (GRCm39) missense probably benign 0.07
R2185:Or9g3 UTSW 2 85,590,363 (GRCm39) missense probably damaging 1.00
R2412:Or9g3 UTSW 2 85,590,024 (GRCm39) missense probably damaging 0.99
R3552:Or9g3 UTSW 2 85,590,237 (GRCm39) missense possibly damaging 0.46
R3785:Or9g3 UTSW 2 85,589,797 (GRCm39) missense probably benign 0.00
R4096:Or9g3 UTSW 2 85,590,040 (GRCm39) missense possibly damaging 0.55
R4097:Or9g3 UTSW 2 85,590,040 (GRCm39) missense possibly damaging 0.55
R5199:Or9g3 UTSW 2 85,590,558 (GRCm39) missense probably damaging 1.00
R5206:Or9g3 UTSW 2 85,589,967 (GRCm39) missense probably benign 0.31
R5444:Or9g3 UTSW 2 85,590,263 (GRCm39) missense probably benign 0.39
R5567:Or9g3 UTSW 2 85,589,994 (GRCm39) missense probably damaging 1.00
R5570:Or9g3 UTSW 2 85,589,994 (GRCm39) missense probably damaging 1.00
R5956:Or9g3 UTSW 2 85,584,183 (GRCm39) unclassified probably benign
R6406:Or9g3 UTSW 2 85,590,651 (GRCm39) missense possibly damaging 0.94
R7355:Or9g3 UTSW 2 85,584,023 (GRCm39) missense probably benign 0.03
R7534:Or9g3 UTSW 2 85,589,803 (GRCm39) missense probably benign 0.03
R7751:Or9g3 UTSW 2 85,583,836 (GRCm39) missense probably benign 0.25
R8260:Or9g3 UTSW 2 85,589,820 (GRCm39) missense probably damaging 1.00
R8983:Or9g3 UTSW 2 85,584,251 (GRCm39) unclassified probably benign
R9025:Or9g3 UTSW 2 85,589,879 (GRCm39) missense possibly damaging 0.61
R9373:Or9g3 UTSW 2 85,590,275 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CCTCAGGATGGCAGCAATGATGAAG -3'
(R):5'- GATATGCAATGACTCCAGGCTCCAC -3'

Sequencing Primer
(F):5'- TGGCAGCAATGATGAAGAGGTAG -3'
(R):5'- TCCAAAGATCCTGGTGACCTG -3'
Posted On 2013-05-23