Incidental Mutation 'R4937:Aasdh'
ID 380460
Institutional Source Beutler Lab
Gene Symbol Aasdh
Ensembl Gene ENSMUSG00000055923
Gene Name aminoadipate-semialdehyde dehydrogenase
Synonyms A230062G08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.159) question?
Stock # R4937 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 77021506-77053361 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 77036501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 347 (E347*)
Ref Sequence ENSEMBL: ENSMUSP00000117639 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000069709] [ENSMUST00000120963] [ENSMUST00000123682] [ENSMUST00000126741] [ENSMUST00000146570]
AlphaFold Q80WC9
Predicted Effect probably null
Transcript: ENSMUST00000069709
AA Change: E347*
SMART Domains Protein: ENSMUSP00000069279
Gene: ENSMUSG00000055923
AA Change: E347*

DomainStartEndE-ValueType
Pfam:AMP-binding 7 449 1.3e-50 PFAM
Pfam:AMP-binding_C 458 526 7.4e-6 PFAM
Pfam:PP-binding 556 628 1.2e-6 PFAM
PQQ 775 808 5.29e-1 SMART
PQQ 818 850 4.37e-2 SMART
PQQ 860 892 2.3e1 SMART
PQQ 901 934 2.83e1 SMART
Blast:PQQ 943 973 2e-9 BLAST
PQQ 982 1014 2.61e2 SMART
PQQ 1029 1061 8.53e0 SMART
Blast:PQQ 1070 1100 2e-12 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000120963
AA Change: E347*
SMART Domains Protein: ENSMUSP00000113792
Gene: ENSMUSG00000055923
AA Change: E347*

DomainStartEndE-ValueType
Pfam:AMP-binding 7 449 1.3e-50 PFAM
Pfam:AMP-binding_C 458 526 7.4e-6 PFAM
Pfam:PP-binding 556 628 1.2e-6 PFAM
PQQ 775 808 5.29e-1 SMART
PQQ 818 850 4.37e-2 SMART
PQQ 860 892 2.3e1 SMART
PQQ 901 934 2.83e1 SMART
Blast:PQQ 943 973 2e-9 BLAST
PQQ 982 1014 2.61e2 SMART
PQQ 1029 1061 8.53e0 SMART
Blast:PQQ 1070 1100 2e-12 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000123059
Predicted Effect probably benign
Transcript: ENSMUST00000123682
SMART Domains Protein: ENSMUSP00000121050
Gene: ENSMUSG00000055923

DomainStartEndE-ValueType
Pfam:AMP-binding 7 231 1.7e-23 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000126741
AA Change: E347*
SMART Domains Protein: ENSMUSP00000118854
Gene: ENSMUSG00000055923
AA Change: E347*

DomainStartEndE-ValueType
Pfam:AMP-binding 7 403 7.5e-51 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135697
Predicted Effect probably null
Transcript: ENSMUST00000146570
AA Change: E347*
SMART Domains Protein: ENSMUSP00000117639
Gene: ENSMUSG00000055923
AA Change: E347*

DomainStartEndE-ValueType
Pfam:AMP-binding 7 449 2.1e-58 PFAM
Pfam:PP-binding 556 628 1e-7 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201283
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 98.9%
  • 3x: 98.0%
  • 10x: 95.1%
  • 20x: 88.3%
Validation Efficiency
MGI Phenotype FUNCTION: The gene product is a cytosolic enzyme involved in the production of alpha-aminoadipic acid from alpha-aminoadipic semialdehyde. It is postulated that this enzyme plays a role in lysine metabolism. There is currently debate regarding this enzyme's putative requirement of pyrroloquinoline quinine as an essential cofactor. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Jan 2010]
Allele List at MGI

All alleles(14) : Gene trapped(14)

Other mutations in this stock
Total: 102 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930522L14Rik A G 5: 109,884,067 (GRCm39) F597S probably benign Het
Abca16 G T 7: 120,126,309 (GRCm39) C1155F probably damaging Het
Adam26a T C 8: 44,021,918 (GRCm39) D524G probably damaging Het
Adamts20 G C 15: 94,277,656 (GRCm39) H269D probably benign Het
Akap9 T A 5: 4,100,145 (GRCm39) probably null Het
Akt3 T C 1: 176,877,693 (GRCm39) I358M possibly damaging Het
Aldh9a1 G T 1: 167,189,376 (GRCm39) A375S probably damaging Het
Alg2 A G 4: 47,473,974 (GRCm39) S105P probably benign Het
Amph A G 13: 19,288,515 (GRCm39) T335A probably damaging Het
Ank2 C T 3: 126,756,050 (GRCm39) V1056M probably damaging Het
Apoh A G 11: 108,298,204 (GRCm39) D168G probably benign Het
Arfgef3 C T 10: 18,465,454 (GRCm39) A2130T probably damaging Het
Arhgap30 A G 1: 171,230,897 (GRCm39) D218G probably benign Het
Ascc3 C T 10: 50,699,894 (GRCm39) P1906S probably damaging Het
Atp11b T G 3: 35,861,157 (GRCm39) probably null Het
B4galnt2 A G 11: 95,759,255 (GRCm39) V343A probably damaging Het
Barhl1 T C 2: 28,799,785 (GRCm39) Y280C probably damaging Het
Bcar1 A T 8: 112,447,669 (GRCm39) Y103N probably damaging Het
Bid A G 6: 120,872,707 (GRCm39) I150T probably benign Het
Ccdc171 T C 4: 83,467,876 (GRCm39) S74P probably damaging Het
Ccni A T 5: 93,336,113 (GRCm39) probably null Het
Cct8l1 A G 5: 25,721,891 (GRCm39) E202G probably benign Het
Cd200r3 A G 16: 44,774,622 (GRCm39) K212E probably benign Het
Cdh19 A G 1: 110,817,694 (GRCm39) S683P probably damaging Het
Ces2b A T 8: 105,559,413 (GRCm39) H93L probably benign Het
Cimip2b T A 4: 43,427,514 (GRCm39) Q270L possibly damaging Het
Clec4a1 G A 6: 122,907,654 (GRCm39) C114Y probably damaging Het
Dcc G T 18: 71,675,320 (GRCm39) S636* probably null Het
Dcdc2c T C 12: 28,580,472 (GRCm39) D187G possibly damaging Het
Dgkb G T 12: 38,164,657 (GRCm39) E150* probably null Het
Dhx30 A G 9: 109,915,029 (GRCm39) L884P probably damaging Het
Dmwd T G 7: 18,815,228 (GRCm39) probably null Het
Dnah17 T A 11: 117,932,980 (GRCm39) N3593Y probably damaging Het
Dnm2 G A 9: 21,392,633 (GRCm39) S447N probably benign Het
Elk4 G A 1: 131,945,419 (GRCm39) G99D probably damaging Het
Entpd1 A T 19: 40,727,965 (GRCm39) probably benign Het
Fam114a1 T A 5: 65,137,070 (GRCm39) D4E probably damaging Het
Fbln2 A G 6: 91,241,681 (GRCm39) D754G probably damaging Het
Fhip2a T C 19: 57,367,069 (GRCm39) V204A probably benign Het
Foxred2 T C 15: 77,840,035 (GRCm39) N85S probably damaging Het
Fut9 A G 4: 25,799,591 (GRCm39) probably benign Het
Gm1818 G A 12: 48,606,607 (GRCm39) noncoding transcript Het
Gm4894 C A 9: 49,190,000 (GRCm39) Q92K unknown Het
Gpx2 T C 12: 76,839,574 (GRCm39) I141M probably benign Het
Gusb T C 5: 130,024,326 (GRCm39) T476A probably damaging Het
Hmmr G A 11: 40,612,667 (GRCm39) T180I possibly damaging Het
Itgbl1 T C 14: 124,210,780 (GRCm39) Y493H probably benign Het
Klhdc9 G T 1: 171,187,951 (GRCm39) C93* probably null Het
Ldaf1 T C 7: 119,715,535 (GRCm39) S120P probably damaging Het
Lpar3 A G 3: 145,990,506 (GRCm39) K275E probably damaging Het
Lrp1b A G 2: 40,692,897 (GRCm39) probably null Het
Lrrc63 C T 14: 75,322,389 (GRCm39) G572S probably damaging Het
Mapk11 A T 15: 89,030,685 (GRCm39) D98E probably benign Het
Mgat4f T A 1: 134,317,714 (GRCm39) M162K probably benign Het
Net1 G A 13: 3,934,905 (GRCm39) R374W probably damaging Het
Nlrp4g T A 9: 124,354,005 (GRCm38) noncoding transcript Het
Nrap T A 19: 56,335,652 (GRCm39) Y923F probably damaging Het
Or13a20 T A 7: 140,232,534 (GRCm39) M214K probably benign Het
Or4c108 T A 2: 88,803,834 (GRCm39) I134F probably damaging Het
Or6c215 A T 10: 129,637,932 (GRCm39) V154E probably benign Het
Plxnc1 A G 10: 94,677,335 (GRCm39) V964A probably damaging Het
Pmfbp1 A G 8: 110,262,498 (GRCm39) I731V probably benign Het
Polq T A 16: 36,848,274 (GRCm39) S294T probably benign Het
Pomgnt2 T C 9: 121,811,620 (GRCm39) D387G probably benign Het
Pramel25 T C 4: 143,520,407 (GRCm39) V53A possibly damaging Het
Prmt2 G A 10: 76,056,842 (GRCm39) T227I probably damaging Het
Psmd1 T A 1: 86,010,947 (GRCm39) F341I probably damaging Het
Ptpn23 T C 9: 110,221,806 (GRCm39) M127V probably benign Het
Ptprc A G 1: 138,017,238 (GRCm39) F483L probably damaging Het
Rab35 A C 5: 115,778,147 (GRCm39) I38L probably damaging Het
Rapgef6 A G 11: 54,548,143 (GRCm39) T486A probably damaging Het
Rgl3 A T 9: 21,899,004 (GRCm39) C68* probably null Het
Rilpl1 T C 5: 124,653,594 (GRCm39) E189G possibly damaging Het
Rnf217 T C 10: 31,393,520 (GRCm39) I354V probably benign Het
Rspo3 T C 10: 29,382,524 (GRCm39) D50G probably damaging Het
Sbno1 A G 5: 124,512,672 (GRCm39) S1366P possibly damaging Het
Sema3c A G 5: 17,899,684 (GRCm39) D392G probably benign Het
Serpinb9e A T 13: 33,436,935 (GRCm39) Y85F probably benign Het
Shprh C T 10: 11,032,863 (GRCm39) T283I probably benign Het
Sipa1l1 T C 12: 82,388,103 (GRCm39) S110P probably benign Het
Slc16a12 T A 19: 34,652,643 (GRCm39) I168F probably damaging Het
Slc23a3 A G 1: 75,109,268 (GRCm39) S221P probably damaging Het
Slc35b3 A T 13: 39,116,887 (GRCm39) I366K possibly damaging Het
Slc44a5 T C 3: 153,949,252 (GRCm39) probably null Het
Slc5a12 A T 2: 110,450,753 (GRCm39) D316V probably damaging Het
Ssr3 A G 3: 65,299,874 (GRCm39) S29P probably damaging Het
Taf2 G A 15: 54,890,619 (GRCm39) Q1055* probably null Het
Them6 A T 15: 74,593,367 (GRCm39) D75V probably damaging Het
Tom1l2 A G 11: 60,149,744 (GRCm39) S239P probably damaging Het
Tspear A G 10: 77,710,877 (GRCm39) T500A probably damaging Het
Tubgcp6 G A 15: 88,985,752 (GRCm39) A1487V probably damaging Het
Uba7 G A 9: 107,856,190 (GRCm39) V522I possibly damaging Het
Virma C A 4: 11,521,147 (GRCm39) C901* probably null Het
Vmn1r172 A T 7: 23,359,312 (GRCm39) I66F possibly damaging Het
Vmn2r82 A T 10: 79,215,010 (GRCm39) Y331F probably benign Het
Wdr55 G A 18: 36,895,451 (GRCm39) V143I probably benign Het
Zbtb49 A T 5: 38,371,307 (GRCm39) D191E possibly damaging Het
Zfhx4 A G 3: 5,307,071 (GRCm39) H99R probably damaging Het
Zfp1005 C T 2: 150,110,680 (GRCm39) H457Y unknown Het
Zfp560 C T 9: 20,259,263 (GRCm39) C533Y probably damaging Het
Zfp646 C T 7: 127,478,354 (GRCm39) A177V probably benign Het
Zfp653 C T 9: 21,967,074 (GRCm39) E604K probably damaging Het
Other mutations in Aasdh
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00823:Aasdh APN 5 77,026,381 (GRCm39) unclassified probably benign
IGL01013:Aasdh APN 5 77,034,053 (GRCm39) missense possibly damaging 0.68
IGL01558:Aasdh APN 5 77,036,464 (GRCm39) missense possibly damaging 0.89
IGL02544:Aasdh APN 5 77,049,961 (GRCm39) missense probably benign 0.27
IGL02614:Aasdh APN 5 77,044,215 (GRCm39) splice site probably benign
IGL02678:Aasdh APN 5 77,035,867 (GRCm39) splice site probably benign
IGL02739:Aasdh APN 5 77,026,364 (GRCm39) missense possibly damaging 0.64
IGL02947:Aasdh APN 5 77,049,957 (GRCm39) missense probably benign 0.01
IGL03116:Aasdh APN 5 77,049,936 (GRCm39) splice site probably null
IGL03398:Aasdh APN 5 77,039,566 (GRCm39) missense probably benign 0.02
1mM(1):Aasdh UTSW 5 77,044,464 (GRCm39) missense possibly damaging 0.91
R0183:Aasdh UTSW 5 77,034,082 (GRCm39) missense probably benign 0.05
R0226:Aasdh UTSW 5 77,049,849 (GRCm39) missense probably damaging 1.00
R0367:Aasdh UTSW 5 77,049,961 (GRCm39) missense probably damaging 0.99
R0386:Aasdh UTSW 5 77,044,308 (GRCm39) missense probably damaging 0.98
R0529:Aasdh UTSW 5 77,024,114 (GRCm39) nonsense probably null
R0881:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R0882:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R1033:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R1034:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R1035:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R1036:Aasdh UTSW 5 77,024,130 (GRCm39) missense probably damaging 1.00
R1366:Aasdh UTSW 5 77,036,651 (GRCm39) missense probably benign 0.10
R1446:Aasdh UTSW 5 77,034,136 (GRCm39) missense probably benign 0.45
R1449:Aasdh UTSW 5 77,034,136 (GRCm39) missense probably benign 0.45
R1469:Aasdh UTSW 5 77,039,526 (GRCm39) missense probably damaging 0.97
R1469:Aasdh UTSW 5 77,039,526 (GRCm39) missense probably damaging 0.97
R1583:Aasdh UTSW 5 77,030,528 (GRCm39) missense probably benign 0.00
R1641:Aasdh UTSW 5 77,039,626 (GRCm39) missense probably benign 0.36
R1876:Aasdh UTSW 5 77,025,396 (GRCm39) missense probably damaging 1.00
R1895:Aasdh UTSW 5 77,039,551 (GRCm39) missense probably damaging 1.00
R1946:Aasdh UTSW 5 77,039,551 (GRCm39) missense probably damaging 1.00
R3615:Aasdh UTSW 5 77,036,629 (GRCm39) missense probably benign 0.20
R3616:Aasdh UTSW 5 77,036,629 (GRCm39) missense probably benign 0.20
R3746:Aasdh UTSW 5 77,036,501 (GRCm39) nonsense probably null
R3747:Aasdh UTSW 5 77,036,501 (GRCm39) nonsense probably null
R3748:Aasdh UTSW 5 77,036,501 (GRCm39) nonsense probably null
R3750:Aasdh UTSW 5 77,036,501 (GRCm39) nonsense probably null
R3836:Aasdh UTSW 5 77,026,315 (GRCm39) missense probably benign 0.32
R4857:Aasdh UTSW 5 77,035,131 (GRCm39) missense probably benign 0.01
R4928:Aasdh UTSW 5 77,044,535 (GRCm39) missense possibly damaging 0.65
R5762:Aasdh UTSW 5 77,044,445 (GRCm39) missense probably benign 0.00
R5866:Aasdh UTSW 5 77,024,058 (GRCm39) missense probably damaging 1.00
R5940:Aasdh UTSW 5 77,030,745 (GRCm39) missense probably benign 0.07
R6253:Aasdh UTSW 5 77,034,105 (GRCm39) missense possibly damaging 0.81
R6542:Aasdh UTSW 5 77,030,902 (GRCm39) missense probably damaging 1.00
R6825:Aasdh UTSW 5 77,036,696 (GRCm39) splice site probably null
R6868:Aasdh UTSW 5 77,039,527 (GRCm39) missense probably damaging 0.99
R6876:Aasdh UTSW 5 77,044,288 (GRCm39) missense probably damaging 1.00
R6961:Aasdh UTSW 5 77,024,148 (GRCm39) missense probably damaging 1.00
R6963:Aasdh UTSW 5 77,044,303 (GRCm39) missense probably damaging 0.99
R7069:Aasdh UTSW 5 77,024,203 (GRCm39) missense probably benign 0.03
R7220:Aasdh UTSW 5 77,049,772 (GRCm39) missense probably benign 0.13
R7545:Aasdh UTSW 5 77,027,861 (GRCm39) missense probably damaging 1.00
R7673:Aasdh UTSW 5 77,030,555 (GRCm39) missense probably benign 0.03
R7703:Aasdh UTSW 5 77,035,924 (GRCm39) missense probably damaging 0.99
R7890:Aasdh UTSW 5 77,031,969 (GRCm39) missense probably benign 0.19
R7978:Aasdh UTSW 5 77,036,515 (GRCm39) missense probably damaging 0.99
R8046:Aasdh UTSW 5 77,044,325 (GRCm39) missense probably benign
R8152:Aasdh UTSW 5 77,044,305 (GRCm39) missense probably damaging 1.00
R8425:Aasdh UTSW 5 77,034,124 (GRCm39) missense possibly damaging 0.49
R8884:Aasdh UTSW 5 77,039,641 (GRCm39) missense possibly damaging 0.94
R9028:Aasdh UTSW 5 77,023,977 (GRCm39) missense probably damaging 1.00
R9361:Aasdh UTSW 5 77,030,225 (GRCm39) missense probably benign 0.01
R9519:Aasdh UTSW 5 77,030,572 (GRCm39) missense probably benign 0.00
Z1088:Aasdh UTSW 5 77,049,004 (GRCm39) splice site probably null
Z1176:Aasdh UTSW 5 77,039,643 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- GCAAGAGTGTGCTTCCTACG -3'
(R):5'- AACGCCAACATTGCTGAGAAG -3'

Sequencing Primer
(F):5'- TACGCAAGGACATGACTTGTAC -3'
(R):5'- GATTTGGATCTGAGCTCATCAAGTCC -3'
Posted On 2016-04-15