Incidental Mutation 'R0399:Olfr215'
ID 38049
Institutional Source Beutler Lab
Gene Symbol Olfr215
Ensembl Gene ENSMUSG00000050654
Gene Name olfactory receptor 215
Synonyms MOR119-2, GA_x54KRFPKN04-58217732-58216800
MMRRC Submission 038604-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.080) question?
Stock # R0399 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 116580084-116584195 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 116582781 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Serine to Isoleucine at position 55 (S55I)
Ref Sequence ENSEMBL: ENSMUSP00000052425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061723]
AlphaFold Q8VF82
Predicted Effect probably benign
Transcript: ENSMUST00000061723
AA Change: S55I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: S55I

Pfam:7tm_4 29 306 5e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 258 1.8e-5 PFAM
Pfam:7tm_1 39 288 2.9e-15 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.4%
Validation Efficiency 99% (71/72)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310035C23Rik A G 1: 105,750,959 (GRCm38) probably benign Het
6030452D12Rik T C 8: 106,504,542 (GRCm38) M120T unknown Het
Actr1a A T 19: 46,385,011 (GRCm38) probably null Het
AI314180 T C 4: 58,827,047 (GRCm38) T1029A possibly damaging Het
Anapc5 A T 5: 122,791,753 (GRCm38) V555D probably damaging Het
Aox1 A G 1: 58,068,849 (GRCm38) probably null Het
Arhgap30 A G 1: 171,404,816 (GRCm38) E343G probably damaging Het
Asap2 C T 12: 21,217,997 (GRCm38) T291I possibly damaging Het
Atp5a1 T A 18: 77,781,836 (GRCm38) Y439* probably null Het
Auts2 A T 5: 131,440,524 (GRCm38) S428T probably benign Het
B3gnt7 T A 1: 86,305,711 (GRCm38) C109* probably null Het
C4b C A 17: 34,728,869 (GRCm38) Q1657H probably damaging Het
Cadm2 A T 16: 66,747,339 (GRCm38) L268* probably null Het
Cep290 G A 10: 100,554,400 (GRCm38) probably benign Het
Cep68 T G 11: 20,230,571 (GRCm38) I687L probably benign Het
Chd6 T A 2: 161,052,688 (GRCm38) D84V probably damaging Het
Clpx A G 9: 65,322,769 (GRCm38) T514A probably benign Het
Cox18 A T 5: 90,215,028 (GRCm38) C324S probably benign Het
Cryzl2 T C 1: 157,462,016 (GRCm38) Y75H probably damaging Het
Cxcr6 C T 9: 123,810,951 (GRCm38) A339V possibly damaging Het
Dock1 T C 7: 135,163,442 (GRCm38) L1721P probably benign Het
Dstyk T C 1: 132,453,080 (GRCm38) probably benign Het
Ehf A G 2: 103,266,870 (GRCm38) Y246H probably damaging Het
Epas1 T C 17: 86,805,193 (GRCm38) V73A probably benign Het
Filip1 A G 9: 79,818,310 (GRCm38) I1009T possibly damaging Het
Glis3 A T 19: 28,298,768 (GRCm38) probably benign Het
Gm17333 A T 16: 77,852,790 (GRCm38) noncoding transcript Het
Gpc1 G A 1: 92,857,309 (GRCm38) R358H possibly damaging Het
Gpr155 A T 2: 73,370,002 (GRCm38) I387N possibly damaging Het
Gria1 A G 11: 57,186,027 (GRCm38) D83G probably damaging Het
Grid2 A G 6: 64,666,052 (GRCm38) I933V probably benign Het
Hhatl C T 9: 121,788,762 (GRCm38) A254T probably benign Het
Hook2 A G 8: 84,993,567 (GRCm38) probably benign Het
Ift140 T A 17: 25,050,340 (GRCm38) S656R possibly damaging Het
Il11ra1 A T 4: 41,766,185 (GRCm38) T241S probably benign Het
Kank1 A G 19: 25,411,242 (GRCm38) I760V probably benign Het
Kansl1 T C 11: 104,424,132 (GRCm38) E360G possibly damaging Het
Klf9 A T 19: 23,142,082 (GRCm38) S110C probably damaging Het
Klhl31 A G 9: 77,650,653 (GRCm38) N217S probably benign Het
Lct T C 1: 128,300,525 (GRCm38) Y1077C probably damaging Het
Lrrc49 A T 9: 60,610,246 (GRCm38) probably benign Het
Lrrn1 T A 6: 107,569,120 (GRCm38) H626Q probably benign Het
Mmp28 A T 11: 83,451,732 (GRCm38) L40Q probably damaging Het
Mroh1 C T 15: 76,452,099 (GRCm38) A1530V probably benign Het
Myo1e A G 9: 70,301,793 (GRCm38) probably benign Het
Naa25 A T 5: 121,435,490 (GRCm38) M761L probably benign Het
Ncln G A 10: 81,488,297 (GRCm38) A465V probably damaging Het
Nktr A G 9: 121,731,484 (GRCm38) N98S probably damaging Het
Olfr1012 T C 2: 85,759,904 (GRCm38) I157M possibly damaging Het
Olfr651 T A 7: 104,553,369 (GRCm38) V150E probably benign Het
Olfr76 G C 19: 12,120,370 (GRCm38) A114G possibly damaging Het
Olfr878 G T 9: 37,919,553 (GRCm38) A304S possibly damaging Het
Pacsin2 T C 15: 83,386,782 (GRCm38) Y222C probably damaging Het
Pcdhb15 C T 18: 37,474,168 (GRCm38) T151M possibly damaging Het
Plcz1 C A 6: 140,023,230 (GRCm38) V161L possibly damaging Het
Ppp6c G A 2: 39,200,124 (GRCm38) probably benign Het
Rhbdf2 T A 11: 116,603,992 (GRCm38) Y286F probably benign Het
Rtn3 A T 19: 7,457,876 (GRCm38) D231E probably damaging Het
Slc35c2 A C 2: 165,280,895 (GRCm38) Y156* probably null Het
Spata46 A G 1: 170,311,537 (GRCm38) D35G probably damaging Het
Tmed3 A G 9: 89,702,873 (GRCm38) F110L possibly damaging Het
Tmem104 T G 11: 115,201,308 (GRCm38) probably benign Het
Tpbg T A 9: 85,844,938 (GRCm38) V320E possibly damaging Het
Trib2 T C 12: 15,793,663 (GRCm38) D190G probably damaging Het
Tspan2 A G 3: 102,759,385 (GRCm38) T26A probably damaging Het
Usp17lb A C 7: 104,841,151 (GRCm38) Y190D possibly damaging Het
Utp18 C T 11: 93,880,147 (GRCm38) probably benign Het
Utp20 A T 10: 88,820,979 (GRCm38) D121E probably damaging Het
Vmn1r80 T A 7: 12,193,317 (GRCm38) M118K possibly damaging Het
Vmn1r84 T C 7: 12,361,867 (GRCm38) S300G probably benign Het
Other mutations in Olfr215
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Olfr215 APN 6 116,582,335 (GRCm38) missense possibly damaging 0.93
IGL02959:Olfr215 APN 6 116,582,544 (GRCm38) missense probably damaging 1.00
IGL03053:Olfr215 APN 6 116,582,245 (GRCm38) missense possibly damaging 0.50
R0078:Olfr215 UTSW 6 116,582,740 (GRCm38) missense probably damaging 0.96
R0277:Olfr215 UTSW 6 116,582,601 (GRCm38) missense probably damaging 0.99
R0323:Olfr215 UTSW 6 116,582,601 (GRCm38) missense probably damaging 0.99
R0545:Olfr215 UTSW 6 116,582,656 (GRCm38) missense probably benign 0.01
R1213:Olfr215 UTSW 6 116,582,866 (GRCm38) missense probably benign 0.00
R1775:Olfr215 UTSW 6 116,582,964 (GRCm38) start gained probably benign
R1789:Olfr215 UTSW 6 116,582,697 (GRCm38) missense probably damaging 1.00
R4724:Olfr215 UTSW 6 116,582,937 (GRCm38) missense probably damaging 1.00
R5391:Olfr215 UTSW 6 116,582,847 (GRCm38) missense probably damaging 1.00
R5392:Olfr215 UTSW 6 116,582,418 (GRCm38) missense probably damaging 1.00
R5686:Olfr215 UTSW 6 116,582,929 (GRCm38) missense probably benign 0.00
R6124:Olfr215 UTSW 6 116,582,485 (GRCm38) missense probably benign 0.05
R7080:Olfr215 UTSW 6 116,582,353 (GRCm38) missense probably damaging 1.00
R7355:Olfr215 UTSW 6 116,582,955 (GRCm38) start gained probably benign
R9084:Olfr215 UTSW 6 116,582,271 (GRCm38) missense probably benign 0.03
Z1177:Olfr215 UTSW 6 116,582,553 (GRCm38) missense probably benign 0.01
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2013-05-23