Incidental Mutation 'R4937:Shprh'
| ID |
380491 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Shprh
|
| Ensembl Gene |
ENSMUSG00000090112 |
| Gene Name |
SNF2 histone linker PHD RING helicase |
| Synonyms |
2610103K11Rik, D230017O13Rik |
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4937 (G1)
|
| Quality Score |
224 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
11149427-11217595 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 11157119 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 283
(T283I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125457
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044053]
[ENSMUST00000054814]
[ENSMUST00000159541]
[ENSMUST00000159810]
|
| AlphaFold |
Q7TPQ3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044053
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000039422
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
Pfam:Helicase_C
|
1500 |
1613 |
1.6e-8 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000054814
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000125849
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1616 |
6e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
4e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159541
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000132870
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
3e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
low complexity region
|
1393 |
1404 |
N/A |
INTRINSIC |
|
RING
|
1423 |
1469 |
9.68e-3 |
SMART |
|
SCOP:d1fuka_
|
1504 |
1619 |
4e-8 |
SMART |
|
Blast:HELICc
|
1533 |
1613 |
6e-46 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159810
AA Change: T283I
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000125457
Gene: ENSMUSG00000090112
AA Change: T283I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
42 |
56 |
N/A |
INTRINSIC |
|
Blast:DEXDc
|
195 |
250 |
2e-12 |
BLAST |
|
low complexity region
|
253 |
265 |
N/A |
INTRINSIC |
|
DEXDc
|
295 |
866 |
4.02e-17 |
SMART |
|
H15
|
431 |
497 |
3.76e-5 |
SMART |
|
PHD
|
651 |
698 |
2.33e-5 |
SMART |
|
Blast:DEXDc
|
948 |
1026 |
2e-9 |
BLAST |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000161858
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.1%
- 20x: 88.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 (Unk et al., 2006 [PubMed 17108083]).[supplied by OMIM, Mar 2008]
PHENOTYPE: The gene product is an E3 ligase involved in poly-ubiquitination of Pcna. Neither homozygous truncation nor KO affect B cell somatic hypermutation or class switching. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,736,201 (GRCm38) |
F597S |
probably benign |
Het |
| Aasdh |
C |
A |
5: 76,888,654 (GRCm38) |
E347* |
probably null |
Het |
| Abca16 |
G |
T |
7: 120,527,086 (GRCm38) |
C1155F |
probably damaging |
Het |
| Adam26a |
T |
C |
8: 43,568,881 (GRCm38) |
D524G |
probably damaging |
Het |
| Adamts20 |
G |
C |
15: 94,379,775 (GRCm38) |
H269D |
probably benign |
Het |
| Akap9 |
T |
A |
5: 4,050,145 (GRCm38) |
|
probably null |
Het |
| Akt3 |
T |
C |
1: 177,050,127 (GRCm38) |
I358M |
possibly damaging |
Het |
| Aldh9a1 |
G |
T |
1: 167,361,807 (GRCm38) |
A375S |
probably damaging |
Het |
| Alg2 |
A |
G |
4: 47,473,974 (GRCm38) |
S105P |
probably benign |
Het |
| Amph |
A |
G |
13: 19,104,345 (GRCm38) |
T335A |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,962,401 (GRCm38) |
V1056M |
probably damaging |
Het |
| Apoh |
A |
G |
11: 108,407,378 (GRCm38) |
D168G |
probably benign |
Het |
| Arfgef3 |
C |
T |
10: 18,589,706 (GRCm38) |
A2130T |
probably damaging |
Het |
| Arhgap30 |
A |
G |
1: 171,403,329 (GRCm38) |
D218G |
probably benign |
Het |
| Ascc3 |
C |
T |
10: 50,823,798 (GRCm38) |
P1906S |
probably damaging |
Het |
| Atp11b |
T |
G |
3: 35,807,008 (GRCm38) |
|
probably null |
Het |
| B4galnt2 |
A |
G |
11: 95,868,429 (GRCm38) |
V343A |
probably damaging |
Het |
| Barhl1 |
T |
C |
2: 28,909,773 (GRCm38) |
Y280C |
probably damaging |
Het |
| Bcar1 |
A |
T |
8: 111,721,037 (GRCm38) |
Y103N |
probably damaging |
Het |
| Bid |
A |
G |
6: 120,895,746 (GRCm38) |
I150T |
probably benign |
Het |
| Ccdc171 |
T |
C |
4: 83,549,639 (GRCm38) |
S74P |
probably damaging |
Het |
| Ccni |
A |
T |
5: 93,188,254 (GRCm38) |
|
probably null |
Het |
| Cct8l1 |
A |
G |
5: 25,516,893 (GRCm38) |
E202G |
probably benign |
Het |
| Cd200r3 |
A |
G |
16: 44,954,259 (GRCm38) |
K212E |
probably benign |
Het |
| Cdh19 |
A |
G |
1: 110,889,964 (GRCm38) |
S683P |
probably damaging |
Het |
| Ces2b |
A |
T |
8: 104,832,781 (GRCm38) |
H93L |
probably benign |
Het |
| Cimip2b |
T |
A |
4: 43,427,514 (GRCm38) |
Q270L |
possibly damaging |
Het |
| Clec4a1 |
G |
A |
6: 122,930,695 (GRCm38) |
C114Y |
probably damaging |
Het |
| Dcc |
G |
T |
18: 71,542,249 (GRCm38) |
S636* |
probably null |
Het |
| Dcdc2c |
T |
C |
12: 28,530,473 (GRCm38) |
D187G |
possibly damaging |
Het |
| Dgkb |
G |
T |
12: 38,114,658 (GRCm38) |
E150* |
probably null |
Het |
| Dhx30 |
A |
G |
9: 110,085,961 (GRCm38) |
L884P |
probably damaging |
Het |
| Dmwd |
T |
G |
7: 19,081,303 (GRCm38) |
|
probably null |
Het |
| Dnah17 |
T |
A |
11: 118,042,154 (GRCm38) |
N3593Y |
probably damaging |
Het |
| Dnm2 |
G |
A |
9: 21,481,337 (GRCm38) |
S447N |
probably benign |
Het |
| Elk4 |
G |
A |
1: 132,017,681 (GRCm38) |
G99D |
probably damaging |
Het |
| Entpd1 |
A |
T |
19: 40,739,521 (GRCm38) |
|
probably benign |
Het |
| Fam114a1 |
T |
A |
5: 64,979,727 (GRCm38) |
D4E |
probably damaging |
Het |
| Fbln2 |
A |
G |
6: 91,264,699 (GRCm38) |
D754G |
probably damaging |
Het |
| Fhip2a |
T |
C |
19: 57,378,637 (GRCm38) |
V204A |
probably benign |
Het |
| Foxred2 |
T |
C |
15: 77,955,835 (GRCm38) |
N85S |
probably damaging |
Het |
| Fut9 |
A |
G |
4: 25,799,591 (GRCm38) |
|
probably benign |
Het |
| Gm13762 |
T |
A |
2: 88,973,490 (GRCm38) |
I134F |
probably damaging |
Het |
| Gm1818 |
G |
A |
12: 48,559,824 (GRCm38) |
|
noncoding transcript |
Het |
| Gm4894 |
C |
A |
9: 49,278,700 (GRCm38) |
Q92K |
unknown |
Het |
| Gpx2 |
T |
C |
12: 76,792,800 (GRCm38) |
I141M |
probably benign |
Het |
| Gusb |
T |
C |
5: 129,995,485 (GRCm38) |
T476A |
probably damaging |
Het |
| Hmmr |
G |
A |
11: 40,721,840 (GRCm38) |
T180I |
possibly damaging |
Het |
| Itgbl1 |
T |
C |
14: 123,973,368 (GRCm38) |
Y493H |
probably benign |
Het |
| Klhdc9 |
G |
T |
1: 171,360,383 (GRCm38) |
C93* |
probably null |
Het |
| Ldaf1 |
T |
C |
7: 120,116,312 (GRCm38) |
S120P |
probably damaging |
Het |
| Lpar3 |
A |
G |
3: 146,284,751 (GRCm38) |
K275E |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,802,885 (GRCm38) |
|
probably null |
Het |
| Lrrc63 |
C |
T |
14: 75,084,949 (GRCm38) |
G572S |
probably damaging |
Het |
| Mapk11 |
A |
T |
15: 89,146,482 (GRCm38) |
D98E |
probably benign |
Het |
| Mgat4f |
T |
A |
1: 134,389,976 (GRCm38) |
M162K |
probably benign |
Het |
| Net1 |
G |
A |
13: 3,884,905 (GRCm38) |
R374W |
probably damaging |
Het |
| Nlrp4g |
T |
A |
9: 124,354,005 (GRCm38) |
|
noncoding transcript |
Het |
| Nrap |
T |
A |
19: 56,347,220 (GRCm38) |
Y923F |
probably damaging |
Het |
| Or13a20 |
T |
A |
7: 140,652,621 (GRCm38) |
M214K |
probably benign |
Het |
| Or6c215 |
A |
T |
10: 129,802,063 (GRCm38) |
V154E |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,841,473 (GRCm38) |
V964A |
probably damaging |
Het |
| Pmfbp1 |
A |
G |
8: 109,535,866 (GRCm38) |
I731V |
probably benign |
Het |
| Polq |
T |
A |
16: 37,027,912 (GRCm38) |
S294T |
probably benign |
Het |
| Pomgnt2 |
T |
C |
9: 121,982,554 (GRCm38) |
D387G |
probably benign |
Het |
| Pramel25 |
T |
C |
4: 143,793,837 (GRCm38) |
V53A |
possibly damaging |
Het |
| Prmt2 |
G |
A |
10: 76,221,008 (GRCm38) |
T227I |
probably damaging |
Het |
| Psmd1 |
T |
A |
1: 86,083,225 (GRCm38) |
F341I |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,392,738 (GRCm38) |
M127V |
probably benign |
Het |
| Ptprc |
A |
G |
1: 138,089,500 (GRCm38) |
F483L |
probably damaging |
Het |
| Rab35 |
A |
C |
5: 115,640,088 (GRCm38) |
I38L |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,657,317 (GRCm38) |
T486A |
probably damaging |
Het |
| Rgl3 |
A |
T |
9: 21,987,708 (GRCm38) |
C68* |
probably null |
Het |
| Rilpl1 |
T |
C |
5: 124,515,531 (GRCm38) |
E189G |
possibly damaging |
Het |
| Rnf217 |
T |
C |
10: 31,517,524 (GRCm38) |
I354V |
probably benign |
Het |
| Rspo3 |
T |
C |
10: 29,506,528 (GRCm38) |
D50G |
probably damaging |
Het |
| Sbno1 |
A |
G |
5: 124,374,609 (GRCm38) |
S1366P |
possibly damaging |
Het |
| Sema3c |
A |
G |
5: 17,694,686 (GRCm38) |
D392G |
probably benign |
Het |
| Serpinb9e |
A |
T |
13: 33,252,952 (GRCm38) |
Y85F |
probably benign |
Het |
| Sipa1l1 |
T |
C |
12: 82,341,329 (GRCm38) |
S110P |
probably benign |
Het |
| Slc16a12 |
T |
A |
19: 34,675,243 (GRCm38) |
I168F |
probably damaging |
Het |
| Slc23a3 |
A |
G |
1: 75,132,624 (GRCm38) |
S221P |
probably damaging |
Het |
| Slc35b3 |
A |
T |
13: 38,932,911 (GRCm38) |
I366K |
possibly damaging |
Het |
| Slc44a5 |
T |
C |
3: 154,243,615 (GRCm38) |
|
probably null |
Het |
| Slc5a12 |
A |
T |
2: 110,620,408 (GRCm38) |
D316V |
probably damaging |
Het |
| Ssr3 |
A |
G |
3: 65,392,453 (GRCm38) |
S29P |
probably damaging |
Het |
| Taf2 |
G |
A |
15: 55,027,223 (GRCm38) |
Q1055* |
probably null |
Het |
| Them6 |
A |
T |
15: 74,721,518 (GRCm38) |
D75V |
probably damaging |
Het |
| Tom1l2 |
A |
G |
11: 60,258,918 (GRCm38) |
S239P |
probably damaging |
Het |
| Tspear |
A |
G |
10: 77,875,043 (GRCm38) |
T500A |
probably damaging |
Het |
| Tubgcp6 |
G |
A |
15: 89,101,549 (GRCm38) |
A1487V |
probably damaging |
Het |
| Uba7 |
G |
A |
9: 107,978,991 (GRCm38) |
V522I |
possibly damaging |
Het |
| Virma |
C |
A |
4: 11,521,147 (GRCm38) |
C901* |
probably null |
Het |
| Vmn1r172 |
A |
T |
7: 23,659,887 (GRCm38) |
I66F |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,379,176 (GRCm38) |
Y331F |
probably benign |
Het |
| Wdr55 |
G |
A |
18: 36,762,398 (GRCm38) |
V143I |
probably benign |
Het |
| Zbtb49 |
A |
T |
5: 38,213,963 (GRCm38) |
D191E |
possibly damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,242,011 (GRCm38) |
H99R |
probably damaging |
Het |
| Zfp1005 |
C |
T |
2: 150,268,760 (GRCm38) |
H457Y |
unknown |
Het |
| Zfp560 |
C |
T |
9: 20,347,967 (GRCm38) |
C533Y |
probably damaging |
Het |
| Zfp646 |
C |
T |
7: 127,879,182 (GRCm38) |
A177V |
probably benign |
Het |
| Zfp653 |
C |
T |
9: 22,055,778 (GRCm38) |
E604K |
probably damaging |
Het |
|
| Other mutations in Shprh |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Shprh
|
APN |
10 |
11,188,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00583:Shprh
|
APN |
10 |
11,188,020 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL00684:Shprh
|
APN |
10 |
11,163,037 (GRCm38) |
missense |
probably benign |
0.11 |
|
IGL01295:Shprh
|
APN |
10 |
11,183,868 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL01387:Shprh
|
APN |
10 |
11,170,254 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01635:Shprh
|
APN |
10 |
11,170,019 (GRCm38) |
nonsense |
probably null |
|
|
IGL01833:Shprh
|
APN |
10 |
11,191,062 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02013:Shprh
|
APN |
10 |
11,181,502 (GRCm38) |
splice site |
probably benign |
|
|
IGL02502:Shprh
|
APN |
10 |
11,194,357 (GRCm38) |
missense |
possibly damaging |
0.66 |
|
IGL02819:Shprh
|
APN |
10 |
11,154,765 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
PIT4581001:Shprh
|
UTSW |
10 |
11,192,494 (GRCm38) |
frame shift |
probably null |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0010:Shprh
|
UTSW |
10 |
11,151,931 (GRCm38) |
missense |
probably benign |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0053:Shprh
|
UTSW |
10 |
11,194,372 (GRCm38) |
splice site |
probably null |
|
|
R0255:Shprh
|
UTSW |
10 |
11,186,391 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R0325:Shprh
|
UTSW |
10 |
11,170,109 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0331:Shprh
|
UTSW |
10 |
11,194,170 (GRCm38) |
splice site |
probably benign |
|
|
R0494:Shprh
|
UTSW |
10 |
11,157,191 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0532:Shprh
|
UTSW |
10 |
11,162,812 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0546:Shprh
|
UTSW |
10 |
11,183,887 (GRCm38) |
splice site |
probably benign |
|
|
R0574:Shprh
|
UTSW |
10 |
11,163,077 (GRCm38) |
unclassified |
probably benign |
|
|
R0605:Shprh
|
UTSW |
10 |
11,207,112 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0662:Shprh
|
UTSW |
10 |
11,186,847 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1148:Shprh
|
UTSW |
10 |
11,213,482 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R1263:Shprh
|
UTSW |
10 |
11,159,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1588:Shprh
|
UTSW |
10 |
11,164,744 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1638:Shprh
|
UTSW |
10 |
11,157,078 (GRCm38) |
missense |
probably benign |
|
|
R1830:Shprh
|
UTSW |
10 |
11,186,911 (GRCm38) |
splice site |
probably null |
|
|
R1898:Shprh
|
UTSW |
10 |
11,186,869 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1903:Shprh
|
UTSW |
10 |
11,183,797 (GRCm38) |
nonsense |
probably null |
|
|
R2060:Shprh
|
UTSW |
10 |
11,152,120 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2225:Shprh
|
UTSW |
10 |
11,162,235 (GRCm38) |
unclassified |
probably benign |
|
|
R2363:Shprh
|
UTSW |
10 |
11,171,953 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2509:Shprh
|
UTSW |
10 |
11,166,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2891:Shprh
|
UTSW |
10 |
11,164,356 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3077:Shprh
|
UTSW |
10 |
11,170,413 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3150:Shprh
|
UTSW |
10 |
11,170,030 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3796:Shprh
|
UTSW |
10 |
11,178,757 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R4196:Shprh
|
UTSW |
10 |
11,207,860 (GRCm38) |
utr 3 prime |
probably benign |
|
|
R4423:Shprh
|
UTSW |
10 |
11,186,518 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R4488:Shprh
|
UTSW |
10 |
11,160,471 (GRCm38) |
missense |
probably benign |
0.17 |
|
R4748:Shprh
|
UTSW |
10 |
11,170,476 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4768:Shprh
|
UTSW |
10 |
11,181,540 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4867:Shprh
|
UTSW |
10 |
11,164,557 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5140:Shprh
|
UTSW |
10 |
11,154,705 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5318:Shprh
|
UTSW |
10 |
11,166,557 (GRCm38) |
missense |
probably benign |
0.04 |
|
R5323:Shprh
|
UTSW |
10 |
11,170,297 (GRCm38) |
splice site |
probably null |
|
|
R5450:Shprh
|
UTSW |
10 |
11,212,330 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R5872:Shprh
|
UTSW |
10 |
11,188,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6030:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
0.37 |
|
R6392:Shprh
|
UTSW |
10 |
11,178,741 (GRCm38) |
nonsense |
probably null |
|
|
R6416:Shprh
|
UTSW |
10 |
11,167,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6470:Shprh
|
UTSW |
10 |
11,171,937 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R6513:Shprh
|
UTSW |
10 |
11,186,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6530:Shprh
|
UTSW |
10 |
11,194,267 (GRCm38) |
missense |
probably benign |
0.02 |
|
R6678:Shprh
|
UTSW |
10 |
11,166,545 (GRCm38) |
missense |
probably benign |
0.16 |
|
R6757:Shprh
|
UTSW |
10 |
11,181,508 (GRCm38) |
splice site |
probably null |
|
|
R6971:Shprh
|
UTSW |
10 |
11,166,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7158:Shprh
|
UTSW |
10 |
11,166,730 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7582:Shprh
|
UTSW |
10 |
11,164,705 (GRCm38) |
missense |
probably benign |
|
|
R7757:Shprh
|
UTSW |
10 |
11,162,180 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7812:Shprh
|
UTSW |
10 |
11,151,991 (GRCm38) |
missense |
probably benign |
|
|
R7998:Shprh
|
UTSW |
10 |
11,185,341 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8061:Shprh
|
UTSW |
10 |
11,212,333 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R8082:Shprh
|
UTSW |
10 |
11,151,811 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8116:Shprh
|
UTSW |
10 |
11,213,461 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8390:Shprh
|
UTSW |
10 |
11,187,983 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8445:Shprh
|
UTSW |
10 |
11,181,569 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8530:Shprh
|
UTSW |
10 |
11,151,934 (GRCm38) |
missense |
probably benign |
0.37 |
|
R8759:Shprh
|
UTSW |
10 |
11,157,164 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R8937:Shprh
|
UTSW |
10 |
11,185,437 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R8995:Shprh
|
UTSW |
10 |
11,164,830 (GRCm38) |
nonsense |
probably null |
|
|
R9053:Shprh
|
UTSW |
10 |
11,154,702 (GRCm38) |
missense |
probably benign |
0.04 |
|
R9131:Shprh
|
UTSW |
10 |
11,162,845 (GRCm38) |
missense |
possibly damaging |
0.58 |
|
R9176:Shprh
|
UTSW |
10 |
11,160,576 (GRCm38) |
missense |
probably benign |
0.02 |
|
R9391:Shprh
|
UTSW |
10 |
11,162,889 (GRCm38) |
missense |
probably benign |
0.05 |
|
R9423:Shprh
|
UTSW |
10 |
11,205,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9563:Shprh
|
UTSW |
10 |
11,166,491 (GRCm38) |
nonsense |
probably null |
|
|
R9668:Shprh
|
UTSW |
10 |
11,206,332 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9709:Shprh
|
UTSW |
10 |
11,162,830 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R9718:Shprh
|
UTSW |
10 |
11,213,504 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9750:Shprh
|
UTSW |
10 |
11,164,460 (GRCm38) |
missense |
probably damaging |
0.98 |
|
RF012:Shprh
|
UTSW |
10 |
11,164,841 (GRCm38) |
missense |
probably benign |
0.02 |
|
V8831:Shprh
|
UTSW |
10 |
11,186,862 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,186,447 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Shprh
|
UTSW |
10 |
11,164,553 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Shprh
|
UTSW |
10 |
11,151,762 (GRCm38) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TTAGGGGTGAGACCAATCCAG -3'
(R):5'- TTGCCGTCACCCCAATACATG -3'
Sequencing Primer
(F):5'- GTGAGACCAATCCAGAGATTATTG -3'
(R):5'- ATGCCCCACTATTAACTATCTGTAAC -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation