Incidental Mutation 'R4937:Arfgef3'
| ID |
380492 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arfgef3
|
| Ensembl Gene |
ENSMUSG00000019852 |
| Gene Name |
ARFGEF family member 3 |
| Synonyms |
B930094H20Rik, BIG3, D10Bwg1379e |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.146)
|
| Stock # |
R4937 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
10 |
| Chromosomal Location |
18463759-18619506 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 18465454 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 2130
(A2130T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000149210
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000019999]
[ENSMUST00000215836]
|
| AlphaFold |
Q3UGY8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000019999
|
| SMART Domains |
Protein: ENSMUSP00000019999
Gene: ENSMUSG00000019852
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DCB
|
1 |
170 |
7.1e-15 |
PFAM |
|
low complexity region
|
236 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
276 |
295 |
N/A |
INTRINSIC |
|
low complexity region
|
452 |
462 |
N/A |
INTRINSIC |
|
Sec7
|
582 |
794 |
6e-54 |
SMART |
|
Blast:Sec7
|
798 |
873 |
3e-20 |
BLAST |
|
low complexity region
|
927 |
940 |
N/A |
INTRINSIC |
|
Pfam:DUF1981
|
1237 |
1312 |
1.9e-14 |
PFAM |
|
low complexity region
|
1641 |
1652 |
N/A |
INTRINSIC |
|
low complexity region
|
1710 |
1723 |
N/A |
INTRINSIC |
|
low complexity region
|
1838 |
1856 |
N/A |
INTRINSIC |
|
low complexity region
|
2088 |
2099 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000215836
AA Change: A2130T
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.0%
- 10x: 95.1%
- 20x: 88.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased insulin granule biogenesis and insulin secretion. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 102 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930522L14Rik |
A |
G |
5: 109,884,067 (GRCm39) |
F597S |
probably benign |
Het |
| Aasdh |
C |
A |
5: 77,036,501 (GRCm39) |
E347* |
probably null |
Het |
| Abca16 |
G |
T |
7: 120,126,309 (GRCm39) |
C1155F |
probably damaging |
Het |
| Adam26a |
T |
C |
8: 44,021,918 (GRCm39) |
D524G |
probably damaging |
Het |
| Adamts20 |
G |
C |
15: 94,277,656 (GRCm39) |
H269D |
probably benign |
Het |
| Akap9 |
T |
A |
5: 4,100,145 (GRCm39) |
|
probably null |
Het |
| Akt3 |
T |
C |
1: 176,877,693 (GRCm39) |
I358M |
possibly damaging |
Het |
| Aldh9a1 |
G |
T |
1: 167,189,376 (GRCm39) |
A375S |
probably damaging |
Het |
| Alg2 |
A |
G |
4: 47,473,974 (GRCm39) |
S105P |
probably benign |
Het |
| Amph |
A |
G |
13: 19,288,515 (GRCm39) |
T335A |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,756,050 (GRCm39) |
V1056M |
probably damaging |
Het |
| Apoh |
A |
G |
11: 108,298,204 (GRCm39) |
D168G |
probably benign |
Het |
| Arhgap30 |
A |
G |
1: 171,230,897 (GRCm39) |
D218G |
probably benign |
Het |
| Ascc3 |
C |
T |
10: 50,699,894 (GRCm39) |
P1906S |
probably damaging |
Het |
| Atp11b |
T |
G |
3: 35,861,157 (GRCm39) |
|
probably null |
Het |
| B4galnt2 |
A |
G |
11: 95,759,255 (GRCm39) |
V343A |
probably damaging |
Het |
| Barhl1 |
T |
C |
2: 28,799,785 (GRCm39) |
Y280C |
probably damaging |
Het |
| Bcar1 |
A |
T |
8: 112,447,669 (GRCm39) |
Y103N |
probably damaging |
Het |
| Bid |
A |
G |
6: 120,872,707 (GRCm39) |
I150T |
probably benign |
Het |
| Ccdc171 |
T |
C |
4: 83,467,876 (GRCm39) |
S74P |
probably damaging |
Het |
| Ccni |
A |
T |
5: 93,336,113 (GRCm39) |
|
probably null |
Het |
| Cct8l1 |
A |
G |
5: 25,721,891 (GRCm39) |
E202G |
probably benign |
Het |
| Cd200r3 |
A |
G |
16: 44,774,622 (GRCm39) |
K212E |
probably benign |
Het |
| Cdh19 |
A |
G |
1: 110,817,694 (GRCm39) |
S683P |
probably damaging |
Het |
| Ces2b |
A |
T |
8: 105,559,413 (GRCm39) |
H93L |
probably benign |
Het |
| Cimip2b |
T |
A |
4: 43,427,514 (GRCm39) |
Q270L |
possibly damaging |
Het |
| Clec4a1 |
G |
A |
6: 122,907,654 (GRCm39) |
C114Y |
probably damaging |
Het |
| Dcc |
G |
T |
18: 71,675,320 (GRCm39) |
S636* |
probably null |
Het |
| Dcdc2c |
T |
C |
12: 28,580,472 (GRCm39) |
D187G |
possibly damaging |
Het |
| Dgkb |
G |
T |
12: 38,164,657 (GRCm39) |
E150* |
probably null |
Het |
| Dhx30 |
A |
G |
9: 109,915,029 (GRCm39) |
L884P |
probably damaging |
Het |
| Dmwd |
T |
G |
7: 18,815,228 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
T |
A |
11: 117,932,980 (GRCm39) |
N3593Y |
probably damaging |
Het |
| Dnm2 |
G |
A |
9: 21,392,633 (GRCm39) |
S447N |
probably benign |
Het |
| Elk4 |
G |
A |
1: 131,945,419 (GRCm39) |
G99D |
probably damaging |
Het |
| Entpd1 |
A |
T |
19: 40,727,965 (GRCm39) |
|
probably benign |
Het |
| Fam114a1 |
T |
A |
5: 65,137,070 (GRCm39) |
D4E |
probably damaging |
Het |
| Fbln2 |
A |
G |
6: 91,241,681 (GRCm39) |
D754G |
probably damaging |
Het |
| Fhip2a |
T |
C |
19: 57,367,069 (GRCm39) |
V204A |
probably benign |
Het |
| Foxred2 |
T |
C |
15: 77,840,035 (GRCm39) |
N85S |
probably damaging |
Het |
| Fut9 |
A |
G |
4: 25,799,591 (GRCm39) |
|
probably benign |
Het |
| Gm1818 |
G |
A |
12: 48,606,607 (GRCm39) |
|
noncoding transcript |
Het |
| Gm4894 |
C |
A |
9: 49,190,000 (GRCm39) |
Q92K |
unknown |
Het |
| Gpx2 |
T |
C |
12: 76,839,574 (GRCm39) |
I141M |
probably benign |
Het |
| Gusb |
T |
C |
5: 130,024,326 (GRCm39) |
T476A |
probably damaging |
Het |
| Hmmr |
G |
A |
11: 40,612,667 (GRCm39) |
T180I |
possibly damaging |
Het |
| Itgbl1 |
T |
C |
14: 124,210,780 (GRCm39) |
Y493H |
probably benign |
Het |
| Klhdc9 |
G |
T |
1: 171,187,951 (GRCm39) |
C93* |
probably null |
Het |
| Ldaf1 |
T |
C |
7: 119,715,535 (GRCm39) |
S120P |
probably damaging |
Het |
| Lpar3 |
A |
G |
3: 145,990,506 (GRCm39) |
K275E |
probably damaging |
Het |
| Lrp1b |
A |
G |
2: 40,692,897 (GRCm39) |
|
probably null |
Het |
| Lrrc63 |
C |
T |
14: 75,322,389 (GRCm39) |
G572S |
probably damaging |
Het |
| Mapk11 |
A |
T |
15: 89,030,685 (GRCm39) |
D98E |
probably benign |
Het |
| Mgat4f |
T |
A |
1: 134,317,714 (GRCm39) |
M162K |
probably benign |
Het |
| Net1 |
G |
A |
13: 3,934,905 (GRCm39) |
R374W |
probably damaging |
Het |
| Nlrp4g |
T |
A |
9: 124,354,005 (GRCm38) |
|
noncoding transcript |
Het |
| Nrap |
T |
A |
19: 56,335,652 (GRCm39) |
Y923F |
probably damaging |
Het |
| Or13a20 |
T |
A |
7: 140,232,534 (GRCm39) |
M214K |
probably benign |
Het |
| Or4c108 |
T |
A |
2: 88,803,834 (GRCm39) |
I134F |
probably damaging |
Het |
| Or6c215 |
A |
T |
10: 129,637,932 (GRCm39) |
V154E |
probably benign |
Het |
| Plxnc1 |
A |
G |
10: 94,677,335 (GRCm39) |
V964A |
probably damaging |
Het |
| Pmfbp1 |
A |
G |
8: 110,262,498 (GRCm39) |
I731V |
probably benign |
Het |
| Polq |
T |
A |
16: 36,848,274 (GRCm39) |
S294T |
probably benign |
Het |
| Pomgnt2 |
T |
C |
9: 121,811,620 (GRCm39) |
D387G |
probably benign |
Het |
| Pramel25 |
T |
C |
4: 143,520,407 (GRCm39) |
V53A |
possibly damaging |
Het |
| Prmt2 |
G |
A |
10: 76,056,842 (GRCm39) |
T227I |
probably damaging |
Het |
| Psmd1 |
T |
A |
1: 86,010,947 (GRCm39) |
F341I |
probably damaging |
Het |
| Ptpn23 |
T |
C |
9: 110,221,806 (GRCm39) |
M127V |
probably benign |
Het |
| Ptprc |
A |
G |
1: 138,017,238 (GRCm39) |
F483L |
probably damaging |
Het |
| Rab35 |
A |
C |
5: 115,778,147 (GRCm39) |
I38L |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,548,143 (GRCm39) |
T486A |
probably damaging |
Het |
| Rgl3 |
A |
T |
9: 21,899,004 (GRCm39) |
C68* |
probably null |
Het |
| Rilpl1 |
T |
C |
5: 124,653,594 (GRCm39) |
E189G |
possibly damaging |
Het |
| Rnf217 |
T |
C |
10: 31,393,520 (GRCm39) |
I354V |
probably benign |
Het |
| Rspo3 |
T |
C |
10: 29,382,524 (GRCm39) |
D50G |
probably damaging |
Het |
| Sbno1 |
A |
G |
5: 124,512,672 (GRCm39) |
S1366P |
possibly damaging |
Het |
| Sema3c |
A |
G |
5: 17,899,684 (GRCm39) |
D392G |
probably benign |
Het |
| Serpinb9e |
A |
T |
13: 33,436,935 (GRCm39) |
Y85F |
probably benign |
Het |
| Shprh |
C |
T |
10: 11,032,863 (GRCm39) |
T283I |
probably benign |
Het |
| Sipa1l1 |
T |
C |
12: 82,388,103 (GRCm39) |
S110P |
probably benign |
Het |
| Slc16a12 |
T |
A |
19: 34,652,643 (GRCm39) |
I168F |
probably damaging |
Het |
| Slc23a3 |
A |
G |
1: 75,109,268 (GRCm39) |
S221P |
probably damaging |
Het |
| Slc35b3 |
A |
T |
13: 39,116,887 (GRCm39) |
I366K |
possibly damaging |
Het |
| Slc44a5 |
T |
C |
3: 153,949,252 (GRCm39) |
|
probably null |
Het |
| Slc5a12 |
A |
T |
2: 110,450,753 (GRCm39) |
D316V |
probably damaging |
Het |
| Ssr3 |
A |
G |
3: 65,299,874 (GRCm39) |
S29P |
probably damaging |
Het |
| Taf2 |
G |
A |
15: 54,890,619 (GRCm39) |
Q1055* |
probably null |
Het |
| Them6 |
A |
T |
15: 74,593,367 (GRCm39) |
D75V |
probably damaging |
Het |
| Tom1l2 |
A |
G |
11: 60,149,744 (GRCm39) |
S239P |
probably damaging |
Het |
| Tspear |
A |
G |
10: 77,710,877 (GRCm39) |
T500A |
probably damaging |
Het |
| Tubgcp6 |
G |
A |
15: 88,985,752 (GRCm39) |
A1487V |
probably damaging |
Het |
| Uba7 |
G |
A |
9: 107,856,190 (GRCm39) |
V522I |
possibly damaging |
Het |
| Virma |
C |
A |
4: 11,521,147 (GRCm39) |
C901* |
probably null |
Het |
| Vmn1r172 |
A |
T |
7: 23,359,312 (GRCm39) |
I66F |
possibly damaging |
Het |
| Vmn2r82 |
A |
T |
10: 79,215,010 (GRCm39) |
Y331F |
probably benign |
Het |
| Wdr55 |
G |
A |
18: 36,895,451 (GRCm39) |
V143I |
probably benign |
Het |
| Zbtb49 |
A |
T |
5: 38,371,307 (GRCm39) |
D191E |
possibly damaging |
Het |
| Zfhx4 |
A |
G |
3: 5,307,071 (GRCm39) |
H99R |
probably damaging |
Het |
| Zfp1005 |
C |
T |
2: 150,110,680 (GRCm39) |
H457Y |
unknown |
Het |
| Zfp560 |
C |
T |
9: 20,259,263 (GRCm39) |
C533Y |
probably damaging |
Het |
| Zfp646 |
C |
T |
7: 127,478,354 (GRCm39) |
A177V |
probably benign |
Het |
| Zfp653 |
C |
T |
9: 21,967,074 (GRCm39) |
E604K |
probably damaging |
Het |
|
| Other mutations in Arfgef3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00769:Arfgef3
|
APN |
10 |
18,536,352 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL00835:Arfgef3
|
APN |
10 |
18,537,106 (GRCm39) |
missense |
probably benign |
|
|
IGL00961:Arfgef3
|
APN |
10 |
18,486,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01400:Arfgef3
|
APN |
10 |
18,528,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01501:Arfgef3
|
APN |
10 |
18,476,308 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01595:Arfgef3
|
APN |
10 |
18,470,660 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01695:Arfgef3
|
APN |
10 |
18,479,167 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01774:Arfgef3
|
APN |
10 |
18,619,363 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02348:Arfgef3
|
APN |
10 |
18,467,095 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02371:Arfgef3
|
APN |
10 |
18,522,287 (GRCm39) |
missense |
probably benign |
|
|
IGL02400:Arfgef3
|
APN |
10 |
18,522,005 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02630:Arfgef3
|
APN |
10 |
18,537,140 (GRCm39) |
splice site |
probably benign |
|
|
IGL02815:Arfgef3
|
APN |
10 |
18,528,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03178:Arfgef3
|
APN |
10 |
18,488,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03182:Arfgef3
|
APN |
10 |
18,476,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03267:Arfgef3
|
APN |
10 |
18,467,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03294:Arfgef3
|
APN |
10 |
18,540,660 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03410:Arfgef3
|
APN |
10 |
18,476,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Bow-wow
|
UTSW |
10 |
18,522,478 (GRCm39) |
nonsense |
probably null |
|
|
R0098:Arfgef3
|
UTSW |
10 |
18,465,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0098:Arfgef3
|
UTSW |
10 |
18,465,390 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0141:Arfgef3
|
UTSW |
10 |
18,473,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0164:Arfgef3
|
UTSW |
10 |
18,523,663 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0164:Arfgef3
|
UTSW |
10 |
18,523,663 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0241:Arfgef3
|
UTSW |
10 |
18,474,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0334:Arfgef3
|
UTSW |
10 |
18,468,029 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0352:Arfgef3
|
UTSW |
10 |
18,537,135 (GRCm39) |
missense |
probably benign |
0.17 |
|
R0415:Arfgef3
|
UTSW |
10 |
18,488,875 (GRCm39) |
splice site |
probably benign |
|
|
R0417:Arfgef3
|
UTSW |
10 |
18,479,259 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0442:Arfgef3
|
UTSW |
10 |
18,553,563 (GRCm39) |
splice site |
probably benign |
|
|
R0507:Arfgef3
|
UTSW |
10 |
18,467,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0573:Arfgef3
|
UTSW |
10 |
18,475,036 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0582:Arfgef3
|
UTSW |
10 |
18,487,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0609:Arfgef3
|
UTSW |
10 |
18,473,179 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0826:Arfgef3
|
UTSW |
10 |
18,465,414 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0919:Arfgef3
|
UTSW |
10 |
18,465,483 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0980:Arfgef3
|
UTSW |
10 |
18,467,866 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1027:Arfgef3
|
UTSW |
10 |
18,467,123 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1140:Arfgef3
|
UTSW |
10 |
18,473,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1491:Arfgef3
|
UTSW |
10 |
18,522,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1493:Arfgef3
|
UTSW |
10 |
18,506,627 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1529:Arfgef3
|
UTSW |
10 |
18,488,970 (GRCm39) |
nonsense |
probably null |
|
|
R1564:Arfgef3
|
UTSW |
10 |
18,467,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1654:Arfgef3
|
UTSW |
10 |
18,500,896 (GRCm39) |
missense |
probably null |
0.15 |
|
R1868:Arfgef3
|
UTSW |
10 |
18,537,135 (GRCm39) |
missense |
probably benign |
0.17 |
|
R1876:Arfgef3
|
UTSW |
10 |
18,473,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1908:Arfgef3
|
UTSW |
10 |
18,528,511 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2211:Arfgef3
|
UTSW |
10 |
18,467,993 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R2316:Arfgef3
|
UTSW |
10 |
18,492,701 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2393:Arfgef3
|
UTSW |
10 |
18,473,535 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2407:Arfgef3
|
UTSW |
10 |
18,553,614 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3076:Arfgef3
|
UTSW |
10 |
18,479,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3077:Arfgef3
|
UTSW |
10 |
18,479,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3963:Arfgef3
|
UTSW |
10 |
18,468,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4201:Arfgef3
|
UTSW |
10 |
18,495,530 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4241:Arfgef3
|
UTSW |
10 |
18,500,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4244:Arfgef3
|
UTSW |
10 |
18,506,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4395:Arfgef3
|
UTSW |
10 |
18,473,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Arfgef3
|
UTSW |
10 |
18,483,423 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4480:Arfgef3
|
UTSW |
10 |
18,476,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4499:Arfgef3
|
UTSW |
10 |
18,484,091 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4589:Arfgef3
|
UTSW |
10 |
18,521,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4635:Arfgef3
|
UTSW |
10 |
18,510,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4776:Arfgef3
|
UTSW |
10 |
18,529,995 (GRCm39) |
missense |
probably benign |
|
|
R4801:Arfgef3
|
UTSW |
10 |
18,467,654 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4802:Arfgef3
|
UTSW |
10 |
18,467,654 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4807:Arfgef3
|
UTSW |
10 |
18,522,385 (GRCm39) |
missense |
probably benign |
|
|
R4828:Arfgef3
|
UTSW |
10 |
18,528,441 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4861:Arfgef3
|
UTSW |
10 |
18,483,479 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4861:Arfgef3
|
UTSW |
10 |
18,483,479 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4917:Arfgef3
|
UTSW |
10 |
18,492,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4918:Arfgef3
|
UTSW |
10 |
18,492,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4922:Arfgef3
|
UTSW |
10 |
18,467,934 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4929:Arfgef3
|
UTSW |
10 |
18,506,599 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5290:Arfgef3
|
UTSW |
10 |
18,476,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5410:Arfgef3
|
UTSW |
10 |
18,486,985 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5807:Arfgef3
|
UTSW |
10 |
18,523,546 (GRCm39) |
splice site |
probably null |
|
|
R5832:Arfgef3
|
UTSW |
10 |
18,506,168 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5887:Arfgef3
|
UTSW |
10 |
18,483,413 (GRCm39) |
nonsense |
probably null |
|
|
R6272:Arfgef3
|
UTSW |
10 |
18,522,711 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6302:Arfgef3
|
UTSW |
10 |
18,528,589 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6397:Arfgef3
|
UTSW |
10 |
18,483,413 (GRCm39) |
nonsense |
probably null |
|
|
R6495:Arfgef3
|
UTSW |
10 |
18,486,950 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6707:Arfgef3
|
UTSW |
10 |
18,496,903 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6814:Arfgef3
|
UTSW |
10 |
18,470,767 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6830:Arfgef3
|
UTSW |
10 |
18,540,637 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6870:Arfgef3
|
UTSW |
10 |
18,522,478 (GRCm39) |
nonsense |
probably null |
|
|
R6941:Arfgef3
|
UTSW |
10 |
18,501,203 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7094:Arfgef3
|
UTSW |
10 |
18,522,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7179:Arfgef3
|
UTSW |
10 |
18,475,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7204:Arfgef3
|
UTSW |
10 |
18,522,210 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7247:Arfgef3
|
UTSW |
10 |
18,501,139 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7249:Arfgef3
|
UTSW |
10 |
18,506,583 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7318:Arfgef3
|
UTSW |
10 |
18,506,211 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7391:Arfgef3
|
UTSW |
10 |
18,522,007 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7527:Arfgef3
|
UTSW |
10 |
18,522,377 (GRCm39) |
missense |
probably benign |
|
|
R7618:Arfgef3
|
UTSW |
10 |
18,522,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7779:Arfgef3
|
UTSW |
10 |
18,470,771 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7851:Arfgef3
|
UTSW |
10 |
18,468,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8112:Arfgef3
|
UTSW |
10 |
18,528,379 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R8133:Arfgef3
|
UTSW |
10 |
18,486,951 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8242:Arfgef3
|
UTSW |
10 |
18,505,824 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8369:Arfgef3
|
UTSW |
10 |
18,465,477 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8396:Arfgef3
|
UTSW |
10 |
18,528,280 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8553:Arfgef3
|
UTSW |
10 |
18,479,278 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8798:Arfgef3
|
UTSW |
10 |
18,522,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8821:Arfgef3
|
UTSW |
10 |
18,528,491 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8831:Arfgef3
|
UTSW |
10 |
18,528,491 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8918:Arfgef3
|
UTSW |
10 |
18,511,453 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8929:Arfgef3
|
UTSW |
10 |
18,479,203 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9001:Arfgef3
|
UTSW |
10 |
18,522,476 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9077:Arfgef3
|
UTSW |
10 |
18,500,899 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R9258:Arfgef3
|
UTSW |
10 |
18,465,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9267:Arfgef3
|
UTSW |
10 |
18,475,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9358:Arfgef3
|
UTSW |
10 |
18,492,628 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9388:Arfgef3
|
UTSW |
10 |
18,505,877 (GRCm39) |
missense |
probably benign |
0.35 |
|
R9389:Arfgef3
|
UTSW |
10 |
18,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9563:Arfgef3
|
UTSW |
10 |
18,522,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9713:Arfgef3
|
UTSW |
10 |
18,528,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0026:Arfgef3
|
UTSW |
10 |
18,528,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arfgef3
|
UTSW |
10 |
18,510,600 (GRCm39) |
missense |
probably benign |
0.26 |
|
Z1176:Arfgef3
|
UTSW |
10 |
18,484,106 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Z1176:Arfgef3
|
UTSW |
10 |
18,467,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Arfgef3
|
UTSW |
10 |
18,503,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Arfgef3
|
UTSW |
10 |
18,483,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGACAGGCAGATGCTGTAG -3'
(R):5'- TGTAGACATTTGCTCTTCCTAGATG -3'
Sequencing Primer
(F):5'- AGGCATTTCCTTAGGATTTGAGTCC -3'
(R):5'- AGAACTATATCCTGACTAAGCCTG -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation