Incidental Mutation 'R4933:Or2a7'
ID 380713
Institutional Source Beutler Lab
Gene Symbol Or2a7
Ensembl Gene ENSMUSG00000043605
Gene Name olfactory receptor family 2 subfamily A member 7
Synonyms MOR261-6, GA_x6K02T2P3E9-4384160-4383228, Olfr13
MMRRC Submission 042533-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.437) question?
Stock # R4933 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 43150922-43151854 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 43151255 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 112 (L112F)
Ref Sequence ENSEMBL: ENSMUSP00000149893 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059512] [ENSMUST00000205175] [ENSMUST00000216179]
AlphaFold P34984
Predicted Effect probably benign
Transcript: ENSMUST00000059512
AA Change: L112F

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000053813
Gene: ENSMUSG00000043605
AA Change: L112F

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 4.8e-60 PFAM
Pfam:7TM_GPCR_Srsx 34 218 1.3e-6 PFAM
Pfam:7tm_1 40 289 6e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205175
SMART Domains Protein: ENSMUSP00000145490
Gene: ENSMUSG00000071481

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 7.5e-60 PFAM
Pfam:7tm_1 40 289 3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000216179
AA Change: L112F

PolyPhen 2 Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency 97% (73/75)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,276,226 (GRCm39) E643G probably damaging Het
Abca2 T C 2: 25,334,839 (GRCm39) V1937A probably benign Het
Acot10 A T 15: 20,666,416 (GRCm39) N108K possibly damaging Het
Agtpbp1 A T 13: 59,648,386 (GRCm39) M478K probably benign Het
Akirin1 G A 4: 123,630,651 (GRCm39) S191F probably damaging Het
Aoc1l3 T C 6: 48,964,426 (GRCm39) S145P probably damaging Het
Aurkb T C 11: 68,938,970 (GRCm39) probably benign Het
Cabyr T C 18: 12,877,549 (GRCm39) probably benign Het
Ccp110 A G 7: 118,324,542 (GRCm39) E688G probably damaging Het
Champ1 T A 8: 13,929,137 (GRCm39) S432T probably benign Het
Crybg1 T A 10: 43,875,209 (GRCm39) N633I probably damaging Het
Dagla A T 19: 10,247,079 (GRCm39) probably null Het
Dkkl1 A T 7: 44,860,949 (GRCm39) L10Q probably null Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Fndc7 G T 3: 108,783,986 (GRCm39) Q208K probably benign Het
Gins4 A T 8: 23,724,796 (GRCm39) C53S probably damaging Het
Gja8 T A 3: 96,826,351 (GRCm39) probably benign Het
Golph3l T A 3: 95,524,734 (GRCm39) N328K probably benign Het
Haus6 A C 4: 86,503,524 (GRCm39) probably benign Het
Hdac5 A G 11: 102,091,389 (GRCm39) probably benign Het
Ide A G 19: 37,255,155 (GRCm39) Y883H unknown Het
Igf2r A G 17: 12,910,764 (GRCm39) probably null Het
Kdm3b T C 18: 34,943,446 (GRCm39) Y723H probably damaging Het
Kif21b G A 1: 136,079,063 (GRCm39) probably null Het
Lancl1 A T 1: 67,060,193 (GRCm39) N77K probably benign Het
Lyst T A 13: 13,812,349 (GRCm39) N920K probably damaging Het
Lyst G A 13: 13,933,963 (GRCm39) V3554I probably benign Het
Map1a G A 2: 121,136,386 (GRCm39) A2163T probably damaging Het
Mapk7 G T 11: 61,384,734 (GRCm39) probably benign Het
Myo10 C A 15: 25,781,204 (GRCm39) Q154K probably damaging Het
Or2h15 A G 17: 38,441,441 (GRCm39) I214T probably damaging Het
Pcdhgb2 G A 18: 37,825,267 (GRCm39) V753M probably benign Het
Pnn T A 12: 59,117,013 (GRCm39) L195Q probably damaging Het
Pot1a A G 6: 25,771,540 (GRCm39) V227A possibly damaging Het
Ppp1r21 T A 17: 88,855,049 (GRCm39) D109E probably benign Het
Prr15l G A 11: 96,825,588 (GRCm39) G73S probably damaging Het
Rnf148 A G 6: 23,654,339 (GRCm39) F219S probably benign Het
Rnpep C A 1: 135,194,764 (GRCm39) probably benign Het
Ryr1 T C 7: 28,803,723 (GRCm39) T643A probably damaging Het
Ryr2 A T 13: 11,960,831 (GRCm39) C36S probably damaging Het
Shc3 G T 13: 51,596,805 (GRCm39) T406N probably benign Het
Slit3 G T 11: 35,579,420 (GRCm39) G1199V probably damaging Het
Spata6l G T 19: 28,919,175 (GRCm39) H195N possibly damaging Het
Sptbn5 G A 2: 119,880,601 (GRCm39) noncoding transcript Het
St8sia6 T C 2: 13,670,253 (GRCm39) N236D probably damaging Het
Stpg1 A T 4: 135,233,727 (GRCm39) Q3L probably benign Het
Sult3a1 T A 10: 33,742,550 (GRCm39) I59N probably damaging Het
Vmn1r208 T G 13: 22,956,958 (GRCm39) I180L probably benign Het
Vmn2r51 A T 7: 9,832,247 (GRCm39) N446K probably damaging Het
Vmn2r63 A T 7: 42,553,402 (GRCm39) I618N probably damaging Het
Wrn T C 8: 33,812,371 (GRCm39) N182S probably benign Het
Zfp296 G T 7: 19,313,637 (GRCm39) C164F possibly damaging Het
Zfp764l1 A G 7: 126,992,521 (GRCm39) Y30H probably damaging Het
Zmynd8 A G 2: 165,676,871 (GRCm39) V249A possibly damaging Het
Zswim2 A G 2: 83,755,571 (GRCm39) L110P probably damaging Het
Other mutations in Or2a7
AlleleSourceChrCoordTypePredicted EffectPPH Score
N/A - 293:Or2a7 UTSW 6 43,151,493 (GRCm39) missense probably benign 0.45
R0279:Or2a7 UTSW 6 43,151,692 (GRCm39) missense probably benign 0.03
R0594:Or2a7 UTSW 6 43,151,541 (GRCm39) missense possibly damaging 0.64
R0669:Or2a7 UTSW 6 43,150,938 (GRCm39) missense probably benign 0.36
R1339:Or2a7 UTSW 6 43,151,544 (GRCm39) missense probably benign 0.39
R1371:Or2a7 UTSW 6 43,151,234 (GRCm39) missense probably benign 0.01
R1669:Or2a7 UTSW 6 43,151,755 (GRCm39) missense probably damaging 1.00
R1832:Or2a7 UTSW 6 43,151,834 (GRCm39) missense probably benign
R2136:Or2a7 UTSW 6 43,151,435 (GRCm39) missense probably benign
R4358:Or2a7 UTSW 6 43,151,160 (GRCm39) missense probably damaging 0.97
R4755:Or2a7 UTSW 6 43,150,977 (GRCm39) missense probably benign 0.00
R5504:Or2a7 UTSW 6 43,151,572 (GRCm39) nonsense probably null
R5677:Or2a7 UTSW 6 43,151,265 (GRCm39) missense probably benign 0.35
R5917:Or2a7 UTSW 6 43,151,646 (GRCm39) missense probably damaging 1.00
R6287:Or2a7 UTSW 6 43,151,369 (GRCm39) missense probably benign 0.00
R6480:Or2a7 UTSW 6 43,151,000 (GRCm39) missense probably benign 0.05
R7020:Or2a7 UTSW 6 43,151,096 (GRCm39) missense possibly damaging 0.91
R7240:Or2a7 UTSW 6 43,151,435 (GRCm39) missense probably benign
R8925:Or2a7 UTSW 6 43,151,669 (GRCm39) missense probably benign 0.44
R8927:Or2a7 UTSW 6 43,151,669 (GRCm39) missense probably benign 0.44
R9652:Or2a7 UTSW 6 43,150,991 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGGGGAATGGAACCATCGTG -3'
(R):5'- GTTCACTTTCTGAGACACACAG -3'

Sequencing Primer
(F):5'- AACCATCGTGGGGCTCATCTG -3'
(R):5'- TCTGAGACACACAGAAGGGTAAG -3'
Posted On 2016-04-15