Mutagenetix > Incidental Mutation

Incidental Mutation 'R4933:Vmn2r51'

380715

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r51

Ensembl Gene

ENSMUSG00000058685

Gene Name

vomeronasal 2, receptor 51

Synonyms

MMRRC Submission

042533-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

R4933 (G1)

Quality Score

181

Status

Validated

Chromosome

Chromosomal Location

10087198-10105659 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 10098320 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 446 (N446K)

Ref Sequence

ENSEMBL: ENSMUSP00000092459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000094863]

AlphaFold

L7N215

Predicted Effect

probably damaging
Transcript: ENSMUST00000094863
AA Change: N446K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000092459
Gene: ENSMUSG00000058685
AA Change: N446K

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	2.4e-31	PFAM
Pfam:NCD3G	512	565	8.1e-21	PFAM
Pfam:7tm_3	598	833	2.7e-54	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.0%
3x: 98.1%
10x: 95.4%
20x: 89.3%

Validation Efficiency

97% (73/75)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	A	G	7: 41,626,802 (GRCm38)	E643G	probably damaging	Het
Abca2	T	C	2: 25,444,827 (GRCm38)	V1937A	probably benign	Het
Acot10	A	T	15: 20,666,330 (GRCm38)	N108K	possibly damaging	Het
Agtpbp1	A	T	13: 59,500,572 (GRCm38)	M478K	probably benign	Het
Akirin1	G	A	4: 123,736,858 (GRCm38)	S191F	probably damaging	Het
Aoc1l3	T	C	6: 48,987,492 (GRCm38)	S145P	probably damaging	Het
Aurkb	T	C	11: 69,048,144 (GRCm38)		probably benign	Het
Cabyr	T	C	18: 12,744,492 (GRCm38)		probably benign	Het
Ccp110	A	G	7: 118,725,319 (GRCm38)	E688G	probably damaging	Het
Champ1	T	A	8: 13,879,137 (GRCm38)	S432T	probably benign	Het
Crybg1	T	A	10: 43,999,213 (GRCm38)	N633I	probably damaging	Het
Dagla	A	T	19: 10,269,715 (GRCm38)		probably null	Het
Dkkl1	A	T	7: 45,211,525 (GRCm38)	L10Q	probably null	Het
Dnah8	G	A	17: 30,748,568 (GRCm38)	D2585N	probably benign	Het
Fndc7	G	T	3: 108,876,670 (GRCm38)	Q208K	probably benign	Het
Gins4	A	T	8: 23,234,780 (GRCm38)	C53S	probably damaging	Het
Gja8	T	A	3: 96,919,035 (GRCm38)		probably benign	Het
Golph3l	T	A	3: 95,617,423 (GRCm38)	N328K	probably benign	Het
Haus6	A	C	4: 86,585,287 (GRCm38)		probably benign	Het
Hdac5	A	G	11: 102,200,563 (GRCm38)		probably benign	Het
Ide	A	G	19: 37,277,756 (GRCm38)	Y883H	unknown	Het
Igf2r	A	G	17: 12,691,877 (GRCm38)		probably null	Het
Kdm3b	T	C	18: 34,810,393 (GRCm38)	Y723H	probably damaging	Het
Kif21b	G	A	1: 136,151,325 (GRCm38)		probably null	Het
Lancl1	A	T	1: 67,021,034 (GRCm38)	N77K	probably benign	Het
Lyst	G	A	13: 13,759,378 (GRCm38)	V3554I	probably benign	Het
Lyst	T	A	13: 13,637,764 (GRCm38)	N920K	probably damaging	Het
Map1a	G	A	2: 121,305,905 (GRCm38)	A2163T	probably damaging	Het
Mapk7	G	T	11: 61,493,908 (GRCm38)		probably benign	Het
Myo10	C	A	15: 25,781,118 (GRCm38)	Q154K	probably damaging	Het
Or2a7	C	T	6: 43,174,321 (GRCm38)	L112F	probably benign	Het
Or2h15	A	G	17: 38,130,550 (GRCm38)	I214T	probably damaging	Het
Pcdhgb2	G	A	18: 37,692,214 (GRCm38)	V753M	probably benign	Het
Pnn	T	A	12: 59,070,227 (GRCm38)	L195Q	probably damaging	Het
Pot1a	A	G	6: 25,771,541 (GRCm38)	V227A	possibly damaging	Het
Ppp1r21	T	A	17: 88,547,621 (GRCm38)	D109E	probably benign	Het
Prr15l	G	A	11: 96,934,762 (GRCm38)	G73S	probably damaging	Het
Rnf148	A	G	6: 23,654,340 (GRCm38)	F219S	probably benign	Het
Rnpep	C	A	1: 135,267,026 (GRCm38)		probably benign	Het
Ryr1	T	C	7: 29,104,298 (GRCm38)	T643A	probably damaging	Het
Ryr2	A	T	13: 11,945,945 (GRCm38)	C36S	probably damaging	Het
Shc3	G	T	13: 51,442,769 (GRCm38)	T406N	probably benign	Het
Slit3	G	T	11: 35,688,593 (GRCm38)	G1199V	probably damaging	Het
Spata6l	G	T	19: 28,941,775 (GRCm38)	H195N	possibly damaging	Het
Sptbn5	G	A	2: 120,050,120 (GRCm38)		noncoding transcript	Het
St8sia6	T	C	2: 13,665,442 (GRCm38)	N236D	probably damaging	Het
Stpg1	A	T	4: 135,506,416 (GRCm38)	Q3L	probably benign	Het
Sult3a1	T	A	10: 33,866,554 (GRCm38)	I59N	probably damaging	Het
Vmn1r208	T	G	13: 22,772,788 (GRCm38)	I180L	probably benign	Het
Vmn2r63	A	T	7: 42,903,978 (GRCm38)	I618N	probably damaging	Het
Wrn	T	C	8: 33,322,343 (GRCm38)	N182S	probably benign	Het
Zfp296	G	T	7: 19,579,712 (GRCm38)	C164F	possibly damaging	Het
Zfp764l1	A	G	7: 127,393,349 (GRCm38)	Y30H	probably damaging	Het
Zmynd8	A	G	2: 165,834,951 (GRCm38)	V249A	possibly damaging	Het
Zswim2	A	G	2: 83,925,227 (GRCm38)	L110P	probably damaging	Het

Other mutations in Vmn2r51

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01398:Vmn2r51	APN	7	10,102,414 (GRCm38)	missense	probably benign
IGL01574:Vmn2r51	APN	7	10,102,454 (GRCm38)	missense	probably damaging	1.00
IGL01743:Vmn2r51	APN	7	10,100,227 (GRCm38)	missense	probably damaging	0.98
IGL01820:Vmn2r51	APN	7	10,105,482 (GRCm38)	missense	probably damaging	1.00
IGL02563:Vmn2r51	APN	7	10,100,316 (GRCm38)	missense	probably benign	0.00
IGL02825:Vmn2r51	APN	7	10,098,119 (GRCm38)	splice site	probably benign
IGL02834:Vmn2r51	APN	7	10,098,136 (GRCm38)	nonsense	probably null
R0617:Vmn2r51	UTSW	7	10,100,469 (GRCm38)	missense	possibly damaging	0.65
R0967:Vmn2r51	UTSW	7	10,100,085 (GRCm38)	missense	probably damaging	0.97
R1465:Vmn2r51	UTSW	7	10,100,322 (GRCm38)	missense	probably damaging	1.00
R1465:Vmn2r51	UTSW	7	10,100,322 (GRCm38)	missense	probably damaging	1.00
R1559:Vmn2r51	UTSW	7	10,102,446 (GRCm38)	missense	possibly damaging	0.87
R1559:Vmn2r51	UTSW	7	10,102,445 (GRCm38)	missense	possibly damaging	0.58
R1598:Vmn2r51	UTSW	7	10,105,505 (GRCm38)	missense	probably benign
R1754:Vmn2r51	UTSW	7	10,099,946 (GRCm38)	missense	probably benign	0.04
R1836:Vmn2r51	UTSW	7	10,098,164 (GRCm38)	nonsense	probably null
R1836:Vmn2r51	UTSW	7	10,098,163 (GRCm38)	nonsense	probably null
R3151:Vmn2r51	UTSW	7	10,100,041 (GRCm38)	missense	probably damaging	1.00
R4566:Vmn2r51	UTSW	7	10,102,414 (GRCm38)	missense	probably benign
R5004:Vmn2r51	UTSW	7	10,088,005 (GRCm38)	missense	probably benign
R5050:Vmn2r51	UTSW	7	10,100,422 (GRCm38)	missense	probably damaging	0.99
R5510:Vmn2r51	UTSW	7	10,102,618 (GRCm38)	missense	possibly damaging	0.95
R5559:Vmn2r51	UTSW	7	10,092,201 (GRCm38)	missense	probably damaging	1.00
R6127:Vmn2r51	UTSW	7	10,105,631 (GRCm38)	missense	probably damaging	1.00
R6154:Vmn2r51	UTSW	7	10,087,994 (GRCm38)	missense	possibly damaging	0.74
R6304:Vmn2r51	UTSW	7	10,098,237 (GRCm38)	missense	probably benign	0.00
R6370:Vmn2r51	UTSW	7	10,098,216 (GRCm38)	missense	probably damaging	1.00
R6471:Vmn2r51	UTSW	7	10,102,583 (GRCm38)	missense	possibly damaging	0.48
R6800:Vmn2r51	UTSW	7	10,098,264 (GRCm38)	missense	probably damaging	0.99
R6883:Vmn2r51	UTSW	7	10,100,098 (GRCm38)	missense	possibly damaging	0.75
R7191:Vmn2r51	UTSW	7	10,100,553 (GRCm38)	missense	probably null	1.00
R7246:Vmn2r51	UTSW	7	10,102,501 (GRCm38)	missense	probably benign	0.00
R8939:Vmn2r51	UTSW	7	10,100,026 (GRCm38)	missense	possibly damaging	0.85
R9154:Vmn2r51	UTSW	7	10,105,553 (GRCm38)	missense	probably damaging	0.96
R9428:Vmn2r51	UTSW	7	10,099,785 (GRCm38)	critical splice donor site	probably benign
R9451:Vmn2r51	UTSW	7	10,099,889 (GRCm38)	missense	probably damaging	1.00
R9729:Vmn2r51	UTSW	7	10,105,552 (GRCm38)	missense	probably benign	0.00
R9767:Vmn2r51	UTSW	7	10,105,480 (GRCm38)	missense	probably benign	0.09
Z1176:Vmn2r51	UTSW	7	10,099,908 (GRCm38)	missense	probably benign	0.12
Z1176:Vmn2r51	UTSW	7	10,088,057 (GRCm38)	missense	possibly damaging	0.76

Predicted Primers

PCR Primer
(F):5'- CTGTGGCCAACTCAATCATG -3'
(R):5'- GGTTTTCTTCGCTGAGAAAACTG -3'

Sequencing Primer
(F):5'- GTCTTCGTATAAGTGAAAGTGTCGAC -3'
(R):5'- CTTCGCTGAGAAAACTGAAATTCTTG -3'

Posted On

2016-04-15