Incidental Mutation 'R4933:Aurkb'
ID 380731
Institutional Source Beutler Lab
Gene Symbol Aurkb
Ensembl Gene ENSMUSG00000020897
Gene Name aurora kinase B
Synonyms Stk5, IPL1, STK-1, AIRK2, aurora B, Aik2, Stk12
MMRRC Submission 042533-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4933 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 68936473-68942490 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 68938970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000104306 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021277] [ENSMUST00000108666]
AlphaFold O70126
Predicted Effect probably benign
Transcript: ENSMUST00000021277
SMART Domains Protein: ENSMUSP00000021277
Gene: ENSMUSG00000020897

DomainStartEndE-ValueType
S_TKc 82 332 2.75e-94 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108666
SMART Domains Protein: ENSMUSP00000104306
Gene: ENSMUSG00000020897

DomainStartEndE-ValueType
S_TKc 82 332 2.75e-94 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000126576
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139457
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139594
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140531
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149018
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156373
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.1%
  • 10x: 95.4%
  • 20x: 89.3%
Validation Efficiency 97% (73/75)
MGI Phenotype FUNCTION: This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 2 and 7. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. [provided by RefSeq, Sep 2015]
PHENOTYPE: Heterozygous null mice may develop oligospermia and show premature death and increased tumor incidence. Homozygous null embryos are small and die post-implantation showing reduced inner cell mass outgrowth, mitotic defects, aberrant trophoblast giant cells, edema, hemorrhage and increased apoptosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610021A01Rik A G 7: 41,276,226 (GRCm39) E643G probably damaging Het
Abca2 T C 2: 25,334,839 (GRCm39) V1937A probably benign Het
Acot10 A T 15: 20,666,416 (GRCm39) N108K possibly damaging Het
Agtpbp1 A T 13: 59,648,386 (GRCm39) M478K probably benign Het
Akirin1 G A 4: 123,630,651 (GRCm39) S191F probably damaging Het
Aoc1l3 T C 6: 48,964,426 (GRCm39) S145P probably damaging Het
Cabyr T C 18: 12,877,549 (GRCm39) probably benign Het
Ccp110 A G 7: 118,324,542 (GRCm39) E688G probably damaging Het
Champ1 T A 8: 13,929,137 (GRCm39) S432T probably benign Het
Crybg1 T A 10: 43,875,209 (GRCm39) N633I probably damaging Het
Dagla A T 19: 10,247,079 (GRCm39) probably null Het
Dkkl1 A T 7: 44,860,949 (GRCm39) L10Q probably null Het
Dnah8 G A 17: 30,967,542 (GRCm39) D2585N probably benign Het
Fndc7 G T 3: 108,783,986 (GRCm39) Q208K probably benign Het
Gins4 A T 8: 23,724,796 (GRCm39) C53S probably damaging Het
Gja8 T A 3: 96,826,351 (GRCm39) probably benign Het
Golph3l T A 3: 95,524,734 (GRCm39) N328K probably benign Het
Haus6 A C 4: 86,503,524 (GRCm39) probably benign Het
Hdac5 A G 11: 102,091,389 (GRCm39) probably benign Het
Ide A G 19: 37,255,155 (GRCm39) Y883H unknown Het
Igf2r A G 17: 12,910,764 (GRCm39) probably null Het
Kdm3b T C 18: 34,943,446 (GRCm39) Y723H probably damaging Het
Kif21b G A 1: 136,079,063 (GRCm39) probably null Het
Lancl1 A T 1: 67,060,193 (GRCm39) N77K probably benign Het
Lyst T A 13: 13,812,349 (GRCm39) N920K probably damaging Het
Lyst G A 13: 13,933,963 (GRCm39) V3554I probably benign Het
Map1a G A 2: 121,136,386 (GRCm39) A2163T probably damaging Het
Mapk7 G T 11: 61,384,734 (GRCm39) probably benign Het
Myo10 C A 15: 25,781,204 (GRCm39) Q154K probably damaging Het
Or2a7 C T 6: 43,151,255 (GRCm39) L112F probably benign Het
Or2h15 A G 17: 38,441,441 (GRCm39) I214T probably damaging Het
Pcdhgb2 G A 18: 37,825,267 (GRCm39) V753M probably benign Het
Pnn T A 12: 59,117,013 (GRCm39) L195Q probably damaging Het
Pot1a A G 6: 25,771,540 (GRCm39) V227A possibly damaging Het
Ppp1r21 T A 17: 88,855,049 (GRCm39) D109E probably benign Het
Prr15l G A 11: 96,825,588 (GRCm39) G73S probably damaging Het
Rnf148 A G 6: 23,654,339 (GRCm39) F219S probably benign Het
Rnpep C A 1: 135,194,764 (GRCm39) probably benign Het
Ryr1 T C 7: 28,803,723 (GRCm39) T643A probably damaging Het
Ryr2 A T 13: 11,960,831 (GRCm39) C36S probably damaging Het
Shc3 G T 13: 51,596,805 (GRCm39) T406N probably benign Het
Slit3 G T 11: 35,579,420 (GRCm39) G1199V probably damaging Het
Spata6l G T 19: 28,919,175 (GRCm39) H195N possibly damaging Het
Sptbn5 G A 2: 119,880,601 (GRCm39) noncoding transcript Het
St8sia6 T C 2: 13,670,253 (GRCm39) N236D probably damaging Het
Stpg1 A T 4: 135,233,727 (GRCm39) Q3L probably benign Het
Sult3a1 T A 10: 33,742,550 (GRCm39) I59N probably damaging Het
Vmn1r208 T G 13: 22,956,958 (GRCm39) I180L probably benign Het
Vmn2r51 A T 7: 9,832,247 (GRCm39) N446K probably damaging Het
Vmn2r63 A T 7: 42,553,402 (GRCm39) I618N probably damaging Het
Wrn T C 8: 33,812,371 (GRCm39) N182S probably benign Het
Zfp296 G T 7: 19,313,637 (GRCm39) C164F possibly damaging Het
Zfp764l1 A G 7: 126,992,521 (GRCm39) Y30H probably damaging Het
Zmynd8 A G 2: 165,676,871 (GRCm39) V249A possibly damaging Het
Zswim2 A G 2: 83,755,571 (GRCm39) L110P probably damaging Het
Other mutations in Aurkb
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01582:Aurkb APN 11 68,939,605 (GRCm39) missense probably damaging 1.00
R0193:Aurkb UTSW 11 68,939,370 (GRCm39) missense probably damaging 1.00
R0924:Aurkb UTSW 11 68,936,822 (GRCm39) nonsense probably null
R4622:Aurkb UTSW 11 68,939,188 (GRCm39) missense probably damaging 1.00
R4664:Aurkb UTSW 11 68,939,435 (GRCm39) missense probably damaging 0.98
R5243:Aurkb UTSW 11 68,936,752 (GRCm39) splice site probably benign
R5705:Aurkb UTSW 11 68,939,641 (GRCm39) missense possibly damaging 0.87
R6457:Aurkb UTSW 11 68,939,172 (GRCm39) missense possibly damaging 0.77
R6604:Aurkb UTSW 11 68,939,388 (GRCm39) nonsense probably null
R7739:Aurkb UTSW 11 68,939,058 (GRCm39) nonsense probably null
R8461:Aurkb UTSW 11 68,941,727 (GRCm39) missense probably damaging 0.98
R9289:Aurkb UTSW 11 68,941,175 (GRCm39) missense probably damaging 1.00
Z1186:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1186:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1187:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1187:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1188:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1188:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1189:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1189:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1190:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1190:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1191:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1191:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Z1192:Aurkb UTSW 11 68,938,696 (GRCm39) missense probably benign
Z1192:Aurkb UTSW 11 68,938,692 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAGGTACCTTGGATGATGGG -3'
(R):5'- TGGATTTCGATCTCTCGGCG -3'

Sequencing Primer
(F):5'- GGATGGACTCAACATAATTCTCTCTC -3'
(R):5'- GGTGCTCTACCCCCTCC -3'
Posted On 2016-04-15