Incidental Mutation 'R4934:Ralgapa1'
| ID |
380839 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa1
|
| Ensembl Gene |
ENSMUSG00000021027 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 1 |
| Synonyms |
Garnl1, 4930400K19Rik, Tulip1, 2310003F20Rik |
| MMRRC Submission |
042534-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.802)
|
| Stock # |
R4934 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
12 |
| Chromosomal Location |
55649681-55867952 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 55809359 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 472
(D472G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000154749
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000085385]
[ENSMUST00000110687]
[ENSMUST00000219432]
[ENSMUST00000220367]
[ENSMUST00000226244]
|
| AlphaFold |
Q6GYP7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000085385
AA Change: D472G
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000082503
Gene: ENSMUSG00000021027
AA Change: D472G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
644 |
651 |
N/A |
INTRINSIC |
|
low complexity region
|
676 |
690 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
894 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
1386 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1784 |
1798 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1824 |
2003 |
7.4e-66 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110687
AA Change: D472G
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000106315
Gene: ENSMUSG00000021027
AA Change: D472G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
644 |
651 |
N/A |
INTRINSIC |
|
low complexity region
|
676 |
690 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
704 |
N/A |
INTRINSIC |
|
low complexity region
|
894 |
915 |
N/A |
INTRINSIC |
|
low complexity region
|
1386 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1784 |
1798 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1824 |
2001 |
1.9e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000219432
AA Change: D472G
PolyPhen 2
Score 0.020 (Sensitivity: 0.95; Specificity: 0.80)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219529
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219542
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000220367
AA Change: D472G
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000226244
AA Change: D472G
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| Meta Mutation Damage Score |
0.0836 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.3%
- 10x: 96.0%
- 20x: 91.4%
|
| Validation Efficiency |
99% (134/135) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a major subunit of the RAL-GTPase activating protein. A similar protein in mouse binds E12, a transcriptional regulator of immunoglobulin genes. The mouse protein also functions in skeletal muscle by binding to the regulatory 14-3-3 proteins upon stimulation with insulin or muscle contraction. A pseudogene of this gene has been identified on chromosome 9. [provided by RefSeq, Oct 2016]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 125 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4931428L18Rik |
A |
T |
1: 31,261,580 (GRCm39) |
|
probably benign |
Het |
| Acy1 |
T |
A |
9: 106,312,321 (GRCm39) |
I14F |
probably null |
Het |
| Ago1 |
T |
C |
4: 126,342,652 (GRCm39) |
D193G |
possibly damaging |
Het |
| Arhgap45 |
A |
T |
10: 79,856,791 (GRCm39) |
H201L |
probably damaging |
Het |
| Armc9 |
G |
A |
1: 86,140,801 (GRCm39) |
D63N |
probably damaging |
Het |
| Asb17 |
A |
T |
3: 153,556,336 (GRCm39) |
I148F |
possibly damaging |
Het |
| Atf7ip2 |
A |
G |
16: 10,059,447 (GRCm39) |
E329G |
possibly damaging |
Het |
| Atp2a1 |
T |
A |
7: 126,052,600 (GRCm39) |
D373V |
probably benign |
Het |
| Cacna1e |
G |
T |
1: 154,357,380 (GRCm39) |
Y603* |
probably null |
Het |
| Cbln4 |
G |
A |
2: 171,880,901 (GRCm39) |
T131I |
probably damaging |
Het |
| Ccdc126 |
A |
G |
6: 49,311,181 (GRCm39) |
E63G |
probably damaging |
Het |
| Ccl4 |
T |
A |
11: 83,553,504 (GRCm39) |
S6T |
unknown |
Het |
| Ccnb1 |
A |
T |
13: 100,918,209 (GRCm39) |
I146K |
possibly damaging |
Het |
| Ccr8 |
T |
A |
9: 119,923,815 (GRCm39) |
M310K |
probably benign |
Het |
| Cd180 |
A |
T |
13: 102,875,672 (GRCm39) |
|
probably null |
Het |
| Cd46 |
G |
C |
1: 194,765,107 (GRCm39) |
|
probably benign |
Het |
| Cebpb |
A |
G |
2: 167,531,005 (GRCm39) |
M22V |
probably benign |
Het |
| Cep152 |
A |
G |
2: 125,453,016 (GRCm39) |
I352T |
possibly damaging |
Het |
| Cep295 |
T |
G |
9: 15,244,456 (GRCm39) |
E1333D |
probably damaging |
Het |
| Ces4a |
A |
G |
8: 105,864,613 (GRCm39) |
H30R |
probably benign |
Het |
| Chrm3 |
A |
G |
13: 9,927,450 (GRCm39) |
Y529H |
probably damaging |
Het |
| Chrnb4 |
T |
C |
9: 54,942,101 (GRCm39) |
Y391C |
probably benign |
Het |
| Clca3a2 |
A |
G |
3: 144,523,692 (GRCm39) |
Y98H |
probably damaging |
Het |
| Clvs1 |
C |
T |
4: 9,424,216 (GRCm39) |
H221Y |
possibly damaging |
Het |
| Col3a1 |
G |
A |
1: 45,379,112 (GRCm39) |
|
probably benign |
Het |
| Cpn2 |
T |
G |
16: 30,079,344 (GRCm39) |
N119T |
probably damaging |
Het |
| Cspg4b |
C |
A |
13: 113,504,882 (GRCm39) |
Q2004K |
probably damaging |
Het |
| Cubn |
T |
A |
2: 13,494,721 (GRCm39) |
Q109H |
probably benign |
Het |
| Cyp26b1 |
A |
G |
6: 84,553,954 (GRCm39) |
V221A |
possibly damaging |
Het |
| Cyp2e1 |
T |
G |
7: 140,350,030 (GRCm39) |
N238K |
probably damaging |
Het |
| Dst |
C |
T |
1: 34,247,669 (GRCm39) |
A1693V |
probably damaging |
Het |
| Dync2li1 |
A |
G |
17: 84,956,683 (GRCm39) |
Q281R |
probably benign |
Het |
| Enpp2 |
C |
T |
15: 54,745,543 (GRCm39) |
G318S |
probably damaging |
Het |
| Entrep1 |
T |
C |
19: 23,950,789 (GRCm39) |
*597W |
probably null |
Het |
| F13a1 |
G |
T |
13: 37,061,736 (GRCm39) |
P676T |
probably benign |
Het |
| Fam227a |
T |
C |
15: 79,521,262 (GRCm39) |
H267R |
possibly damaging |
Het |
| Fam78a |
G |
A |
2: 31,959,427 (GRCm39) |
R228C |
probably damaging |
Het |
| Fbxw25 |
T |
C |
9: 109,480,705 (GRCm39) |
N325S |
possibly damaging |
Het |
| Foxred1 |
T |
C |
9: 35,121,210 (GRCm39) |
|
probably benign |
Het |
| Fstl5 |
T |
A |
3: 76,496,272 (GRCm39) |
V345E |
probably damaging |
Het |
| Fzd8 |
GAAAAACTCA |
GA |
18: 9,214,492 (GRCm39) |
|
probably null |
Het |
| Hand1 |
T |
C |
11: 57,722,078 (GRCm39) |
R179G |
possibly damaging |
Het |
| Hk1 |
G |
T |
10: 62,194,165 (GRCm39) |
|
probably benign |
Het |
| Hmcn1 |
A |
C |
1: 150,598,286 (GRCm39) |
L1672R |
probably damaging |
Het |
| Hps5 |
G |
A |
7: 46,418,775 (GRCm39) |
Q297* |
probably null |
Het |
| Iars1 |
T |
A |
13: 49,871,460 (GRCm39) |
F699I |
probably benign |
Het |
| Ift140 |
G |
A |
17: 25,267,462 (GRCm39) |
G620E |
probably benign |
Het |
| Igkv4-80 |
A |
C |
6: 68,993,649 (GRCm39) |
S81A |
probably benign |
Het |
| Inpp4a |
T |
G |
1: 37,426,922 (GRCm39) |
Y628D |
possibly damaging |
Het |
| Itk |
C |
T |
11: 46,280,152 (GRCm39) |
R29H |
probably damaging |
Het |
| Kcnv1 |
A |
G |
15: 44,972,644 (GRCm39) |
F413S |
probably damaging |
Het |
| Klhl3 |
A |
T |
13: 58,250,231 (GRCm39) |
Y4* |
probably null |
Het |
| Lonrf1 |
C |
A |
8: 36,701,103 (GRCm39) |
C369F |
probably damaging |
Het |
| Magohb |
A |
T |
6: 131,261,558 (GRCm39) |
|
probably benign |
Het |
| Map3k4 |
G |
A |
17: 12,490,787 (GRCm39) |
R215C |
probably damaging |
Het |
| Map3k8 |
A |
T |
18: 4,339,548 (GRCm39) |
S274R |
possibly damaging |
Het |
| Masp1 |
T |
G |
16: 23,283,826 (GRCm39) |
M470L |
probably damaging |
Het |
| Mfng |
C |
T |
15: 78,648,588 (GRCm39) |
R163H |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,576,472 (GRCm39) |
|
probably benign |
Het |
| Myo1c |
T |
A |
11: 75,562,676 (GRCm39) |
V981E |
probably damaging |
Het |
| Nedd9 |
A |
T |
13: 41,492,411 (GRCm39) |
I27K |
probably damaging |
Het |
| Nkd2 |
C |
A |
13: 73,970,841 (GRCm39) |
G247V |
probably damaging |
Het |
| Nucb2 |
A |
C |
7: 116,139,199 (GRCm39) |
Q398P |
possibly damaging |
Het |
| Numa1 |
T |
A |
7: 101,660,064 (GRCm39) |
D376E |
probably benign |
Het |
| Or2w1 |
G |
A |
13: 21,317,241 (GRCm39) |
V99I |
probably benign |
Het |
| Or4c101 |
C |
T |
2: 88,389,930 (GRCm39) |
T39I |
probably benign |
Het |
| Or4n5 |
T |
C |
14: 50,133,206 (GRCm39) |
T18A |
probably benign |
Het |
| Or4p23 |
A |
T |
2: 88,576,398 (GRCm39) |
L278* |
probably null |
Het |
| Or4q3 |
C |
T |
14: 50,583,345 (GRCm39) |
V185M |
probably damaging |
Het |
| Or5b119 |
G |
A |
19: 13,456,956 (GRCm39) |
T202I |
possibly damaging |
Het |
| Or6c76b |
A |
T |
10: 129,692,896 (GRCm39) |
N170Y |
possibly damaging |
Het |
| Or8d23 |
A |
T |
9: 38,842,129 (GRCm39) |
I221F |
probably damaging |
Het |
| Otx1 |
C |
A |
11: 21,947,037 (GRCm39) |
A91S |
probably damaging |
Het |
| Pamr1 |
C |
T |
2: 102,472,549 (GRCm39) |
T616I |
probably benign |
Het |
| Pcnx1 |
G |
A |
12: 82,038,599 (GRCm39) |
V1955I |
possibly damaging |
Het |
| Pira13 |
A |
G |
7: 3,825,676 (GRCm39) |
Y398H |
probably damaging |
Het |
| Plekha3 |
T |
A |
2: 76,510,571 (GRCm39) |
D35E |
possibly damaging |
Het |
| Pnpla2 |
T |
G |
7: 141,038,085 (GRCm39) |
N184K |
probably damaging |
Het |
| Polr3a |
C |
T |
14: 24,502,692 (GRCm39) |
E1216K |
probably benign |
Het |
| Ppp1r21 |
A |
T |
17: 88,852,803 (GRCm39) |
S61C |
probably damaging |
Het |
| Ppp1r21 |
G |
C |
17: 88,852,804 (GRCm39) |
S61T |
probably damaging |
Het |
| Prdm13 |
G |
T |
4: 21,678,223 (GRCm39) |
|
probably benign |
Het |
| Prss53 |
T |
C |
7: 127,487,879 (GRCm39) |
N201S |
probably benign |
Het |
| Rab11fip2 |
A |
G |
19: 59,924,290 (GRCm39) |
L338S |
probably damaging |
Het |
| Rad50 |
T |
C |
11: 53,575,102 (GRCm39) |
N546S |
probably benign |
Het |
| Rexo4 |
A |
G |
2: 26,850,346 (GRCm39) |
I277T |
probably damaging |
Het |
| Rimbp2 |
C |
T |
5: 128,865,579 (GRCm39) |
V590I |
probably benign |
Het |
| Ripor3 |
A |
G |
2: 167,824,736 (GRCm39) |
V864A |
probably benign |
Het |
| Rnpc3 |
G |
A |
3: 113,418,628 (GRCm39) |
H107Y |
possibly damaging |
Het |
| Ryr1 |
A |
T |
7: 28,767,520 (GRCm39) |
D2927E |
probably damaging |
Het |
| Samd9l |
G |
A |
6: 3,375,621 (GRCm39) |
Q547* |
probably null |
Het |
| Scaper |
T |
C |
9: 55,716,459 (GRCm39) |
E724G |
probably damaging |
Het |
| Secisbp2l |
C |
T |
2: 125,582,409 (GRCm39) |
V1016I |
probably damaging |
Het |
| Selenoo |
T |
A |
15: 88,982,970 (GRCm39) |
M499K |
probably damaging |
Het |
| Sema4a |
T |
A |
3: 88,345,568 (GRCm39) |
D505V |
probably damaging |
Het |
| Sema5a |
T |
C |
15: 32,679,310 (GRCm39) |
M863T |
probably damaging |
Het |
| Slc24a5 |
T |
C |
2: 124,929,940 (GRCm39) |
C414R |
probably damaging |
Het |
| Slc34a2 |
A |
G |
5: 53,224,942 (GRCm39) |
D361G |
probably damaging |
Het |
| Slc5a1 |
T |
C |
5: 33,261,858 (GRCm39) |
Y20H |
probably benign |
Het |
| Slx4ip |
A |
T |
2: 136,910,267 (GRCm39) |
|
probably benign |
Het |
| Snx14 |
T |
A |
9: 88,280,341 (GRCm39) |
E538V |
probably damaging |
Het |
| Sspo |
C |
A |
6: 48,442,486 (GRCm39) |
L1994I |
probably damaging |
Het |
| St13 |
G |
C |
15: 81,283,786 (GRCm39) |
R4G |
probably benign |
Het |
| Stap2 |
A |
G |
17: 56,304,901 (GRCm39) |
S294P |
possibly damaging |
Het |
| Stat1 |
C |
A |
1: 52,193,082 (GRCm39) |
Y651* |
probably null |
Het |
| Syne2 |
A |
G |
12: 75,946,046 (GRCm39) |
T373A |
probably benign |
Het |
| Tacc2 |
A |
G |
7: 130,330,318 (GRCm39) |
S201G |
probably damaging |
Het |
| Tdpoz3 |
G |
A |
3: 93,734,287 (GRCm39) |
E321K |
probably benign |
Het |
| Thumpd1 |
T |
C |
7: 119,316,002 (GRCm39) |
T316A |
probably benign |
Het |
| Tlr3 |
A |
T |
8: 45,850,072 (GRCm39) |
C866S |
probably benign |
Het |
| Tmprss11g |
T |
A |
5: 86,644,401 (GRCm39) |
I148F |
probably benign |
Het |
| Topbp1 |
T |
A |
9: 103,205,568 (GRCm39) |
|
probably benign |
Het |
| Tpm1 |
T |
C |
9: 66,935,331 (GRCm39) |
|
probably null |
Het |
| Traf3ip2 |
T |
A |
10: 39,502,096 (GRCm39) |
S81R |
probably damaging |
Het |
| Trim29 |
T |
A |
9: 43,222,265 (GRCm39) |
N31K |
probably benign |
Het |
| Ubn2 |
C |
T |
6: 38,467,433 (GRCm39) |
P563S |
probably benign |
Het |
| Usp24 |
T |
C |
4: 106,283,743 (GRCm39) |
Y2418H |
probably benign |
Het |
| Vmn2r6 |
T |
A |
3: 64,463,766 (GRCm39) |
D267V |
probably damaging |
Het |
| Wapl |
T |
A |
14: 34,414,052 (GRCm39) |
C305S |
probably benign |
Het |
| Yme1l1 |
C |
A |
2: 23,058,333 (GRCm39) |
S155* |
probably null |
Het |
| Ythdf3 |
T |
A |
3: 16,258,220 (GRCm39) |
H126Q |
probably damaging |
Het |
| Zbtb32 |
A |
T |
7: 30,290,678 (GRCm39) |
C206S |
possibly damaging |
Het |
| Zbtb47 |
T |
C |
9: 121,593,045 (GRCm39) |
V455A |
probably damaging |
Het |
| Zfp518a |
A |
T |
19: 40,902,707 (GRCm39) |
I879F |
probably benign |
Het |
| Zfp938 |
A |
T |
10: 82,062,012 (GRCm39) |
Y203N |
possibly damaging |
Het |
|
| Other mutations in Ralgapa1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Ralgapa1
|
APN |
12 |
55,769,558 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL00494:Ralgapa1
|
APN |
12 |
55,793,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00731:Ralgapa1
|
APN |
12 |
55,749,237 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00851:Ralgapa1
|
APN |
12 |
55,756,360 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01133:Ralgapa1
|
APN |
12 |
55,689,144 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01133:Ralgapa1
|
APN |
12 |
55,689,133 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01354:Ralgapa1
|
APN |
12 |
55,824,101 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL01514:Ralgapa1
|
APN |
12 |
55,766,442 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02033:Ralgapa1
|
APN |
12 |
55,689,262 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02064:Ralgapa1
|
APN |
12 |
55,754,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02556:Ralgapa1
|
APN |
12 |
55,689,234 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02605:Ralgapa1
|
APN |
12 |
55,759,450 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL02657:Ralgapa1
|
APN |
12 |
55,720,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02676:Ralgapa1
|
APN |
12 |
55,723,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02894:Ralgapa1
|
APN |
12 |
55,763,854 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02944:Ralgapa1
|
APN |
12 |
55,804,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
Anhydrous
|
UTSW |
12 |
55,842,563 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Aqueous
|
UTSW |
12 |
55,745,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
bantam
|
UTSW |
12 |
55,769,558 (GRCm39) |
critical splice donor site |
probably null |
|
|
Deliquescent
|
UTSW |
12 |
55,829,685 (GRCm39) |
splice site |
probably benign |
|
|
wickedwarlock
|
UTSW |
12 |
55,824,077 (GRCm39) |
missense |
probably null |
0.99 |
|
F5770:Ralgapa1
|
UTSW |
12 |
55,842,438 (GRCm39) |
splice site |
probably benign |
|
|
IGL03046:Ralgapa1
|
UTSW |
12 |
55,741,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Ralgapa1
|
UTSW |
12 |
55,833,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0096:Ralgapa1
|
UTSW |
12 |
55,786,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0277:Ralgapa1
|
UTSW |
12 |
55,724,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0323:Ralgapa1
|
UTSW |
12 |
55,724,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0333:Ralgapa1
|
UTSW |
12 |
55,829,685 (GRCm39) |
splice site |
probably benign |
|
|
R0361:Ralgapa1
|
UTSW |
12 |
55,723,354 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0385:Ralgapa1
|
UTSW |
12 |
55,723,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0386:Ralgapa1
|
UTSW |
12 |
55,754,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0498:Ralgapa1
|
UTSW |
12 |
55,736,576 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0552:Ralgapa1
|
UTSW |
12 |
55,723,550 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0564:Ralgapa1
|
UTSW |
12 |
55,829,670 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0611:Ralgapa1
|
UTSW |
12 |
55,842,483 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0730:Ralgapa1
|
UTSW |
12 |
55,712,448 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0741:Ralgapa1
|
UTSW |
12 |
55,723,366 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0815:Ralgapa1
|
UTSW |
12 |
55,829,562 (GRCm39) |
splice site |
probably benign |
|
|
R0815:Ralgapa1
|
UTSW |
12 |
55,809,466 (GRCm39) |
nonsense |
probably null |
|
|
R0863:Ralgapa1
|
UTSW |
12 |
55,829,562 (GRCm39) |
splice site |
probably benign |
|
|
R0863:Ralgapa1
|
UTSW |
12 |
55,809,466 (GRCm39) |
nonsense |
probably null |
|
|
R1068:Ralgapa1
|
UTSW |
12 |
55,837,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1147:Ralgapa1
|
UTSW |
12 |
55,749,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1147:Ralgapa1
|
UTSW |
12 |
55,749,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1256:Ralgapa1
|
UTSW |
12 |
55,809,446 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1343:Ralgapa1
|
UTSW |
12 |
55,754,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1378:Ralgapa1
|
UTSW |
12 |
55,723,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1474:Ralgapa1
|
UTSW |
12 |
55,788,265 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1494:Ralgapa1
|
UTSW |
12 |
55,731,309 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1593:Ralgapa1
|
UTSW |
12 |
55,817,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1607:Ralgapa1
|
UTSW |
12 |
55,788,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1681:Ralgapa1
|
UTSW |
12 |
55,809,388 (GRCm39) |
missense |
probably benign |
0.35 |
|
R1689:Ralgapa1
|
UTSW |
12 |
55,723,552 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1714:Ralgapa1
|
UTSW |
12 |
55,689,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1832:Ralgapa1
|
UTSW |
12 |
55,804,752 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1870:Ralgapa1
|
UTSW |
12 |
55,723,817 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2040:Ralgapa1
|
UTSW |
12 |
55,833,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2043:Ralgapa1
|
UTSW |
12 |
55,723,811 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2046:Ralgapa1
|
UTSW |
12 |
55,741,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2109:Ralgapa1
|
UTSW |
12 |
55,822,973 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2114:Ralgapa1
|
UTSW |
12 |
55,833,134 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2115:Ralgapa1
|
UTSW |
12 |
55,833,134 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2202:Ralgapa1
|
UTSW |
12 |
55,659,585 (GRCm39) |
splice site |
probably null |
|
|
R2203:Ralgapa1
|
UTSW |
12 |
55,659,585 (GRCm39) |
splice site |
probably null |
|
|
R2233:Ralgapa1
|
UTSW |
12 |
55,763,856 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2235:Ralgapa1
|
UTSW |
12 |
55,763,856 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2341:Ralgapa1
|
UTSW |
12 |
55,723,909 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2507:Ralgapa1
|
UTSW |
12 |
55,764,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2508:Ralgapa1
|
UTSW |
12 |
55,764,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2972:Ralgapa1
|
UTSW |
12 |
55,867,540 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R3160:Ralgapa1
|
UTSW |
12 |
55,756,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Ralgapa1
|
UTSW |
12 |
55,756,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3401:Ralgapa1
|
UTSW |
12 |
55,705,922 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3416:Ralgapa1
|
UTSW |
12 |
55,817,398 (GRCm39) |
splice site |
probably benign |
|
|
R3499:Ralgapa1
|
UTSW |
12 |
55,741,928 (GRCm39) |
splice site |
probably benign |
|
|
R3799:Ralgapa1
|
UTSW |
12 |
55,705,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3948:Ralgapa1
|
UTSW |
12 |
55,745,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4039:Ralgapa1
|
UTSW |
12 |
55,842,486 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4120:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4165:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4166:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4212:Ralgapa1
|
UTSW |
12 |
55,786,115 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4232:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Ralgapa1
|
UTSW |
12 |
55,687,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4399:Ralgapa1
|
UTSW |
12 |
55,842,563 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4698:Ralgapa1
|
UTSW |
12 |
55,724,061 (GRCm39) |
splice site |
probably null |
|
|
R4715:Ralgapa1
|
UTSW |
12 |
55,740,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4755:Ralgapa1
|
UTSW |
12 |
55,759,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4810:Ralgapa1
|
UTSW |
12 |
55,841,778 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4827:Ralgapa1
|
UTSW |
12 |
55,723,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4849:Ralgapa1
|
UTSW |
12 |
55,745,588 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5006:Ralgapa1
|
UTSW |
12 |
55,764,899 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5114:Ralgapa1
|
UTSW |
12 |
55,659,508 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5140:Ralgapa1
|
UTSW |
12 |
55,712,459 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5140:Ralgapa1
|
UTSW |
12 |
55,822,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Ralgapa1
|
UTSW |
12 |
55,804,817 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5407:Ralgapa1
|
UTSW |
12 |
55,723,582 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5441:Ralgapa1
|
UTSW |
12 |
55,766,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5473:Ralgapa1
|
UTSW |
12 |
55,723,495 (GRCm39) |
missense |
probably benign |
0.41 |
|
R5624:Ralgapa1
|
UTSW |
12 |
55,659,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5766:Ralgapa1
|
UTSW |
12 |
55,867,551 (GRCm39) |
start codon destroyed |
probably null |
0.99 |
|
R5826:Ralgapa1
|
UTSW |
12 |
55,723,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5950:Ralgapa1
|
UTSW |
12 |
55,785,050 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R5980:Ralgapa1
|
UTSW |
12 |
55,817,401 (GRCm39) |
splice site |
probably null |
|
|
R6019:Ralgapa1
|
UTSW |
12 |
55,730,827 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6065:Ralgapa1
|
UTSW |
12 |
55,804,709 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6326:Ralgapa1
|
UTSW |
12 |
55,793,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Ralgapa1
|
UTSW |
12 |
55,745,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6408:Ralgapa1
|
UTSW |
12 |
55,730,695 (GRCm39) |
nonsense |
probably null |
|
|
R6448:Ralgapa1
|
UTSW |
12 |
55,766,446 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6453:Ralgapa1
|
UTSW |
12 |
55,785,104 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6590:Ralgapa1
|
UTSW |
12 |
55,769,558 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6690:Ralgapa1
|
UTSW |
12 |
55,769,558 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6738:Ralgapa1
|
UTSW |
12 |
55,809,512 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Ralgapa1
|
UTSW |
12 |
55,651,058 (GRCm39) |
splice site |
probably null |
|
|
R6936:Ralgapa1
|
UTSW |
12 |
55,832,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6945:Ralgapa1
|
UTSW |
12 |
55,822,976 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7028:Ralgapa1
|
UTSW |
12 |
55,804,844 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7075:Ralgapa1
|
UTSW |
12 |
55,867,508 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7076:Ralgapa1
|
UTSW |
12 |
55,768,361 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7098:Ralgapa1
|
UTSW |
12 |
55,837,095 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7231:Ralgapa1
|
UTSW |
12 |
55,650,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7254:Ralgapa1
|
UTSW |
12 |
55,741,978 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7326:Ralgapa1
|
UTSW |
12 |
55,755,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7485:Ralgapa1
|
UTSW |
12 |
55,759,457 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7580:Ralgapa1
|
UTSW |
12 |
55,765,013 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7677:Ralgapa1
|
UTSW |
12 |
55,705,928 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7702:Ralgapa1
|
UTSW |
12 |
55,756,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7702:Ralgapa1
|
UTSW |
12 |
55,756,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7707:Ralgapa1
|
UTSW |
12 |
55,824,077 (GRCm39) |
missense |
probably null |
0.99 |
|
R7723:Ralgapa1
|
UTSW |
12 |
55,788,298 (GRCm39) |
missense |
probably benign |
|
|
R7763:Ralgapa1
|
UTSW |
12 |
55,804,740 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7791:Ralgapa1
|
UTSW |
12 |
55,788,304 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7812:Ralgapa1
|
UTSW |
12 |
55,766,413 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7868:Ralgapa1
|
UTSW |
12 |
55,659,423 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7895:Ralgapa1
|
UTSW |
12 |
55,793,934 (GRCm39) |
missense |
probably benign |
0.44 |
|
R7896:Ralgapa1
|
UTSW |
12 |
55,744,663 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8004:Ralgapa1
|
UTSW |
12 |
55,749,242 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8094:Ralgapa1
|
UTSW |
12 |
55,829,631 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8213:Ralgapa1
|
UTSW |
12 |
55,769,699 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8307:Ralgapa1
|
UTSW |
12 |
55,788,308 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8423:Ralgapa1
|
UTSW |
12 |
55,705,847 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8462:Ralgapa1
|
UTSW |
12 |
55,723,303 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8469:Ralgapa1
|
UTSW |
12 |
55,786,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8675:Ralgapa1
|
UTSW |
12 |
55,785,002 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8802:Ralgapa1
|
UTSW |
12 |
55,785,101 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8937:Ralgapa1
|
UTSW |
12 |
55,749,345 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8953:Ralgapa1
|
UTSW |
12 |
55,867,546 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8974:Ralgapa1
|
UTSW |
12 |
55,723,791 (GRCm39) |
missense |
probably benign |
|
|
R9011:Ralgapa1
|
UTSW |
12 |
55,652,314 (GRCm39) |
intron |
probably benign |
|
|
R9089:Ralgapa1
|
UTSW |
12 |
55,723,351 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9124:Ralgapa1
|
UTSW |
12 |
55,781,881 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9254:Ralgapa1
|
UTSW |
12 |
55,769,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9320:Ralgapa1
|
UTSW |
12 |
55,755,843 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R9379:Ralgapa1
|
UTSW |
12 |
55,769,583 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9446:Ralgapa1
|
UTSW |
12 |
55,754,808 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9684:Ralgapa1
|
UTSW |
12 |
55,659,485 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
Z1176:Ralgapa1
|
UTSW |
12 |
55,755,865 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCGACAATTCCACATGTACAATCTCTC -3'
(R):5'- TGGCAATAAAAGGCTTTCTCTG -3'
Sequencing Primer
(F):5'- CTCTCTTGTAAATGTGAACAGTCTC -3'
(R):5'- GTTTATGCAAGAGCCTGA -3'
|
| Posted On |
2016-04-15 |
Incidental Mutation