Incidental Mutation 'R4929:Ints2'
ID 381102
Institutional Source Beutler Lab
Gene Symbol Ints2
Ensembl Gene ENSMUSG00000018068
Gene Name integrator complex subunit 2
Synonyms 2810417D08Rik
MMRRC Submission 042530-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R4929 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 86210681-86257575 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to T at 86212653 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 1192 (N1192K)
Ref Sequence ENSEMBL: ENSMUSP00000103674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000018212] [ENSMUST00000108039]
AlphaFold Q80UK8
Predicted Effect possibly damaging
Transcript: ENSMUST00000018212
AA Change: N1192K

PolyPhen 2 Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000018212
Gene: ENSMUSG00000018068
AA Change: N1192K

DomainStartEndE-ValueType
Pfam:INTS2 24 1131 N/A PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000108039
AA Change: N1192K

PolyPhen 2 Score 0.565 (Sensitivity: 0.88; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000103674
Gene: ENSMUSG00000018068
AA Change: N1192K

DomainStartEndE-ValueType
Pfam:INTS2 24 1132 N/A PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128960
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143819
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.4%
  • 20x: 92.9%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930432E11Rik A G 7: 29,574,042 (GRCm38) noncoding transcript Het
Abcd3 A T 3: 121,768,746 (GRCm38) probably null Het
Adamts12 C T 15: 11,259,022 (GRCm38) R551C probably damaging Het
Adamtsl4 A G 3: 95,678,005 (GRCm38) C818R probably damaging Het
Arfgef3 T A 10: 18,630,851 (GRCm38) Q842L probably benign Het
Aurka A T 2: 172,370,406 (GRCm38) V17E probably benign Het
Ccdc144b G A 3: 36,035,338 (GRCm38) L146F probably damaging Het
Cdh24 C T 14: 54,633,516 (GRCm38) V132I probably benign Het
Cep57l1 T C 10: 41,745,914 (GRCm38) D2G possibly damaging Het
Cntn5 T A 9: 9,976,395 (GRCm38) probably null Het
Col10a1 T C 10: 34,395,124 (GRCm38) I364T probably benign Het
Dpp6 G A 5: 27,049,787 (GRCm38) A67T probably benign Het
Dym T A 18: 75,243,286 (GRCm38) V583E probably damaging Het
Efcab5 T G 11: 77,103,383 (GRCm38) K1259N probably benign Het
Ehbp1 T G 11: 22,239,169 (GRCm38) I78L possibly damaging Het
Epha1 C A 6: 42,364,599 (GRCm38) A469S probably benign Het
Fam135a T C 1: 24,030,000 (GRCm38) D596G probably benign Het
Filip1 T C 9: 79,819,747 (GRCm38) N530S probably benign Het
Grhl2 A G 15: 37,360,802 (GRCm38) N610S probably benign Het
Haus6 T C 4: 86,595,433 (GRCm38) I331V probably benign Het
Itga5 A G 15: 103,353,235 (GRCm38) V445A probably benign Het
Itga9 C A 9: 118,807,249 (GRCm38) D82E probably damaging Het
Jam2 G A 16: 84,822,862 (GRCm38) probably benign Het
Klhl32 T A 4: 24,709,030 (GRCm38) I112F probably damaging Het
Lepr A G 4: 101,815,117 (GRCm38) I1113V probably benign Het
Lrrc3b C A 14: 15,357,888 (GRCm38) L239F probably damaging Het
Lzic T A 4: 149,488,128 (GRCm38) probably null Het
Mxra8 T A 4: 155,842,661 (GRCm38) F351I probably damaging Het
Naa40 A G 19: 7,229,982 (GRCm38) F126L probably damaging Het
Nbeal1 C T 1: 60,238,654 (GRCm38) S733F probably damaging Het
Olfr183 A C 16: 59,000,219 (GRCm38) Y178S probably damaging Het
Olfr259 A G 2: 87,108,183 (GRCm38) F68S possibly damaging Het
Olfr686 A G 7: 105,204,025 (GRCm38) I106T probably damaging Het
Olr1 T C 6: 129,500,081 (GRCm38) T74A probably damaging Het
Pgam5 A T 5: 110,265,825 (GRCm38) V130D probably damaging Het
Pop4 A G 7: 38,266,149 (GRCm38) C115R probably damaging Het
Prpf18 A T 2: 4,624,537 (GRCm38) probably null Het
Psg16 G A 7: 17,095,106 (GRCm38) R205H possibly damaging Het
Ptgr1 C A 4: 58,981,879 (GRCm38) A53S probably benign Het
Shank2 A G 7: 144,411,271 (GRCm38) D1451G probably benign Het
Slfn10-ps A G 11: 83,029,519 (GRCm38) noncoding transcript Het
Sox8 G A 17: 25,570,356 (GRCm38) A56V probably benign Het
Ssr3 A G 3: 65,387,754 (GRCm38) S113P probably damaging Het
Stx16 T C 2: 174,096,928 (GRCm38) Y296H possibly damaging Het
Tfcp2 A T 15: 100,528,489 (GRCm38) N60K probably benign Het
Thada T C 17: 84,444,226 (GRCm38) T441A probably benign Het
Trf G T 9: 103,227,875 (GRCm38) probably benign Het
Vamp2 T A 11: 69,088,662 (GRCm38) probably benign Het
Vmn2r105 A T 17: 20,228,018 (GRCm38) D181E probably benign Het
Vmn2r12 A T 5: 109,091,678 (GRCm38) Y340N probably damaging Het
Wasf2 C A 4: 133,195,859 (GRCm38) D493E unknown Het
Wdfy4 T C 14: 33,047,256 (GRCm38) D2084G possibly damaging Het
Zfp229 T A 17: 21,746,373 (GRCm38) I528N probably damaging Het
Zfp703 T A 8: 26,978,851 (GRCm38) V181E possibly damaging Het
Other mutations in Ints2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00807:Ints2 APN 11 86,233,135 (GRCm38) missense probably damaging 1.00
IGL02490:Ints2 APN 11 86,233,183 (GRCm38) missense possibly damaging 0.93
IGL02612:Ints2 APN 11 86,215,578 (GRCm38) missense probably damaging 1.00
IGL03396:Ints2 APN 11 86,213,062 (GRCm38) missense probably damaging 0.99
R0015:Ints2 UTSW 11 86,249,287 (GRCm38) missense probably damaging 1.00
R0015:Ints2 UTSW 11 86,249,287 (GRCm38) missense probably damaging 1.00
R0355:Ints2 UTSW 11 86,234,749 (GRCm38) missense probably benign 0.00
R0389:Ints2 UTSW 11 86,248,851 (GRCm38) missense probably damaging 1.00
R0631:Ints2 UTSW 11 86,233,196 (GRCm38) missense probably benign 0.02
R0944:Ints2 UTSW 11 86,244,463 (GRCm38) missense possibly damaging 0.85
R1268:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1269:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1270:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1396:Ints2 UTSW 11 86,249,248 (GRCm38) missense probably damaging 0.98
R1474:Ints2 UTSW 11 86,226,781 (GRCm38) missense probably damaging 0.97
R1503:Ints2 UTSW 11 86,226,781 (GRCm38) missense probably damaging 0.97
R1840:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R1987:Ints2 UTSW 11 86,217,800 (GRCm38) missense probably benign 0.03
R1990:Ints2 UTSW 11 86,248,934 (GRCm38) missense possibly damaging 0.58
R1991:Ints2 UTSW 11 86,248,934 (GRCm38) missense possibly damaging 0.58
R3694:Ints2 UTSW 11 86,243,001 (GRCm38) missense probably benign 0.41
R4056:Ints2 UTSW 11 86,242,952 (GRCm38) missense probably damaging 1.00
R4057:Ints2 UTSW 11 86,242,952 (GRCm38) missense probably damaging 1.00
R4569:Ints2 UTSW 11 86,256,198 (GRCm38) missense probably damaging 1.00
R4585:Ints2 UTSW 11 86,249,275 (GRCm38) missense probably damaging 1.00
R4586:Ints2 UTSW 11 86,249,275 (GRCm38) missense probably damaging 1.00
R4806:Ints2 UTSW 11 86,256,209 (GRCm38) missense probably benign 0.10
R5031:Ints2 UTSW 11 86,256,200 (GRCm38) missense probably damaging 1.00
R5064:Ints2 UTSW 11 86,249,274 (GRCm38) missense probably damaging 1.00
R5270:Ints2 UTSW 11 86,215,795 (GRCm38) missense probably damaging 1.00
R5621:Ints2 UTSW 11 86,242,947 (GRCm38) missense probably benign 0.32
R5875:Ints2 UTSW 11 86,238,312 (GRCm38) missense probably benign 0.04
R5908:Ints2 UTSW 11 86,215,545 (GRCm38) critical splice donor site probably null
R5914:Ints2 UTSW 11 86,222,174 (GRCm38) missense probably benign 0.03
R5941:Ints2 UTSW 11 86,250,972 (GRCm38) missense probably benign 0.01
R5975:Ints2 UTSW 11 86,226,748 (GRCm38) missense possibly damaging 0.72
R6003:Ints2 UTSW 11 86,238,468 (GRCm38) missense probably damaging 1.00
R6091:Ints2 UTSW 11 86,236,603 (GRCm38) missense probably damaging 0.96
R6209:Ints2 UTSW 11 86,225,058 (GRCm38) missense probably damaging 1.00
R6567:Ints2 UTSW 11 86,226,661 (GRCm38) missense probably benign 0.42
R6764:Ints2 UTSW 11 86,212,779 (GRCm38) missense probably benign 0.00
R7033:Ints2 UTSW 11 86,233,085 (GRCm38) missense probably damaging 1.00
R7132:Ints2 UTSW 11 86,217,754 (GRCm38) missense probably benign 0.26
R7337:Ints2 UTSW 11 86,217,842 (GRCm38) missense probably benign 0.00
R7410:Ints2 UTSW 11 86,233,226 (GRCm38) missense probably benign 0.02
R7483:Ints2 UTSW 11 86,215,618 (GRCm38) missense probably damaging 1.00
R7503:Ints2 UTSW 11 86,232,055 (GRCm38) missense probably benign
R7804:Ints2 UTSW 11 86,212,663 (GRCm38) missense possibly damaging 0.92
R7845:Ints2 UTSW 11 86,238,263 (GRCm38) missense possibly damaging 0.93
R7875:Ints2 UTSW 11 86,213,062 (GRCm38) missense probably damaging 0.99
R7918:Ints2 UTSW 11 86,222,217 (GRCm38) missense probably damaging 1.00
R7922:Ints2 UTSW 11 86,244,627 (GRCm38) missense probably benign 0.29
R8058:Ints2 UTSW 11 86,255,353 (GRCm38) missense probably benign 0.05
R8134:Ints2 UTSW 11 86,212,660 (GRCm38) missense probably damaging 1.00
R8189:Ints2 UTSW 11 86,215,570 (GRCm38) missense probably damaging 1.00
R8295:Ints2 UTSW 11 86,225,088 (GRCm38) missense probably damaging 0.97
R8348:Ints2 UTSW 11 86,255,423 (GRCm38) missense probably benign
R8448:Ints2 UTSW 11 86,255,423 (GRCm38) missense probably benign
R8784:Ints2 UTSW 11 86,225,115 (GRCm38) nonsense probably null
R8784:Ints2 UTSW 11 86,222,137 (GRCm38) missense probably damaging 1.00
R8942:Ints2 UTSW 11 86,212,894 (GRCm38) missense probably benign 0.00
R9037:Ints2 UTSW 11 86,215,704 (GRCm38) missense probably benign
R9154:Ints2 UTSW 11 86,234,698 (GRCm38) missense probably damaging 1.00
R9397:Ints2 UTSW 11 86,244,485 (GRCm38) missense probably benign 0.01
R9412:Ints2 UTSW 11 86,226,763 (GRCm38) missense probably damaging 0.99
R9472:Ints2 UTSW 11 86,242,998 (GRCm38) missense
R9476:Ints2 UTSW 11 86,244,509 (GRCm38) missense probably benign
R9510:Ints2 UTSW 11 86,244,509 (GRCm38) missense probably benign
Predicted Primers PCR Primer
(F):5'- CCATCAGAGCAGATCCAAAGATATG -3'
(R):5'- CTCTGATGTTGCCACTCAGAC -3'

Sequencing Primer
(F):5'- GCCAATCAAACAAGTATAATTCTCAG -3'
(R):5'- TCTGATGTTGCCACTCAGACAAGAG -3'
Posted On 2016-04-15