Mutagenetix > Incidental Mutation

Incidental Mutation 'R4930:Ahnak'

381197

Institutional Source

Beutler Lab

Gene Symbol

Ahnak

Ensembl Gene

ENSMUSG00000069833

Gene Name

AHNAK nucleoprotein (desmoyokin)

Synonyms

1110004P15Rik, 2310047C17Rik, DY6

MMRRC Submission

042531-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.368) question?

Stock #

R4930 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

8989284-9076919 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 9010967 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 3205 (M3205T)

Ref Sequence

ENSEMBL: ENSMUSP00000090633 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000092955] [ENSMUST00000092956]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000092955

SMART Domains

Protein: ENSMUSP00000090632
Gene: ENSMUSG00000069833

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
PDZ	20	91	2.31e-5	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000092956
AA Change: M3205T

PolyPhen 2 Score 0.785 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000090633
Gene: ENSMUSG00000069833
AA Change: M3205T

Domain	Start	End	E-Value	Type
low complexity region	2	13	N/A	INTRINSIC
PDZ	20	91	2.31e-5	SMART
internal_repeat_2	163	1515	5.22e-182	PROSPERO
internal_repeat_1	224	2314	N/A	PROSPERO
internal_repeat_2	1532	3028	5.22e-182	PROSPERO
internal_repeat_1	2660	5095	N/A	PROSPERO
low complexity region	5336	5353	N/A	INTRINSIC
low complexity region	5493	5504	N/A	INTRINSIC
low complexity region	5580	5600	N/A	INTRINSIC
low complexity region	5620	5636	N/A	INTRINSIC

Meta Mutation Damage Score

0.0788

Coding Region Coverage

1x: 99.0%
3x: 98.2%
10x: 95.9%
20x: 91.1%

Validation Efficiency

99% (88/89)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a large (700 kDa) structural scaffold protein consisting of a central domain with 128 aa repeats. The encoded protein may play a role in such diverse processes as blood-brain barrier formation, cell structure and migration, cardiac calcium channel regulation, and tumor metastasis. A much shorter variant encoding a 17 kDa isoform exists for this gene, and the shorter isoform initiates a feedback loop that regulates alternative splicing of this gene. [provided by RefSeq, Oct 2016]
PHENOTYPE: Mice homozygous for one knock-out allele exhibit decreased T cell proliferation and increased susceptibility to parasitic infection. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930447C04Rik	C	T	12: 72,906,234 (GRCm38)	E242K	possibly damaging	Het
A930011G23Rik	A	G	5: 99,222,404 (GRCm38)	M499T	possibly damaging	Het
Abcb8	G	A	5: 24,400,781 (GRCm38)	V196M	possibly damaging	Het
Ankrd1	A	G	19: 36,115,033 (GRCm38)	Y265H	probably damaging	Het
Apeh	A	G	9: 108,087,825 (GRCm38)	S446P	probably benign	Het
Apip	C	A	2: 103,091,881 (GRCm38)	Y197*	probably null	Het
Arhgef11	T	G	3: 87,728,594 (GRCm38)	V925G	probably damaging	Het
Arid4b	T	C	13: 14,187,477 (GRCm38)	V929A	probably damaging	Het
Asah2	T	A	19: 32,052,906 (GRCm38)	D122V	probably benign	Het
B2m	A	T	2: 122,151,647 (GRCm38)	D116V	possibly damaging	Het
BC067074	G	T	13: 113,327,662 (GRCm38)	G1453C	probably damaging	Het
Bhmt-ps1	A	G	4: 26,369,184 (GRCm38)		noncoding transcript	Het
Cacna1g	T	A	11: 94,444,073 (GRCm38)	I803F	probably damaging	Het
Ccdc43	A	T	11: 102,690,285 (GRCm38)	V113E	probably damaging	Het
Cenpj	A	T	14: 56,534,781 (GRCm38)	Y388*	probably null	Het
Chd3	G	A	11: 69,354,208 (GRCm38)		probably benign	Het
Chil3	C	T	3: 106,164,208 (GRCm38)	D47N	possibly damaging	Het
Colgalt2	A	G	1: 152,499,959 (GRCm38)	T361A	possibly damaging	Het
Cops3	C	A	11: 59,835,367 (GRCm38)		probably benign	Het
Crb2	G	T	2: 37,783,314 (GRCm38)	G74V	probably damaging	Het
Cyp20a1	A	T	1: 60,366,719 (GRCm38)	Y224F	probably damaging	Het
Diaph3	A	G	14: 87,141,166 (GRCm38)		probably benign	Het
Dnah3	A	T	7: 119,951,681 (GRCm38)	Y3127*	probably null	Het
Eef1akmt3	A	C	10: 127,041,355 (GRCm38)	S14A	possibly damaging	Het
Ehf	C	A	2: 103,266,857 (GRCm38)	R250L	probably damaging	Het
Eps8l1	G	A	7: 4,460,916 (GRCm38)	R13Q	possibly damaging	Het
Frem2	A	C	3: 53,656,315 (GRCm38)	V257G	possibly damaging	Het
Gc	T	C	5: 89,439,589 (GRCm38)	T259A	probably benign	Het
Gm4952	A	T	19: 12,627,012 (GRCm38)	N263Y	probably benign	Het
Gpcpd1	T	A	2: 132,546,874 (GRCm38)	H326L	probably damaging	Het
Helz	T	C	11: 107,620,168 (GRCm38)	F617L	probably damaging	Het
Hoxb4	T	C	11: 96,318,836 (GRCm38)	Y23H	probably damaging	Het
Hsf4	T	A	8: 105,272,698 (GRCm38)		probably null	Het
Ighv1-81	T	C	12: 115,920,304 (GRCm38)	D109G	probably damaging	Het
Irx4	T	C	13: 73,268,913 (GRCm38)	V476A	probably benign	Het
Katnb1	T	A	8: 95,097,294 (GRCm38)		probably null	Het
L3mbtl1	A	G	2: 162,965,772 (GRCm38)	Y490C	probably damaging	Het
Lemd2	A	G	17: 27,193,832 (GRCm38)		probably null	Het
Lrrc38	A	T	4: 143,369,868 (GRCm38)	T250S	probably damaging	Het
Map3k8	A	T	18: 4,349,215 (GRCm38)	Y34*	probably null	Het
Mgst1	T	A	6: 138,153,509 (GRCm38)	F79I	probably benign	Het
Midn	T	C	10: 80,155,355 (GRCm38)	S357P	probably benign	Het
Mmp3	T	A	9: 7,447,640 (GRCm38)	D208E	probably benign	Het
Mrps26	A	G	2: 130,564,942 (GRCm38)	E163G	probably damaging	Het
Mycbpap	A	T	11: 94,503,157 (GRCm38)	M371K	probably benign	Het
Mynn	A	C	3: 30,607,042 (GRCm38)	N91T	probably damaging	Het
Nek11	A	G	9: 105,300,066 (GRCm38)	L292P	probably damaging	Het
Nid1	A	T	13: 13,510,011 (GRCm38)	R1228W	probably damaging	Het
Nphs2	T	C	1: 156,320,929 (GRCm38)	Y121H	probably damaging	Het
Olfr1020	T	A	2: 85,849,893 (GRCm38)	I147N	probably benign	Het
Olfr1166	A	C	2: 88,124,340 (GRCm38)	I215S	probably benign	Het
Olfr1178	G	A	2: 88,391,940 (GRCm38)	R231H	probably benign	Het
Olfr1497	T	C	19: 13,795,551 (GRCm38)	H20R	probably benign	Het
Olfr161	T	G	16: 3,592,435 (GRCm38)	L13R	probably damaging	Het
Olfr204	C	A	16: 59,314,873 (GRCm38)	C178F	probably damaging	Het
Olfr872	T	C	9: 20,260,017 (GRCm38)	I59T	probably damaging	Het
P2rx7	C	T	5: 122,670,479 (GRCm38)	T308M	probably damaging	Het
Prdx6	C	T	1: 161,241,693 (GRCm38)		probably benign	Het
Rad54b	T	A	4: 11,615,579 (GRCm38)	D862E	probably damaging	Het
Ripor1	A	G	8: 105,617,182 (GRCm38)	Y344C	probably damaging	Het
Rnf112	T	C	11: 61,453,465 (GRCm38)	M43V	probably benign	Het
Rp1l1	A	G	14: 64,032,206 (GRCm38)	N1747S	probably benign	Het
Rps27	A	G	3: 90,212,999 (GRCm38)	V22A	probably damaging	Het
Spaca1	A	G	4: 34,044,236 (GRCm38)	V86A	possibly damaging	Het
Spdef	A	G	17: 27,718,162 (GRCm38)	Y156H	probably damaging	Het
Specc1	A	C	11: 62,118,958 (GRCm38)	E433D	possibly damaging	Het
Srpr	T	A	9: 35,215,030 (GRCm38)	F506L	probably benign	Het
Stxbp5	A	G	10: 9,760,866 (GRCm38)		probably benign	Het
Syne1	C	T	10: 5,052,777 (GRCm38)	R8046Q	probably damaging	Het
Tbx5	T	A	5: 119,883,025 (GRCm38)	S365R	probably benign	Het
Terb1	G	T	8: 104,447,948 (GRCm38)	P698Q	probably benign	Het
Tmbim7	T	A	5: 3,661,948 (GRCm38)	Y27*	probably null	Het
Tmem106c	C	A	15: 97,965,028 (GRCm38)	A60E	possibly damaging	Het
Ttc26	A	T	6: 38,391,540 (GRCm38)	Y174F	probably damaging	Het
Ttc6	T	A	12: 57,673,823 (GRCm38)		probably null	Het
Ttn	T	C	2: 76,732,370 (GRCm38)	I28747V	possibly damaging	Het
Unc13a	C	T	8: 71,630,504 (GRCm38)		probably null	Het
Wdr81	T	C	11: 75,451,924 (GRCm38)	D839G	probably benign	Het
Wfdc15a	G	C	2: 164,199,805 (GRCm38)	Q33E	probably benign	Het
Zfp456	T	C	13: 67,366,946 (GRCm38)	R214G	probably benign	Het
Zfp457	T	A	13: 67,294,100 (GRCm38)	Y137F	probably damaging	Het

Other mutations in Ahnak

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00467:Ahnak	APN	19	9,007,223 (GRCm38)	missense	probably damaging	0.99
IGL00509:Ahnak	APN	19	9,009,951 (GRCm38)	missense	possibly damaging	0.94
IGL00539:Ahnak	APN	19	9,007,908 (GRCm38)	missense	possibly damaging	0.50
IGL00558:Ahnak	APN	19	9,004,307 (GRCm38)	missense	possibly damaging	0.93
IGL00567:Ahnak	APN	19	9,013,383 (GRCm38)	missense	probably benign	0.24
IGL00706:Ahnak	APN	19	9,013,730 (GRCm38)	nonsense	probably null
IGL00807:Ahnak	APN	19	9,008,522 (GRCm38)	missense	possibly damaging	0.92
IGL00870:Ahnak	APN	19	9,013,698 (GRCm38)	missense	probably damaging	1.00
IGL01101:Ahnak	APN	19	9,012,887 (GRCm38)	intron	probably benign
IGL01118:Ahnak	APN	19	9,012,578 (GRCm38)	missense	probably damaging	1.00
IGL01288:Ahnak	APN	19	9,002,494 (GRCm38)	missense	possibly damaging	0.94
IGL01324:Ahnak	APN	19	9,003,032 (GRCm38)	missense	probably damaging	1.00
IGL01341:Ahnak	APN	19	9,011,703 (GRCm38)	missense	probably benign
IGL01541:Ahnak	APN	19	9,007,879 (GRCm38)	missense	possibly damaging	0.95
IGL01580:Ahnak	APN	19	9,002,839 (GRCm38)	missense	probably benign	0.02
IGL01595:Ahnak	APN	19	9,003,501 (GRCm38)	nonsense	probably null
IGL01746:Ahnak	APN	19	9,004,912 (GRCm38)	missense	possibly damaging	0.89
IGL01766:Ahnak	APN	19	9,000,118 (GRCm38)	missense	unknown
IGL01821:Ahnak	APN	19	9,012,118 (GRCm38)	missense	probably benign
IGL01913:Ahnak	APN	19	9,006,064 (GRCm38)	nonsense	probably null
IGL01934:Ahnak	APN	19	9,002,657 (GRCm38)	missense	probably damaging	1.00
IGL01940:Ahnak	APN	19	9,006,557 (GRCm38)	missense	probably benign	0.14
IGL01958:Ahnak	APN	19	9,014,909 (GRCm38)	missense	possibly damaging	0.59
IGL02145:Ahnak	APN	19	9,002,855 (GRCm38)	missense	probably benign	0.11
IGL02246:Ahnak	APN	19	9,008,268 (GRCm38)	missense	probably damaging	1.00
IGL02282:Ahnak	APN	19	9,005,987 (GRCm38)	missense	probably damaging	1.00
IGL02428:Ahnak	APN	19	9,014,833 (GRCm38)	missense	possibly damaging	0.83
IGL02442:Ahnak	APN	19	9,004,016 (GRCm38)	missense	probably damaging	1.00
IGL02474:Ahnak	APN	19	9,004,933 (GRCm38)	missense	probably benign	0.13
IGL02483:Ahnak	APN	19	9,003,308 (GRCm38)	missense	probably benign	0.01
IGL02616:Ahnak	APN	19	9,005,627 (GRCm38)	missense	probably benign	0.03
IGL02630:Ahnak	APN	19	9,012,077 (GRCm38)	missense	probably damaging	1.00
IGL02690:Ahnak	APN	19	9,012,584 (GRCm38)	nonsense	probably null
IGL02717:Ahnak	APN	19	9,002,387 (GRCm38)	missense	probably benign	0.00
IGL02721:Ahnak	APN	19	9,009,707 (GRCm38)	missense	probably benign	0.07
IGL02737:Ahnak	APN	19	9,004,593 (GRCm38)	missense	probably benign	0.17
IGL02850:Ahnak	APN	19	9,002,596 (GRCm38)	missense	probably benign	0.00
IGL03071:Ahnak	APN	19	9,011,918 (GRCm38)	missense	possibly damaging	0.63
IGL03072:Ahnak	APN	19	9,006,508 (GRCm38)	missense	probably benign	0.11
IGL03094:Ahnak	APN	19	9,003,547 (GRCm38)	missense	possibly damaging	0.64
IGL03140:Ahnak	APN	19	9,005,212 (GRCm38)	intron	probably benign
IGL03176:Ahnak	APN	19	9,002,449 (GRCm38)	missense	probably damaging	1.00
IGL03176:Ahnak	APN	19	9,008,166 (GRCm38)	missense	possibly damaging	0.56
IGL03189:Ahnak	APN	19	9,011,239 (GRCm38)	missense	possibly damaging	0.65
IGL03357:Ahnak	APN	19	9,009,325 (GRCm38)	intron	probably benign
IGL03371:Ahnak	APN	19	9,004,228 (GRCm38)	missense	possibly damaging	0.91
Eskimo	UTSW	19	9,009,574 (GRCm38)	missense	probably benign	0.31
Nanook	UTSW	19	9,003,231 (GRCm38)	missense	probably benign	0.42
Netsilik	UTSW	19	9,002,321 (GRCm38)	missense	probably benign	0.00
IGL03097:Ahnak	UTSW	19	9,002,387 (GRCm38)	missense	probably benign	0.00
PIT4403001:Ahnak	UTSW	19	9,006,176 (GRCm38)	missense	possibly damaging	0.87
R0054:Ahnak	UTSW	19	9,012,056 (GRCm38)	missense	probably damaging	1.00
R0094:Ahnak	UTSW	19	9,013,893 (GRCm38)	missense	probably benign	0.12
R0110:Ahnak	UTSW	19	9,018,232 (GRCm38)	nonsense	probably null
R0141:Ahnak	UTSW	19	9,006,680 (GRCm38)	missense	probably damaging	1.00
R0166:Ahnak	UTSW	19	9,005,725 (GRCm38)	missense	probably damaging	1.00
R0309:Ahnak	UTSW	19	9,002,495 (GRCm38)	missense	probably damaging	1.00
R0368:Ahnak	UTSW	19	9,008,350 (GRCm38)	nonsense	probably null
R0386:Ahnak	UTSW	19	9,011,144 (GRCm38)	missense	possibly damaging	0.94
R0401:Ahnak	UTSW	19	9,015,116 (GRCm38)	missense	probably benign	0.24
R0415:Ahnak	UTSW	19	9,012,871 (GRCm38)	intron	probably benign
R0463:Ahnak	UTSW	19	9,009,407 (GRCm38)	intron	probably benign
R0469:Ahnak	UTSW	19	9,018,232 (GRCm38)	nonsense	probably null
R0470:Ahnak	UTSW	19	9,008,967 (GRCm38)	missense	probably benign	0.29
R0487:Ahnak	UTSW	19	9,014,120 (GRCm38)	missense	probably damaging	0.99
R0487:Ahnak	UTSW	19	9,007,151 (GRCm38)	missense	probably benign	0.00
R0499:Ahnak	UTSW	19	9,000,264 (GRCm38)	splice site	probably benign
R0506:Ahnak	UTSW	19	9,009,128 (GRCm38)	missense	probably damaging	1.00
R0510:Ahnak	UTSW	19	9,018,232 (GRCm38)	nonsense	probably null
R0557:Ahnak	UTSW	19	9,001,944 (GRCm38)	missense	probably benign	0.10
R0570:Ahnak	UTSW	19	9,013,698 (GRCm38)	missense	probably damaging	1.00
R0610:Ahnak	UTSW	19	9,007,878 (GRCm38)	missense	probably benign	0.08
R0646:Ahnak	UTSW	19	9,013,402 (GRCm38)	nonsense	probably null
R0659:Ahnak	UTSW	19	9,015,002 (GRCm38)	missense	possibly damaging	0.60
R0791:Ahnak	UTSW	19	9,016,734 (GRCm38)	missense	probably benign	0.01
R0792:Ahnak	UTSW	19	9,016,734 (GRCm38)	missense	probably benign	0.01
R0840:Ahnak	UTSW	19	9,005,063 (GRCm38)	missense	probably damaging	1.00
R0847:Ahnak	UTSW	19	9,006,433 (GRCm38)	nonsense	probably null
R0941:Ahnak	UTSW	19	9,009,914 (GRCm38)	missense	probably damaging	1.00
R0962:Ahnak	UTSW	19	9,012,848 (GRCm38)	intron	probably benign
R1017:Ahnak	UTSW	19	9,010,543 (GRCm38)	missense	probably damaging	0.99
R1037:Ahnak	UTSW	19	9,007,618 (GRCm38)	missense	probably benign	0.27
R1085:Ahnak	UTSW	19	9,013,125 (GRCm38)	missense	possibly damaging	0.50
R1113:Ahnak	UTSW	19	9,005,620 (GRCm38)	missense	probably benign	0.29
R1140:Ahnak	UTSW	19	9,004,245 (GRCm38)	missense	probably damaging	1.00
R1158:Ahnak	UTSW	19	9,013,926 (GRCm38)	missense	probably benign	0.00
R1218:Ahnak	UTSW	19	9,015,619 (GRCm38)	missense	probably damaging	1.00
R1225:Ahnak	UTSW	19	9,002,883 (GRCm38)	missense	probably damaging	1.00
R1245:Ahnak	UTSW	19	9,004,169 (GRCm38)	missense	probably benign	0.44
R1421:Ahnak	UTSW	19	9,015,631 (GRCm38)	missense	possibly damaging	0.95
R1447:Ahnak	UTSW	19	9,007,082 (GRCm38)	missense	probably damaging	0.98
R1464:Ahnak	UTSW	19	9,004,896 (GRCm38)	missense	probably damaging	1.00
R1464:Ahnak	UTSW	19	9,004,896 (GRCm38)	missense	probably damaging	1.00
R1466:Ahnak	UTSW	19	9,015,875 (GRCm38)	missense	probably damaging	1.00
R1466:Ahnak	UTSW	19	9,015,875 (GRCm38)	missense	probably damaging	1.00
R1471:Ahnak	UTSW	19	9,012,932 (GRCm38)	intron	probably benign
R1507:Ahnak	UTSW	19	9,010,077 (GRCm38)	missense	probably damaging	1.00
R1521:Ahnak	UTSW	19	9,004,728 (GRCm38)	missense	probably benign	0.11
R1568:Ahnak	UTSW	19	9,002,375 (GRCm38)	missense	probably damaging	0.98
R1569:Ahnak	UTSW	19	9,004,094 (GRCm38)	missense	possibly damaging	0.78
R1616:Ahnak	UTSW	19	9,008,987 (GRCm38)	missense	possibly damaging	0.94
R1638:Ahnak	UTSW	19	9,009,449 (GRCm38)	missense	probably benign	0.01
R1680:Ahnak	UTSW	19	9,009,963 (GRCm38)	missense	probably benign	0.05
R1713:Ahnak	UTSW	19	9,011,809 (GRCm38)	missense	possibly damaging	0.95
R1722:Ahnak	UTSW	19	9,010,655 (GRCm38)	missense	probably damaging	0.99
R1771:Ahnak	UTSW	19	9,013,753 (GRCm38)	missense	probably benign	0.24
R1795:Ahnak	UTSW	19	9,002,438 (GRCm38)	missense	possibly damaging	0.79
R1823:Ahnak	UTSW	19	9,004,905 (GRCm38)	missense	probably damaging	0.99
R1842:Ahnak	UTSW	19	9,005,867 (GRCm38)	missense	probably damaging	0.99
R1854:Ahnak	UTSW	19	9,013,832 (GRCm38)	missense	possibly damaging	0.61
R1856:Ahnak	UTSW	19	9,002,048 (GRCm38)	missense	possibly damaging	0.86
R1886:Ahnak	UTSW	19	9,015,979 (GRCm38)	missense	probably damaging	0.98
R1888:Ahnak	UTSW	19	9,007,088 (GRCm38)	missense	probably damaging	1.00
R1888:Ahnak	UTSW	19	9,007,088 (GRCm38)	missense	probably damaging	1.00
R1912:Ahnak	UTSW	19	9,017,881 (GRCm38)	missense	probably damaging	1.00
R1913:Ahnak	UTSW	19	9,007,922 (GRCm38)	missense	probably damaging	0.99
R1942:Ahnak	UTSW	19	9,015,083 (GRCm38)	missense	probably damaging	0.98
R1987:Ahnak	UTSW	19	9,015,251 (GRCm38)	missense	probably damaging	1.00
R2006:Ahnak	UTSW	19	9,007,075 (GRCm38)	missense	probably damaging	1.00
R2013:Ahnak	UTSW	19	9,014,573 (GRCm38)	missense	probably damaging	0.98
R2014:Ahnak	UTSW	19	9,013,181 (GRCm38)	missense	probably damaging	0.99
R2047:Ahnak	UTSW	19	9,014,300 (GRCm38)	missense	possibly damaging	0.67
R2048:Ahnak	UTSW	19	9,007,056 (GRCm38)	missense	probably damaging	0.99
R2060:Ahnak	UTSW	19	9,008,041 (GRCm38)	missense	probably benign	0.08
R2083:Ahnak	UTSW	19	9,011,557 (GRCm38)	missense	probably damaging	1.00
R2157:Ahnak	UTSW	19	9,000,684 (GRCm38)	missense	possibly damaging	0.92
R2167:Ahnak	UTSW	19	9,011,494 (GRCm38)	nonsense	probably null
R2208:Ahnak	UTSW	19	9,017,732 (GRCm38)	missense	probably benign	0.00
R2224:Ahnak	UTSW	19	9,012,991 (GRCm38)	intron	probably benign
R2268:Ahnak	UTSW	19	9,010,574 (GRCm38)	missense	possibly damaging	0.66
R2420:Ahnak	UTSW	19	9,009,256 (GRCm38)	missense	possibly damaging	0.89
R2426:Ahnak	UTSW	19	9,002,851 (GRCm38)	missense	possibly damaging	0.81
R2910:Ahnak	UTSW	19	9,011,654 (GRCm38)	missense	probably damaging	0.99
R2911:Ahnak	UTSW	19	9,011,654 (GRCm38)	missense	probably damaging	0.99
R2981:Ahnak	UTSW	19	9,000,148 (GRCm38)	missense	probably damaging	0.97
R3151:Ahnak	UTSW	19	9,009,944 (GRCm38)	missense	probably benign	0.12
R3155:Ahnak	UTSW	19	9,010,177 (GRCm38)	missense	possibly damaging	0.49
R3422:Ahnak	UTSW	19	9,006,752 (GRCm38)	missense	probably benign	0.05
R3422:Ahnak	UTSW	19	9,005,708 (GRCm38)	missense	probably benign	0.39
R3430:Ahnak	UTSW	19	9,006,958 (GRCm38)	missense	probably benign	0.42
R3433:Ahnak	UTSW	19	9,009,994 (GRCm38)	missense	probably benign	0.01
R3711:Ahnak	UTSW	19	9,007,898 (GRCm38)	missense	probably benign
R3723:Ahnak	UTSW	19	9,016,853 (GRCm38)	missense	possibly damaging	0.79
R3775:Ahnak	UTSW	19	9,009,023 (GRCm38)	missense	possibly damaging	0.91
R3858:Ahnak	UTSW	19	9,010,859 (GRCm38)	missense	possibly damaging	0.82
R3859:Ahnak	UTSW	19	9,010,859 (GRCm38)	missense	possibly damaging	0.82
R3922:Ahnak	UTSW	19	9,006,328 (GRCm38)	missense	probably benign	0.20
R3924:Ahnak	UTSW	19	9,006,328 (GRCm38)	missense	probably benign	0.20
R3926:Ahnak	UTSW	19	9,006,328 (GRCm38)	missense	probably benign	0.20
R4026:Ahnak	UTSW	19	9,011,299 (GRCm38)	missense	probably damaging	0.97
R4051:Ahnak	UTSW	19	9,014,327 (GRCm38)	missense	probably damaging	1.00
R4209:Ahnak	UTSW	19	9,002,600 (GRCm38)	missense	probably damaging	1.00
R4234:Ahnak	UTSW	19	9,000,786 (GRCm38)	nonsense	probably null
R4237:Ahnak	UTSW	19	9,001,783 (GRCm38)	missense	probably benign	0.02
R4285:Ahnak	UTSW	19	9,016,839 (GRCm38)	nonsense	probably null
R4331:Ahnak	UTSW	19	9,015,820 (GRCm38)	missense	probably damaging	1.00
R4342:Ahnak	UTSW	19	9,012,083 (GRCm38)	missense	possibly damaging	0.79
R4430:Ahnak	UTSW	19	9,003,040 (GRCm38)	missense	probably benign	0.00
R4554:Ahnak	UTSW	19	9,014,930 (GRCm38)	missense	probably damaging	1.00
R4602:Ahnak	UTSW	19	9,010,825 (GRCm38)	missense	possibly damaging	0.66
R4612:Ahnak	UTSW	19	9,003,724 (GRCm38)	missense	probably benign	0.44
R4655:Ahnak	UTSW	19	9,008,701 (GRCm38)	missense	probably damaging	1.00
R4656:Ahnak	UTSW	19	9,004,855 (GRCm38)	missense	possibly damaging	0.80
R4700:Ahnak	UTSW	19	9,004,681 (GRCm38)	missense	probably benign	0.02
R4704:Ahnak	UTSW	19	9,012,258 (GRCm38)	intron	probably benign
R4704:Ahnak	UTSW	19	9,013,181 (GRCm38)	missense	probably damaging	0.99
R4705:Ahnak	UTSW	19	9,016,906 (GRCm38)	missense	probably benign	0.07
R4707:Ahnak	UTSW	19	9,016,735 (GRCm38)	missense	probably benign	0.03
R4732:Ahnak	UTSW	19	9,007,301 (GRCm38)	missense	probably damaging	1.00
R4733:Ahnak	UTSW	19	9,007,301 (GRCm38)	missense	probably damaging	1.00
R4778:Ahnak	UTSW	19	9,011,975 (GRCm38)	missense	possibly damaging	0.79
R4782:Ahnak	UTSW	19	9,012,499 (GRCm38)	intron	probably benign
R4832:Ahnak	UTSW	19	9,012,460 (GRCm38)	intron	probably benign
R4882:Ahnak	UTSW	19	9,005,897 (GRCm38)	missense	probably damaging	0.98
R4884:Ahnak	UTSW	19	9,012,754 (GRCm38)	intron	probably benign
R4895:Ahnak	UTSW	19	9,017,441 (GRCm38)	missense	probably benign	0.43
R4951:Ahnak	UTSW	19	9,017,835 (GRCm38)	missense	probably damaging	1.00
R4968:Ahnak	UTSW	19	9,015,100 (GRCm38)	missense	probably damaging	1.00
R5026:Ahnak	UTSW	19	9,010,631 (GRCm38)	missense	possibly damaging	0.46
R5050:Ahnak	UTSW	19	9,012,458 (GRCm38)	intron	probably benign
R5073:Ahnak	UTSW	19	9,003,231 (GRCm38)	missense	probably benign	0.42
R5110:Ahnak	UTSW	19	9,014,759 (GRCm38)	missense	probably damaging	1.00
R5119:Ahnak	UTSW	19	9,013,644 (GRCm38)	missense	probably benign	0.00
R5128:Ahnak	UTSW	19	9,017,087 (GRCm38)	missense	probably damaging	1.00
R5139:Ahnak	UTSW	19	9,004,655 (GRCm38)	missense	probably damaging	1.00
R5150:Ahnak	UTSW	19	9,010,904 (GRCm38)	missense	possibly damaging	0.46
R5151:Ahnak	UTSW	19	9,017,569 (GRCm38)	missense	probably benign	0.03
R5165:Ahnak	UTSW	19	9,015,665 (GRCm38)	missense	possibly damaging	0.95
R5236:Ahnak	UTSW	19	9,000,684 (GRCm38)	missense	possibly damaging	0.92
R5361:Ahnak	UTSW	19	9,015,341 (GRCm38)	missense	possibly damaging	0.92
R5366:Ahnak	UTSW	19	9,016,735 (GRCm38)	missense	possibly damaging	0.65
R5387:Ahnak	UTSW	19	9,003,691 (GRCm38)	missense	probably damaging	1.00
R5396:Ahnak	UTSW	19	9,007,175 (GRCm38)	missense	probably damaging	0.99
R5583:Ahnak	UTSW	19	9,006,917 (GRCm38)	missense	probably damaging	0.99
R5587:Ahnak	UTSW	19	9,009,476 (GRCm38)	missense	possibly damaging	0.88
R5620:Ahnak	UTSW	19	9,013,094 (GRCm38)	nonsense	probably null
R5643:Ahnak	UTSW	19	9,010,657 (GRCm38)	missense	possibly damaging	0.66
R5644:Ahnak	UTSW	19	9,010,657 (GRCm38)	missense	possibly damaging	0.66
R5657:Ahnak	UTSW	19	9,014,615 (GRCm38)	missense	probably damaging	0.99
R5688:Ahnak	UTSW	19	9,002,519 (GRCm38)	missense	probably benign	0.01
R5702:Ahnak	UTSW	19	9,001,840 (GRCm38)	missense	probably damaging	1.00
R5727:Ahnak	UTSW	19	9,016,747 (GRCm38)	missense	probably damaging	0.99
R5730:Ahnak	UTSW	19	9,010,253 (GRCm38)	missense	possibly damaging	0.81
R5755:Ahnak	UTSW	19	9,001,732 (GRCm38)	missense	probably benign	0.06
R5760:Ahnak	UTSW	19	9,013,562 (GRCm38)	missense	probably damaging	1.00
R5789:Ahnak	UTSW	19	9,002,321 (GRCm38)	missense	probably benign	0.00
R5790:Ahnak	UTSW	19	9,015,248 (GRCm38)	missense	probably damaging	0.99
R5795:Ahnak	UTSW	19	9,012,382 (GRCm38)	nonsense	probably null
R5808:Ahnak	UTSW	19	9,010,235 (GRCm38)	missense	possibly damaging	0.91
R5867:Ahnak	UTSW	19	9,010,052 (GRCm38)	missense	probably damaging	0.99
R5878:Ahnak	UTSW	19	9,008,342 (GRCm38)	missense	probably damaging	1.00
R5898:Ahnak	UTSW	19	9,018,211 (GRCm38)	missense	probably damaging	1.00
R5898:Ahnak	UTSW	19	9,013,767 (GRCm38)	missense	possibly damaging	0.63
R5912:Ahnak	UTSW	19	9,011,903 (GRCm38)	missense	probably damaging	0.99
R5935:Ahnak	UTSW	19	9,015,182 (GRCm38)	missense	possibly damaging	0.91
R5969:Ahnak	UTSW	19	9,016,585 (GRCm38)	missense	probably damaging	1.00
R5988:Ahnak	UTSW	19	9,009,347 (GRCm38)	intron	probably benign
R6000:Ahnak	UTSW	19	9,013,111 (GRCm38)	nonsense	probably null
R6005:Ahnak	UTSW	19	9,015,161 (GRCm38)	missense	possibly damaging	0.61
R6101:Ahnak	UTSW	19	9,004,099 (GRCm38)	missense	probably benign	0.20
R6105:Ahnak	UTSW	19	9,004,099 (GRCm38)	missense	probably benign	0.20
R6116:Ahnak	UTSW	19	9,012,963 (GRCm38)	intron	probably benign
R6209:Ahnak	UTSW	19	9,012,566 (GRCm38)	missense	probably damaging	1.00
R6240:Ahnak	UTSW	19	9,013,583 (GRCm38)	missense	probably damaging	1.00
R6255:Ahnak	UTSW	19	9,008,025 (GRCm38)	missense	possibly damaging	0.95
R6263:Ahnak	UTSW	19	9,018,277 (GRCm38)	missense	probably benign	0.03
R6287:Ahnak	UTSW	19	9,015,003 (GRCm38)	missense	probably benign	0.02
R6296:Ahnak	UTSW	19	9,003,305 (GRCm38)	missense	probably damaging	0.99
R6315:Ahnak	UTSW	19	9,006,626 (GRCm38)	missense	probably damaging	0.99
R6328:Ahnak	UTSW	19	9,007,148 (GRCm38)	missense	probably benign	0.11
R6331:Ahnak	UTSW	19	9,006,625 (GRCm38)	missense	probably benign	0.18
R6355:Ahnak	UTSW	19	9,008,762 (GRCm38)	missense	probably benign	0.02
R6409:Ahnak	UTSW	19	9,009,574 (GRCm38)	missense	probably benign	0.31
R6567:Ahnak	UTSW	19	9,008,806 (GRCm38)	missense	probably benign	0.27
R6572:Ahnak	UTSW	19	9,007,976 (GRCm38)	missense	probably damaging	0.99
R6574:Ahnak	UTSW	19	9,017,047 (GRCm38)	missense	probably benign	0.04
R6590:Ahnak	UTSW	19	9,009,581 (GRCm38)	missense	probably benign	0.29
R6620:Ahnak	UTSW	19	9,015,310 (GRCm38)	missense	possibly damaging	0.95
R6690:Ahnak	UTSW	19	9,009,581 (GRCm38)	missense	probably benign	0.29
R6731:Ahnak	UTSW	19	9,011,562 (GRCm38)	missense	possibly damaging	0.85
R6756:Ahnak	UTSW	19	9,007,561 (GRCm38)	missense	possibly damaging	0.59
R6846:Ahnak	UTSW	19	9,011,857 (GRCm38)	missense	possibly damaging	0.66
R6854:Ahnak	UTSW	19	9,015,235 (GRCm38)	missense	probably damaging	1.00
R6857:Ahnak	UTSW	19	9,037,168 (GRCm38)	nonsense	probably null
R6863:Ahnak	UTSW	19	9,012,365 (GRCm38)	intron	probably benign
R6876:Ahnak	UTSW	19	9,014,120 (GRCm38)	missense	probably damaging	0.99
R6958:Ahnak	UTSW	19	9,015,215 (GRCm38)	missense	possibly damaging	0.88
R7126:Ahnak	UTSW	19	9,002,359 (GRCm38)	missense	possibly damaging	0.61
R7181:Ahnak	UTSW	19	9,013,488 (GRCm38)	missense	probably damaging	1.00
R7183:Ahnak	UTSW	19	9,017,668 (GRCm38)	missense	probably damaging	1.00
R7202:Ahnak	UTSW	19	9,017,799 (GRCm38)	missense	probably damaging	1.00
R7235:Ahnak	UTSW	19	9,012,488 (GRCm38)	missense	unknown
R7241:Ahnak	UTSW	19	9,009,031 (GRCm38)	missense	possibly damaging	0.65
R7269:Ahnak	UTSW	19	9,006,617 (GRCm38)	missense	probably damaging	1.00
R7311:Ahnak	UTSW	19	9,002,143 (GRCm38)	missense	probably benign	0.04
R7311:Ahnak	UTSW	19	9,009,827 (GRCm38)	missense	possibly damaging	0.56
R7329:Ahnak	UTSW	19	9,001,792 (GRCm38)	missense	probably damaging	0.99
R7339:Ahnak	UTSW	19	9,008,165 (GRCm38)	missense	possibly damaging	0.75
R7390:Ahnak	UTSW	19	9,003,205 (GRCm38)	missense	probably benign	0.02
R7400:Ahnak	UTSW	19	9,014,613 (GRCm38)	missense	probably damaging	0.99
R7444:Ahnak	UTSW	19	9,007,423 (GRCm38)	missense	probably benign	0.08
R7483:Ahnak	UTSW	19	9,004,822 (GRCm38)	missense	probably damaging	1.00
R7498:Ahnak	UTSW	19	9,012,019 (GRCm38)	missense	probably benign	0.14
R7521:Ahnak	UTSW	19	9,002,351 (GRCm38)	missense	possibly damaging	0.89
R7522:Ahnak	UTSW	19	9,002,322 (GRCm38)	missense	probably benign	0.01
R7552:Ahnak	UTSW	19	9,006,824 (GRCm38)	missense	probably benign	0.18
R7563:Ahnak	UTSW	19	9,011,165 (GRCm38)	missense	probably damaging	0.99
R7565:Ahnak	UTSW	19	9,016,156 (GRCm38)	missense	probably benign	0.05
R7571:Ahnak	UTSW	19	9,000,786 (GRCm38)	nonsense	probably null
R7583:Ahnak	UTSW	19	9,006,093 (GRCm38)	missense	possibly damaging	0.90
R7600:Ahnak	UTSW	19	9,004,574 (GRCm38)	missense	possibly damaging	0.89
R7771:Ahnak	UTSW	19	9,015,047 (GRCm38)	missense	probably damaging	0.99
R7787:Ahnak	UTSW	19	9,009,315 (GRCm38)	missense	unknown
R7827:Ahnak	UTSW	19	9,005,344 (GRCm38)	nonsense	probably null
R7857:Ahnak	UTSW	19	9,007,468 (GRCm38)	missense	probably damaging	0.97
R7916:Ahnak	UTSW	19	9,005,832 (GRCm38)	missense	possibly damaging	0.66
R7939:Ahnak	UTSW	19	9,014,084 (GRCm38)	nonsense	probably null
R7959:Ahnak	UTSW	19	9,010,649 (GRCm38)	missense	possibly damaging	0.46
R7962:Ahnak	UTSW	19	9,012,800 (GRCm38)	missense	unknown
R7979:Ahnak	UTSW	19	9,011,432 (GRCm38)	missense	probably damaging	1.00
R8006:Ahnak	UTSW	19	9,012,083 (GRCm38)	missense	possibly damaging	0.79
R8013:Ahnak	UTSW	19	9,009,335 (GRCm38)	missense	unknown
R8033:Ahnak	UTSW	19	9,003,710 (GRCm38)	missense	probably benign	0.10
R8124:Ahnak	UTSW	19	9,007,123 (GRCm38)	missense	probably damaging	0.99
R8125:Ahnak	UTSW	19	9,011,876 (GRCm38)	missense	possibly damaging	0.95
R8129:Ahnak	UTSW	19	9,000,100 (GRCm38)	start codon destroyed	not run
R8151:Ahnak	UTSW	19	9,004,679 (GRCm38)	missense	possibly damaging	0.59
R8190:Ahnak	UTSW	19	9,002,255 (GRCm38)	missense	probably benign	0.01
R8221:Ahnak	UTSW	19	9,010,436 (GRCm38)	nonsense	probably null
R8241:Ahnak	UTSW	19	9,007,295 (GRCm38)	missense	probably benign	0.15
R8244:Ahnak	UTSW	19	9,015,673 (GRCm38)	missense	probably benign	0.44
R8248:Ahnak	UTSW	19	9,001,946 (GRCm38)	missense	probably damaging	1.00
R8261:Ahnak	UTSW	19	9,005,453 (GRCm38)	missense	probably damaging	1.00
R8330:Ahnak	UTSW	19	9,009,662 (GRCm38)	missense	possibly damaging	0.86
R8380:Ahnak	UTSW	19	9,017,855 (GRCm38)	missense	probably benign	0.05
R8407:Ahnak	UTSW	19	9,015,673 (GRCm38)	missense	probably benign	0.44
R8409:Ahnak	UTSW	19	9,015,673 (GRCm38)	missense	probably benign	0.44
R8463:Ahnak	UTSW	19	9,008,749 (GRCm38)	missense	probably benign	0.07
R8511:Ahnak	UTSW	19	9,012,355 (GRCm38)	missense	unknown
R8528:Ahnak	UTSW	19	9,007,728 (GRCm38)	missense	probably damaging	1.00
R8549:Ahnak	UTSW	19	9,011,483 (GRCm38)	missense	probably damaging	1.00
R8674:Ahnak	UTSW	19	9,005,996 (GRCm38)	missense	probably damaging	0.98
R8716:Ahnak	UTSW	19	9,009,074 (GRCm38)	missense	probably damaging	1.00
R8722:Ahnak	UTSW	19	9,013,346 (GRCm38)	nonsense	probably null
R8751:Ahnak	UTSW	19	9,010,145 (GRCm38)	missense	probably damaging	1.00
R8752:Ahnak	UTSW	19	9,015,537 (GRCm38)	missense	probably damaging	1.00
R8783:Ahnak	UTSW	19	9,011,473 (GRCm38)	missense	probably damaging	1.00
R8844:Ahnak	UTSW	19	9,006,890 (GRCm38)	missense	probably damaging	1.00
R8859:Ahnak	UTSW	19	9,007,203 (GRCm38)	missense	probably damaging	1.00
R8882:Ahnak	UTSW	19	9,000,742 (GRCm38)	missense	probably damaging	1.00
R8907:Ahnak	UTSW	19	9,009,088 (GRCm38)	missense	probably benign	0.24
R8938:Ahnak	UTSW	19	9,011,735 (GRCm38)	missense	probably benign	0.00
R8975:Ahnak	UTSW	19	9,012,737 (GRCm38)	missense	probably damaging	1.00
R8983:Ahnak	UTSW	19	9,004,113 (GRCm38)	missense	possibly damaging	0.75
R9017:Ahnak	UTSW	19	9,010,123 (GRCm38)	missense	probably damaging	1.00
R9027:Ahnak	UTSW	19	9,007,253 (GRCm38)	missense	possibly damaging	0.94
R9081:Ahnak	UTSW	19	9,008,526 (GRCm38)	missense	possibly damaging	0.81
R9104:Ahnak	UTSW	19	9,010,347 (GRCm38)	missense	probably benign	0.01
R9112:Ahnak	UTSW	19	9,009,785 (GRCm38)	missense	probably damaging	0.98
R9145:Ahnak	UTSW	19	9,014,923 (GRCm38)	missense	probably benign	0.38
R9189:Ahnak	UTSW	19	9,010,883 (GRCm38)	missense	possibly damaging	0.92
R9221:Ahnak	UTSW	19	9,012,579 (GRCm38)	missense	probably damaging	1.00
R9261:Ahnak	UTSW	19	9,016,139 (GRCm38)	missense	possibly damaging	0.63
R9299:Ahnak	UTSW	19	9,012,460 (GRCm38)	intron	probably benign
R9325:Ahnak	UTSW	19	9,013,893 (GRCm38)	missense	probably benign	0.12
R9337:Ahnak	UTSW	19	9,012,460 (GRCm38)	intron	probably benign
R9340:Ahnak	UTSW	19	9,017,047 (GRCm38)	missense	probably benign	0.04
R9351:Ahnak	UTSW	19	9,007,868 (GRCm38)	missense	probably damaging	1.00
R9416:Ahnak	UTSW	19	9,012,902 (GRCm38)	missense	unknown
R9462:Ahnak	UTSW	19	9,003,935 (GRCm38)	missense	probably damaging	0.96
R9469:Ahnak	UTSW	19	9,010,861 (GRCm38)	missense	probably damaging	1.00
R9485:Ahnak	UTSW	19	9,002,074 (GRCm38)	missense	probably benign	0.16
R9503:Ahnak	UTSW	19	9,010,094 (GRCm38)	missense	probably damaging	1.00
R9524:Ahnak	UTSW	19	9,037,253 (GRCm38)	missense
R9534:Ahnak	UTSW	19	9,003,612 (GRCm38)	missense	probably benign	0.20
R9598:Ahnak	UTSW	19	9,003,785 (GRCm38)	missense	probably benign	0.42
R9611:Ahnak	UTSW	19	9,011,798 (GRCm38)	missense	probably damaging	0.99
R9624:Ahnak	UTSW	19	9,012,482 (GRCm38)	missense	unknown
R9649:Ahnak	UTSW	19	9,008,422 (GRCm38)	nonsense	probably null
R9683:Ahnak	UTSW	19	9,007,355 (GRCm38)	missense	possibly damaging	0.94
R9691:Ahnak	UTSW	19	9,011,726 (GRCm38)	missense	possibly damaging	0.49
R9712:Ahnak	UTSW	19	9,007,029 (GRCm38)	small deletion	probably benign
R9712:Ahnak	UTSW	19	9,007,028 (GRCm38)	small deletion	probably benign
R9713:Ahnak	UTSW	19	9,007,029 (GRCm38)	small deletion	probably benign
R9715:Ahnak	UTSW	19	9,007,029 (GRCm38)	small deletion	probably benign
R9725:Ahnak	UTSW	19	9,014,243 (GRCm38)	missense	probably damaging	1.00
R9725:Ahnak	UTSW	19	9,004,169 (GRCm38)	missense	probably benign	0.44
R9747:Ahnak	UTSW	19	9,010,177 (GRCm38)	missense	possibly damaging	0.49
R9798:Ahnak	UTSW	19	9,013,619 (GRCm38)	missense	probably damaging	0.99
RF007:Ahnak	UTSW	19	9,013,601 (GRCm38)	missense	possibly damaging	0.45
X0021:Ahnak	UTSW	19	9,013,619 (GRCm38)	missense	probably damaging	0.99
X0027:Ahnak	UTSW	19	9,012,037 (GRCm38)	missense	probably damaging	1.00
Z1088:Ahnak	UTSW	19	9,016,082 (GRCm38)	missense	probably damaging	0.99
Z1176:Ahnak	UTSW	19	9,008,856 (GRCm38)	missense	probably damaging	0.97
Z1177:Ahnak	UTSW	19	9,017,468 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCTGAGCATTTCATCTCCCAAAG -3'
(R):5'- GGCTTTGATGTTCATCTCAGGC -3'

Sequencing Primer
(F):5'- AAAGTCTCCATGCCCGATGTG -3'
(R):5'- CATCTCAGGCATCTTAAATTTGGGGC -3'

Posted On

2016-04-15