Incidental Mutation 'R4953:Copa'
| ID |
381350 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Copa
|
| Ensembl Gene |
ENSMUSG00000026553 |
| Gene Name |
coatomer protein complex subunit alpha |
| Synonyms |
xenin |
| MMRRC Submission |
042550-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.970)
|
| Stock # |
R4953 (G1)
|
| Quality Score |
138 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
171910096-171949897 bp(+) (GRCm39) |
| Type of Mutation |
unclassified |
| DNA Base Change (assembly) |
A to G
at 171910453 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000120663
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000003550]
[ENSMUST00000027833]
[ENSMUST00000124289]
[ENSMUST00000135192]
[ENSMUST00000140643]
[ENSMUST00000146137]
|
| AlphaFold |
Q8CIE6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000003550
|
| SMART Domains |
Protein: ENSMUSP00000003550
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
Pfam:Peptidase_M28
|
254 |
468 |
2.9e-7 |
PFAM |
|
Pfam:Nicastrin
|
273 |
498 |
1.6e-94 |
PFAM |
|
transmembrane domain
|
669 |
691 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027833
|
| SMART Domains |
Protein: ENSMUSP00000027833
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
2 |
37 |
2.86e0 |
SMART |
|
WD40
|
40 |
79 |
1.11e-6 |
SMART |
|
WD40
|
82 |
121 |
4.76e-6 |
SMART |
|
WD40
|
124 |
163 |
2.24e-11 |
SMART |
|
WD40
|
194 |
233 |
2.98e-7 |
SMART |
|
WD40
|
238 |
277 |
8.42e-7 |
SMART |
|
WD40
|
280 |
318 |
1.38e1 |
SMART |
|
Pfam:Coatomer_WDAD
|
338 |
776 |
5.4e-144 |
PFAM |
|
Pfam:COPI_C
|
824 |
1233 |
1.4e-190 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124289
|
| SMART Domains |
Protein: ENSMUSP00000118899
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
1 |
37 |
2e-19 |
BLAST |
|
PDB:4J8G|B
|
1 |
52 |
2e-23 |
PDB |
|
SCOP:d1erja_
|
1 |
52 |
1e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126634
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134468
AA Change: D19G
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135192
|
| SMART Domains |
Protein: ENSMUSP00000118179
Gene: ENSMUSG00000026553
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
2 |
37 |
2.86e0 |
SMART |
|
WD40
|
40 |
79 |
1.11e-6 |
SMART |
|
WD40
|
82 |
121 |
4.76e-6 |
SMART |
|
WD40
|
124 |
163 |
2.24e-11 |
SMART |
|
WD40
|
194 |
233 |
2.98e-7 |
SMART |
|
WD40
|
238 |
277 |
8.42e-7 |
SMART |
|
WD40
|
280 |
318 |
1.38e1 |
SMART |
|
Pfam:Coatomer_WDAD
|
338 |
767 |
1.1e-148 |
PFAM |
|
Pfam:COPI_C
|
815 |
1224 |
3.6e-216 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138407
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000142825
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140643
|
| SMART Domains |
Protein: ENSMUSP00000119128
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146137
|
| SMART Domains |
Protein: ENSMUSP00000120663
Gene: ENSMUSG00000003458
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
32 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.0%
|
| Validation Efficiency |
97% (113/116) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(6) : Gene trapped(6)
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad9 |
T |
C |
3: 36,128,525 (GRCm39) |
Y129H |
probably damaging |
Het |
| Adcy4 |
C |
T |
14: 56,016,486 (GRCm39) |
D322N |
probably damaging |
Het |
| Adgre1 |
G |
A |
17: 57,748,321 (GRCm39) |
G507E |
probably damaging |
Het |
| Agpat5 |
G |
A |
8: 18,918,971 (GRCm39) |
V118I |
probably benign |
Het |
| Aif1 |
T |
C |
17: 35,390,074 (GRCm39) |
|
probably null |
Het |
| Akr1c6 |
A |
T |
13: 4,488,608 (GRCm39) |
|
probably null |
Het |
| Akt2 |
T |
A |
7: 27,337,597 (GRCm39) |
|
probably null |
Het |
| Ankrd35 |
T |
A |
3: 96,590,989 (GRCm39) |
L425Q |
possibly damaging |
Het |
| Arhgap40 |
A |
G |
2: 158,385,326 (GRCm39) |
T520A |
possibly damaging |
Het |
| Arhgef28 |
T |
A |
13: 98,066,062 (GRCm39) |
D1597V |
possibly damaging |
Het |
| Aspm |
A |
G |
1: 139,399,472 (GRCm39) |
D1079G |
probably benign |
Het |
| Atp1a2 |
A |
T |
1: 172,119,009 (GRCm39) |
|
probably benign |
Het |
| Cage1 |
C |
A |
13: 38,207,406 (GRCm39) |
E252D |
possibly damaging |
Het |
| Ccdc185 |
A |
G |
1: 182,576,582 (GRCm39) |
S36P |
possibly damaging |
Het |
| Cd300a |
T |
C |
11: 114,784,247 (GRCm39) |
V85A |
probably damaging |
Het |
| Cd38 |
A |
C |
5: 44,064,887 (GRCm39) |
D235A |
possibly damaging |
Het |
| Cdcp1 |
T |
C |
9: 123,009,088 (GRCm39) |
K530R |
probably benign |
Het |
| Ceacam20 |
T |
A |
7: 19,705,651 (GRCm39) |
L214Q |
probably damaging |
Het |
| Cntn4 |
G |
A |
6: 106,502,379 (GRCm39) |
A379T |
probably benign |
Het |
| Col4a2 |
A |
T |
8: 11,479,505 (GRCm39) |
E796V |
probably benign |
Het |
| Cpa5 |
A |
G |
6: 30,631,363 (GRCm39) |
T426A |
possibly damaging |
Het |
| Csmd1 |
A |
G |
8: 16,249,931 (GRCm39) |
F1016L |
probably damaging |
Het |
| Cyb5r3 |
A |
T |
15: 83,042,822 (GRCm39) |
L290* |
probably null |
Het |
| Ddx42 |
A |
G |
11: 106,133,766 (GRCm39) |
T581A |
probably damaging |
Het |
| Deaf1 |
C |
T |
7: 140,902,381 (GRCm39) |
G221S |
probably damaging |
Het |
| Dnah6 |
A |
G |
6: 73,165,366 (GRCm39) |
S580P |
probably benign |
Het |
| Dock1 |
A |
G |
7: 134,754,017 (GRCm39) |
E1598G |
probably benign |
Het |
| Drg2 |
T |
C |
11: 60,350,262 (GRCm39) |
|
probably benign |
Het |
| Eif3f |
C |
A |
7: 108,533,847 (GRCm39) |
|
probably benign |
Het |
| Fam184a |
G |
T |
10: 53,574,901 (GRCm39) |
T236K |
probably benign |
Het |
| Gas7 |
C |
T |
11: 67,550,876 (GRCm39) |
T126M |
possibly damaging |
Het |
| Gckr |
T |
G |
5: 31,465,608 (GRCm39) |
F408C |
probably damaging |
Het |
| Gm17472 |
A |
G |
6: 42,958,004 (GRCm39) |
D91G |
probably damaging |
Het |
| Gm5117 |
G |
A |
8: 32,228,608 (GRCm39) |
|
noncoding transcript |
Het |
| Gsto1 |
T |
A |
19: 47,843,759 (GRCm39) |
I47N |
probably damaging |
Het |
| Hck |
C |
T |
2: 152,976,597 (GRCm39) |
P244S |
probably damaging |
Het |
| Hif3a |
T |
C |
7: 16,784,490 (GRCm39) |
T250A |
probably damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,752,111 (GRCm39) |
|
probably benign |
Het |
| Impa1 |
G |
A |
3: 10,380,340 (GRCm39) |
S247F |
probably damaging |
Het |
| Ints14 |
G |
C |
9: 64,889,340 (GRCm39) |
R397P |
probably damaging |
Het |
| Iqgap1 |
T |
C |
7: 80,373,524 (GRCm39) |
|
probably null |
Het |
| Krt1c |
T |
C |
15: 101,722,377 (GRCm39) |
K436R |
probably damaging |
Het |
| Lama3 |
G |
A |
18: 12,581,362 (GRCm39) |
C607Y |
probably damaging |
Het |
| Loxl4 |
G |
T |
19: 42,599,133 (GRCm39) |
|
probably benign |
Het |
| Lrrc8d |
C |
T |
5: 105,961,234 (GRCm39) |
T548M |
probably damaging |
Het |
| Man1b1 |
T |
A |
2: 25,228,196 (GRCm39) |
D155E |
probably damaging |
Het |
| Mapk8ip2 |
C |
T |
15: 89,341,431 (GRCm39) |
P214L |
probably benign |
Het |
| Mast1 |
G |
A |
8: 85,645,357 (GRCm39) |
T696I |
probably damaging |
Het |
| Muc15 |
C |
T |
2: 110,561,617 (GRCm39) |
P18S |
probably damaging |
Het |
| Mybl2 |
T |
C |
2: 162,922,716 (GRCm39) |
S205P |
probably damaging |
Het |
| Mylk |
T |
C |
16: 34,809,331 (GRCm39) |
S1763P |
probably damaging |
Het |
| Nek10 |
T |
A |
14: 14,860,986 (GRCm38) |
L513M |
possibly damaging |
Het |
| Nfib |
A |
G |
4: 82,271,808 (GRCm39) |
M252T |
probably benign |
Het |
| Nid2 |
C |
A |
14: 19,828,146 (GRCm39) |
Y261* |
probably null |
Het |
| Nmd3 |
C |
T |
3: 69,638,970 (GRCm39) |
R187C |
possibly damaging |
Het |
| Nomo1 |
G |
T |
7: 45,700,155 (GRCm39) |
|
probably benign |
Het |
| Npy4r |
A |
G |
14: 33,868,437 (GRCm39) |
F284L |
probably damaging |
Het |
| Nt5dc2 |
T |
C |
14: 30,860,878 (GRCm39) |
V351A |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or5b121 |
T |
A |
19: 13,507,178 (GRCm39) |
L91Q |
probably null |
Het |
| Or5g27 |
T |
A |
2: 85,410,069 (GRCm39) |
L162* |
probably null |
Het |
| Pcdhb12 |
T |
A |
18: 37,569,209 (GRCm39) |
D118E |
probably damaging |
Het |
| Pdcd11 |
C |
T |
19: 47,116,404 (GRCm39) |
T1518I |
probably benign |
Het |
| Pde6a |
T |
A |
18: 61,364,434 (GRCm39) |
C163* |
probably null |
Het |
| Pign |
A |
T |
1: 105,572,227 (GRCm39) |
W314R |
probably benign |
Het |
| Pip5k1b |
T |
A |
19: 24,367,799 (GRCm39) |
H76L |
probably damaging |
Het |
| Plcz1 |
T |
C |
6: 139,974,277 (GRCm39) |
N55S |
possibly damaging |
Het |
| Pou5f1 |
A |
T |
17: 35,821,438 (GRCm39) |
H350L |
possibly damaging |
Het |
| Rchy1 |
A |
T |
5: 92,110,487 (GRCm39) |
|
probably null |
Het |
| Ric8b |
A |
G |
10: 84,793,946 (GRCm39) |
T270A |
possibly damaging |
Het |
| Rprml |
A |
G |
11: 103,540,644 (GRCm39) |
E13G |
probably benign |
Het |
| Secisbp2 |
T |
A |
13: 51,836,063 (GRCm39) |
I719N |
probably damaging |
Het |
| Sergef |
C |
T |
7: 46,283,259 (GRCm39) |
R148H |
probably benign |
Het |
| Serpina6 |
T |
A |
12: 103,618,221 (GRCm39) |
|
probably null |
Het |
| Sirpb1b |
C |
A |
3: 15,613,887 (GRCm39) |
W65L |
probably damaging |
Het |
| Slc32a1 |
A |
T |
2: 158,455,977 (GRCm39) |
I211F |
possibly damaging |
Het |
| Slc5a9 |
C |
A |
4: 111,748,941 (GRCm39) |
|
probably null |
Het |
| Smarce1 |
A |
G |
11: 99,105,977 (GRCm39) |
V226A |
probably benign |
Het |
| Spata31d1b |
A |
T |
13: 59,864,097 (GRCm39) |
E415V |
probably damaging |
Het |
| Speg |
G |
A |
1: 75,400,508 (GRCm39) |
R2556H |
possibly damaging |
Het |
| Suclg2 |
A |
C |
6: 95,543,417 (GRCm39) |
V338G |
probably damaging |
Het |
| Tarbp1 |
T |
C |
8: 127,174,184 (GRCm39) |
E874G |
possibly damaging |
Het |
| Tex14 |
G |
T |
11: 87,427,727 (GRCm39) |
|
probably null |
Het |
| Trim36 |
T |
A |
18: 46,329,245 (GRCm39) |
D53V |
possibly damaging |
Het |
| Tsga10ip |
T |
A |
19: 5,444,368 (GRCm39) |
Y21F |
possibly damaging |
Het |
| Ttn |
C |
T |
2: 76,620,289 (GRCm39) |
V15849M |
probably damaging |
Het |
| Ube3b |
T |
C |
5: 114,539,471 (GRCm39) |
S421P |
probably benign |
Het |
| Unc5a |
A |
T |
13: 55,147,683 (GRCm39) |
M498L |
probably benign |
Het |
| Vipr2 |
A |
G |
12: 116,107,876 (GRCm39) |
I420M |
probably benign |
Het |
| Vmn1r179 |
T |
A |
7: 23,628,515 (GRCm39) |
H235Q |
probably damaging |
Het |
| Vps35 |
T |
A |
8: 86,008,475 (GRCm39) |
I267F |
probably damaging |
Het |
| Wdr26 |
G |
A |
1: 181,025,216 (GRCm39) |
R279W |
probably damaging |
Het |
| Xpo6 |
C |
A |
7: 125,768,443 (GRCm39) |
R88L |
probably damaging |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp105 |
T |
A |
9: 122,758,880 (GRCm39) |
S184T |
probably benign |
Het |
| Zfp574 |
G |
A |
7: 24,780,388 (GRCm39) |
R470H |
probably damaging |
Het |
| Zswim9 |
T |
A |
7: 13,003,484 (GRCm39) |
H122L |
probably damaging |
Het |
|
| Other mutations in Copa |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00848:Copa
|
APN |
1 |
171,938,255 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01360:Copa
|
APN |
1 |
171,915,155 (GRCm39) |
splice site |
probably null |
|
|
IGL01434:Copa
|
APN |
1 |
171,947,128 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01744:Copa
|
APN |
1 |
171,940,756 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01837:Copa
|
APN |
1 |
171,946,419 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01988:Copa
|
APN |
1 |
171,945,831 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02059:Copa
|
APN |
1 |
171,927,320 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02123:Copa
|
APN |
1 |
171,939,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02731:Copa
|
APN |
1 |
171,929,785 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL03114:Copa
|
APN |
1 |
171,946,835 (GRCm39) |
nonsense |
probably null |
|
|
P0027:Copa
|
UTSW |
1 |
171,939,515 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
PIT4434001:Copa
|
UTSW |
1 |
171,933,742 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0233:Copa
|
UTSW |
1 |
171,915,234 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0465:Copa
|
UTSW |
1 |
171,945,872 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Copa
|
UTSW |
1 |
171,949,254 (GRCm39) |
splice site |
probably benign |
|
|
R0568:Copa
|
UTSW |
1 |
171,939,704 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0628:Copa
|
UTSW |
1 |
171,918,592 (GRCm39) |
splice site |
probably benign |
|
|
R1328:Copa
|
UTSW |
1 |
171,949,258 (GRCm39) |
splice site |
probably benign |
|
|
R1494:Copa
|
UTSW |
1 |
171,931,694 (GRCm39) |
missense |
probably benign |
0.27 |
|
R1728:Copa
|
UTSW |
1 |
171,939,554 (GRCm39) |
missense |
probably benign |
|
|
R1758:Copa
|
UTSW |
1 |
171,931,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1784:Copa
|
UTSW |
1 |
171,939,554 (GRCm39) |
missense |
probably benign |
|
|
R1942:Copa
|
UTSW |
1 |
171,939,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2054:Copa
|
UTSW |
1 |
171,946,524 (GRCm39) |
nonsense |
probably null |
|
|
R2299:Copa
|
UTSW |
1 |
171,949,292 (GRCm39) |
missense |
probably benign |
0.10 |
|
R2518:Copa
|
UTSW |
1 |
171,947,468 (GRCm39) |
missense |
probably benign |
|
|
R2680:Copa
|
UTSW |
1 |
171,948,971 (GRCm39) |
nonsense |
probably null |
|
|
R3080:Copa
|
UTSW |
1 |
171,940,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3160:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3161:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Copa
|
UTSW |
1 |
171,918,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3973:Copa
|
UTSW |
1 |
171,948,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3975:Copa
|
UTSW |
1 |
171,948,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4031:Copa
|
UTSW |
1 |
171,935,942 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4155:Copa
|
UTSW |
1 |
171,928,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4227:Copa
|
UTSW |
1 |
171,945,682 (GRCm39) |
intron |
probably benign |
|
|
R4244:Copa
|
UTSW |
1 |
171,938,285 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4254:Copa
|
UTSW |
1 |
171,929,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4291:Copa
|
UTSW |
1 |
171,919,964 (GRCm39) |
intron |
probably benign |
|
|
R4323:Copa
|
UTSW |
1 |
171,946,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4402:Copa
|
UTSW |
1 |
171,929,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4711:Copa
|
UTSW |
1 |
171,947,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4721:Copa
|
UTSW |
1 |
171,931,841 (GRCm39) |
splice site |
probably benign |
|
|
R4773:Copa
|
UTSW |
1 |
171,932,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4794:Copa
|
UTSW |
1 |
171,946,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4887:Copa
|
UTSW |
1 |
171,919,843 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5139:Copa
|
UTSW |
1 |
171,948,896 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5152:Copa
|
UTSW |
1 |
171,945,628 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5297:Copa
|
UTSW |
1 |
171,940,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5586:Copa
|
UTSW |
1 |
171,932,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5698:Copa
|
UTSW |
1 |
171,946,511 (GRCm39) |
nonsense |
probably null |
|
|
R6283:Copa
|
UTSW |
1 |
171,946,415 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6921:Copa
|
UTSW |
1 |
171,939,491 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R6934:Copa
|
UTSW |
1 |
171,938,253 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R7009:Copa
|
UTSW |
1 |
171,918,567 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7194:Copa
|
UTSW |
1 |
171,947,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7348:Copa
|
UTSW |
1 |
171,929,790 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7710:Copa
|
UTSW |
1 |
171,937,411 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R7745:Copa
|
UTSW |
1 |
171,939,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7893:Copa
|
UTSW |
1 |
171,947,132 (GRCm39) |
nonsense |
probably null |
|
|
R8168:Copa
|
UTSW |
1 |
171,927,239 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8273:Copa
|
UTSW |
1 |
171,946,546 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8704:Copa
|
UTSW |
1 |
171,931,693 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8754:Copa
|
UTSW |
1 |
171,935,926 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8757:Copa
|
UTSW |
1 |
171,947,081 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8759:Copa
|
UTSW |
1 |
171,947,081 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8885:Copa
|
UTSW |
1 |
171,925,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8891:Copa
|
UTSW |
1 |
171,946,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8927:Copa
|
UTSW |
1 |
171,931,737 (GRCm39) |
missense |
probably null |
0.03 |
|
R8928:Copa
|
UTSW |
1 |
171,931,737 (GRCm39) |
missense |
probably null |
0.03 |
|
R8956:Copa
|
UTSW |
1 |
171,937,480 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R9063:Copa
|
UTSW |
1 |
171,944,529 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9295:Copa
|
UTSW |
1 |
171,939,823 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9364:Copa
|
UTSW |
1 |
171,944,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9437:Copa
|
UTSW |
1 |
171,931,712 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9673:Copa
|
UTSW |
1 |
171,945,648 (GRCm39) |
missense |
probably benign |
0.11 |
|
T0722:Copa
|
UTSW |
1 |
171,939,515 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1177:Copa
|
UTSW |
1 |
171,933,690 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCGTAGCCATCTTGCCTC -3'
(R):5'- ATACGAAGCAGCACGGACTG -3'
Sequencing Primer
(F):5'- AAGCCTCAGGTCCCTTCCAG -3'
(R):5'- GCACGGACTGCAGACTACTC -3'
|
| Posted On |
2016-04-27 |
Incidental Mutation