Mutagenetix > Incidental Mutation

Incidental Mutation 'R4954:Oog2'

381472

Institutional Source

Beutler Lab

Gene Symbol

Oog2

Ensembl Gene

ENSMUSG00000066030

Gene Name

oogenesin 2

Synonyms

MMRRC Submission

042551-MU

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4954 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

144190719-144196934 bp(+) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

A to T at 144190732 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000115150 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000080405] [ENSMUST00000143978]

AlphaFold

Q7TPX8

Predicted Effect

probably benign
Transcript: ENSMUST00000080405

SMART Domains

Protein: ENSMUSP00000079267
Gene: ENSMUSG00000066030

Domain	Start	End	E-Value	Type
SCOP:d1a4ya_	204	391	2e-7	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129781

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141847

Predicted Effect

probably benign
Transcript: ENSMUST00000143978

Coding Region Coverage

1x: 99.2%
3x: 98.4%
10x: 96.7%
20x: 93.7%

Validation Efficiency

100% (66/66)

Allele List at MGI

Other mutations in this stock

Total: 55 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb5	G	A	12: 118,911,434	H668Y	probably benign	Het
AI464131	G	A	4: 41,498,241	A463V	possibly damaging	Het
Alk	C	T	17: 71,902,692	W919*	probably null	Het
Aoc3	G	A	11: 101,332,099	G387D	probably damaging	Het
Arhgap26	T	A	18: 39,243,641	C441S	probably benign	Het
Arhgap28	C	A	17: 67,869,013	E100*	probably null	Het
Ate1	C	T	7: 130,509,018	G186D	probably benign	Het
Birc6	T	A	17: 74,612,031	L1948H	probably damaging	Het
Bmp2k	C	T	5: 97,086,764		probably benign	Het
Ccin	A	T	4: 43,985,077	I495F	probably benign	Het
Cir1	T	A	2: 73,310,504	E40D	probably benign	Het
Cyp3a57	A	T	5: 145,370,955		probably null	Het
Dennd1b	A	G	1: 139,053,386	T113A	probably damaging	Het
Dnah2	G	A	11: 69,539,496	P79S	possibly damaging	Het
Dync1h1	C	A	12: 110,658,126	T3700N	probably damaging	Het
Enpep	A	T	3: 129,284,180	I596N	probably damaging	Het
Eps15	G	A	4: 109,370,678		probably null	Het
Ext1	T	C	15: 53,344,492	D291G	probably damaging	Het
Gm12883	T	C	4: 121,395,001		noncoding transcript	Het
Gm7257	A	T	9: 36,432,860	K46N	probably benign	Het
Gm9921	A	G	12: 45,437,600		noncoding transcript	Het
H2-T22	C	A	17: 36,041,959	W85C	probably damaging	Het
Heatr1	G	A	13: 12,407,516		probably null	Het
Hspa4l	T	A	3: 40,785,400		probably null	Het
Kcnc3	CTT	CT	7: 44,591,296		probably null	Het
Kpna1	T	C	16: 36,033,326	V442A	probably damaging	Het
Mogat2	T	C	7: 99,238,517	T17A	possibly damaging	Het
Musk	C	T	4: 58,344,222	T285I	probably damaging	Het
Nbea	T	G	3: 56,035,958	Q632P	probably damaging	Het
Ncoa3	T	C	2: 166,065,786	V1105A	probably benign	Het
Neb	T	C	2: 52,177,518		probably null	Het
Nlrp4e	A	T	7: 23,361,893	K970*	probably null	Het
Olfr309	T	C	7: 86,306,601	I171V	probably benign	Het
Olfr47	A	G	6: 43,236,384	M259V	probably benign	Het
Olfr628	A	G	7: 103,732,207	I94V	probably damaging	Het
Otos	T	C	1: 92,644,445	Y53C	probably damaging	Het
Oxct2a	A	T	4: 123,322,459	C376*	probably null	Het
Phf14	C	A	6: 11,987,620	Q633K	probably benign	Het
Pkdrej	T	A	15: 85,816,401	N1778I	probably damaging	Het
Psmc3	C	T	2: 91,055,629		probably benign	Het
Rbm33	A	T	5: 28,339,276	I177F	probably damaging	Het
Rps6ka2	A	G	17: 7,271,604	D307G	probably benign	Het
Rps6ka2	G	A	17: 7,299,286	V648I	probably benign	Het
Scn11a	C	T	9: 119,758,659	V1340M	possibly damaging	Het
Sema7a	T	C	9: 57,956,380	W279R	probably damaging	Het
Slc2a10	A	T	2: 165,514,755	I112F	probably damaging	Het
Stk4	C	A	2: 164,151,681	S77R	possibly damaging	Het
Stk4	T	A	2: 164,151,682	W78R	probably damaging	Het
Syf2	T	A	4: 134,934,972	L99*	probably null	Het
Tas2r104	A	T	6: 131,685,005	I247K	probably damaging	Het
Usp15	G	T	10: 123,131,398	R368S	probably damaging	Het
Usp5	C	G	6: 124,822,630	K318N	possibly damaging	Het
Vmn2r2	T	A	3: 64,140,484	L20F	probably benign	Het
Wdr60	T	C	12: 116,256,025	D99G	probably damaging	Het
Zcchc4	A	T	5: 52,819,217	H451L	probably damaging	Het

Other mutations in Oog2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00843:Oog2	APN	4	144195172	missense	probably damaging	1.00
IGL01317:Oog2	APN	4	144195267	missense	probably benign	0.16
IGL01697:Oog2	APN	4	144195184	missense	possibly damaging	0.90
IGL02237:Oog2	APN	4	144196446	missense	possibly damaging	0.95
IGL02411:Oog2	APN	4	144195048	missense	probably damaging	0.99
IGL02476:Oog2	APN	4	144195229	missense	probably benign	0.02
IGL03284:Oog2	APN	4	144196607	unclassified	probably benign
IGL03394:Oog2	APN	4	144194006	missense	probably benign	0.17
R0538:Oog2	UTSW	4	144196084	nonsense	probably null
R0892:Oog2	UTSW	4	144196499	missense	probably benign	0.00
R1024:Oog2	UTSW	4	144196286	missense	probably damaging	1.00
R4156:Oog2	UTSW	4	144193953	intron	probably benign
R4157:Oog2	UTSW	4	144193953	intron	probably benign
R4166:Oog2	UTSW	4	144194841	missense	probably damaging	1.00
R4167:Oog2	UTSW	4	144196212	missense	probably benign	0.18
R4732:Oog2	UTSW	4	144193941	intron	probably benign
R4734:Oog2	UTSW	4	144196451	missense	probably benign	0.00
R4741:Oog2	UTSW	4	144195145	missense	possibly damaging	0.94
R4909:Oog2	UTSW	4	144195099	missense	possibly damaging	0.78
R6437:Oog2	UTSW	4	144195108	splice site	probably null
R6487:Oog2	UTSW	4	144196485	missense	possibly damaging	0.48
R6946:Oog2	UTSW	4	144196464	missense	possibly damaging	0.95
R7000:Oog2	UTSW	4	144195327	missense	probably damaging	1.00
R7167:Oog2	UTSW	4	144195175	missense	probably benign	0.04
R7303:Oog2	UTSW	4	144195342	missense	probably benign	0.04
R7399:Oog2	UTSW	4	144195281	missense	probably benign	0.01
R8004:Oog2	UTSW	4	144194251	missense	probably benign	0.00
R8141:Oog2	UTSW	4	144194207	missense	probably damaging	0.97
R8411:Oog2	UTSW	4	144194173	missense	probably damaging	1.00
R8932:Oog2	UTSW	4	144194115	missense	probably benign	0.00
R9290:Oog2	UTSW	4	144196445	missense	probably benign	0.02
R9348:Oog2	UTSW	4	144195219	missense	probably damaging	1.00
R9614:Oog2	UTSW	4	144196137	missense	probably damaging	1.00
RF009:Oog2	UTSW	4	144195285	missense	probably benign	0.36
Z1177:Oog2	UTSW	4	144194015	missense	probably damaging	0.99

Predicted Primers

PCR Primer
(F):5'- CTGCCTGGCCTAAGAATCTTCC -3'
(R):5'- TCAGGCAAACTTTCTTAGAGGG -3'

Sequencing Primer
(F):5'- GGCCTAAGAATCTTCCTCTGTATGG -3'
(R):5'- GCTAGACTAGGTTGTGTGAG -3'

Posted On

2016-04-27