Incidental Mutation 'R4956:Dcaf6'
ID 381560
Institutional Source Beutler Lab
Gene Symbol Dcaf6
Ensembl Gene ENSMUSG00000026571
Gene Name DDB1 and CUL4 associated factor 6
Synonyms NRIP, Iqwd1, 1200006M05Rik, PC326
MMRRC Submission 042553-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4956 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 165157069-165288475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 165216354 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 416 (D416E)
Ref Sequence ENSEMBL: ENSMUSP00000027856 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027856]
AlphaFold Q9DC22
Predicted Effect probably benign
Transcript: ENSMUST00000027856
AA Change: D416E

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000027856
Gene: ENSMUSG00000026571
AA Change: D416E

DomainStartEndE-ValueType
WD40 40 79 5.77e-5 SMART
WD40 82 124 1.2e-2 SMART
WD40 130 170 2.15e-1 SMART
WD40 184 220 3.33e-1 SMART
WD40 238 281 6.66e-1 SMART
low complexity region 364 374 N/A INTRINSIC
low complexity region 499 510 N/A INTRINSIC
low complexity region 669 676 N/A INTRINSIC
IQ 691 713 1.25e1 SMART
WD40 722 763 3.84e0 SMART
WD40 766 805 1.22e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000194869
Predicted Effect probably benign
Transcript: ENSMUST00000195220
Predicted Effect noncoding transcript
Transcript: ENSMUST00000195686
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.0%
  • 3x: 98.2%
  • 10x: 95.9%
  • 20x: 91.1%
Validation Efficiency 96% (70/73)
Allele List at MGI

All alleles(2) : Gene trapped(2)

Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3110009E18Rik G C 1: 120,096,840 (GRCm39) probably benign Het
3110009E18Rik C T 1: 120,096,850 (GRCm39) probably benign Het
3110009E18Rik G T 1: 120,096,849 (GRCm39) probably benign Het
4930562C15Rik A G 16: 4,672,816 (GRCm39) K866E probably damaging Het
Afap1l2 T C 19: 56,931,879 (GRCm39) M49V probably benign Het
Atf7ip C T 6: 136,583,808 (GRCm39) R1280C probably damaging Het
Atp2a2 A G 5: 122,599,643 (GRCm39) F583L probably benign Het
Atxn7l3b A G 10: 112,764,501 (GRCm39) C43R probably damaging Het
Axin2 T C 11: 108,833,904 (GRCm39) V617A probably damaging Het
Bltp3a T A 17: 28,108,958 (GRCm39) probably null Het
Brd1 A T 15: 88,614,316 (GRCm39) F193Y probably damaging Het
Cdc27 T C 11: 104,420,221 (GRCm39) S141G probably damaging Het
Chst9 A T 18: 15,851,045 (GRCm39) F7Y probably damaging Het
Cpn2 T A 16: 30,079,233 (GRCm39) Q156L possibly damaging Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Eif2s3y A G Y: 1,023,407 (GRCm39) T430A possibly damaging Het
Enah G A 1: 181,745,854 (GRCm39) T401I probably damaging Het
Esp38 T G 17: 40,266,053 (GRCm39) I54R probably damaging Het
Ffar4 C T 19: 38,086,028 (GRCm39) R152W probably benign Het
Flvcr1 A G 1: 190,758,383 (GRCm39) probably benign Het
Fzd9 G A 5: 135,278,796 (GRCm39) A363V probably damaging Het
Gadl1 T A 9: 115,869,987 (GRCm39) I451N probably benign Het
Hmg20a A G 9: 56,388,948 (GRCm39) T172A probably damaging Het
Ints1 G A 5: 139,742,885 (GRCm39) T1695M probably damaging Het
Ipo13 G A 4: 117,758,768 (GRCm39) A699V probably benign Het
Ipo9 A G 1: 135,331,960 (GRCm39) probably null Het
Klra17 A G 6: 129,850,279 (GRCm39) L57P probably damaging Het
Map3k8 A C 18: 4,339,530 (GRCm39) D280E probably benign Het
Mycbp2 A G 14: 103,524,675 (GRCm39) F662L probably damaging Het
Ncor1 T A 11: 62,231,431 (GRCm39) H792L probably damaging Het
Nlrx1 T A 9: 44,173,909 (GRCm39) K431* probably null Het
Nos1 A G 5: 118,085,575 (GRCm39) N1301S probably benign Het
Obp2b A G 2: 25,627,087 (GRCm39) T7A probably damaging Het
Odc1 T C 12: 17,597,958 (GRCm39) I95T probably damaging Het
Or2t43 A G 11: 58,457,344 (GRCm39) Y276H probably damaging Het
Or4c127 G A 2: 89,833,187 (GRCm39) V146M probably benign Het
Or5b97 C T 19: 12,878,963 (GRCm39) M60I probably damaging Het
Or6ae1 A G 7: 139,741,993 (GRCm39) I290T possibly damaging Het
Or6c1 A T 10: 129,517,968 (GRCm39) F213L probably benign Het
Pcif1 A T 2: 164,731,610 (GRCm39) Q521L probably damaging Het
Plekhg2 A C 7: 28,067,780 (GRCm39) L223R probably damaging Het
Plod3 A G 5: 137,018,772 (GRCm39) N270D probably damaging Het
Ppp1r37 A T 7: 19,266,636 (GRCm39) L417* probably null Het
Psmd6 C T 14: 14,116,166 (GRCm38) V141I probably benign Het
Rcn1 A T 2: 105,225,121 (GRCm39) Y111* probably null Het
Rell2 G A 18: 38,090,758 (GRCm39) R145H probably damaging Het
Scaper T C 9: 55,745,426 (GRCm39) K614R probably damaging Het
Scart2 A G 7: 139,878,275 (GRCm39) I1001V probably benign Het
Shbg C T 11: 69,508,045 (GRCm39) E107K probably damaging Het
Slc30a3 G A 5: 31,244,247 (GRCm39) P345L possibly damaging Het
Tchp A C 5: 114,857,681 (GRCm39) E391D probably damaging Het
Timeless A G 10: 128,077,520 (GRCm39) D200G probably damaging Het
Tspear A G 10: 77,700,601 (GRCm39) T144A possibly damaging Het
Usp5 C G 6: 124,799,593 (GRCm39) K318N possibly damaging Het
Vgll3 T C 16: 65,624,820 (GRCm39) V56A possibly damaging Het
Vmn2r71 C T 7: 85,268,436 (GRCm39) T213I probably benign Het
Wtap T C 17: 13,186,423 (GRCm39) T375A probably benign Het
Yipf2 T G 9: 21,503,204 (GRCm39) T88P probably damaging Het
Zfp382 T A 7: 29,830,979 (GRCm39) D89E probably benign Het
Zfp955b C T 17: 33,524,209 (GRCm39) probably benign Het
Zpr1 C T 9: 46,185,961 (GRCm39) T144I probably damaging Het
Other mutations in Dcaf6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00828:Dcaf6 APN 1 165,165,916 (GRCm39) splice site probably benign
IGL01377:Dcaf6 APN 1 165,216,293 (GRCm39) missense probably benign 0.01
IGL02027:Dcaf6 APN 1 165,251,910 (GRCm39) missense probably damaging 1.00
IGL02390:Dcaf6 APN 1 165,250,490 (GRCm39) missense possibly damaging 0.50
IGL02754:Dcaf6 APN 1 165,165,915 (GRCm39) critical splice acceptor site probably null
IGL02900:Dcaf6 APN 1 165,227,344 (GRCm39) missense probably damaging 1.00
IGL03119:Dcaf6 APN 1 165,167,545 (GRCm39) missense probably damaging 1.00
IGL03211:Dcaf6 APN 1 165,250,502 (GRCm39) missense possibly damaging 0.55
R0588:Dcaf6 UTSW 1 165,247,792 (GRCm39) missense possibly damaging 0.89
R1494:Dcaf6 UTSW 1 165,160,942 (GRCm39) missense probably damaging 0.99
R1512:Dcaf6 UTSW 1 165,179,589 (GRCm39) missense probably benign 0.22
R1840:Dcaf6 UTSW 1 165,227,317 (GRCm39) missense probably damaging 0.96
R2191:Dcaf6 UTSW 1 165,250,433 (GRCm39) missense probably benign 0.07
R2297:Dcaf6 UTSW 1 165,227,431 (GRCm39) missense probably damaging 1.00
R3082:Dcaf6 UTSW 1 165,250,421 (GRCm39) splice site probably benign
R3861:Dcaf6 UTSW 1 165,256,838 (GRCm39) missense probably damaging 1.00
R3907:Dcaf6 UTSW 1 165,251,949 (GRCm39) nonsense probably null
R4521:Dcaf6 UTSW 1 165,218,059 (GRCm39) missense probably damaging 0.98
R4531:Dcaf6 UTSW 1 165,239,036 (GRCm39) missense probably damaging 1.00
R4906:Dcaf6 UTSW 1 165,239,032 (GRCm39) critical splice donor site probably null
R4916:Dcaf6 UTSW 1 165,247,774 (GRCm39) missense probably damaging 1.00
R5080:Dcaf6 UTSW 1 165,247,690 (GRCm39) missense probably damaging 1.00
R5091:Dcaf6 UTSW 1 165,157,572 (GRCm39) missense possibly damaging 0.76
R5277:Dcaf6 UTSW 1 165,251,915 (GRCm39) missense probably benign 0.09
R5512:Dcaf6 UTSW 1 165,227,404 (GRCm39) missense possibly damaging 0.84
R5914:Dcaf6 UTSW 1 165,178,724 (GRCm39) missense probably benign
R6004:Dcaf6 UTSW 1 165,216,254 (GRCm39) missense probably benign 0.00
R6239:Dcaf6 UTSW 1 165,178,839 (GRCm39) missense possibly damaging 0.47
R6736:Dcaf6 UTSW 1 165,227,354 (GRCm39) missense possibly damaging 0.77
R7051:Dcaf6 UTSW 1 165,251,886 (GRCm39) missense possibly damaging 0.82
R7110:Dcaf6 UTSW 1 165,179,537 (GRCm39) missense probably benign 0.22
R7583:Dcaf6 UTSW 1 165,160,879 (GRCm39) missense probably damaging 1.00
R7776:Dcaf6 UTSW 1 165,179,623 (GRCm39) nonsense probably null
R7790:Dcaf6 UTSW 1 165,227,284 (GRCm39) missense probably damaging 1.00
R8369:Dcaf6 UTSW 1 165,185,043 (GRCm39) missense probably damaging 1.00
R8411:Dcaf6 UTSW 1 165,216,244 (GRCm39) missense probably benign 0.03
R9061:Dcaf6 UTSW 1 165,164,332 (GRCm39) missense probably damaging 0.99
R9307:Dcaf6 UTSW 1 165,227,236 (GRCm39) missense possibly damaging 0.90
R9375:Dcaf6 UTSW 1 165,185,052 (GRCm39) missense probably damaging 1.00
R9626:Dcaf6 UTSW 1 165,227,264 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- GTTCCTCGGTGTTCAGAGATC -3'
(R):5'- CTAGGTTCATGTCACCAGATCAC -3'

Sequencing Primer
(F):5'- TCGGTGTTCAGAGATCAGCAC -3'
(R):5'- GTTCATGTCACCAGATCACTCACATG -3'
Posted On 2016-04-27