|Institutional Source||Beutler Lab|
|Gene Name||odorant binding protein 2B|
|Is this an essential gene?||Probably non essential (E-score: 0.064)|
|Stock #||R4956 (G1)|
|Chromosomal Location||25737009-25740097 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 25737075 bp|
|Amino Acid Change||Threonine to Alanine at position 7 (T7A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000109830 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000114192]|
|Predicted Effect||probably damaging
AA Change: T7A
PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
AA Change: T7A
|Meta Mutation Damage Score||0.6467|
|Coding Region Coverage||
|Validation Efficiency||96% (70/73)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small extracellular protein belonging to the lipocalin superfamily. The protein is thought to transport small, hydrophobic, volatile molecules or odorants through the nasal mucus to olfactory receptors, and may also function as a scavenger of highly concentrated or toxic odors. The protein is expressed as a monomer in the nasal mucus, and can bind diverse types of odorants with a higher affinity for aldehydes and fatty acids. This gene and a highly similar family member are located in a cluster of lipocalin genes on chromosome 9. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Obp2b||
(F):5'- AACAACCTTCAGCTCCATGATG -3'
(R):5'- ACCTGATCTGACCATTCCATGC -3'
(F):5'- CCATGATGGATGTGTGTTTGGCC -3'
(R):5'- ATCTGACCATTCCATGCTGGGG -3'