|Institutional Source||Beutler Lab|
|Gene Name||Y box protein 1|
|Synonyms||dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1|
|Essential gene?||Essential (E-score: 1.000)|
|Stock #||R4957 (G1)|
|Chromosomal Location||119277981-119294604 bp(-) (GRCm38)|
|Type of Mutation||utr 3 prime|
|DNA Base Change (assembly)||A to T at 119278938 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000117225 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000079644] [ENSMUST00000127737]|
|Coding Region Coverage||
|Validation Efficiency||99% (80/81)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015]
PHENOTYPE: Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Ybx1||
(F):5'- CTGTCTTCAGAGCACAGGAAG -3'
(R):5'- TCGCCAAAGACAGCCTAGAG -3'
(F):5'- CACAGGAAGTAAGACTTTGCTTAGC -3'
(R):5'- AGGTCAGCAGCCACCTC -3'